| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 7490 |
Name | WT1 |
Synonym | AWT1|EWS-WT1|GUD|NPHS4|WAGR|WIT-2|WT33;Wilms tumor 1;WT1;Wilms tumor 1 |
Definition | Wilms tumor protein|amino-terminal domain of EWS|last three zinc fingers of the DNA-binding domain of WT1 |
Position | 11p13 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 81 |
TUSON P-value | 5.76E-07 |
| Caution | This gene might be oncogene according to our integrated oncogene list. |
|
Pathways and Diseases |
|
Pathway | chaperones modulate interferon signaling pathway;PID BioCarta;100016 |
Pathway | overview of telomerase protein component gene htert transcriptional regulation;PID BioCarta;100019 |
Pathway | Regulation of Telomerase;PID Curated;200072 |
Disease | Denys-Drash syndrome;GAD |
Disease | Nephrotic syndrome, typ 4;OMIM |
Disease | Alzheimer's disease;GAD |
Disease | Cancer;FunDO |
Disease | WAGR Syndrome;GAD |
Disease | DEVELOPMENTAL;GAD |
Disease | glomerulosclerosis, focal;GAD |
Disease | Pleural effusion, Malignant;FunDO |
Disease | Meacham syndrome;OMIM |
Disease | Frasier syndrome;OMIM |
Disease | Wilm's tumor;GAD |
Disease | Aplastic anemia;FunDO |
Disease | Yersinia infection;FunDO |
Disease | Cirrhosis;FunDO |
Disease | Alzheimer's disease;FunDO |
Disease | wilms' tumor and congenital male genitourinary malformation;GAD |
Disease | Nephritis;FunDO |
Disease | Proteinuria;FunDO |
Disease | Wilms tumor, type 1;OMIM |
Disease | CANCER;GAD |
Disease | hypospadias;GAD |
Disease | Endometriosis;FunDO |
Disease | NEUROLOGICAL;GAD |
Disease | abnormal urogenital development;GAD |
Disease | Hyperparathyroidism;FunDO |
Disease | nephrotic syndrome;GAD |
Disease | Urogenital abnormalities;FunDO |
Disease | Denys-Drash syndrome;OMIM |
Disease | RENAL;GAD |
|
External Links |
|
Links to Entrez Gene | 7490 |
Links to all GeneRIF Items | 7490 |
Links to iHOP | 7490 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>7490 : length: 1494 ctgcaggacccggcttccacgtgtgtcccggagccggcgtctcagcacacgctccgctcc gggcctgggtgcctacagcagccagagcagcagggagtccgggacccgggcggcatctgg gccaagttaggcgccgccgaggccagcgctgaacgtctccagggccggaggagccgcggg gcgtccgggtctgagccgcagcaaatgggctccgacgtgcgggacctgaacgcgctgctg cccgccgtcccctccctgggtggcggcggcggctgtgccctgcctgtgagcggcgcggcg cagtgggcgccggtgctggactttgcgcccccgggcgcttcggcttacgggtcgttgggc ggccccgcgccgccaccggctccgccgccacccccgccgccgccgcctcactccttcatc aaacaggagccgagctggggcggcgcggagccgcacgaggagcagtgcctgagcgccttc actgtccacttttccggccagttcactggcacagccggagcctgtcgctacgggcccttc ggtcctcctccgcccagccaggcgtcatccggccaggccaggatgtttcctaacgcgccc tacctgcccagctgcctcgagagccagcccgctattcgcaatcagggttacagcacggtc accttcgacgggacgcccagctacggtcacacgccctcgcaccatgcggcgcagttcccc aaccactcattcaagcatgaggatcccatgggccagcagggctcgctgggtgagcagcag tactcggtgccgcccccggtctatggctgccacacccccaccgacagctgcaccggcagc caggctttgctgctgaggacgccctacagcagtgacaatttataccaaatgacatcccag cttgaatgcatgacctggaatcagatgaacttaggagccaccttaaagggccacagcaca gggtacgagagcgataaccacacaacgcccatcctctgcggagcccaatacagaatacac acgcacggtgtcttcagaggcattcaggatgtgcgacgtgtgcctggagtagccccgact cttgtacggtcggcatctgagaccagtgagaaacgccccttcatgtgtgcttacccaggc tgcaataagagatattttaagctgtcccacttacagatgcacagcaggaagcacactggt gagaaaccataccagtgtgacttcaaggactgtgaacgaaggttttctcgttcagaccag ctcaaaagacaccaaaggagacatacaggtgtgaaaccattccagtgtaaaacttgtcag cgaaagttctcccggtccgaccacctgaagacccacaccaggactcatacaggtgaaaag cccttcagctgtcggtggccaagttgtcagaaaaagtttgcccggtcagatgaattagtc cgccatcacaacatgcatcagagaaacatgaccaaactccagctggcgctttga |
Protein Sequence |
>7490 : length: 497 MQDPASTCVPEPASQHTLRSGPGCLQQPEQQGVRDPGGIWAKLGAAEASAERLQGRRSRG ASGSEPQQMGSDVRDLNALLPAVPSLGGGGGCALPVSGAAQWAPVLDFAPPGASAYGSLG GPAPPPAPPPPPPPPPHSFIKQEPSWGGAEPHEEQCLSAFTVHFSGQFTGTAGACRYGPF GPPPPSQASSGQARMFPNAPYLPSCLESQPAIRNQGYSTVTFDGTPSYGHTPSHHAAQFP NHSFKHEDPMGQQGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQ LECMTWNQMNLGATLKGHSTGYESDNHTTPILCGAQYRIHTHGVFRGIQDVRRVPGVAPT LVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSDQ LKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGEKPFSCRWPSCQKKFARSDELV RHHNMHQRNMTKLQLAL |