| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 8567 |
Name | MADD |
Synonym | DENN|IG20|RAB3GEP;MAP-kinase activating death domain;MADD;MAP-kinase activating death domain |
Definition | MAP kinase-activating death domain protein|Rab3 GDP/GTP exchange factor|differentially expressed in normal and neoplastic cells|insulinoma glucagonoma clone 20 |
Position | 11p11.2 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 10203 |
TUSON P-value | 1 |
|
Pathways and Diseases |
|
Pathway | Caspase cascade in apoptosis;PID Curated;200148 |
Pathway | Ceramide signaling pathway;PID Curated;200100 |
Pathway | Apoptosis signaling pathway;PANTHER;P00006 |
Pathway | ceramide signaling pathway;PID BioCarta;100206 |
Pathway | sodd/tnfr1 signaling pathway;PID BioCarta;100031 |
Pathway | tnfr1 signaling pathway;PID BioCarta;100015 |
Disease | HDL cholesterol;GAD |
Disease | Fasting glucose-related traits;NHGRI |
Disease | fasting glucose-related traits;GAD |
Disease | METABOLIC;GAD |
Disease | HDL cholesterol;NHGRI |
|
External Links |
|
Links to Entrez Gene | 8567 |
Links to all GeneRIF Items | 8567 |
Links to iHOP | 8567 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>8567 : length: 4635 atggtgcaaaagaagaagttctgtcctcggttacttgactatctagtgatcgtaggggcc aggcacccgagcagtgatagcgtggcccagactcctgaattgctacggcgataccccttg gaggatcacactgagtttcccctgcccccagatgtagtgttcttctgccagcccgagggc tgcctgagcgtgcggcagcggcgcatgagccttcgggatgatacctcttttgtcttcacc ctcactgacaaggacactggagtcacgcgatatggcatctgtgttaacttctaccgctcc ttccaaaagcgaatctctaaggagaagggggaaggtggggcagggtcccgtgggaaggaa ggaacccatgccacctgtgcctcagaagagggtggcactgagagctcagagagtggctca tccctgcagcctctcagtgctgactctacccctgatgtgaaccagtctcctcggggcaaa cgccgggccaaggcggggagccgctcccgcaacagtactctcacgtccctgtgcgtgctc agccactaccctttcttctccaccttccgagagtgtttgtatactctcaagcgcctggtg gactgctgtagtgagcgccttctgggcaagaaactgggcatccctcgaggcgtacaaagg gacaccatgtggcggatctttactggatcgctgctggtagaggagaagtcaagtgccctt ctgcatgaccttcgagagattgaggcctggatctatcgattgctgcgctccccagtaccc gtctctgggcagaagcgagtagacatcgaggtcctaccccaagagctccagccagctctg acctttgctcttccagacccatctcgattcaccctagtggatttcccactgcaccttccc ttggaacttctaggtgtggacgcctgtctccaggtgctaacctgcattctgttagagcac aaggtggtgctacagtcccgagactacaatgcactctccatgtctgtgatggcattcgtg gcaatgatctacccactggagtatatgtttcctgtcatcccgctgctacccacctgcatg gcatcagcagagcagctgctgttggctccaaccccgtacatcattggggttcctgccagc ttcttcctctacaaactggacttcaaaatgcctgatgatgtatggctagtggatctggac agcaatagggtgattgcccccaccaatgcagaagtgctgcctatcctgccagaaccagaa tcactagagctgaaaaagcatttaaagcaggccttggccagcatgagtctcaacacccag cccatcctcaatctggagaaatttcatgagggccaggagatcccccttctcttgggaagg ccttctaatgacctgcagtccacaccgtccactgaattcaacccactcatctatggcaat gatgtggattctgtggatgttgcaaccagggttgccatggtacggttcttcaattccgcc aacgtgctgcagggatttcagatgcacacgcgtaccctgcgcctctttcctcggcctgtg gtagcttttcaagctggctcctttctagcctcacgtccccggcagactccttttgccgag aaattggccaggactcaggctgtggagtactttggggaatggatccttaaccccaccaac tatgcctttcagcgaattcacaacaatatgtttgatccagccctgattggtgacaagcca aagtggtatgctcatcagctgcagcctatccactatcgcgtctatgacagcaattcccag ctggctgaggccctgagtgtaccaccagagcgggactctgactccgaacctactgatgat agtggcagtgatagtatggattatgacgattcaagctcttcttactcctcccttggtgac tttgtcagtgaaatgatgaaatgtgacattaatggtgatactcccaatgtggaccctctg acacatgcagcactgggggatgccagcgaggtggagattgacgagctgcagaatcagaag gaagcagaagagcctggcccagacagtgagaactctcaggaaaaccccccactgcgctcc agctctagcaccacagccagcagcagccccagcactgtcatccacggagccaactctgaa cctgctgactctacggagatggatgataaggcagcagtaggcgtctccaagcccctccct tccgtgcctcccagcattggcaaatcgaacgtggacagacgtcaggcagaaattggagag ggggctcaaaagctgctgcggcccaacagcttgagactggcaagtgactcagatgcagag tcagactctcgggcaagctctcccaactccaccgtctccaacaccagcaccgagggcttc gggggcatcatgtcttttgccagcagcctctatcggaaccacagtaccagcttcagtctt tcaaacctcacactgcccaccaaaggtgcccgagagaaggccacgcccttccccagtctg aaaggaaacaggagggcgttagtggatcagaagtcatctgtcattaaacacagcccaaca gtgaaaagagaacctccatcaccccagggtcgatccagcaattctagtgagaaccagcag ttcctgaaggaggtggtgcacagcgtgctggacggccagggagttggctggctcaacatg aaaaaggtgcgccggctgctggagagcgagcagctgcgagtctttgtcctgagcaagctg aaccgcatggtgcagtcagaggacgatgcccggcaggacatcatcccggatgtggagatc agtcggaaggtgtacaagggaatgttagacctcctcaagtgtacagtcctcagcttggag cagtcctatgcccacgcgggtctgggtggcatggccagcatctttgggcttttggagatt gcccagacccactactatagtaaagaaccagacaagcggaagagaagtccaacagaaagt gtaaataccccagttggcaaggatcctggcctagctgggcggggggacccaaaggctatg gcacaactgagagttccacaactgggacctcgggcaccaagtgccacaggaaagggtcct aaggaactggacaccagaagtttaaaggaagaaaattttatagcatctattgggcctgaa gtaatcaaacctgtctttgaccttggtgagacagaggagaaaaagtcccagatcagcgca gacagtggtgtgagcctgacgtctagttcccagaggactgatcaagactctgtcatcggc gtgagtccagctgttatgatccgcagctcaagtcaggattctgaagttagcaccgtgagt aatagctctggagagacccttggagctgacagtgacttgagcagcaatgcaggtgatgga ccaggtggcgagggcagtgttcacctggcaagctctcggggcactttgtctgatagtgaa attgagaccaactctgccacaagcaccatctttggtaaagcccacagcttgaagccaagc ataaaggagaagctggcaggcagccccattcgtacttctgaagatgtgagccagcgagtc tatctctatgagggactcctaggcaaagagcgttctactttatgggaccaaatgcaattc tgggaagatgccttcttagatgctgtgatgttggagagagaagggatgggtatggaccag ggtccccaggaaatgatcgacaggtacctgtcccttggagaacatgaccggaagcgcctg gaagatgatgaagatcgcttgctggccacacttctgcacaacctcatctcctacatgctg ctgatgaaggtaaataagaatgacatccgcaagaaggtgaggcgcctaatgggaaagtcg cacattgggcttgtgtacagccagcaaatcaatgaggtgcttgatcagctggcgaacctg aatggacgcgatctctctatctggtccagtggcagccggcacatgaagaagcagacattt gtggtacatgcagggacagatacaaacggagatatctttttcatggaggtgtgcgatgac tgtgtggtgttgcgtagtaacatcggaacagtgtatgagcgctggtggtacgagaagctc atcaacatgacctactgtcccaagacgaaggtgttgtgcttgtggcgtagaaatggctct gagacccagctcaacaagttctatactaaaaagtgtcgggagctgtactactgtgtgaag gacagcatggagcgcgctgccgcccgacagcaaagcatcaaacccggacctgaattgggt ggcgagttccctgtgcaggacctgaagactggtgagggtggcctgctgcaggtgaccctg gaagggatcaacctcaaattcatgcacaatcaggttttcatagagctgaatcacattaaa aagtgcaatacagttcgaggcgtctttgtcctggaggaatttgttcctgaaattaaagaa gtggtgagccacaagtacaagacaccaatggcccacgaaatctgctactccgtattatgt ctcttctcgtacgtggctgcagttcatagcagtgaggaagatctcagaaccccgccccgg cctgtctctagctga |
Protein Sequence |
>8567 : length: 1544 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL KGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNM KKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLE QSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAM AQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISA DSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVSNSSGETLGADSDLSSNAGDG PGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRV YLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRL EDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANL NGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKL INMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELG GEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKE VVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPPRPVSS |