| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 920 |
Name | CD4 |
Synonym | CD4mut;CD4 molecule;CD4;CD4 molecule |
Definition | CD4 antigen (p55)|CD4 receptor|T-cell surface antigen T4/Leu-3|T-cell surface glycoprotein CD4 |
Position | 12p13.31 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 4582 |
TUSON P-value | 1 |
|
Pathways and Diseases |
|
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | Translocation of ZAP-70 to Immunological synapse;PID Reactome;500480 |
Pathway | Phosphorylation of CD3 and TCR zeta chains;PID Reactome;500479 |
Pathway | Cell adhesion molecules (CAMs);KEGG PATHWAY;hsa04514 |
Pathway | CXCR4-mediated signaling events;PID Curated;200083 |
Pathway | role of mef2d in t-cell apoptosis;PID BioCarta;100109 |
Pathway | HIV Infection;Reactome;REACT:6185 |
Pathway | IL12 signaling mediated by STAT4;PID Curated;200197 |
Pathway | IL12-mediated signaling events;PID Curated;200034 |
Pathway | T cell receptor signaling pathway;KEGG PATHWAY;hsa04660 |
Pathway | Hematopoietic cell lineage;KEGG PATHWAY;hsa04640 |
Pathway | Notch-mediated HES/HEY network;PID Curated;200196 |
Pathway | Primary immunodeficiency;KEGG PATHWAY;hsa05340 |
Pathway | TCR signaling in naive CD4+ T cells;PID Curated;200022 |
Pathway | Binding and entry of HIV virion;PID Reactome;500725 |
Pathway | activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor;PID BioCarta;100196 |
Pathway | Downstream TCR signaling;PID Reactome;500482 |
Pathway | Antigen processing and presentation;KEGG PATHWAY;hsa04612 |
Pathway | t cell receptor signaling pathway;PID BioCarta;100022 |
Pathway | PD-1 signaling;PID Reactome;500488 |
Pathway | TCR signaling;PID Reactome;500478 |
Pathway | IL23-mediated signaling events;PID Curated;200131 |
Pathway | lck and fyn tyrosine kinases in initiation of tcr activation;PID BioCarta;100023 |
Pathway | Nef Mediated CD4 Down-regulation;PID Reactome;500759 |
Pathway | Vpu mediated degradation of CD4;PID Reactome;500761 |
Pathway | C-MYB transcription factor network;PID Curated;200130 |
Pathway | Arf1 pathway;PID Curated;200167 |
Disease | Drug abuse;FunDO |
Disease | Lupus erythematosus;FunDO |
Disease | Embryoma;FunDO |
Disease | Squamous cell cancer;FunDO |
Disease | Diabetes mellitus;FunDO |
Disease | diabetes, type 1;GAD |
Disease | Pancreatitis;FunDO |
Disease | Metastasis to lymph nodes;FunDO |
Disease | Mycosis fungoides;FunDO |
Disease | IMMUNE;GAD |
Disease | Multiple sclerosis;FunDO |
Disease | Testicular dysfunction;FunDO |
Disease | INFECTION;GAD |
Disease | Systemic infection;FunDO |
Disease | Lupus erythematosus, susceptibility to;OMIM |
Disease | HIV Infections;GAD |
Disease | Breast cancer;FunDO |
Disease | HIV infection;FunDO |
Disease | CD4+ lymphocyte deficiency;OMIM |
Disease | Acquired Immunodeficiency Syndrome;GAD |
|
External Links |
|
Links to Entrez Gene | 920 |
Links to all GeneRIF Items | 920 |
Links to iHOP | 920 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>920 : length: 1377 atgaaccggggagtcccttttaggcacttgcttctggtgctgcaactggcgctcctccca gcagccactcagggaaagaaagtggtgctgggcaaaaaaggggatacagtggaactgacc tgtacagcttcccagaagaagagcatacaattccactggaaaaactccaaccagataaag attctgggaaatcagggctccttcttaactaaaggtccatccaagctgaatgatcgcgct gactcaagaagaagcctttgggaccaaggaaactttcccctgatcatcaagaatcttaag atagaagactcagatacttacatctgtgaagtggaggaccagaaggaggaggtgcaattg ctagtgttcggattgactgccaactctgacacccacctgcttcaggggcagagcctgacc ctgaccttggagagcccccctggtagtagcccctcagtgcaatgtaggagtccaaggggt aaaaacatacagggggggaagaccctctccgtgtctcagctggagctccaggatagtggc acctggacatgcactgtcttgcagaaccagaagaaggtggagttcaaaatagacatcgtg gtgctagctttccagaaggcctccagcatagtctataagaaagagggggaacaggtggag ttctccttcccactcgcctttacagttgaaaagctgacgggcagtggcgagctgtggtgg caggcggagagggcttcctcctccaagtcttggatcacctttgacctgaagaacaaggaa gtgtctgtaaaacgggttacccaggaccctaagctccagatgggcaagaagctcccgctc cacctcaccctgccccaggccttgcctcagtatgctggctctggaaacctcaccctggcc cttgaagcgaaaacaggaaagttgcatcaggaagtgaacctggtggtgatgagagccact cagctccagaaaaatttgacctgtgaggtgtggggacccacctcccctaagctgatgctg agtttgaaactggagaacaaggaggcaaaggtctcgaagcgggagaaggcggtgtgggtg ctgaaccctgaggcggggatgtggcagtgtctgctgagtgactcgggacaggtcctgctg gaatccaacatcaaggttctgcccacatggtccaccccggtgcagccaatggccctgatt gtgctggggggcgtcgccggcctcctgcttttcattgggctaggcatcttcttctgtgtc aggtgccggcaccgaaggcgccaagcagagcggatgtctcagatcaagagactcctcagt gagaagaagacctgccagtgtcctcaccggtttcagaagacatgtagccccatttga |
Protein Sequence |
>920 : length: 458 MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIK ILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQL LVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSG TWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWW QAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLA LEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWV LNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCV RCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI |