| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 58508 |
Name | KMT2C |
Synonym | HALR|MLL3;lysine (K)-specific methyltransferase 2C;KMT2C;lysine (K)-specific methyltransferase 2C |
Definition | ALR-like protein|histone-lysine N-methyltransferase 2C|histone-lysine N-methyltransferase MLL3|histone-lysine N-methyltransferase, H3 lysine-4 specific|homologous to ALR protein|myeloid/lymphoid or mixed-lineage leukemia protein 3 |
Position | 7q36.1 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 20 |
TUSON P-value | 1.99E-27 |
|
External Links |
|
Links to Entrez Gene | 58508 |
Links to all GeneRIF Items | 58508 |
Links to iHOP | 58508 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>58508 : length: 14736 atgtcgtcggaggaggacaagagcgtggagcagccgcagccgccgccaccaccccccgag gagcctggagccccggccccgagccccgcagccgcagacaaaagacctcggggccggcct cgcaaagatggcgcttcccctttccagagagccagaaagaaacctcgaagtagggggaaa actgcagtggaagatgaggacagcatggatgggctggagacaacagaaacagaaacgatt gtggaaacagaaatcaaagaacaatctgcagaagaggatgctgaagcagaagtggataac agcaaacagctaattccaactcttcagcgatctgtgtctgaggaatcggcaaactccctg gtctctgttggtgtagaagccaaaatcagtgaacagctctgcgctttttgttactgtggg gaaaaaagttccttaggacaaggagacttaaaacaattcagaataacgcctggatttatc ttgccatggagaaaccaaccttctaacaagaaggacattgatgacaacagcaatggaacc tatgagaaaatgcaaaactcagcaccacgaaaacaaagaggacagagaaaagaacgatct cctcagcagaatatagtatcttgtgtaagtgtaagcacccagacagcttcagatgatcaa gctggtaaactgtgggatgaactcagtctggttgggcttccagatgccattgatatccaa gccttatttgattctacaggcacttgttgggctcatcaccgttgtgtggagtggtcacta ggagtatgccagatggaagaaccattgttagtgaacgtggacaaagctgttgtctcaggg agcacagaacgatgtgcattttgtaagcaccttggagccactatcaaatgctgtgaagag aaatgtacccagatgtatcattatccttgtgctgcaggagccggcacctttcaggatttc agtcacatcttcctgctttgtccagaacacattgaccaagctcctgaaagatcgaaggaa gatgcaaactgtgcagtgtgcgacagcccgggagacctcttagatcagttcttttgtact acttgtggtcagcactatcatggaatgtgcctggatatagcggttactccattaaaacgt gcaggttggcaatgtcctgagtgcaaagtgtgccagaactgcaaacaatcgggagaagat agcaagatgctagtgtgtgatacgtgtgacaaagggtatcatactttttgtcttcaacca gttatgaaatcagtaccaaccaatggctggaaatgcaaaaattgcagaatatgtatagag tgtggcacacggtctagttctcagtggcaccacaattgcctgatatgtgacaattgttac caacagcaggataacttatgtcccttctgtgggaagtgttatcatccagaattgcagaaa gacatgcttcattgtaatatgtgcaaaaggtgggttcacctagagtgtgacaaaccaaca gatcatgaactggatactcagctcaaagaagagtatatctgcatgtattgtaaacacctg ggagctgagatggatcgtttacagccaggtgaggaagtggagatagctgagctcactaca gattataacaatgaaatggaagttgaaggccctgaagatcaaatggtattctcagagcag gcagctaataaagatgtcaacggtcaggagtccactcctggaattgttccagatgcggtt caagtccacactgaagagcaacagaagagtcatccctcagaaagtcttgacacagatagt cttcttattgctgtatcatcccaacatacagtgaatactgaattggaaaaacagatttct aatgaagttgatagtgaagacctgaaaatgtcttctgaagtgaagcatatttgtggcgaa gatcaaattgaagataaaatggaagtgacagaaaacattgaagtcgttacacaccagatc actgtgcagcaagaacaactgcagttgttagaggaacctgaaacagtggtatccagagaa gaatcaaggcctccaaaattagtcatggaatctgtcactcttccactagaaaccttagtg tccccacatgaggaaagtatttcattatgtcctgaggaacagttggttatagaaaggcta caaggagaaaaggaacagaaagaaaattctgaactttctactggattgatggactctgaa atgactcctacaattgagggttgtgtgaaagatgtttcataccaaggaggcaaatctata aagttatcatctgagacagagtcatcattttcatcatcagcagacataagcaaggcagat gtgtcttcctccccaacaccttcttcagacttgccttcgcatgacatgctgcataattac ccttcagctcttagttcctctgctggaaacatcatgccaacaacttacatctcagtcact ccaaaaattggcatgggtaaaccagctattactaagagaaaattttctcctggtagacct cggtccaaacagggggcttggagtacccataatacagtgagcccaccttcctggtcccca gacatttcagaaggtcgggaaatttttaaacccaggcagcttcctggcagtgccatttgg agcatcaaagtgggccgtgggtctggatttccaggaaagcggagacctcgaggtgcagga ctgtcggggcgaggtggccgaggcaggtcaaagctgaaaagtggaatcggagctgttgta ttacctggggtgtctactgcagatatttcatcaaataaggatgatgaagaaaactctatg cacaatacagttgtgttgttttctagcagtgacaagttcactttgaatcaggatatgtgt gtagtttgtggcagttttggccaaggagcagaaggaagattacttgcctgttctcagtgt ggtcagtgttaccatccatactgtgtcagtattaagatcactaaagtggttcttagcaaa ggttggaggtgtcttgagtgcactgtgtgtgaggcctgtgggaaggcaactgacccagga agactcctgctgtgtgatgactgtgacataagttatcacacctactgcctagaccctcca ttgcagacagttcccaaaggaggctggaagtgcaaatggtgtgtttggtgcagacactgt ggagcaacatctgcaggtctaagatgtgaatggcagaacaattacacacagtgcgctcct tgtgcaagcttatcttcctgtccagtctgctatcgaaactatagagaagaagatcttatt ctgcaatgtagacaatgtgatagatggatgcatgcagtttgtcagaacttaaatactgag gaagaagtggaaaatgtagcagacattggttttgattgtagcatgtgcagaccctatatg cctgcgtctaatgtgccttcctcagactgctgtgaatcttcacttgtagcacaaattgtc acaaaagtaaaagagctagacccacccaagacttatacccaggatggtgtgtgtttgact gaatcagggatgactcagttacagagcctcacagttacagttccaagaagaaaacggtca aaaccaaaattgaaattgaagattataaatcagaatagcgtggccgtccttcagacccct ccagacatccaatcagagcattcaagggatggtgaaatggatgatagtcgagaaggagaa cttatggattgtgatggaaaatcagaatctagtcctgagcgggaagctgtggatgatgaa actaagggagtggaaggaacagatggtgtcaaaaagagaaaaaggaaaccatacagacca ggtattggtggatttatggtgcggcaaagaagtcgaactgggcaagggaaaaccaaaaga tctgtgatcagaaaagattcctcaggctctatttccgagcagttaccttgcagagatgat ggctggagtgagcagttaccagatactttagttgatgaatctgtttctgttactgaaagc actgaaaaaataaagaagagataccgaaaaaggaaaaataagcttgaagaaactttccct gcctatttacaagaagctttctttggaaaagatcttctagatacaagtagacaaagcaag ataagtttagataatctgtcagaagatggagctcagcttttatataaaacaaacatgaac acaggtttcttggatccttccttagatccactacttagttcatcctcggctccaacaaaa tctggaactcacggtcctgctgatgacccattagctgatatttctgaagttttaaacaca gatgatgacattcttggaataatttcagatgatctagcaaaatcagttgatcattcagat attggtcctgtcactgatgatccttcctctttgcctcagccaaatgtcaatcagagttca cgaccattaagtgaagaacagctagatgggatcctcagtcctgaactagacaaaatggtc acagatggagcaattcttggaaaattatataaaattccagagcttggcggaaaagatgtt gaagacttatttacagctgtacttagtcctgcgaacactcagccaactccattgccacag cctcccccaccaacacagctgttgccaatacacaatcaggatgctttttcacggatgcct ctcatgaatggccttattggatccagtcctcatctcccacataattctttgccacctgga agcggactgggaactttctctgcaattgcacaatcctcttatcctgatgccagggataaa aattcagcctttaatccaatggcaagtgatcctaacaactcttggacatcatcagctccc actgtggaaggagaaaatgacacaatgtcgaatgcccagagaagcacgcttaagtgggag aaagaggaggctctgggtgaaatggcaactgttgccccagttctctacaccaatattaat ttccccaacttaaaggaagaattccctgattggactactagagtgaagcaaattgccaaa ttgtggagaaaagcaagctcacaagaaagagcaccatatgtgcaaaaagccagagataac agagctgctttacgcattaataaagtacagatgtcaaatgattccatgaaaaggcagcaa cagcaagatagcattgatcccagctctcgtattgattcggagctttttaaagatccttta aagcaaagagaatcagaacatgaacaggaatggaaatttagacagcaaatgcgtcagaaa agtaagcagcaagctaaaattgaagccacacagaaacttgaacaggtgaaaaatgagcag cagcagcagcaacaacagcaatttggttctcagcatcttctggtgcagtctggttcagat acaccaagtagtgggatacagagtcccttgacacctcagcctggcaatggaaatatgtct cctgcacagtcattccataaagaactgtttacaaaacagccacccagtacccctacgtct acatcttcagatgatgtgtttgtaaagccacaagctccacctcctcctccagccccatcc cggattcccatccaggatagtctttctcaggctcagacttctcagccaccctcaccgcaa gtgttttcacctgggtcctctaactcacgaccaccatctccaatggatccatatgcaaaa atggttggtacccctcgaccacctcctgtgggccatagtttttccagaagaaattctgct gcaccagtggaaaactgtacacctttatcatcggtatctaggccccttcaaatgaatgag acaacagcaaataggccatcccctgtcagagatttatgttcttcttccacgacaaataat gacccctatgcaaaacctccagacacacctaggcctgtgatgacagatcaatttcccaaa tccttgggcctatcccggtctcctgtagtttcagaacaaactgcaaaaggccctatagca gctggaaccagtgatcactttactaaaccatctcctagggcagatgtgtttcaaagacaa aggatacctgactcatatgcacgacccttgttgacacctgcacctcttgatagtggtcct ggaccttttaagactccaatgcaacctcctccatcctctcaggatccttatggatcagtg tcacaggcatcaaggcgattgtctgttgacccttatgaaaggcctgctttgacaccaaga cctatagataatttttctcataatcagtcaaatgatccatatagtcagcctccccttacc ccacatccagcagtgaatgaatcttttgcccatccttcaagggctttttcccagcctgga accatatcaaggccaacatctcaggacccatactcccaacccccaggaactccacgacct gttgtagattcttattcccaatcttcaggaacagctaggtccaatacagacccttactct caacctcctggaactccccggcctactactgttgacccatatagtcagcagccccaaacc ccaagaccatctacacaaactgacttgtttgttacacctgtaacaaatcagaggcattct gatccatatgctcatcctcctggaacaccaagacctggaatttctgtcccttactctcag ccaccagcaacaccaaggccaaggatttcagagggttttactaggtcctcaatgacaaga ccagtcctcatgccaaatcaggatcctttcctgcaagcagcacaaaaccgaggaccagct ttacctggcccgttggtaaggccacctgatacatgttcccagacacctaggccccctgga cctggtctttcagacacatttagccgtgtttccccatctgctgcccgtgatccctatgat cagtctccaatgactccaagatctcagtctgactcttttggaacaagtcaaactgcccat gatgttgctgatcagccaaggcctggatcagaggggagcttctgtgcatcttcaaactct ccaatgcactcccaaggccagcagttctctggtgtctcccaacttcctggacctgtgcca acttcaggagtaactgatacacagaatactgtaaatatggcccaagcagatacagagaaa ttgagacagcggcagaagttacgtgaaatcattctccagcagcaacagcagaagaagatt gcaggtcgacaggagaaggggtcacaggactcacccgcagtgcctcatccagggcctctt caacactggcaaccagagaatgttaaccaggctttcaccagacccccacctccctatcct gggaacattaggtctcctgttgcccctcctttaggacctagatatgctgttttcccaaaa gatcagcgtggaccctatcctcctgatgttgctagtatggggatgagacctcatggattt agatttggatttccaggaggtagtcatggtaccatgccgagtcaagagcgcttccttgtg cctcctcagcaaatacagggatctggagtttctccacagctaagaagatcagtatctgta gatatgcctaggcctttaaataactcacaaatgaataatccagttggacttcctcagcat ttttcaccacagagcttgccagttcagcagcacaacatactgggccaagcatatattgaa ctgagacatagggctcctgacggaaggcaacggctgcctttcagtgctccacctggcagc gttgtagaggcatcttctaatctgagacatggaaacttcattccccggccagactttccg ggccctagacacacagaccccatgcgacgacctccccagggtctacctaatcagctacct gtgcacccagatttggaacaagtgccaccatctcaacaagagcaaggtcattctgtccat tcatcttctatggtcatgaggactctgaaccatccactaggtggtgaattttcagaagct cctttgtcaacatctgtaccgtctgaaacaacgtctgataatttacagataaccacccag ccttctgatggtctagaggaaaaacttgattctgatgacccttctgtgaaggaactggat gttaaagaccttgagggggttgaagtcaaagacttagatgatgaagatcttgaaaactta aatttagatacagaggatggcaaggtagttgaattggatactttagataatttggaaact aatgatcccaacctggatgacctcttaaggtcaggagagtttgatatcattgcatataca gatccagaacttgacatgggagataagaaaagcatgtttaatgaggaactagaccttcca attgatgataagttagataatcagtgtgtatctgttgaaccaaaaaaaaaggaacaagaa aacaaaactctggttctctctgataaacattcaccacagaaaaaatccactgttaccaat gaggtaaaaacggaagtactgtctccaaattctaaggtggaatccaaatgtgaaactgaa aaaaatgatgagaataaagataatgttgacactccttgctcacaggcttctgctcactca gacctaaatgatggagaaaagacttctttgcatccttgtgatccagatctatttgagaaa agaaccaatcgagaaactgctggccccagtgcaaatgtcattcaggcatccactcaacta cctgctcaagatgtaataaactcttgtggcataactggatcaactccagttctctcaagt ttacttgctaatgagaaatctgataattcagacattaggccatcggggtctccaccacca ccaactctgccggcctccccatccaatcatgtgtcaagtttgcctcctttcatagcaccg cctggccgtgttttggataatgccatgaattctaatgtgacagtagtctctagggtaaac catgttttttctcagggtgtgcaggtaaacccagggctcattccaggtcaatcaacagtt aaccacagtctggggacaggaaaacctgcaactcaaactgggcctcaaacaagtcagtct ggtaccagtagcatgtctggaccccaacagctaatgattcctcaaacattagcacagcag aatagagagaggccccttcttctagaagaacagcctctacttctacaggatcttttggat caagaaaggcaagaacagcagcagcaaagacagatgcaagccatgattcgtcagcgatca gaaccgttcttccctaatattgattttgatgcaattacagatcctataatgaaagccaaa atggtggcccttaaaggtataaataaagtgatggcacaaaacaatctgggcatgccacca atggtgatgagcaggttcccttttatgggccaggtggtaactggaacacagaacagtgaa ggacagaaccttggaccacaggccattcctcaggatggcagtataacacatcagatttct aggcctaatcctccaaattttggtccaggctttgtcaatgattcacagcgtaagcagtat gaagagtggctccaggagacccaacagctgcttcaaatgcagcagaagtatcttgaagaa caaattggtgctcacagaaaatctaagaaggccctttcagctaaacaacgtactgccaag aaagctgggcgtgaatttccagaggaagatgcagaacaactcaagcatgttactgaacag caaagcatggttcagaaacagctagaacagattcgtaaacaacagaaagaacatgctgaa ttgattgaagattatcggatcaaacagcagcagcaatgtgcaatggccccacctaccatg atgcccagtgtccagccccagccacccctaattccaggtgccactccacccaccatgagc caacccacctttcccatggtgccacagcagcttcagcaccagcagcacacaacagttatt tctggccatactagccctgttagaatgcccagtttacctggatggcaacccaacagtgct cctgcccacctgcccctcaatcctcctagaattcagcccccaattgcccagttaccaata aaaacttgtacaccagccccagggacagtctcaaatgcaaatccacagagtggaccacca cctcgggtagaatttgatgacaacaatccctttagtgaaagttttcaagaacgggaacgt aaggaacgtttacgagaacagcaagagagacaacggatccaactcatgcaggaggtagat agacaaagagctttgcagcagaggatggaaatggagcagcatggtatggtgggctctgag ataagtagtagtaggacatctgtgtcccagattcccttctacagttccgacttaccttgt gattttatgcaacctctaggaccccttcagcagtctccacaacaccaacagcaaatgggg caggttttacagcagcagaatatacaacaaggatcaattaattcaccctccacccaaact ttcatgcagactaatgagcgaaggcaggtaggccctccttcatttgttcctgattcacca tcaatccctgttggaagcccaaatttttcttctgtgaagcagggacatggaaatctttct gggaccagcttccagcagtccccagtgaggccttcttttacacctgctttaccagcagca cctccagtagctaatagcagtctcccatgtggccaagattctactataacccatggacac agttatccgggatcaacccaatcgctcattcagttgtattctgatataatcccagaggaa aaagggaaaaagaaaagaacaagaaagaagaaaagagatgatgatgcagaatccaccaag gctccatcaactccccattcagatataactgccccaccgactccaggcatctcagaaact acctctactcctgcagtgagcacacccagtgagcttcctcaacaagccgaccaagagtcg gtggaaccagtcggcccatccactcccaatatggcagcaggccagctatgtacagaatta gagaacaaactgcccaatagtgatttctcacaagcaactccaaatcaacagacgtatgca aattcagaagtagacaagctctccatggaaacccctgccaaaacagaagagataaaactg gaaaaggctgagacagagtcctgcccaggccaagaggagcctaaattggaggaacagaat ggtagtaaggtagaaggaaacgctgtagcctgtcctgtctcctcagcacagagtcctccc cattctgctggggcccctgctgccaaaggagactcagggaatgaacttctgaaacacttg ttgaaaaataaaaagtcatcttctcttttgaatcaaaaacctgagggcagtatttgttca gaagatgactgtacaaaggataataaactagttgagaagcagaacccagctgaaggactg caaactttgggggctcaaatgcaaggtggttttggatgtggcaaccagttgccaaaaaca gatggaggaagtgaaaccaagaaacagcgaagcaaacggactcagaggacgggtgagaaa gcagcacctcgctcaaagaaaaggaaaaaggacgaagaggagaaacaagctatgtactct agcactgacacgtttacccacttgaaacagcagaataatttaagtaatcctccaacaccc cctgcctctcttcctcctacaccacctcctatggcttgtcagaagatggccaatggtttt gcaacaactgaagaacttgctggaaaagccggagtgttagtgagccatgaagttaccaaa actctaggacctaaaccatttcagctgcccttcagaccccaggacgacttgttggcccga gctcttgctcagggccccaagacagttgatgtgccagcctccctcccaacaccacctcat aacaatcaggaagaattaaggatacaggatcactgtggtgatcgagatactcctgacagt tttgttccctcatcctctcctgagagtgtggttggggtagaagtgagcaggtatccagat ctgtcattggtcaaggaggagcctccagaaccggtgccgtcccccatcattccaattctt cctagcactgctgggaaaagttcagaatcaagaaggaatgacatcaaaactgagccaggc actttatattttgcgtcaccttttggtccttccccaaatggtcccagatcaggtcttata tctgtagcaattactctgcatcctacagctgctgagaacattagcagtgttgtggctgca ttttccgaccttcttcacgtccgaatccctaacagctatgaggttagcagtgctccagat gtcccatccatgggtttggtcagtagccacagaatcaacccgggtttggagtatcgacag catttacttctccgtgggcctccgccaggatctgcaaaccctcccagattagtgagctct taccggctgaagcagcctaatgtaccatttcctccaacaagcaatggtctttctggatat aaggattctagtcatggtattgcagaaagcgcagcactcagaccacagtggtgttgtcat tgtaaagtggttattcttggaagtggtgtgcggaaatctttcaaagatctgacccttttg aacaaggattcccgagaaagcaccaagagggtagagaaggacattgtcttctgtagtaat aactgctttattctttattcatcaactgcacaagcgaaaaactcagaaaacaaggaatcc attccttcattgccacaatcacctatgagagaaacgccttccaaagcatttcatcagtac agcaacaacatctccactttggatgtgcactgtctcccccagctcccagagaaagcttct ccccctgcctcaccacccatcgccttccctcctgcttttgaagcagcccaagtcgaggcc aagccagatgagctgaaggtgacagtcaagctgaagcctcggctaagagctgtccatggt gggtttgaagattgcaggccgctcaataaaaaatggagaggaatgaaatggaagaagtgg agcattcatattgtaatccctaaggggacatttaaaccaccttgtgaggatgaaatagat gaatttctaaagaaattgggcacttcccttaaacctgatcctgtgcccaaagactatcgg aaatgttgcttttgtcatgaagaaggtgatggattgacagatggaccagcaaggctactc aaccttgacttggatctgtgggtccacttgaactgcgctctgtggtccacggaggtctat gagactcaggctggtgccttaataaatgtggagctagctctgaggagaggcctacaaatg aaatgtgtcttctgtcacaagacgggtgccactagtggatgccacagatttcgatgcacc aacatttatcacttcacttgcgccattaaagcacaatgcatgttttttaaggacaaaact atgctttgccccatgcacaaaccaaagggaattcatgagcaagaattaagttactttgca gtcttcaggagggtctatgttcagcgtgatgaggtgcgacagattgctagcatcgtgcaa cgaggagaacgggaccatacctttcgcgtgggtagcctcatcttccacacaattggtcag ctgcttccacagcagatgcaagcattccattctcctaaagcactcttccctgtgggctat gaagccagccggctgtactggagcactcgctatgccaataggcgctgccgctacctgtgc tccattgaggagaaggatgggcgcccagtgtttgtcatcaggattgtggaacaaggccat gaagacctggttctaagtgacatctcacctaaaggtgtctgggataagattttggagcct gtggcatgtgtgagaaaaaagtctgaaatgctccagcttttcccagcgtatttaaaagga gaggatctgtttggcctgaccgtctctgcagtggcacgcatagcggaatcacttcctggg gttgaggcatgtgaaaattataccttccgatacggccgaaatcctctcatggaacttcct cttgccgttaaccccacaggttgtgcccgttctgaacctaaaatgagtgcccatgtcaag aggtttgtgttaaggcctcacaccttaaacagcaccagcacctcaaagtcatttcagagc acagtcactggagaactgaacgcaccttatagtaaacagtttgttcactccaagtcatcg cagtaccggaagatgaaaactgaatggaaatccaatgtgtatctggcacggtctcggatt caggggctgggcctgtatgctgctcgagacattgagaaacacaccatggtcattgagtac atcgggactatcattcgaaacgaagtagccaacaggaaagagaagctttatgagtctcag aaccgtggtgtgtacatgttccgcatggataacgaccatgtgattgacgcgacgctcaca ggagggcccgcaaggtatatcaaccattcgtgtgcacctaattgtgtggctgaagtggtg acttttgagagaggacacaaaattatcatcagctccagtcggagaatccagaaaggagaa gagctctgctatgactataagtttgactttgaagatgaccagcacaagattccgtgtcac tgtggagctgtgaactgccggaagtggatgaactga |
Protein Sequence |
>58508 : length: 4911 MSSEEDKSVEQPQPPPPPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGK TAVEDEDSMDGLETTETETIVETEIKEQSAEEDAEAEVDNSKQLIPTLQRSVSEESANSL VSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRITPGFILPWRNQPSNKKDIDDNSNGT YEKMQNSAPRKQRGQRKERSPQQNIVSCVSVSTQTASDDQAGKLWDELSLVGLPDAIDIQ ALFDSTGTCWAHHRCVEWSLGVCQMEEPLLVNVDKAVVSGSTERCAFCKHLGATIKCCEE KCTQMYHYPCAAGAGTFQDFSHIFLLCPEHIDQAPERSKEDANCAVCDSPGDLLDQFFCT TCGQHYHGMCLDIAVTPLKRAGWQCPECKVCQNCKQSGEDSKMLVCDTCDKGYHTFCLQP VMKSVPTNGWKCKNCRICIECGTRSSSQWHHNCLICDNCYQQQDNLCPFCGKCYHPELQK DMLHCNMCKRWVHLECDKPTDHELDTQLKEEYICMYCKHLGAEMDRLQPGEEVEIAELTT DYNNEMEVEGPEDQMVFSEQAANKDVNGQESTPGIVPDAVQVHTEEQQKSHPSESLDTDS LLIAVSSQHTVNTELEKQISNEVDSEDLKMSSEVKHICGEDQIEDKMEVTENIEVVTHQI TVQQEQLQLLEEPETVVSREESRPPKLVMESVTLPLETLVSPHEESISLCPEEQLVIERL QGEKEQKENSELSTGLMDSEMTPTIEGCVKDVSYQGGKSIKLSSETESSFSSSADISKAD VSSSPTPSSDLPSHDMLHNYPSALSSSAGNIMPTTYISVTPKIGMGKPAITKRKFSPGRP RSKQGAWSTHNTVSPPSWSPDISEGREIFKPRQLPGSAIWSIKVGRGSGFPGKRRPRGAG LSGRGGRGRSKLKSGIGAVVLPGVSTADISSNKDDEENSMHNTVVLFSSSDKFTLNQDMC VVCGSFGQGAEGRLLACSQCGQCYHPYCVSIKITKVVLSKGWRCLECTVCEACGKATDPG RLLLCDDCDISYHTYCLDPPLQTVPKGGWKCKWCVWCRHCGATSAGLRCEWQNNYTQCAP CASLSSCPVCYRNYREEDLILQCRQCDRWMHAVCQNLNTEEEVENVADIGFDCSMCRPYM PASNVPSSDCCESSLVAQIVTKVKELDPPKTYTQDGVCLTESGMTQLQSLTVTVPRRKRS KPKLKLKIINQNSVAVLQTPPDIQSEHSRDGEMDDSREGELMDCDGKSESSPEREAVDDE TKGVEGTDGVKKRKRKPYRPGIGGFMVRQRSRTGQGKTKRSVIRKDSSGSISEQLPCRDD GWSEQLPDTLVDESVSVTESTEKIKKRYRKRKNKLEETFPAYLQEAFFGKDLLDTSRQSK ISLDNLSEDGAQLLYKTNMNTGFLDPSLDPLLSSSSAPTKSGTHGPADDPLADISEVLNT DDDILGIISDDLAKSVDHSDIGPVTDDPSSLPQPNVNQSSRPLSEEQLDGILSPELDKMV TDGAILGKLYKIPELGGKDVEDLFTAVLSPANTQPTPLPQPPPPTQLLPIHNQDAFSRMP LMNGLIGSSPHLPHNSLPPGSGLGTFSAIAQSSYPDARDKNSAFNPMASDPNNSWTSSAP TVEGENDTMSNAQRSTLKWEKEEALGEMATVAPVLYTNINFPNLKEEFPDWTTRVKQIAK LWRKASSQERAPYVQKARDNRAALRINKVQMSNDSMKRQQQQDSIDPSSRIDSELFKDPL KQRESEHEQEWKFRQQMRQKSKQQAKIEATQKLEQVKNEQQQQQQQQFGSQHLLVQSGSD TPSSGIQSPLTPQPGNGNMSPAQSFHKELFTKQPPSTPTSTSSDDVFVKPQAPPPPPAPS RIPIQDSLSQAQTSQPPSPQVFSPGSSNSRPPSPMDPYAKMVGTPRPPPVGHSFSRRNSA APVENCTPLSSVSRPLQMNETTANRPSPVRDLCSSSTTNNDPYAKPPDTPRPVMTDQFPK SLGLSRSPVVSEQTAKGPIAAGTSDHFTKPSPRADVFQRQRIPDSYARPLLTPAPLDSGP GPFKTPMQPPPSSQDPYGSVSQASRRLSVDPYERPALTPRPIDNFSHNQSNDPYSQPPLT PHPAVNESFAHPSRAFSQPGTISRPTSQDPYSQPPGTPRPVVDSYSQSSGTARSNTDPYS QPPGTPRPTTVDPYSQQPQTPRPSTQTDLFVTPVTNQRHSDPYAHPPGTPRPGISVPYSQ PPATPRPRISEGFTRSSMTRPVLMPNQDPFLQAAQNRGPALPGPLVRPPDTCSQTPRPPG PGLSDTFSRVSPSAARDPYDQSPMTPRSQSDSFGTSQTAHDVADQPRPGSEGSFCASSNS PMHSQGQQFSGVSQLPGPVPTSGVTDTQNTVNMAQADTEKLRQRQKLREIILQQQQQKKI AGRQEKGSQDSPAVPHPGPLQHWQPENVNQAFTRPPPPYPGNIRSPVAPPLGPRYAVFPK DQRGPYPPDVASMGMRPHGFRFGFPGGSHGTMPSQERFLVPPQQIQGSGVSPQLRRSVSV DMPRPLNNSQMNNPVGLPQHFSPQSLPVQQHNILGQAYIELRHRAPDGRQRLPFSAPPGS VVEASSNLRHGNFIPRPDFPGPRHTDPMRRPPQGLPNQLPVHPDLEQVPPSQQEQGHSVH SSSMVMRTLNHPLGGEFSEAPLSTSVPSETTSDNLQITTQPSDGLEEKLDSDDPSVKELD VKDLEGVEVKDLDDEDLENLNLDTEDGKVVELDTLDNLETNDPNLDDLLRSGEFDIIAYT DPELDMGDKKSMFNEELDLPIDDKLDNQCVSVEPKKKEQENKTLVLSDKHSPQKKSTVTN EVKTEVLSPNSKVESKCETEKNDENKDNVDTPCSQASAHSDLNDGEKTSLHPCDPDLFEK RTNRETAGPSANVIQASTQLPAQDVINSCGITGSTPVLSSLLANEKSDNSDIRPSGSPPP PTLPASPSNHVSSLPPFIAPPGRVLDNAMNSNVTVVSRVNHVFSQGVQVNPGLIPGQSTV NHSLGTGKPATQTGPQTSQSGTSSMSGPQQLMIPQTLAQQNRERPLLLEEQPLLLQDLLD QERQEQQQQRQMQAMIRQRSEPFFPNIDFDAITDPIMKAKMVALKGINKVMAQNNLGMPP MVMSRFPFMGQVVTGTQNSEGQNLGPQAIPQDGSITHQISRPNPPNFGPGFVNDSQRKQY EEWLQETQQLLQMQQKYLEEQIGAHRKSKKALSAKQRTAKKAGREFPEEDAEQLKHVTEQ QSMVQKQLEQIRKQQKEHAELIEDYRIKQQQQCAMAPPTMMPSVQPQPPLIPGATPPTMS QPTFPMVPQQLQHQQHTTVISGHTSPVRMPSLPGWQPNSAPAHLPLNPPRIQPPIAQLPI KTCTPAPGTVSNANPQSGPPPRVEFDDNNPFSESFQERERKERLREQQERQRIQLMQEVD RQRALQQRMEMEQHGMVGSEISSSRTSVSQIPFYSSDLPCDFMQPLGPLQQSPQHQQQMG QVLQQQNIQQGSINSPSTQTFMQTNERRQVGPPSFVPDSPSIPVGSPNFSSVKQGHGNLS GTSFQQSPVRPSFTPALPAAPPVANSSLPCGQDSTITHGHSYPGSTQSLIQLYSDIIPEE KGKKKRTRKKKRDDDAESTKAPSTPHSDITAPPTPGISETTSTPAVSTPSELPQQADQES VEPVGPSTPNMAAGQLCTELENKLPNSDFSQATPNQQTYANSEVDKLSMETPAKTEEIKL EKAETESCPGQEEPKLEEQNGSKVEGNAVACPVSSAQSPPHSAGAPAAKGDSGNELLKHL LKNKKSSSLLNQKPEGSICSEDDCTKDNKLVEKQNPAEGLQTLGAQMQGGFGCGNQLPKT DGGSETKKQRSKRTQRTGEKAAPRSKKRKKDEEEKQAMYSSTDTFTHLKQQNNLSNPPTP PASLPPTPPPMACQKMANGFATTEELAGKAGVLVSHEVTKTLGPKPFQLPFRPQDDLLAR ALAQGPKTVDVPASLPTPPHNNQEELRIQDHCGDRDTPDSFVPSSSPESVVGVEVSRYPD LSLVKEEPPEPVPSPIIPILPSTAGKSSESRRNDIKTEPGTLYFASPFGPSPNGPRSGLI SVAITLHPTAAENISSVVAAFSDLLHVRIPNSYEVSSAPDVPSMGLVSSHRINPGLEYRQ HLLLRGPPPGSANPPRLVSSYRLKQPNVPFPPTSNGLSGYKDSSHGIAESAALRPQWCCH CKVVILGSGVRKSFKDLTLLNKDSRESTKRVEKDIVFCSNNCFILYSSTAQAKNSENKES IPSLPQSPMRETPSKAFHQYSNNISTLDVHCLPQLPEKASPPASPPIAFPPAFEAAQVEA KPDELKVTVKLKPRLRAVHGGFEDCRPLNKKWRGMKWKKWSIHIVIPKGTFKPPCEDEID EFLKKLGTSLKPDPVPKDYRKCCFCHEEGDGLTDGPARLLNLDLDLWVHLNCALWSTEVY ETQAGALINVELALRRGLQMKCVFCHKTGATSGCHRFRCTNIYHFTCAIKAQCMFFKDKT MLCPMHKPKGIHEQELSYFAVFRRVYVQRDEVRQIASIVQRGERDHTFRVGSLIFHTIGQ LLPQQMQAFHSPKALFPVGYEASRLYWSTRYANRRCRYLCSIEEKDGRPVFVIRIVEQGH EDLVLSDISPKGVWDKILEPVACVRKKSEMLQLFPAYLKGEDLFGLTVSAVARIAESLPG VEACENYTFRYGRNPLMELPLAVNPTGCARSEPKMSAHVKRFVLRPHTLNSTSTSKSFQS TVTGELNAPYSKQFVHSKSSQYRKMKTEWKSNVYLARSRIQGLGLYAARDIEKHTMVIEY IGTIIRNEVANRKEKLYESQNRGVYMFRMDNDHVIDATLTGGPARYINHSCAPNCVAEVV TFERGHKIIISSSRRIQKGEELCYDYKFDFEDDQHKIPCHCGAVNCRKWMN |