| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 5465 |
Name | PPARA |
Synonymous | NR1C1|PPAR|PPARalpha|hPPAR;peroxisome proliferator-activated receptor alpha;PPARA;peroxisome proliferator-activated receptor alpha |
Definition | PPAR-alpha|nuclear receptor subfamily 1 group C member 1|peroxisome proliferative activated receptor, alpha|peroxisome proliferator-activated nuclear receptor alpha variant 3 |
Position | 22q13.31 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
PPARalpha(h) + RXR(m) <==> PPARalpha(h):RXR(m) (binding) | PPARalpha(h) + DRIP205-isoform1(h) <==> PPARalpha(h):DRIP205-isoform1(h) (binding) | PPARalpha(h) + DRIP100(h) <==> PPARalpha(h):DRIP100(h) (binding) | SDP1(h) + PPARalpha(h) <==> SDP1(h):PPARalpha(h) (binding) | PPARalpha(h) + PGC-2(m) <==> PPARalpha(h):PGC-2(m) (binding) | PPARalpha(h) + stac3(h) <==> PPARalpha(h):stac3(h) (binding) | PPARalpha(h) --> PTGS2(h) (DNA binding). | PPARalpha(h) --> NR1I2(h) (DNA binding). | PPARalpha(h) --> TXN(h) (DNA binding). | PPARalpha(h) --> CD36(h) (DNA binding). | PPARalpha(h) --> ACOX1(h) (DNA binding). | PPARalpha(h) --> UGDH(h) (DNA binding). | PPARalpha(h) --> BRS3(h) (DNA binding). | RXR-gamma(h) + PPARalpha(h) <==> RXR-gamma(h):PPARalpha(h) (binding) | PPARalpha(h) + RelA-p65(h) <==> PPARalpha(h):RelA-p65(h) (binding) | PPARalpha(h) --> LTB4 (decrease of secretion) | PPARalpha(h) --> SLC22A5(h) (transactivation) | PPARA(h) --> PPARalpha(h) (expression). | Jagged1(h) --> PPARalpha(h) (increase of abundance) | PPARalpha(h) + Pit-1B(r) <==> PPARalpha(h):Pit-1B(r) (binding) | PPARalpha(h) + COPR1(h) <==> PPARalpha(h):COPR1(h) (binding) | PPARalpha(h) + COPR2(h) <==> PPARalpha(h):COPR2(h) (binding) | PPARalpha(h) + CAP350(h) <==> PPARalpha(h):CAP350(h) (binding) | PPARalpha(h) --> PPARalpha(h) (translocation) | PPARalpha(h) + LXR-alpha(h) <==> PPARalpha(h):LXR-alpha(h) (binding) | PPARalpha(h) + LXR-beta(h) <==> PPARalpha(h):LXR-beta(h) (binding) | PPARalpha(h) + ubiquitin(h) --> PPARalpha(h){ub} (ubiquitination) | phytanic acid + PPARalpha(h) <==> phytanic acid:PPARalpha(h) (binding) | 3S,7R,11R phytanic acid + PPARalpha(h) <==> 3S,7R,11R phytanic acid:PPARalpha(h) (binding) | 3R,7R,11R phytanic acid + PPARalpha(h) <==> 3R,7R,11R phytanic acid:PPARalpha(h) (binding) | palmitic acid + PPARalpha(h) <==> palmitic acid:PPARalpha(h) (binding) | cervonic acid + PPARalpha(h) <==> cervonic acid:PPARalpha(h) (binding) | PGA1 + PPARalpha(h) <==> PGA1:PPARalpha(h) (binding) | myristic acid + PPARalpha(h) <==> myristic acid:PPARalpha(h) (binding) | stearic acid + PPARalpha(h) <==> stearic acid:PPARalpha(h) (binding) | gamma-linolenic acid + PPARalpha(h) <==> gamma-linolenic acid:PPARalpha(h) (binding) | LDL(h){ox} + PPARalpha(h) <==> LDL(h){ox}:PPARalpha(h) (binding) | dihomo-gamma-linolenic acid + PPARalpha(h) <==> dihomo-gamma-linolenic acid:PPARalpha(h) (binding) | oxidized phospholipids + PPARalpha(h) <==> oxidized phospholipids:PPARalpha(h) (binding) | arachidonic acid + PPARalpha(h) <==> arachidonic acid:PPARalpha(h) (binding) | eicosapentaenoic acid + PPARalpha(h) <==> eicosapentaenoic acid:PPARalpha(h) (binding) | oxPAPC + PPARalpha(h) <==> oxPAPC:PPARalpha(h) (binding) | 9(S)-HODE + PPARalpha(h) <==> 9(S)-HODE:PPARalpha(h) (binding) | 13(S)-HODE + PPARalpha(h) <==> 13(S)-HODE:PPARalpha(h) (binding) | linoleic acid + PPARalpha(h) <==> linoleic acid:PPARalpha(h) (binding) | PGA2 + PPARalpha(h) <==> PGA2:PPARalpha(h) (binding) | PGD1 + PPARalpha(h) <==> PGD1:PPARalpha(h) (binding) | prostaglandin D2 + PPARalpha(h) <==> prostaglandin D2:PPARalpha(h) (binding) | PGJ2 + PPARalpha(h) <==> PGJ2:PPARalpha(h) (binding) | 8(S)-HETE + PPARalpha(h) <==> 8(S)-HETE:PPARalpha(h) (binding) | 8(R)-HETE + PPARalpha(h) <==> 8(R)-HETE:PPARalpha(h) (binding) | lauric acid + PPARalpha(h) <==> lauric acid:PPARalpha(h) (binding) | oleic acid + PPARalpha(h) <==> oleic acid:PPARalpha(h) (binding) | alpha-linolenic acid + PPARalpha(h) <==> alpha-linolenic acid:PPARalpha(h) (binding) | LTB4 + PPARalpha(h) <==> LTB4:PPARalpha(h) (binding) | 20,14,15-HEET + PPARalpha(h) <==> 20,14,15-HEET:PPARalpha(h) (binding) | 5,6-EET + PPARalpha(h) <==> 5,6-EET:PPARalpha(h) (binding) | 8,9-EET + PPARalpha(h) <==> 8,9-EET:PPARalpha(h) (binding) | 11,12-EET + PPARalpha(h) <==> 11,12-EET:PPARalpha(h) (binding) | 14,14-EET + PPARalpha(h) <==> 14,14-EET:PPARalpha(h) (binding) | 20-HETE + PPARalpha(h) <==> 20-HETE:PPARalpha(h) (binding) | 11,12-EEZE + PPARalpha(h) <==> 11,12-EEZE:PPARalpha(h) (binding) | 14,15-EET + PPARalpha(h) <==> 14,15-EET:PPARalpha(h) (binding) | 11,12-DHET + PPARalpha(h) <==> 11,12-DHET:PPARalpha(h) (binding) | 14,15-DHET + PPARalpha(h) <==> 14,15-DHET:PPARalpha(h) (binding) | nitrolinoleic acid + PPARalpha(h) <==> nitrolinoleic acid:PPARalpha(h) (binding) | palmitoylethanolamide + PPARalpha(h) <==> palmitoylethanolamide:PPARalpha(h) (binding) | farnesol + PPARalpha(h) <==> farnesol:PPARalpha(h) (binding) | geranylgeraniol + PPARalpha(h) <==> geranylgeraniol:PPARalpha(h) (binding) | geraniol + PPARalpha(h) <==> geraniol:PPARalpha(h) (binding) | nitrated oleic acid + PPARalpha(h) <==> nitrated oleic acid:PPARalpha(h) (binding) | 9Z,11E-CLA + PPARalpha(h) <==> 9Z,11E-CLA:PPARalpha(h) (binding) | 10E,12Z-CLA + PPARalpha(h) <==> 10E,12Z-CLA:PPARalpha(h) (binding) | 9E,11E-CLA + PPARalpha(h) <==> 9E,11E-CLA:PPARalpha(h) (binding) | furan-CLA + PPARalpha(h) <==> furan-CLA:PPARalpha(h) (binding) | phytol + PPARalpha(h) <==> phytol:PPARalpha(h) (binding) | oleylethanolamide + PPARalpha(h) <==> oleylethanolamide:PPARalpha(h) (binding) | PPARalpha(h) --> APOA2(h) (transactivation) | PPARalpha(h) --> CPT1A(h) (transactivation) | PPARalpha(h) --/ FGB(h) (transrepression) | PPARalpha(h) + 2 ATP --> PPARalpha(h){pS12}{pS21} + 2 ADP (phosphorylation) | PPARalpha(h) + ATP --> PPARalpha(h){p} + ADP (phosphorylation) | PPARalpha(h) --> TXN(h) (transactivation) | PPARalpha(h) --> CD36(h) (transactivation) | PPARalpha(h) --> LTB4 (decrease of secretion) | PPARalpha(h) --> 20-hydroxy-LTB4 (increase of secretion) | PPARalpha(h) + Ubc9(m.s.) <==> PPARalpha(h):Ubc9(m.s.) (binding) | PPARalpha(h) + sumo1(m.s.) --Ubc9(m.s.)--> PPARalpha(h){sumoK185} (sumoylation) | PPARalpha(h) + sumo1(m.s.) --> PPARalpha(h){sumoK185} (sumoylation) | PPARalpha(h) + sumo1(m.s.) --PIASy(m.s.)--> PPARalpha(h){sumoK185} (sumoylation) | NCOR1(m.s.) + PPARalpha(h) <==> NCOR1(m.s.):PPARalpha(h) (binding) | SMRT(m.s.) + PPARalpha(h) <==> SMRT(m.s.):PPARalpha(h) (binding) | NCOR1(h) + PPARalpha(h) <==> NCOR1(h):PPARalpha(h) (binding) | PPARA(h) --> PPARalpha(h) (expression). | PPARalpha(h) --> PPARalpha(h) (translocation) |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
|---|---|---|---|
Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr22 |
Promoter: 44923663 - 44925663 | Agilent_014791 |
chr22 |
Promoter: 44923663 - 44925663 | GSE27584 |
chr22 |
Promoter: 44923663 - 44925663 | GSE27584 |
chr22 |
Promoter: 44923663 - 44925663 | Agilent_014791_44K |
chr22 |
Promoter: 44923663 - 44925663 | Agilent_014791_44K |