| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 5465 |
Name | PPARA |
Synonym | NR1C1|PPAR|PPARalpha|hPPAR;peroxisome proliferator-activated receptor alpha;PPARA;peroxisome proliferator-activated receptor alpha |
Definition | PPAR-alpha|nuclear receptor subfamily 1 group C member 1|peroxisome proliferative activated receptor, alpha|peroxisome proliferator-activated nuclear receptor alpha variant 3 |
Position | 22q13.31 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 13147 |
TUSON P-value | 1 |
|
Pathways and Diseases |
|
Pathway | Adipocytokine signaling pathway;KEGG PATHWAY;hsa04920 |
Pathway | basic mechanism of action of ppara pparb(d) and pparg and effects on gene expression;PID BioCarta;100064 |
Pathway | beta-arrestins in gpcr desensitization;PID BioCarta;100231 |
Pathway | mechanism of gene regulation by peroxisome proliferators via ppara;PID BioCarta;100066 |
Pathway | toll-like receptor pathway;PID BioCarta;100013 |
Pathway | Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha);PID Reactome;500817 |
Pathway | Metabolism of lipids and lipoproteins;Reactome;REACT:22258 |
Pathway | PPAR signaling pathway;KEGG PATHWAY;hsa03320 |
Pathway | Hepatitis C;KEGG PATHWAY;hsa05160 |
Pathway | regulation of pgc-1a;PID BioCarta;100075 |
Pathway | Gene Expression;Reactome;REACT:71 |
Disease | hyperlipidemia;GAD |
Disease | lower body mass index;GAD |
Disease | Alzheimer's disease;GAD |
Disease | cardiovascular;GAD |
Disease | physical performance;GAD |
Disease | cholesterol, total;GAD |
Disease | obesity;GAD |
Disease | triglycerides;GAD |
Disease | cardiac growth;GAD |
Disease | hypertension;GAD |
Disease | atherosclerosis, coronary;GAD |
Disease | coronary heart disease;GAD |
Disease | apolipoproteins;GAD |
Disease | Plasma Lipid Levels;GAD |
Disease | coronary atherosclerosis;GAD |
Disease | METABOLIC;GAD |
Disease | diabetes, type 2;GAD |
Disease | Hyperapobetalipoproteinemia, susceptibility to;OMIM |
Disease | Coronary Artery Disease;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | fatty acid;GAD |
Disease | NORMALVARIATION;GAD |
Disease | plasma total and LDL-apolipoprotein B;GAD |
Disease | cholesterol, LDL;GAD |
Disease | NEUROLOGICAL;GAD |
Disease | lipoprotein;GAD |
Disease | cholesterol;GAD |
Disease | Type II diabetic;GAD |
Disease | serum lipid levels;GAD |
Disease | lipoproteins;GAD |
Disease | muscle testing;GAD |
Disease | metabolic syndrome;GAD |
Disease | exercise;GAD |
|
External Links |
|
Links to Entrez Gene | 5465 |
Links to all GeneRIF Items | 5465 |
Links to iHOP | 5465 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>5465 : length: 1407 atggtggacacggaaagcccactctgccccctctccccactcgaggccggcgatctagag agcccgttatctgaagagttcctgcaagaaatgggaaacatccaagagatttcgcaatcc atcggcgaggatagttctggaagctttggctttacggaataccagtatttaggaagctgt cctggctcagatggctcggtcatcacggacacgctttcaccagcttcgagcccctcctcg gtgacttatcctgtggtccccggcagcgtggacgagtctcccagtggagcattgaacatc gaatgtagaatctgcggggacaaggcctcaggctatcattacggagtccacgcgtgtgaa ggctgcaagggcttctttcggcgaacgattcgactcaagctggtgtatgacaagtgcgac cgcagctgcaagatccagaaaaagaacagaaacaaatgccagtattgtcgatttcacaag tgcctttctgtcgggatgtcacacaacgcgattcgttttggacgaatgccaagatctgag aaagcaaaactgaaagcagaaattcttacctgtgaacatgacatagaagattctgaaact gcagatctcaaatctctggccaagagaatctacgaggcctacttgaagaacttcaacatg aacaaggtcaaagcccgggtcatcctctcaggaaaggccagtaacaatccaccttttgtc atacatgatatggagacactgtgtatggctgagaagacgctggtggccaagctggtggcc aatggcatccagaacaaggaggcggaggtccgcatctttcactgctgccagtgcacgtca gtggagaccgtcacggagctcacggaattcgccaaggccatcccaggcttcgcaaacttg gacctgaacgatcaagtgacattgctaaaatacggagtttatgaggccatattcgccatg ctgtcttctgtgatgaacaaagacgggatgctggtagcgtatggaaatgggtttataact cgtgaattcctaaaaagcctaaggaaaccgttctgtgatatcatggaacccaagtttgat tttgccatgaagttcaatgcactggaactggatgacagtgatatctccctttttgtggct gctatcatttgctgtggagatcgtcctggccttctaaacgtaggacacattgaaaaaatg caggagggtattgtacatgtgctcagactccacctgcagagcaaccacccggacgatatc tttctcttcccaaaacttcttcaaaaaatggcagacctccggcagctggtgacggagcat gcgcagctggtgcagatcatcaagaagacggagtcggatgctgcgctgcacccgctactg caggagatctacagggacatgtactga |
Protein Sequence |
>5465 : length: 468 MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY |