Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

999

Name

CDH1

Synonymous

Arc-1|CD324|CDHE|ECAD|LCAM|UVO;cadherin 1, type 1, E-cadherin (epithelial);CDH1;cadherin 1, type 1, E-cadherin (epithelial)

Definition

CAM 120/80|E-Cadherin|cadherin 1, E-cadherin (epithelial)|cadherin-1|calcium-dependent adhesion protein, epithelial|cell-CAM 120/80|epithelial cadherin|uvomorulin

Position

16q22.1

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

E-cadherin(h) + IQGAP1(h) <==> E-cadherin(h):IQGAP1(h) (binding)
alpha-catenin1(h) + beta-catenin(h) + E-cadherin(h) + p120CAS(h) + plakoglobin(h) <==> alpha-catenin1(h):beta-catenin(h):E-cadherin(h):plakoglobin(h):p120CAS(h) (binding)
beta-catenin(h) + E-cadherin(h) <==> beta-catenin(h):E-cadherin(h) (binding)
alpha-catenin1(h) + beta-catenin(h){pY} + E-cadherin(h) + LAR(h) + plakoglobin(h){pY} <==> alpha-catenin1(h):beta-catenin(h){pY}:E-cadherin(h):plakoglobin(h){pY}:LAR(h) (binding)
E-cadherin(h) --gamma-secretase(h)--> E-cadherin-CTF2(h) + E-cadherin-NTF2(h) (processing)
E-cadherin(h) + cortactin(ha) <==> cortactin(ha):E-cadherin(h) (binding)
Arp3(h) + E-cadherin(h) <==> Arp3(h):E-cadherin(h) (binding)
p34arc(ha) + E-cadherin(h) <==> E-cadherin(h):p34arc(ha) (binding)
Arp3(h) + p34arc(ha) + E-cadherin(h) <==> Arp3(h):p34arc(ha):E-cadherin(h) (binding)
E-cadherin(h) + ATP --> E-cadherin(h){pY} + ADP (phosphorylation)
E-cadherin(h) --> E-cadherin-p29(h) + protein remnants (cleavage)
E-cadherin(h) --> E-cadherin-p24(h) + protein remnants (cleavage)
NPRAPa(m) + ABP-S(r) + E-cadherin(h) <==> NPRAPa(m):ABP-S(r):E-cadherin(h) (binding)
E-cadherin(h) + Smad7(m.s.) <==> E-cadherin(h):Smad7(m.s.) (binding)
E-cadherin(h) + DDB1(h) <==> E-cadherin(h):DDB1(h) (binding)
E-cadherin(h) --/ Skp2(h) (decrease of abundance)
CDH1(h) --> E-cadherin(h) (expression).
EGF(m.s.) --/ E-cadherin(h) (decrease of abundance)
Smad7(m.s.) --> E-cadherin(h) (increase of abundance)
calcitriol --> E-cadherin(h) (increase of abundance)
insulin(m.s.) --> E-cadherin(h) (increase of abundance)
p53(h) --> E-cadherin(h) (increase of abundance)
slug(m) --/ E-cadherin(h) (decrease of abundance)
Chfr(h) --> E-cadherin(h) (increase of abundance)
slc7a11(h) --/ E-cadherin(h) (decrease of abundance)
E-cadherin(h) --Mdc15(m.s.)--> E-cadherin-ECD(h) + protein remnants (cleavage)
E-cadherin(h) + DDB1(m.s.) <==> E-cadherin(h):DDB1(m.s.) (binding)
DDB1(h) + E-cadherin(h) <==> DDB1(h):E-cadherin(h) (binding)
E-cadherin(h) --/ Geminin(h) (decrease of abundance)
CDH1(h) --> E-cadherin(h) (expression).
CDH1(h) --> E-cadherin(h) (expression).
hsa-miR-373 --> E-cadherin(h) (activation).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

558N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
637N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
838Phosphoserine (By similarity).Swiss-Prot 53.0
840Phosphoserine (By similarity).Swiss-Prot 53.0
846Phosphoserine (By similarity).Swiss-Prot 53.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr16

 Promoter: 67327196 - 67329196Agilent_014791

chr16

 Promoter: 67327196 - 67329196GoldenGate_Methylation_Cancer_Panel_I

chr16

 Promoter: 67327196 - 67329196GSE27584

chr16

 Promoter: 67327196 - 67329196Agilent_014791_44K

chr16

 Promoter: 67327196 - 67329196PMID:17348438

chr16

 Promoter: 67327196 - 67329196PMID:20568901

chr16

 Promoter: 67327196 - 67329196PMID:21455633

chr16

 Promoter: 67327196 - 67329196PMID:21775555

chr16

 Promoter: 67327196 - 67329196PMID:20064646

chr16

 Promoter: 67327196 - 67329196PMID:11496321

chr16

 Promoter: 67327196 - 67329196PMID:12448005

chr16

 Promoter: 67327196 - 67329196PMID:12210063

chr16

 Promoter: 67327196 - 67329196PMID:12695555

chr16

 Promoter: 67327196 - 67329196PMID:16830381

chr16

 Promoter: 67327196 - 67329196PMID:12692837

chr16

 Promoter: 67327196 - 67329196PMID:14998854

chr16

 Promoter: 67327196 - 67329196PMID:14556664

chr16

 Promoter: 67327196 - 67329196PMID:12746473

chr16

 Promoter: 67327196 - 67329196PMID:11413518

chr16

 Promoter: 67327196 - 67329196PMID:16219136

chr16

 Promoter: 67327196 - 67329196PMID:10749913

chr16

 Promoter: 67327196 - 67329196PMID:12763209

chr16

 Promoter: 67327196 - 67329196PMID:14750169

chr16

 Promoter: 67327196 - 67329196PMID:16108828

chr16

 Promoter: 67327196 - 67329196PMID:16531765

chr16

 Promoter: 67327196 - 67329196PMID:12776596

chr16

 Promoter: 67327196 - 67329196PMID:16475210

chr16

 Promoter: 67327196 - 67329196PMID:14507661

chr16

 Promoter: 67327196 - 67329196PMID:10495421

chr16

 Promoter: 67327196 - 67329196PMID:12631658

chr16

 Promoter: 67327196 - 67329196PMID:12163364

chr16

 Promoter: 67327196 - 67329196PMID:17369979

chr16

 Promoter: 67327196 - 67329196PMID:16163424

chr16

 Promoter: 67327196 - 67329196PMID:17139167

chr16

 Promoter: 67327196 - 67329196PMID:15942635

chr16

 Promoter: 67327196 - 67329196PMID:12060614

chr16

 Promoter: 67327196 - 67329196PMID:11313896

chr16

 Promoter: 67327196 - 67329196PMID:15313375

chr16

 Promoter: 67327196 - 67329196PMID:14675710

chr16

 Promoter: 67327196 - 67329196PMID:16598757

chr16

 Promoter: 67327196 - 67329196PMID:15254707

chr16

 Promoter: 67327196 - 67329196PMID:11196170

chr16

 Promoter: 67327196 - 67329196PMID:12841866

chr16

 Promoter: 67327196 - 67329196PMID:15042681

chr16

 Promoter: 67327196 - 67329196PMID:16644104

chr16

 Promoter: 67327196 - 67329196PMID:14714493

chr16

 Promoter: 67327196 - 67329196PMID:15201980

chr16

 Promoter: 67327196 - 67329196PMID:12467239

chr16

 Promoter: 67327196 - 67329196PMID:11895880

chr16

 Promoter: 67327196 - 67329196PMID:15639718

chr16

 Promoter: 67327196 - 67329196PMID:15073103

chr16

 Promoter: 67327196 - 67329196PMID:15758578

chr16

 Promoter: 67327196 - 67329196PMID:15495254

chr16

 Promoter: 67327196 - 67329196PMID:16732935

chr16

 Promoter: 67327196 - 67329196PMID:15863205

chr16

 Promoter: 67327196 - 67329196PMID:12899712

chr16

 Promoter: 67327196 - 67329196PMID:11106238

chr16

 Promoter: 67327196 - 67329196PMID:15198948

chr16

 Promoter: 67327196 - 67329196PMID:16192589

chr16

 Promoter: 67327196 - 67329196PMID:12082624

chr16

 Promoter: 67327196 - 67329196PMID:16343268

chr16

 Promoter: 67327196 - 67329196PMID:12660822

chr16

 Promoter: 67327196 - 67329196PMID:12937151

chr16

 Promoter: 67327196 - 67329196PMID:17121887

chr16

 Promoter: 67327196 - 67329196PMID:11297254

chr16

 Promoter: 67327196 - 67329196PMID:15911243

chr16

 Promoter: 67327196 - 67329196PMID:16613325

chr16

 Promoter: 67327196 - 67329196PMID:14507645

chr16

 Promoter: 67327196 - 67329196PMID:16565510

chr16

 Promoter: 67327196 - 67329196PMID:15831995

chr16

 Promoter: 67327196 - 67329196PMID:15467712

chr16

 Promoter: 67327196 - 67329196PMID:12213730

chr16

 Promoter: 67327196 - 67329196PMID:15122305

chr16

 Promoter: 67327196 - 67329196PMID:15389252

chr16

 Promoter: 67327196 - 67329196PMID:14719065

chr16

 Promoter: 67327196 - 67329196PMID:12397640

chr16

 Promoter: 67327196 - 67329196PMID:12824891

chr16

 Promoter: 67327196 - 67329196PMID:17276933

chr16

 Promoter: 67327196 - 67329196PMID:11171827

chr16

 Promoter: 67327196 - 67329196PMID:15476557

chr16

 Promoter: 67327196 - 67329196PMID:16512896

chr16

 Promoter: 67327196 - 67329196PMID:15788661

chr16

 Promoter: 67327196 - 67329196PMID:15328171

chr16

 Promoter: 67327196 - 67329196PMID:16495925

chr16

 Promoter: 67327196 - 67329196PMID:15172987

chr16

 Promoter: 67327196 - 67329196PMID:15543763

chr16

 Promoter: 67327196 - 67329196PMID:12163387

chr16

 Promoter: 67327196 - 67329196PMID:12942643

chr16

 Promoter: 67327196 - 67329196PMID:12800196

chr16

 Promoter: 67327196 - 67329196PMID:14534701

chr16

 Promoter: 67327196 - 67329196PMID:15589597

chr16

 Promoter: 67327196 - 67329196PMID:16331610

chr16

 Promoter: 67327196 - 67329196PMID:11448914

chr16

 Promoter: 67327196 - 67329196PMID:16803511

chr16

 Promoter: 67327196 - 67329196PMID:12751384

chr16

 Promoter: 67327196 - 67329196PMID:12773202

chr16

 Promoter: 67327196 - 67329196PMID:15713962

chr16

 Promoter: 67327196 - 67329196PMID:11549575

chr16

 Promoter: 67327196 - 67329196PMID:12124340

chr16

 Promoter: 67327196 - 67329196PMID:12203370

chr16

 Promoter: 67327196 - 67329196PMID:16849682

chr16

 Promoter: 67327196 - 67329196PMID:11839665

chr16

 Promoter: 67327196 - 67329196PMID:15154012

chr16

 Promoter: 67327196 - 67329196PMID:16242928

chr16

 Promoter: 67327196 - 67329196PMID:16639696

chr16

 Promoter: 67327196 - 67329196PMID:15036650

chr16

 Promoter: 67327196 - 67329196PMID:11458121

chr16

 Promoter: 67327196 - 67329196PMID:15289848

chr16

 Promoter: 67327196 - 67329196PMID:11839671

chr16

 Promoter: 67327196 - 67329196PMID:16170165

chr16

 Promoter: 67327196 - 67329196PMID:17363525

chr16

 Promoter: 67327196 - 67329196PMID:17139617

chr16

 Promoter: 67327196 - 67329196PMID:11753952

chr16

 Promoter: 67327196 - 67329196PMID:16483154

chr16

 Promoter: 67327196 - 67329196PMID:15361301

chr16

 Promoter: 67327196 - 67329196PMID:12767073

chr16

 Promoter: 67327196 - 67329196PMID:12553040

chr16

 Promoter: 67327196 - 67329196PMID:12839684

chr16

 Promoter: 67327196 - 67329196PMID:15073117

chr16

 Promoter: 67327196 - 67329196PMID:12632081

chr16

 Promoter: 67327196 - 67329196PMID:12751385

chr16

 Promoter: 67327196 - 67329196PMID:12760799

chr16

 Promoter: 67327196 - 67329196PMID:15029256

chr16

 Promoter: 67327196 - 67329196PMID:17206475

chr16

 Promoter: 67327196 - 67329196PMID:16688669

chr16

 Promoter: 67327196 - 67329196PMID:15367334

chr16

 Promoter: 67327196 - 67329196PMID:16353169

chr16

 Promoter: 67327196 - 67329196PMID:17272309

chr16

 Promoter: 67327196 - 67329196PMID:11568972

chr16

 Promoter: 67327196 - 67329196PMID:15217927

chr16

 Promoter: 67327196 - 67329196PMID:15289362

chr16

 Promoter: 67327196 - 67329196PMID:12559313

chr16

 Promoter: 67327196 - 67329196PMID:14555992

chr16

 Promoter: 67327196 - 67329196PMID:11477576

chr16

 Promoter: 67327196 - 67329196PMID:12672028

chr16

 Promoter: 67327196 - 67329196PMID:9458351

chr16

 Promoter: 67327196 - 67329196PMID:14985090

chr16

 Promoter: 67327196 - 67329196PMID:11900224

chr16

 Promoter: 67327196 - 67329196PMID:16449996

chr16

 Promoter: 67327196 - 67329196PMID:17034532

chr16

 Promoter: 67327196 - 67329196PMID:16494996

chr16

 Promoter: 67327196 - 67329196PMID:14559984

chr16

 Promoter: 67327196 - 67329196PMID:15596045

chr16

 Promoter: 67327196 - 67329196PMID:16303245

chr16

 Promoter: 67327196 - 67329196PMID:12429618

chr16

 Promoter: 67327196 - 67329196PMID:14970867

chr16

 Promoter: 67327196 - 67329196PMID:16061849

chr16

 Promoter: 67327196 - 67329196PMID:10766168

chr16

 Promoter: 67327196 - 67329196PMID:12584167

chr16

 Promoter: 67327196 - 67329196PMID:16596173

chr16

 Promoter: 67327196 - 67329196PMID:14501508

chr16

 Promoter: 67327196 - 67329196PMID:15272533

chr16

 Promoter: 67327196 - 67329196PMID:15870861

chr16

 Promoter: 67327196 - 67329196PMID:11578811

chr16

 Promoter: 67327196 - 67329196PMID:15447999

chr16

 Promoter: 67327196 - 67329196PMID:15471559

chr16

 Promoter: 67327196 - 67329196PMID:16699861

chr16

 Promoter: 67327196 - 67329196PMID:15915369

chr16

 Promoter: 67327196 - 67329196PMID:15197802

chr16

 Promoter: 67327196 - 67329196PMID:15109538

chr16

 Promoter: 67327196 - 67329196PMID:15318245

chr16

 Promoter: 67327196 - 67329196PMID:15173091

chr16

 Promoter: 67327196 - 67329196PMID:12082610

chr16

 Promoter: 67327196 - 67329196PMID:12569599

chr16

 Promoter: 67327196 - 67329196PMID:12896902

chr16

 Promoter: 67327196 - 67329196PMID:15999364

chr16

 Promoter: 67327196 - 67329196PMID:15662588

chr16

 Promoter: 67327196 - 67329196PMID:15840741

chr16

 Promoter: 67327196 - 67329196PMID:12874790

chr16

 Promoter: 67327196 - 67329196PMID:15507671

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