| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 5563 |
Name | PRKAA2 |
Synonym | AMPK|AMPK2|AMPKa2|PRKAA;protein kinase, AMP-activated, alpha 2 catalytic subunit;PRKAA2;protein kinase, AMP-activated, alpha 2 catalytic subunit |
Definition | 5'-AMP-activated protein kinase catalytic subunit alpha-2|5'-AMP-activated protein kinase, catalytic alpha-2 chain|ACACA kinase|AMP-activated protein kinase alpha-2 subunit variant 2|AMP-activated protein kinase alpha-2 subunit variant 3|AMPK alpha 2|AMPK |
Position | 1p31 |
Gene Type | protein-coding |
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TSG scores |
Description |
| TUSON ranking | 13323 |
TUSON P-value | 1 |
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Pathways and Diseases |
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Pathway | Adipocytokine signaling pathway;KEGG PATHWAY;hsa04920 |
Pathway | Activated AMPK stimulates fatty-acid oxidation in muscle;PID Reactome;500601 |
Pathway | Insulin signaling pathway;KEGG PATHWAY;hsa04910 |
Pathway | Import of palmitoyl-CoA into the mitochondrial matrix;PID Reactome;500602 |
Pathway | AMPK inhibits chREBP transcriptional activation activity;PID Reactome;500719 |
Pathway | Signaling by Insulin receptor;Reactome;REACT:498 |
Pathway | Integration of energy metabolism;Reactome;REACT:1505 |
Pathway | p53 pathway by glucose deprivation;PANTHER;P04397 |
Pathway | Activated AMPK stimulates fatty-acid oxidation in muscle;Reactome;REACT:11163 |
Pathway | Hypertrophic cardiomyopathy (HCM);KEGG PATHWAY;hsa05410 |
Pathway | Regulation of autophagy;KEGG PATHWAY;hsa04140 |
Pathway | mTOR signaling pathway;KEGG PATHWAY;hsa04150 |
Pathway | Metabolism of lipids and lipoproteins;Reactome;REACT:22258 |
Disease | cholesterol cholesterol, HDL cholesterol, LDL;GAD |
Disease | diabetes, type 2 insulin;GAD |
Disease | METABOLIC;GAD |
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External Links |
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Links to Entrez Gene | 5563 |
Links to all GeneRIF Items | 5563 |
Links to iHOP | 5563 |
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Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>5563 : length: 1659 atggctgagaagcagaagcacgacgggcgggtgaagatcggacactacgtgctgggcgac acgctgggcgtcggcaccttcggcaaagtgaagattggagaacatcaattaacaggccat aaagtggcagttaaaatcttaaatagacagaagattcgcagtttagatgttgttggaaaa ataaaacgagaaattcaaaatctaaaactctttcgtcatcctcatattatcaaactatac caggtgatcagcactccaacagatttttttatggtaatggaatatgtgtctggaggtgaa ttatttgactacatctgtaagcatggacgggttgaagagatggaagccaggcggctcttt cagcagattctgtctgctgtggattactgtcataggcatatggttgttcatcgagacctg aaaccagagaatgtcctgttggatgcacacatgaatgccaagatagccgatttcggatta tctaatatgatgtcagatggtgaatttctgagaactagttgcggatctccaaattatgca gcacctgaagtcatctcaggcagattgtatgcaggtcctgaagttgatatctggagctgt ggtgttatcttgtatgctcttctttgtggcaccctcccatttgatgatgagcatgtacct acgttatttaagaagatccgagggggtgtcttttatatcccagaatatctcaatcgttct gtcgccactctcctgatgcatatgctgcaggttgacccactgaaacgagcaactatcaaa gacataagagagcatgaatggtttaaacaagatttgcccagttacttatttcctgaagac ccttcctatgatgctaacgtcattgatgatgaggctgtgaaagaagtgtgtgaaaaattt gaatgtacagaatcagaagtaatgaacagtttatatagtggtgaccctcaagaccagctt gcagtggcttatcatcttatcattgacaatcggagaataatgaaccaagccagtgagttc tacctcgcctctagtcctccatctggttcttttatggatgatagtgccatgcatattccc ccaggcctgaaacctcatccagaaaggatgccacctcttatagcagacagccccaaagca agatgtccattggatgcactgaatacgactaagcccaaatctttagctgtgaaaaaagcc aagtggcatcttggaatccgaagtcagagcaaaccgtatgacattatggctgaagtttac cgagctatgaagcagctggattttgaatggaaggtagtgaatgcataccatcttcgtgta agaagaaaaaatccagtgactggcaattacgtgaaaatgagcttacaactttacctggtt gataacaggagctatcttttggactttaaaagcattgatgatgaagtagtggagcagaga tctggttcctcaacacctcagcgttcctgttctgctgctggcttacacagaccaagatca agttttgattccacaactgcagagagccattcactttctggctctctcactggctctttg accggaagcacattgtcttcagtttcacctcgcctgggcagtcacaccatggattttttt gaaatgtgtgccagtctgattactactttagcccgttga |
Protein Sequence |
>5563 : length: 552 MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEMEARRLF QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPSGSFMDDSAMHIP PGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVY RAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQR SGSSTPQRSCSAAGLHRPRSSFDSTTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFF EMCASLITTLAR |