| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 6091 |
Name | ROBO1 |
Synonym | DUTT1|SAX3;roundabout, axon guidance receptor, homolog 1 (Drosophila);ROBO1;roundabout, axon guidance receptor, homolog 1 (Drosophila) |
Definition | deleted in U twenty twenty|roundabout homolog 1 |
Position | 3p12 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 14239 |
TUSON P-value | 1 |
|
Pathways and Diseases |
|
Pathway | Inactivation of Cdc42 and Rac;PID Reactome;500094 |
Pathway | Role of Abl in Robo-Slit signaling;PID Reactome;500096 |
Pathway | Axon guidance mediated by Slit/Robo;PANTHER;P00008 |
Pathway | Axon guidance;Reactome;REACT:18266 |
Pathway | Activation of Rac;PID Reactome;500095 |
Pathway | Netrin-1 signaling;PID Reactome;500088 |
Pathway | Axon guidance;KEGG PATHWAY;hsa04360 |
Pathway | Signaling by Robo receptor;PID Reactome;500092 |
Disease | PSYCH;GAD |
Disease | protein quantitative trait loci;GAD |
Disease | Brain imaging in schizophrenia (interaction);GAD |
Disease | Cancer;FunDO |
Disease | Protein quantitative trait loci;NHGRI |
|
External Links |
|
Links to Entrez Gene | 6091 |
Links to all GeneRIF Items | 6091 |
Links to iHOP | 6091 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>6091 : length: 4656 atgattgcggagcccgctcacttttacctgtttggattaatatgtctctgttcaggctcc cgtcttcgtcaggaagattttccacctcgcattgttgaacacccttcagacctgattgtc tcaaaaggagaacctgcaactttgaactgcaaagctgaaggccgccccacacccactatt gaatggtacaaagggggagagagagtggagacagacaaagatgaccctcgctcacaccga atgttgctgccgagtggatctttatttttcttacgtatagtacatggacggaaaagtaga cctgatgaaggagtctatgtctgtgtagcaaggaattaccttggagaggctgtgagccac aatgcatcgctggaagtagccatacttcgggatgacttcagacaaaacccttcggatgtc atggttgcagtaggagagcctgcagtaatggaatgccaacctccacgaggccatcctgag cccaccatttcatggaagaaagatggctctccactggatgataaagatgaaagaataact atacgaggaggaaagctcatgatcacttacacccgtaaaagtgacgctggcaaatatgtt tgtgttggtaccaatatggttggggaacgtgagagtgaagtagccgagctgactgtctta gagagaccatcatttgtgaagagacccagtaacttggcagtaactgtggatgacagtgca gaatttaaatgtgaggcccgaggtgaccctgtacctacagtacgatggaggaaagatgat ggagagctgcccaaatccagatatgaaatccgagatgatcataccttgaaaattaggaag gtgacagctggtgacatgggttcatacacttgtgttgcagaaaatatggtgggcaaagct gaagcatctgctactctgactgttcaagttgggtctgaacctccacattttgttgtgaaa ccccgtgaccaggttgttgctttgggacggactgtaacttttcagtgtgaagcaaccgga aatcctcaaccagctattttctggaggagagaagggagtcagaatctacttttctcatat caaccaccacagtcatccagccgattttcagtctcccagactggcgacctcacaattact aatgtccagcgatctgatgttggttattacatctgccagactttaaatgttgctggaagc atcatcacaaaggcatatttggaagttacagatgtgattgcagatcggcctcccccagtt attcgacaaggtcctgtgaatcagactgtagccgtggatggcactttcgtcctcagctgt gtggccacaggcagtccagtgcccaccattctgtggagaaaggatggagtcctcgtttca acccaagactctcgaatcaaacagttggagaatggagtactgcagatccgatatgctaag ctgggtgatactggtcggtacacctgcattgcatcaacccccagtggtgaagcaacatgg agtgcttacattgaagttcaagaatttggagttccagttcagcctccaagacctactgac ccaaatttaatccctagtgccccatcaaaacctgaagtgacagatgtcagcagaaataca gtcacattatcgtggcaaccaaatttgaattcaggagcaactccaacatcttatattata gaagccttcagccatgcatctggtagcagctggcagaccgtagcagagaatgtgaaaaca gaaacatctgccattaaaggactcaaacctaatgcaatttaccttttccttgtgagggca gctaatgcatatggaattagtgatccaagccaaatatcagatccagtgaaaacacaagat gtcctaccaacaagtcagggggtggaccacaagcaggtccagagagagctgggaaatgct gttctgcacctccacaaccccaccgtcctttcttcctcttccatcgaagtgcactggaca gtagatcaacagtctcagtatatacaaggatataaaattctctatcggccatctggagcc aaccacggagaatcagactggttagtttttgaagtgaggacgccagccaaaaacagtgtg gtaatccctgatctcagaaagggagtcaactatgaaattaaggctcgccctttttttaat gaatttcaaggagcagatagtgaaatcaagtttgccaaaaccctggaagaagcacccagt gccccaccccaaggtgtaactgtatccaagaatgatggaaacggaactgcaattctagtt agttggcagccacctccagaagacactcaaaatggaatggtccaagagtataaggtttgg tgtctgggcaatgaaactcgataccacatcaacaaaacagtggatggttccaccttttcc gtggtcattccctttcttgttcctggaatccgatacagtgtggaagtggcagccagcact ggggctgggtctggggtaaagagtgagcctcagttcatccagctggatgcccatggaaac cctgtgtcacctgaggaccaagtcagcctcgctcagcagatttcagatgtggtgaagcag ccggccttcatagcaggtattggagcagcctgttggatcatcctcatggtcttcagcatc tggctttatcgacaccgcaagaagagaaacggacttactagtacctacgcgggtatcaga aaagtaacttaccagagaggaggcgaagctgtcagcagtggagggaggcctggacttctc aacatcagtgaacctgccgcgcagccatggctggcagacacgtggcctaatactggcaac aaccacaatgactgctccatcagctgctgcacggcaggcaatggaaacagcgacagcaac ctcactacctacagtcgcccagggcagcctactccttacgccaccactcagctcatccag tcaaacctcagcaacaacatgaacaatggcagcggggactctggcgagaagcactggaaa ccactgggacagcagaaacaagaagtggcaccagttcagtacaacatcgtggagcaaaac aagctgaacaaagattatcgagcaaatgacacagttcctccaactatcccatacaaccaa tcatacgaccagaacacaggaggatcctacaacagctcagaccggggcagtagtacatct gggagtcaggggcacaagaaaggggcaagaacacccaaggtaccaaaacagggtggcatg aactgggcagacctgcttcctcctcccccagcacatcctcctccacacagcaatagcgaa gagtacaacatttctgtagatgaaagctatgaccaagaaatgccatgtcccgtgccacca gcaaggatgtatttgcaacaagatgaattagaagaggaggaagatgaacgaggccccact ccccctgttcggggagcagcttcttctccagctgccgtgtcctatagccatcagtccact gccactctgactccctccccacaggaagaactccagcccatgttacaggattgtccagag gagactggccacatgcagcaccagcccgacaggagacggcagcctgtgagtcctcctcca ccaccacggccgatctcccctccacatacctatggctacatttcaggacccctggtctca gatatggatacggatgcgccagaagaggaagaagacgaagccgacatggaggtagccaag atgcaaaccagaaggcttttgttacgtgggcttgagcagacacctgcctccagtgttggg gacctggagagctctgtcacggggtccatgatcaacggctggggctcagcctcagaggag gacaacatttccagcggacgctccagtgttagttcttcggacggctcctttttcactgat gctgactttgcccaggcagtcgcagcagcggcagagtatgctggtctgaaagtagcacga cggcaaatgcaggatgctgctggccgtcgacattttcatgcgtctcagtgccctaggccc acaagtcccgtgtctacagacagcaacatgagtgccgccgtaatgcagaaaaccagacca gccaagaaactgaaacaccagccaggacatctgcgcagagaaacctacacagatgatctt ccaccacctcctgtgccgccacctgctataaagtcacctactgcccaatccaagacacag ctggaagtacgacctgtagtggtgccaaaactcccttctatggatgcaagaacagacaga tcatcagacagaaaaggaagcagttacaaggggagagaagtgttggatggaagacaggtt gttgacatgcgaacaaatccaggtgatcccagagaagcacaggaacagcaaaatgacggg aaaggacgtggaaacaaggcagcaaaacgagaccttccaccagcaaagactcatctcatc caagaggatattctaccttattgtagacctacttttccaacatcaaataatcccagagat cccagttcctcaagctcaatgtcatcaagaggatcaggaagcagacaaagagaacaagca aatgtaggtcgaagaaatattgcagaaatgcaggtacttggaggatatgaaagaggagaa gataataatgaagaattagaggaaactgaaagctga |
Protein Sequence |
>6091 : length: 1551 MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTI EWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH NASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERIT IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSA EFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA EASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT VTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRA ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFN EFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW CLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGN PVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIR KVTYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSN LTTYSRPGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQN KLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGM NWADLLPPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPT PPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPP PPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVG DLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVAR RQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDL PPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQV VDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRD PSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES |