| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 7490 |
Name | WT1 |
Synonymous | AWT1|EWS-WT1|GUD|NPHS4|WAGR|WIT-2|WT33;Wilms tumor 1;WT1;Wilms tumor 1 |
Definition | Wilms tumor protein|amino-terminal domain of EWS|last three zinc fingers of the DNA-binding domain of WT1 |
Position | 11p13 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
 |
Transcription Factors [Top] |
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Regulation From TransFac database |
pawr(h) + WT1(h) <==> pawr(h):WT1(h) (binding) | WT1(h) --> Egr1(m) (DNA binding). | WT1(h) --> IGF2(h) (DNA binding). | WT1(h) --> PDGFA(h) (DNA binding). | WT1(h) --> IGF-1 receptor(r) (DNA binding). | WT1(h) --> FOXD1(h) (DNA binding). | WT1(h) + p53(r) <==> WT1(h):p53(r) (binding) | WT1(h) + p53(h) <==> WT1(h):p53(h) (binding). | p73alpha(mo) + WT1(h) <==> p73alpha(mo):WT1(h) (binding) | WT1(h) --/ IGF-1 receptor(r) (transrepression) | WT1(h) --> WT1(h) (expression). | WT1 I -KTS(h) --> IGF-1 receptor(r) (DNA binding). | p73alpha(mo) + WT1 I -KTS(h) <==> p73alpha(mo):WT1 I -KTS(h) (binding) | p73beta(mo) + WT1 I -KTS(h) <==> p73beta(mo):WT1 I -KTS(h) (binding) | p53(h) + WT1 I -KTS(h) <==> p53(h):WT1 I -KTS(h) (binding) | p63(r) + WT1 I -KTS(h) <==> p63(r):WT1 I -KTS(h) (binding) | WT1 I -KTS(h) --/ IGF-1 receptor(r) (transrepression) | WT1 I -KTS(h) + ER-alpha(m.s.) <==> WT1 I -KTS(h):ER-alpha(m.s.) (binding) | WT1 I -KTS(h) + Slim-3(h) <==> WT1 I -KTS(h):Slim-3(h) (binding) | Slim-3(m.s.) + WT1 I -KTS(h) <==> Slim-3(m.s.):WT1 I -KTS(h) (binding) | WT1 I -KTS(h) --> DAX1(m) (transactivation) | WT1(h) --> WT1 I -KTS(h) (expression). | WT1 -KTS(h) --> IGF-1 receptor(r) (DNA binding). | p73alpha(mo) + WT1 -KTS(h) <==> p73alpha(mo):WT1 -KTS(h) (binding) | WT1 -KTS(h) --/ IGF-1 receptor(r) (transrepression) | WT1(h) --> WT1 -KTS(h) (expression). | WT1 I(h) --> IGF-1 receptor(r) (DNA binding). | p73alpha(mo) + WT1 I(h) <==> p73alpha(mo):WT1 I(h) (binding) | WT1 I(h) --/ IGF-1 receptor(r) (transrepression) | WT1(h) --> WT1 I(h) (expression). | WT1(h) --> WT1-del2(h) (expression). | WT1(h) --> WT1 I-del2(h) (expression). | WT1(h) --> c-myb(h) (DNA binding). | WT1(h) --> TBXA2R(h) (DNA binding). | WT1(h) --> WT1(h) (expression). |
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Post Transcriptional Modification [Top] | |||
|
Location (AA) |
PTM type |
Literature |
Database |
|---|---|---|---|
Methylation Profile [Top] | ||
|
Chromosome |
Location |
Source |
|---|---|---|
chr11 |
Promoter: 32413163 - 32415163 | GoldenGate_Methylation_Cancer_Panel_I |
chr11 |
Promoter: 32413163 - 32415163 | GoldenGate_Methylation_Cancer_Panel_I |
chr11 |
Promoter: 32413163 - 32415163 | GoldenGate_Methylation_Cancer_Panel_I |
chr11 |
Promoter: 32413163 - 32415163 | GoldenGate_Methylation_Cancer_Panel_I |
chr11 |
Promoter: 32413163 - 32415163 | GSE27584 |
chr11 |
Promoter: 32413163 - 32415163 | GSE27584 |
chr11 |
Promoter: 32413163 - 32415163 | GSE27584 |
chr11 |
Promoter: 32413163 - 32415163 | GSE27584 |
chr11 |
Promoter: 32413163 - 32415163 | Agilent_014791_44K |
chr11 |
Promoter: 32413163 - 32415163 | E-GEOD-20553 |
chr11 |
Promoter: 32413163 - 32415163 | E-GEOD-20553 |
chr11 |
Promoter: 32413163 - 32415163 | E-GEOD-20553 |
chr11 |
Promoter: 32413163 - 32415163 | E-GEOD-20553 |
chr11 |
Promoter: 32413163 - 32415163 | PMID:16134181 |
chr11 |
Promoter: 32413163 - 32415163 | PMID:16134181 |
chr11 |
Promoter: 32413163 - 32415163 | PMID:16134181 |
chr11 |
Promoter: 32413163 - 32415163 | PMID:16134181 |
chr11 |
Promoter: 32413163 - 32415163 | PMID:17289889 |
chr11 |
Promoter: 32413163 - 32415163 | PMID:17289889 |
chr11 |
Promoter: 32413163 - 32415163 | PMID:17289889 |
chr11 |
Promoter: 32413163 - 32415163 | PMID:17289889 |
chr11 |
Promoter: 32413163 - 32415163 | PMID:15367334 |
chr11 |
Promoter: 32413163 - 32415163 | PMID:15367334 |
chr11 |
Promoter: 32413163 - 32415163 | PMID:15367334 |
chr11 |
Promoter: 32413163 - 32415163 | PMID:15367334 |
chr11 |
Promoter: 32413163 - 32415163 | PMID:16435073 |
chr11 |
Promoter: 32413163 - 32415163 | PMID:16435073 |
chr11 |
Promoter: 32413163 - 32415163 | PMID:16435073 |
chr11 |
Promoter: 32413163 - 32415163 | PMID:16435073 |