Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

9365

Name

KL

Synonymous

-;klotho;KL;klotho

Definition

-

Position

13q12

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

KL(h) --> klotho isoform-membrane-bound(h) (expression).
klotho(h) --> ERK1(h){p} (increase of phosphorylation)
klotho(h) --> ERK2(h){p} (increase of phosphorylation)
KL(h) --> klotho(h) (expression).
KL(h) --> klotho isoform-secreted(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

106N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
159N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
283N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
344N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
497Phosphotyrosine (By similarity).Swiss-Prot 53.0
607N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
612N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
694N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr13

Promoter: 32487071 - 32489071Agilent_014791

chr13

Promoter: 32487071 - 32489071GSE27584

chr13

Promoter: 32487071 - 32489071Agilent_014791_44K


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