| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 999 |
Name | CDH1 |
Synonym | Arc-1|CD324|CDHE|ECAD|LCAM|UVO;cadherin 1, type 1, E-cadherin (epithelial);CDH1;cadherin 1, type 1, E-cadherin (epithelial) |
Definition | CAM 120/80|E-Cadherin|cadherin 1, E-cadherin (epithelial)|cadherin-1|calcium-dependent adhesion protein, epithelial|cell-CAM 120/80|epithelial cadherin|uvomorulin |
Position | 16q22.1 |
Gene Type | protein-coding |
|
TSG scores |
Description |
| TUSON ranking | 23 |
TUSON P-value | 2.16E-23 |
|
Pathways and Diseases |
|
Pathway | Apoptosis;Reactome;REACT:578 |
Pathway | Cell junction organization;Reactome;REACT:20676 |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | Integrin cell surface interactions;PID Reactome;500004 |
Pathway | Endometrial cancer;KEGG PATHWAY;hsa05213 |
Pathway | Cell adhesion molecules (CAMs);KEGG PATHWAY;hsa04514 |
Pathway | tgf beta signaling pathway;PID BioCarta;100017 |
Pathway | E-cadherin signaling in keratinocytes;PID Curated;200125 |
Pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met);PID Curated;200032 |
Pathway | Integrin cell surface interactions;Reactome;REACT:13552 |
Pathway | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell;PID Reactome;500477 |
Pathway | Bacterial invasion of epithelial cells;KEGG PATHWAY;hsa05100 |
Pathway | Adherens junction;KEGG PATHWAY;hsa04520 |
Pathway | a6b1 and a6b4 Integrin signaling;PID Curated;200162 |
Pathway | Nectin adhesion pathway;PID Curated;200053 |
Pathway | Thyroid cancer;KEGG PATHWAY;hsa05216 |
Pathway | CDC42 signaling events;PID Curated;200057 |
Pathway | Pathogenic Escherichia coli infection;KEGG PATHWAY;hsa05130 |
Pathway | Regulation of Wnt-mediated beta catenin signaling and target gene transcription;PID Curated;200106 |
Pathway | downregulated of mta-3 in er-negative breast tumors;PID BioCarta;100102 |
Pathway | Wnt signaling pathway;PANTHER;P00057 |
Pathway | Cadherin signaling pathway;PANTHER;P00012 |
Pathway | E-cadherin signaling events;PID Curated;200094 |
Pathway | E-cadherin signaling in the nascent adherens junction;PID Curated;200105 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Bladder cancer;KEGG PATHWAY;hsa05219 |
Pathway | Melanoma;KEGG PATHWAY;hsa05218 |
Pathway | Alzheimer disease-presenilin pathway;PANTHER;P00004 |
Pathway | Arf6 trafficking events;PID Curated;200046 |
Pathway | RAC1 signaling pathway;PID Curated;200190 |
Pathway | Stabilization and expansion of the E-cadherin adherens junction;PID Curated;200155 |
Pathway | sumoylation as a mechanism to modulate ctbp-dependent gene responses;PID BioCarta;100195 |
Pathway | Apoptotic cleavage of cell adhesion proteins;PID Reactome;500272 |
Pathway | FGF signaling pathway;PID Curated;200189 |
Disease | Thyroid cancer;KEGG DISEASE;H00032 |
Disease | Gastric cancer;KEGG DISEASE;H00018 |
Disease | urothelial cancer;GAD |
Disease | urinary calculus;GAD |
Disease | bladder cancer;GAD |
Disease | Breast cancer, lobular;OMIM |
Disease | Endometrial carcinoma;OMIM |
Disease | Cleft lip with or without cleft palate, with gastric cancer, familial diffuse;OMIM |
Disease | IMMUNE;GAD |
Disease | transitional cell carcinoma of the bladder.;GAD |
Disease | Cancers of endocrine organs;KEGG DISEASE |
Disease | prostate cancer;GAD |
Disease | METABOLIC;GAD |
Disease | Cancers of the digestive system;KEGG DISEASE |
Disease | Ulcerative colitis;NHGRI |
Disease | gastric carcinoma risk;GAD |
Disease | colorectal cancer;GAD |
Disease | Breast cancer;KEGG DISEASE;H00031 |
Disease | Gastric cancer, familial diffuse;OMIM |
Disease | Hepatocellular carcinoma;KEGG DISEASE;H00048 |
Disease | Crohn Disease;GAD |
Disease | Penile cancer;KEGG DISEASE;H00025 |
Disease | CANCER;GAD |
Disease | Colorectal cancer;NHGRI |
Disease | Ovarian carcinoma;OMIM |
Disease | Cancers of the breast and female genital organs;KEGG DISEASE |
Disease | Listeria monocytogenes, susceptibility to;OMIM |
Disease | Cancers;KEGG DISEASE |
Disease | diffuse gastric cancer;GAD |
Disease | Cancers of the urinary system and male genital organs;KEGG DISEASE |
Disease | Nasopharyngeal cancer;KEGG DISEASE;H00054 |
Disease | Head and neck cancers;KEGG DISEASE |
Disease | ulcerative colitis;GAD |
Disease | stomach cancer;GAD |
|
External Links |
|
Links to Entrez Gene | 999 |
Links to all GeneRIF Items | 999 |
Links to iHOP | 999 |
|
Sequence Information |
The sequences provided here are only the longest representative sequences, not covering all the isoforms. |
Nucleotide Sequence |
>999 : length: 2649 atgggcccttggagccgcagcctctcggcgctgctgctgctgctgcaggtctcctcttgg ctctgccaggagccggagccctgccaccctggctttgacgccgagagctacacgttcacg gtgccccggcgccacctggagagaggccgcgtcctgggcagagtgaattttgaagattgc accggtcgacaaaggacagcctatttttccctcgacacccgattcaaagtgggcacagat ggtgtgattacagtcaaaaggcctctacggtttcataacccacagatccatttcttggtc tacgcctgggactccacctacagaaagttttccaccaaagtcacgctgaatacagtgggg caccaccaccgccccccgccccatcaggcctccgtttctggaatccaagcagaattgctc acatttcccaactcctctcctggcctcagaagacagaagagagactgggttattcctccc atcagctgcccagaaaatgaaaaaggcccatttcctaaaaacctggttcagatcaaatcc aacaaagacaaagaaggcaaggttttctacagcatcactggccaaggagctgacacaccc cctgttggtgtctttattattgaaagagaaacaggatggctgaaggtgacagagcctctg gatagagaacgcattgccacatacactctcttctctcacgctgtgtcatccaacgggaat gcagttgaggatccaatggagattttgatcacggtaaccgatcagaatgacaacaagccc gaattcacccaggaggtctttaaggggtctgtcatggaaggtgctcttccaggaacctct gtgatggaggtcacagccacagacgcggacgatgatgtgaacacctacaatgccgccatc gcttacaccatcctcagccaagatcctgagctccctgacaaaaatatgttcaccattaac aggaacacaggagtcatcagtgtggtcaccactgggctggaccgagagagtttccctacg tataccctggtggttcaagctgctgaccttcaaggtgaggggttaagcacaacagcaaca gctgtgatcacagtcactgacaccaacgataatcctccgatcttcaatcccaccacgtac aagggtcaggtgcctgagaacgaggctaacgtcgtaatcaccacactgaaagtgactgat gctgatgcccccaataccccagcgtgggaggctgtatacaccatattgaatgatgatggt ggacaatttgtcgtcaccacaaatccagtgaacaacgatggcattttgaaaacagcaaag ggcttggattttgaggccaagcagcagtacattctacacgtagcagtgacgaatgtggta ccttttgaggtctctctcaccacctccacagccaccgtcaccgtggatgtgctggatgtg aatgaagcccccatctttgtgcctcctgaaaagagagtggaagtgtccgaggactttggc gtgggccaggaaatcacatcctacactgcccaggagccagacacatttatggaacagaaa ataacatatcggatttggagagacactgccaactggctggagattaatccggacactggt gccatttccactcgggctgagctggacagggaggattttgagcacgtgaagaacagcacg tacacagccctaatcatagctacagacaatggttctccagttgctactggaacagggaca cttctgctgatcctgtctgatgtgaatgacaacgcccccataccagaacctcgaactata ttcttctgtgagaggaatccaaagcctcaggtcataaacatcattgatgcagaccttcct cccaatacatctcccttcacagcagaactaacacacggggcgagtgccaactggaccatt cagtacaacgacccaacccaagaatctatcattttgaagccaaagatggccttagaggtg ggtgactacaaaatcaatctcaagctcatggataaccagaataaagaccaagtgaccacc ttagaggtcagcgtgtgtgactgtgaaggggccgctggcgtctgtaggaaggcacagcct gtcgaagcaggattgcaaattcctgccattctggggattcttggaggaattcttgctttg ctaattctgattctgctgctcttgctgtttcttcggaggagagcggtggtcaaagagccc ttactgcccccagaggatgacacccgggacaacgtttattactatgatgaagaaggaggc ggagaagaggaccaggactttgacttgagccagctgcacaggggcctggacgctcggcct gaagtgactcgtaacgacgttgcaccaaccctcatgagtgtcccccggtatcttccccgc cctgccaatcccgatgaaattggaaattttattgatgaaaatctgaaagcggctgatact gaccccacagccccgccttatgattctctgctcgtgtttgactatgaaggaagcggttcc gaagctgctagtctgagctccctgaactcctcagagtcagacaaagaccaggactatgac tacttgaacgaatggggcaatcgcttcaagaagctggctgacatgtacggaggcggcgag gacgactag |
Protein Sequence |
>999 : length: 882 MGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFTVPRRHLERGRVLGRVNFEDC TGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKFSTKVTLNTVG HHHRPPPHQASVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKS NKDKEGKVFYSITGQGADTPPVGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGN AVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDADDDVNTYNAAI AYTILSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTAT AVITVTDTNDNPPIFNPTTYKGQVPENEANVVITTLKVTDADAPNTPAWEAVYTILNDDG GQFVVTTNPVNNDGILKTAKGLDFEAKQQYILHVAVTNVVPFEVSLTTSTATVTVDVLDV NEAPIFVPPEKRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDTANWLEINPDTG AISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTI FFCERNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESIILKPKMALEV GDYKINLKLMDNQNKDQVTTLEVSVCDCEGAAGVCRKAQPVEAGLQIPAILGILGGILAL LILILLLLLFLRRRAVVKEPLLPPEDDTRDNVYYYDEEGGGEEDQDFDLSQLHRGLDARP EVTRNDVAPTLMSVPRYLPRPANPDEIGNFIDENLKAADTDPTAPPYDSLLVFDYEGSGS EAASLSSLNSSESDKDQDYDYLNEWGNRFKKLADMYGGGEDD |