| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 9365 |
Name | KL |
Synonym | -;klotho;KL;klotho |
Definition | - |
Position | 13q12 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 1369 |
TUSON P-value | 0.080096808 |
|
Pathways and Diseases |
|
Pathway | Signaling by Insulin receptor;Reactome;REACT:498 |
Pathway | Signaling by FGFR;Reactome;REACT:9470 |
Disease | bone density and spondylosis;GAD |
Disease | angina, vasospastic atherosclerosis, coronary;GAD |
Disease | Coronary artery disease, susceptibility to;OMIM |
Disease | cholesterol, HDL;GAD |
Disease | blood pressure, arterial body mass glucose insulin lipids;GAD |
Disease | spondylosis, lumbar;GAD |
Disease | AGING;GAD |
Disease | longevity;GAD |
Disease | Cardiomyopathies;GAD |
Disease | Coronary Stenosis;GAD |
Disease | stroke, ischemic;GAD |
Disease | atherosclerosis, coronary;GAD |
Disease | Aseptic necrosis of bone;FunDO |
Disease | osteoarthritis;GAD |
Disease | METABOLIC;GAD |
Disease | Calcinosis;GAD |
Disease | Tumoral calcinosis, hyperphosphatemic;OMIM |
Disease | Stroke;FunDO |
Disease | aging;GAD |
Disease | bone density;GAD |
Disease | age-related skeletal disorders;GAD |
Disease | Diabetes mellitus;FunDO |
Disease | CHEMDEPENDENCY;GAD |
Disease | bone density osteoarthritis osteoporosis;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | Stroke;GAD |
Disease | Kidney failure;FunDO |
Disease | NEUROLOGICAL;GAD |
Disease | blood pressure, arterial;GAD |
Disease | smoking cessation;GAD |
Disease | memory impairment;GAD |
Disease | Spondylarthropathies;FunDO |
Disease | Arthritis;FunDO |
Disease | Atherosclerosis;FunDO |
|
External Links |
|
Links to Entrez Gene | 9365 |
Links to all GeneRIF Items | 9365 |
Links to iHOP | 9365 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>9365 : length: 3039 atgcccgccagcgccccgccgcgccgcccgcggccgccgccgccgtcgctgtcgctgctg ctggtgctgctgggcctgggcggccgccgcctgcgtgcggagccgggcgacggcgcgcag acctgggcccgtttctcgcggcctcctgcccccgaggccgcgggcctcttccagggcacc ttccccgacggcttcctctgggccgtgggcagcgccgcctaccagaccgagggcggctgg cagcagcacggcaagggtgcgtccatctgggatacgttcacccaccaccccctggcaccc ccgggagactcccggaacgccagtctgccgttgggcgccccgtcgccgctgcagcccgcc accggggacgtagccagcgacagctacaacaacgtcttccgcgacacggaggcgctgcgc gagctcggggtcactcactaccgcttctccatctcgtgggcgcgagtgctccccaatggc agcgcgggcgtccccaaccgcgaggggctgcgctactaccggcgcctgctggagcggctg cgggagctgggcgtgcagcccgtggtcaccctgtaccactgggacctgccccagcgcctg caggacgcctacggcggctgggccaaccgcgccctggccgaccacttcagggattacgcg gagctctgcttccgccacttcggcggtcaggtcaagtactggatcaccatcgacaacccc tacgtggtggcctggcacggctacgccaccgggcgcctggcccccggcatccggggcagc ccgcggctcgggtacctggtggcgcacaacctcctcctggctcatgccaaagtctggcat ctctacaatacttctttccgtcccactcagggaggtcaggtgtccattgccctaagctct cactggatcaatcctcgaagaatgaccgaccacagcatcaaagaatgtcaaaaatctctg gactttgtactaggttggtttgccaaacccgtatttattgatggtgactatcccgagagc atgaagaataacctttcatctattctgcctgattttactgaatctgagaaaaagttcatc aaaggaactgctgacttttttgctctttgctttggacccaccttgagttttcaacttttg gaccctcacatgaagttccgccaattggaatctcccaacctgaggcaactgctttcctgg attgaccttgaatttaaccatcctcaaatatttattgtggaaaatggctggtttgtctca gggaccaccaagagagatgatgccaaatatatgtattacctcaaaaagttcatcatggaa accttaaaagccatcaagctggatggggtggatgtcatcgggtataccgcatggtccctc atggatggtttcgagtggcacagaggttacagcatcaggcgtggactcttctatgttgac tttctaagccaggacaagatgttgttgccaaagtcttcagccttgttctaccaaaagctg atagagaaaaatggcttccctcctttacctgaaaatcagcccctagaagggacatttccc tgtgactttgcttggggagttgttgacaactacattcaagtagataccactctgtctcag tttaccgacctgaatgtttacctgtgggatgtccaccacagtaaaaggcttattaaagtg gatggggttgtgaccaagaagaggaaatcctactgtgttgactttgctgccatccagccc cagatcgctttactccaggaaatgcacgttacacattttcgcttctccctggactgggcc ctgattctccctctgggtaaccagtcccaggtgaaccacaccatcctgcagtactatcgc tgcatggccagcgagcttgtccgtgtcaacatcaccccagtggtggccctgtggcagcct atggccccgaaccaaggactgccgcgcctcctggccaggcagggcgcctgggagaacccc tacactgccctggcctttgcagagtatgcccgactgtgctttcaagagctcggccatcac gtcaagctttggataacgatgaatgagccgtatacaaggaatatgacatacagtgctggc cacaaccttctgaaggcccatgccctggcttggcatgtgtacaatgaaaagtttaggcat gctcagaatgggaaaatatccatagccttgcaggctgattggatagaacctgcctgccct ttctcccaaaaggacaaagaggtggctgagagagttttggaatttgacattggctggctg gctgagcccattttcggctctggagattatccatgggtgatgagggactggctgaaccaa agaaacaattttcttcttccttatttcactgaagatgaaaaaaagctaatccagggtacc tttgactttttggctttaagccattataccaccatccttgtagactcagaaaaagaagat ccaataaaatacaatgattacctagaagtgcaagaaatgaccgacatcacgtggctcaac tcccccagtcaggtggcggtagtgccctgggggttgcgcaaagtgctgaactggctgaag ttcaagtacggagacctccccatgtacataatatccaatggaatcgatgacgggctgcat gctgaggacgaccagctgagggtgtattatatgcagaattacataaacgaagctctcaaa gcccacatactggatggtatcaatctttgcggatactttgcttattcgtttaacgaccgc acagctccgaggtttggcctctatcgttatgctgcagatcagtttgagcccaaggcatcc atgaaacattacaggaaaattattgacagcaatggtttcccgggcccagaaactctggaa agattttgtccagaagaattcaccgtgtgtactgagtgcagtttttttcacacccgaaag tctttactggctttcatagcttttctattttttgcttctattatttctctctcccttata ttttactactcgaagaaaggcagaagaagttacaaatag |
Protein Sequence |
>9365 : length: 1012 MPASAPPRRPRPPPPSLSLLLVLLGLGGRRLRAEPGDGAQTWARFSRPPAPEAAGLFQGT FPDGFLWAVGSAAYQTEGGWQQHGKGASIWDTFTHHPLAPPGDSRNASLPLGAPSPLQPA TGDVASDSYNNVFRDTEALRELGVTHYRFSISWARVLPNGSAGVPNREGLRYYRRLLERL RELGVQPVVTLYHWDLPQRLQDAYGGWANRALADHFRDYAELCFRHFGGQVKYWITIDNP YVVAWHGYATGRLAPGIRGSPRLGYLVAHNLLLAHAKVWHLYNTSFRPTQGGQVSIALSS HWINPRRMTDHSIKECQKSLDFVLGWFAKPVFIDGDYPESMKNNLSSILPDFTESEKKFI KGTADFFALCFGPTLSFQLLDPHMKFRQLESPNLRQLLSWIDLEFNHPQIFIVENGWFVS GTTKRDDAKYMYYLKKFIMETLKAIKLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVD FLSQDKMLLPKSSALFYQKLIEKNGFPPLPENQPLEGTFPCDFAWGVVDNYIQVDTTLSQ FTDLNVYLWDVHHSKRLIKVDGVVTKKRKSYCVDFAAIQPQIALLQEMHVTHFRFSLDWA LILPLGNQSQVNHTILQYYRCMASELVRVNITPVVALWQPMAPNQGLPRLLARQGAWENP YTALAFAEYARLCFQELGHHVKLWITMNEPYTRNMTYSAGHNLLKAHALAWHVYNEKFRH AQNGKISIALQADWIEPACPFSQKDKEVAERVLEFDIGWLAEPIFGSGDYPWVMRDWLNQ RNNFLLPYFTEDEKKLIQGTFDFLALSHYTTILVDSEKEDPIKYNDYLEVQEMTDITWLN SPSQVAVVPWGLRKVLNWLKFKYGDLPMYIISNGIDDGLHAEDDQLRVYYMQNYINEALK AHILDGINLCGYFAYSFNDRTAPRFGLYRYAADQFEPKASMKHYRKIIDSNGFPGPETLE RFCPEEFTVCTECSFFHTRKSLLAFIAFLFFASIISLSLIFYYSKKGRRSYK |