| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 64682 |
Name | ANAPC1 |
Synonym | APC1|MCPR|TSG24;anaphase promoting complex subunit 1;ANAPC1;anaphase promoting complex subunit 1 |
Definition | anaphase-promoting complex 1 (meiotic checkpoint regulator)|anaphase-promoting complex subunit 1|cyclosome subunit 1|mitotic checkpoint regulator|testis-specific gene 24 protein |
Position | 2q12.1 |
Gene Type | protein-coding |
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TSG scores |
Description |
| TUSON ranking | 2733 |
TUSON P-value | 1 |
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Pathways and Diseases |
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Pathway | Autodegradation of Cdh1 by Cdh1:APC/C;PID Reactome;500401 |
Pathway | Progesterone-mediated oocyte maturation;KEGG PATHWAY;hsa04914 |
Pathway | Ubiquitin mediated proteolysis;KEGG PATHWAY;hsa04120 |
Pathway | APC-Cdc20 mediated degradation of Nek2A;Reactome;REACT:8017 |
Pathway | Cell Cycle Checkpoints;Reactome;REACT:1538 |
Pathway | Cdc20:Phospho-APC/C mediated degradation of Cyclin A;Reactome;REACT:6850 |
Pathway | Regulation of APC/C activators between G1/S and early anaphase;PID Reactome;500391 |
Pathway | Oocyte meiosis;KEGG PATHWAY;hsa04114 |
Pathway | APC/C-mediated degradation of cell cycle proteins;PID Reactome;500390 |
Pathway | Cell cycle;KEGG PATHWAY;hsa04110 |
Pathway | Phosphorylation of the APC/C;PID Reactome;500395 |
Pathway | Cell Cycle, Mitotic;Reactome;REACT:152 |
Disease | Colon cancer;FunDO |
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External Links |
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Links to Entrez Gene | 64682 |
Links to all GeneRIF Items | 64682 |
Links to iHOP | 64682 |
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Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>64682 : length: 5835 atgtcgaacttctatgaagaaaggacaacgatgattgcagcaagggatttgcaggaattt gttccttttggtcgagaccactgcaagcaccaccctaatgctttgaaccttcaacttcgc cagctgcagccagcttctgaattatggtcttctgatggtgctgctggcttggtgggatcc cttcaggaggttacaatccacgagaaacagaaggaaagctggcagttaaggaaaggagta agtgaaattggagaagatgtggactatgatgaggaactctatgttgctggaaatatggtg atatggagcaaaggaagtaaaagccaggcattggcagtttataaagcatttacagttgac agtcctgttcagcaggcattgtggtgtgacttcattatatcacaggataagtctgaaaag gcctacagtagcaatgaagtagaaaaatgcatatgtatattgcaaagctcatgtattaac atgcatagcatagaaggaaaggattacatagcttcattaccatttcaggttgcaaatgtt tggcccactaaatatggattgctgtttgaacgaagcgcttcttcacatgaagtacctcca ggttcacccagagaacctttacctactatgttcagcatgctgcacccactagatgaaata actccacttgtttgtaaatctggaagtctttttggttcatcacgggtgcaatatgttgta gatcatgcaatgaaaattgttttcctcaatactgacccctctattgtaatgacttatgat gctgttcaaaatgtgcattctgtgtggactctccggagagtcaaatcagaggaagagaat gttgttttaaagttctctgaacaggggggaaccccacagaatgtggccactagcagctcc ctcacagcacatctcagaagcctctccaaaggagattcccctgtgacttcacctttccag aattactcctccattcacagccagagtcgctcaacctcatcacccagtctacattctcgc tcaccttctatttccaacatggcagctctaagtcgtgctcattctcctgcgttaggagtg cactctttttcaggggtgcaaaggttcaacatttcaagccataatcagtctccaaagaga catagtatttctcattctccaaatagtaattctaatggctcctttcttgcaccagaaacg gagccaattgttcctgaactgtgtattgaccatttgtggacagaaacgattactaatata agagagaaaaattcacaagcctcaaaagtgtttattacatctgacctatgtgggcaaaag ttcctgtgctttttagtagagtcccagctccagttacgctgtgtaaagtttcaagagagt aatgataaaacccagctcatctttggttcagtgaccaacataccagcaaaggatgcagca ccagtggagaaaatagacaccatgctggtcttggaaggcagtggaaacctggtgctatac acaggagtggttcgggtgggaaaggtttttattcctggactgccagctccctctctgacg atgtccaacacaatgcctcggcccagtactccactagatggcgttagtactccaaagcct cttagtaaactccttggatcattggacgaggttgttctgttgtccccagttccagaactg agggattcttcaaaacttcatgattctctctataatgaggattgtactttccaacagctt ggaacttacattcattctatcagagatcctgtccataacagagtcaccctggaactgagt aatggctccatggttaggatcactattcctgaaattgccacctctgagttagtacaaacg tgtttgcaagcaattaagtttatcctgccaaaagaaatagcagttcagatgcttgtcaag tggtacaatgtccacagtgctccaggaggacccagttatcactcagagtggaatttattt gtgacttgtctcatgaacatgatgggttataacacagaccgcttagcatggactagaaat tttgactttgaaggatcactttctcctgtcattgcgcccaaaaaagcaaggccttccgag actggatctgatgatgactgggaatatttactaaattcagactaccaccagaatgttgag tctcatcttttgaacagatctttatgtctgagtccttcagaagcttcacagatgaaggat gaggatttttcacagaatctcagtctggattcttctacacttctctttactcacatacct gcaatttttttcgttcttcaccttgtgtatgaggagcttaagttgaatactctaatggga gaaggaatttgttcacttgttgaacttctcgttcagttggcaagggacttaaaattgggg ccttatgtagatcattactatagagactacccaacgcttgtcagaactactggacaagtg tgcacaattgatccaggtcaaacaggatttatgcatcatccatcattttttacgtctgag ccaccaagtatttatcagtgggtgagttcttgtctgaagggtgaaggaatgccaccttat ccttacctccctggaatctgtgaaagaagcagacttgtagtcttgagtattgcactgtac atacttggtgatgagagcttggtttctgatgaatcctcacagtatttaaccagaataact atagccccccagaagttgcaagtagaacaagaggaaaacaggtttagtttcaggcattct acatctgtttctagtctagctgaaagattggttgtctggatgactaatgtaggattcact ttaagagatttggaaactcttccctttggaattgctcttcccatcagagatgcaatttat cactgtcgtgagcagcctgcctcagactggccagaagctgtctgtctcttgattggacgt caggatctttccaagcaggcctgcgaaggaaacttacccaaagggaagtctgtgctctca tcagatgttccttcaggaacagaaactgaggaggaagatgacggcatgaatgacatgaat cacgaggtcatgtcattaatatggagtgaagatttaagggtgcaggatgtgcgaaggctt cttcagagtgcgcatcctgtccgtgtcaacgtagtgcagtacccagagctcagtgaccac gagttcatcgaggaaaaggaaaacagattgctccaattgtgtcagcgaactatggctctt cctgtaggacgaggaatgtttaccttgttttcgtaccatcctgttccaacagagccattg cctattcctaaattgaatctgactgggcgtgcccctcctcggaacacaacagtagacctt aatagtggaaacatcgatgtgcctcccaacatgacaagctgggccagctttcataatggt gtggctgctggcctgaagatagctcctgcctcccagatcgactcagcttggattgtttac aataagcccaagcatgctgagttggccaatgagtatgctggctttctcatggctctgggt ttgaatgggcaccttaccaagctggcgactctcaatatccatgactacttgaccaagggc catgaaatgacaagcattggactgctacttggtgtttctgctgcaaaactaggcaccatg gatatgtctattactcggcttcttagcattcacattcctgctctcttacccccaacgtcc acagagctggatgttcctcacaatgtccaagtggctgcagtggttggcattggccttgta tatcaagggacagctcacagacatactgcagaagtcctgttggctgagataggacggcct cctggtcctgaaatggaatactgcactgacagagagtcatactccttagctgctggcttg gccctgggcatggtctgcttggggcatggcagcaatttgataggtatgtctgatctcaat gtgcctgagcagctctatcagtacatggttggaggacataggcgctttcaaacaggaatg catagggagaaacataaatcaccaagttatcaaatcaaagaaggagataccataaatgtg gatgtgacttgtccaggtgctactctagctttggctatgatctacttaaaaaccaataac agatctattgcagattggctccgagcccctgacaccatgtatttgttggactttgtgaag ccagaatttctcttgcttaggacacttgctcgatgcctgattttgtgggatgatatttta ccaaattccaagtgggttgacagcaatgttcctcaaattataagagaaaatagtatctct ctcagtgaaatcgaattgccgtgctcagaggatttgaatttggaaactttgtcccaagca catgtctacataattgcaggagcctgcttgtctctgggttttcgatttgctggctcagaa aacttatcagcatttaactgtttgcataaatttgccaaagattttatgacttatttgtcc gcacctaatgcttctgttacaggtcctcataacctagaaacttgtctgagcgtggtgctg ctgtctctcgccatggtcatggctggctcaggaaacctaaaggttttgcagctttgtcgc ttcttacacatgaaaacgggtggtgaaatgaactatggttttcacttagcccaccacatg gcccttggacttctatttttgggaggaggaaggtactctttgagcacatcaaattcttcc attgccgctcttctctgtgccctttatccgcacttcccagctcacagcactgacaaccgg tatcatctccaggctctccggcacctctatgtgctggccgcggagcccaggcttctagtg cctgtggatgtggacacaaacacgccctgctatgccctcttagaagttacctacaagggc actcagtggtatgaacaaaccaaagaagaattgatggctcctacccttcttccagaactc catcttttaaagcagattaaagtaaaaggcccaagatactgggaactgctcatagattta agcaaaggaacacaacacttgaagtccatcctttccaaggatggggttttatatgttaaa ctccgggcgggtcagctctcctacaaagaagatccaatgggatggcaaagtttgttggct cagactgttgctaacaggaactctgaagcccgggctttcaagccagaaacaatctcagca ttcacttctgatccagcacttctgtcatttgctgaatatttctgcaagccaactgtgaac atgggtcagaaacaggaaattctggatctcttttcttcagtactctatgaatgtgttacc caggagaccccagagatgttgcctgcatacatagcaatggatcaggctataagaagactt gggagaagagaaatgtctgagacttctgaactttggcagataaagttggtgttagagttt ttcagctcccgaagccatcaggagcggctgcagaaccaccctaagcgggggctctttatg aactcggaattcctccctgttgtgaagtgcaccattgataataccctggaccagtggcta caagtcgggggtgatatgtgtgtgcacgcctacctcagcgggcagcccttggaggaatca cagctgagcatgctggcctgcttcctcgtctaccactctgtgccagctccacagcacctg ccacctataggactagaagggagcacaagctttgctgaactgctcttcaaatttaagcag ctaaaaatgccagtgcgagctttgctgagattggctcctttgcttcttggaaatccacag ccaatggtgatgtga |
Protein Sequence |
>64682 : length: 1944 MSNFYEERTTMIAARDLQEFVPFGRDHCKHHPNALNLQLRQLQPASELWSSDGAAGLVGS LQEVTIHEKQKESWQLRKGVSEIGEDVDYDEELYVAGNMVIWSKGSKSQALAVYKAFTVD SPVQQALWCDFIISQDKSEKAYSSNEVEKCICILQSSCINMHSIEGKDYIASLPFQVANV WPTKYGLLFERSASSHEVPPGSPREPLPTMFSMLHPLDEITPLVCKSGSLFGSSRVQYVV DHAMKIVFLNTDPSIVMTYDAVQNVHSVWTLRRVKSEEENVVLKFSEQGGTPQNVATSSS LTAHLRSLSKGDSPVTSPFQNYSSIHSQSRSTSSPSLHSRSPSISNMAALSRAHSPALGV HSFSGVQRFNISSHNQSPKRHSISHSPNSNSNGSFLAPETEPIVPELCIDHLWTETITNI REKNSQASKVFITSDLCGQKFLCFLVESQLQLRCVKFQESNDKTQLIFGSVTNIPAKDAA PVEKIDTMLVLEGSGNLVLYTGVVRVGKVFIPGLPAPSLTMSNTMPRPSTPLDGVSTPKP LSKLLGSLDEVVLLSPVPELRDSSKLHDSLYNEDCTFQQLGTYIHSIRDPVHNRVTLELS NGSMVRITIPEIATSELVQTCLQAIKFILPKEIAVQMLVKWYNVHSAPGGPSYHSEWNLF VTCLMNMMGYNTDRLAWTRNFDFEGSLSPVIAPKKARPSETGSDDDWEYLLNSDYHQNVE SHLLNRSLCLSPSEASQMKDEDFSQNLSLDSSTLLFTHIPAIFFVLHLVYEELKLNTLMG EGICSLVELLVQLARDLKLGPYVDHYYRDYPTLVRTTGQVCTIDPGQTGFMHHPSFFTSE PPSIYQWVSSCLKGEGMPPYPYLPGICERSRLVVLSIALYILGDESLVSDESSQYLTRIT IAPQKLQVEQEENRFSFRHSTSVSSLAERLVVWMTNVGFTLRDLETLPFGIALPIRDAIY HCREQPASDWPEAVCLLIGRQDLSKQACEGNLPKGKSVLSSDVPSGTETEEEDDGMNDMN HEVMSLIWSEDLRVQDVRRLLQSAHPVRVNVVQYPELSDHEFIEEKENRLLQLCQRTMAL PVGRGMFTLFSYHPVPTEPLPIPKLNLTGRAPPRNTTVDLNSGNIDVPPNMTSWASFHNG VAAGLKIAPASQIDSAWIVYNKPKHAELANEYAGFLMALGLNGHLTKLATLNIHDYLTKG HEMTSIGLLLGVSAAKLGTMDMSITRLLSIHIPALLPPTSTELDVPHNVQVAAVVGIGLV YQGTAHRHTAEVLLAEIGRPPGPEMEYCTDRESYSLAAGLALGMVCLGHGSNLIGMSDLN VPEQLYQYMVGGHRRFQTGMHREKHKSPSYQIKEGDTINVDVTCPGATLALAMIYLKTNN RSIADWLRAPDTMYLLDFVKPEFLLLRTLARCLILWDDILPNSKWVDSNVPQIIRENSIS LSEIELPCSEDLNLETLSQAHVYIIAGACLSLGFRFAGSENLSAFNCLHKFAKDFMTYLS APNASVTGPHNLETCLSVVLLSLAMVMAGSGNLKVLQLCRFLHMKTGGEMNYGFHLAHHM ALGLLFLGGGRYSLSTSNSSIAALLCALYPHFPAHSTDNRYHLQALRHLYVLAAEPRLLV PVDVDTNTPCYALLEVTYKGTQWYEQTKEELMAPTLLPELHLLKQIKVKGPRYWELLIDL SKGTQHLKSILSKDGVLYVKLRAGQLSYKEDPMGWQSLLAQTVANRNSEARAFKPETISA FTSDPALLSFAEYFCKPTVNMGQKQEILDLFSSVLYECVTQETPEMLPAYIAMDQAIRRL GRREMSETSELWQIKLVLEFFSSRSHQERLQNHPKRGLFMNSEFLPVVKCTIDNTLDQWL QVGGDMCVHAYLSGQPLEESQLSMLACFLVYHSVPAPQHLPPIGLEGSTSFAELLFKFKQ LKMPVRALLRLAPLLLGNPQPMVM |