Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

2099

Name

ESR1

Synonymous

ER|ESR|ESRA|ESTRR|Era|NR3A1;estrogen receptor 1;ESR1;estrogen receptor 1

Definition

ER-alpha|estradiol receptor|estrogen nuclear receptor alpha|estrogen receptor|estrogen receptor alpha E1-E2-1-2|estrogen receptor alpha E1-N2-E2-1-2|nuclear receptor subfamily 3 group A member 1

Position

6q25.1

Gene Type

protein-coding

Gene Interactions:

Physical Interaction
Metabolic Interaction
Signaling Interaction

Physical Interaction   [Top]

Interaction Type

Interactor

Data Source

in same component

 ANP32ANCI_NATURE;

in same component

 APBB1NCI_NATURE;

in same component

 ATF2NCI_NATURE;

in same component

 BCAR1NCI_NATURE;

in same component

 BRCA1NCI_NATURE;

in same component

 CALCOCO1NCI_NATURE;

in same component

 CEBPBNCI_NATURE;

in same component

 DDX17NCI_NATURE;

in same component

 DDX54NCI_NATURE;

in same component

 EP300NCI_NATURE;

in same component

 ESR2NCI_NATURE;

in same component

 FOSNCI_NATURE;

in same component

 GNG2NCI_NATURE;

in same component

 HDAC1NCI_NATURE;

in same component

 HDAC4NCI_NATURE;

in same component

 HSF2NCI_NATURE;

in same component

 JUNNCI_NATURE;

in same component

 LCORNCI_NATURE;

in same component

 MED1NCI_NATURE;

in same component

 MPGNCI_NATURE;

in same component

 MTA1NCI_NATURE;

in same component

 NCOA1NCI_NATURE;

in same component

 NCOA2NCI_NATURE;

in same component

 NCOA3NCI_NATURE;

in same component

 NCOA7NCI_NATURE;

in same component

 NCOR1NCI_NATURE;

in same component

 NCOR2NCI_NATURE;

in same component

 NEDD8NCI_NATURE;

in same component

 NR0B1NCI_NATURE;

in same component

 NR0B2NCI_NATURE;

in same component

 PCNANCI_NATURE;

in same component

 PDIA2NCI_NATURE;

in same component

 PELP1NCI_NATURE;

in same component

 PHB2NCI_NATURE;

in same component

 PIK3CANCI_NATURE;

in same component

 PIK3R1NCI_NATURE;

in same component

 POU4F1NCI_NATURE;

in same component

 POU4F2NCI_NATURE;

in same component

 SAFBNCI_NATURE;

in same component

 SMAD4NCI_NATURE;

in same component

 SOS1NCI_NATURE;

in same component

 SRA1NCI_NATURE;

in same component

 SRCNCI_NATURE;

in same component

 STAT5ANCI_NATURE;

in same component

 STK11NCI_NATURE;

in same component

 STRNNCI_NATURE;

in same component

 TRIM59NCI_NATURE;

in same component

 UBA3NCI_NATURE;

in same component

 UBE2MNCI_NATURE;

interacts with

 ACTBBIOGRID;

interacts with

 ACTC1BIOGRID;

interacts with

 ACTR3BIOGRID;

interacts with

 AHRBIOGRID;

interacts with

 AHRHPRD;

interacts with

 AHRRBIOGRID;

interacts with

 AKAP13BIOGRID;

interacts with

 AKAP13HPRD;

interacts with

 AKT1HPRD;

interacts with

 AKT2HPRD;

interacts with

 ARCELL_MAP;

interacts with

 ARHPRD;

interacts with

 ARHGEF15HPRD;

interacts with

 ASF1AINTACT;

interacts with

 ASH2LHPRD;

interacts with

 ATAD2BIOGRID;

interacts with

 ATAD2HPRD;

interacts with

 ATF1INTACT;

interacts with

 BAG1BIOGRID;

interacts with

 BAG1HPRD;

interacts with

 BAZ1BBIOGRID;

interacts with

 BCAS2HPRD;

interacts with

 BDNFHPRD;

interacts with

 BRCA1BIOGRID;

interacts with

 BRCA1MINT;

interacts with

 CALM1HPRD;

interacts with

 CAV1BIOGRID;

interacts with

 CAV1HPRD;

interacts with

 CCNCBIOGRID;

interacts with

 CCND1BIOGRID;

interacts with

 CCND1HPRD;

interacts with

 CCNE1HPRD;

interacts with

 CCNHBIOGRID;

interacts with

 CCNHHPRD;

interacts with

 CCNT1HPRD;

interacts with

 CDC25BBIOGRID;

interacts with

 CDC25BHPRD;

interacts with

 CDK2HPRD;

interacts with

 CDK7BIOGRID;

interacts with

 CDK7HPRD;

interacts with

 CDK8BIOGRID;

interacts with

 CDKN1ABIOGRID;

interacts with

 CDKN1AHPRD;

interacts with

 CEBPABIOGRID;

interacts with

 CEBPBBIOGRID;

interacts with

 CEBPBHPRD;

interacts with

 CHD3MINT;

interacts with

 CHUKHPRD;

interacts with

 CITED1BIOGRID;

interacts with

 CITED1HPRD;

interacts with

 COBRA1BIOGRID;

interacts with

 COBRA1HPRD;

interacts with

 COPS5HPRD;

interacts with

 CREBBPBIOGRID;

interacts with

 CREBBPHPRD;

interacts with

 CSNK2BHPRD;

interacts with

 CTNNB1BIOGRID;

interacts with

 CTNNB1HPRD;

interacts with

 CUEDC2HPRD;

interacts with

 CUEDC2MINT;

interacts with

 CUL4BHPRD;

interacts with

 DAP3BIOGRID;

interacts with

 DDX17BIOGRID;

interacts with

 DDX3XBIOGRID;

interacts with

 DDX54BIOGRID;

interacts with

 DDX54HPRD;

interacts with

 DDX5BIOGRID;

interacts with

 DDX5HPRD;

interacts with

 DNM1LINTACT;

interacts with

 DNTTIP2BIOGRID;

interacts with

 DNTTIP2HPRD;

interacts with

 DUTHPRD;

interacts with

 EDF1INTACT;

interacts with

 EGFRHPRD;

interacts with

 EGFRMINT;

interacts with

 EIF3IHPRD;

interacts with

 EP300BIOGRID;

interacts with

 EP300HPRD;

interacts with

 ERBB2HPRD;

interacts with

 ESR2BIOGRID;

interacts with

 ESR2HPRD;

interacts with

 ESRRAHPRD;

interacts with

 FHL2HPRD;

interacts with

 FKBP4BIOGRID;

interacts with

 FKBP5BIOGRID;

interacts with

 FLIIBIOGRID;

interacts with

 FLIIHPRD;

interacts with

 FOSBIOGRID;

interacts with

 FOXO1BIOGRID;

interacts with

 FOXO1HPRD;

interacts with

 FOXO3HPRD;

interacts with

 FOXO4BIOGRID;

interacts with

 FOXO4HPRD;

interacts with

 GADD45ABIOGRID;

interacts with

 Gadd45bBIOGRID;

interacts with

 GADD45BHPRD;

interacts with

 GADD45GBIOGRID;

interacts with

 GADD45GHPRD;

interacts with

 GNAI1HPRD;

interacts with

 GRIP1BIOGRID;

interacts with

 GRIP1HPRD;

interacts with

 GRIP1MINT;

interacts with

 GSNBIOGRID;

interacts with

 GTF2BBIOGRID;

interacts with

 GTF2BHPRD;

interacts with

 GTF2H1BIOGRID;

interacts with

 GTF2H1HPRD;

interacts with

 HAX1INTACT;

interacts with

 HDAC1BIOGRID;

interacts with

 HDAC1MINT;

interacts with

 HDAC2BIOGRID;

interacts with

 HDAC3BIOGRID;

interacts with

 HDAC4BIOGRID;

interacts with

 HDAC5BIOGRID;

interacts with

 HDAC7BIOGRID;

interacts with

 HDAC9BIOGRID;

interacts with

 HEXIM1HPRD;

interacts with

 HNF4AHPRD;

interacts with

 HSP90AA1BIOGRID;

interacts with

 HSP90AA1HPRD;

interacts with

 HSP90AB1HPRD;

interacts with

 HSPA4BIOGRID;

interacts with

 HSPA4HPRD;

interacts with

 HSPA8BIOGRID;

interacts with

 IGF1RBIOGRID;

interacts with

 IGF1RHPRD;

interacts with

 ING1BIOGRID;

interacts with

 IRS1BIOGRID;

interacts with

 IRS2BIOGRID;

interacts with

 ISL1BIOGRID;

interacts with

 ISL1HPRD;

interacts with

 ITGB3BPHPRD;

interacts with

 JUNBHPRD;

interacts with

 JUNDHPRD;

interacts with

 JUNBIOGRID;

interacts with

 JUNHPRD;

interacts with

 KAT2ABIOGRID;

interacts with

 KAT5BIOGRID;

interacts with

 KDM1ABIOGRID;

interacts with

 KDM5ABIOGRID;

interacts with

 KDM5AHPRD;

interacts with

 KIF1AHPRD;

interacts with

 KLF5BIOGRID;

interacts with

 LCKHPRD;

interacts with

 LCORBIOGRID;

interacts with

 LDB1BIOGRID;

interacts with

 LDB1HPRD;

interacts with

 LRIF1BIOGRID;

interacts with

 MAP3K1MINT;

interacts with

 MAPK14HPRD;

interacts with

 MAPK1BIOGRID;

interacts with

 MAPK1HPRD;

interacts with

 MAPK3HPRD;

interacts with

 MBD2BIOGRID;

interacts with

 MDM2BIOGRID;

interacts with

 MDM2HPRD;

interacts with

 MED10BIOGRID;

interacts with

 MED12BIOGRID;

interacts with

 MED13BIOGRID;

interacts with

 MED14BIOGRID;

interacts with

 MED16BIOGRID;

interacts with

 MED17BIOGRID;

interacts with

 MED1BIOGRID;

interacts with

 MED1HPRD;

interacts with

 MED20BIOGRID;

interacts with

 MED21BIOGRID;

interacts with

 MED23BIOGRID;

interacts with

 MED24BIOGRID;

interacts with

 MED24HPRD;

interacts with

 MED6BIOGRID;

interacts with

 MED7BIOGRID;

interacts with

 MEN1BIOGRID;

interacts with

 MKNK2HPRD;

interacts with

 MLL2HPRD;

interacts with

 MMS19HPRD;

interacts with

 MNAT1BIOGRID;

interacts with

 MNAT1HPRD;

interacts with

 MPGHPRD;

interacts with

 MSH2BIOGRID;

interacts with

 MSH6BIOGRID;

interacts with

 MTA1BIOGRID;

interacts with

 MTA1HPRD;

interacts with

 MTA1MINT;

interacts with

 MTA2BIOGRID;

interacts with

 MTA2MINT;

interacts with

 MTA3MINT;

interacts with

 MTCH2HPRD;

interacts with

 MUC1BIOGRID;

interacts with

 MVPBIOGRID;

interacts with

 MVPHPRD;

interacts with

 MYCBIOGRID;

interacts with

 MYL6BIOGRID;

interacts with

 MYL6INTACT;

interacts with

 MYO1CBIOGRID;

interacts with

 MYOD1BIOGRID;

interacts with

 MYST3BIOGRID;

interacts with

 NCOA1BIOGRID;

interacts with

 NCOA1HPRD;

interacts with

 NCOA1MINT;

interacts with

 NCOA2BIOGRID;

interacts with

 NCOA2HPRD;

interacts with

 NCOA3BIOGRID;

interacts with

 NCOA3HPRD;

interacts with

 NCOA4BIOGRID;

interacts with

 NCOA6BIOGRID;

interacts with

 NCOA6HPRD;

interacts with

 NCOA7BIOGRID;

interacts with

 NCOA7HPRD;

interacts with

 NCOR1BIOGRID;

interacts with

 NCOR1HPRD;

interacts with

 NCOR2BIOGRID;

interacts with

 NCOR2HPRD;

interacts with

 NCRNA00312HPRD;

interacts with

 NCRNA00312MINT;

interacts with

 NDRG2INTACT;

interacts with

 NFKB1HPRD;

interacts with

 NGG1BIOGRID;

interacts with

 NPPAHPRD;

interacts with

 NR0B1HPRD;

interacts with

 Nr0b2BIOGRID;

interacts with

 NR0B2BIOGRID;

interacts with

 NR0B2HPRD;

interacts with

 NR1H4HPRD;

interacts with

 Nr1i2BIOGRID;

interacts with

 NR2C1BIOGRID;

interacts with

 NR2C1HPRD;

interacts with

 NR2C2BIOGRID;

interacts with

 NR2C2HPRD;

interacts with

 NR2F1BIOGRID;

interacts with

 NR2F1HPRD;

interacts with

 NR2F6BIOGRID;

interacts with

 NR2F6HPRD;

interacts with

 NRIP1BIOGRID;

interacts with

 NRIP1HPRD;

interacts with

 NSD1HPRD;

interacts with

 PA1MINT;

interacts with

 PAK1HPRD;

interacts with

 PAK6BIOGRID;

interacts with

 PAK6HPRD;

interacts with

 PARP1BIOGRID;

interacts with

 PDLIM1BIOGRID;

interacts with

 PELP1BIOGRID;

interacts with

 PELP1HPRD;

interacts with

 PGCBIOGRID;

interacts with

 PGRHPRD;

interacts with

 PHB2BIOGRID;

interacts with

 PHB2HPRD;

interacts with

 PHBBIOGRID;

interacts with

 PIAS1HPRD;

interacts with

 PIAS2BIOGRID;

interacts with

 PIAS3HPRD;

interacts with

 PIK3R1BIOGRID;

interacts with

 PIK3R1HPRD;

interacts with

 PIK3R3HPRD;

interacts with

 PNRC2HPRD;

interacts with

 PNRC2MINT;

interacts with

 POLR1BHPRD;

interacts with

 POLR2ABIOGRID;

interacts with

 POLR2DHPRD;

interacts with

 POU2F1BIOGRID;

interacts with

 POU2F1HPRD;

interacts with

 POU2F2BIOGRID;

interacts with

 POU4F1BIOGRID;

interacts with

 POU4F1HPRD;

interacts with

 POU4F2BIOGRID;

interacts with

 POU4F2HPRD;

interacts with

 PPARGC1ABIOGRID;

interacts with

 PPARGC1AHPRD;

interacts with

 PPARGC1BBIOGRID;

interacts with

 PPARGC1BHPRD;

interacts with

 PPIDBIOGRID;

interacts with

 PRDM2BIOGRID;

interacts with

 PRDM2HPRD;

interacts with

 PRKACAHPRD;

interacts with

 PRKDCBIOGRID;

interacts with

 PRMT1BIOGRID;

interacts with

 PRMT1HPRD;

interacts with

 PRMT2BIOGRID;

interacts with

 PRMT2HPRD;

interacts with

 PRPF6HPRD;

interacts with

 PSMB9MINT;

interacts with

 PSMC5HPRD;

interacts with

 PTENBIOGRID;

interacts with

 PTGES3BIOGRID;

interacts with

 PTGES3HPRD;

interacts with

 PTMABIOGRID;

interacts with

 PTPN1HPRD;

interacts with

 PTPN1MINT;

interacts with

 PTPN6HPRD;

interacts with

 PTPN6MINT;

interacts with

 RAC3INTACT;

interacts with

 RBBP4BIOGRID;

interacts with

 RBBP5HPRD;

interacts with

 RBBP6BIOGRID;

interacts with

 RBBP7BIOGRID;

interacts with

 RBFOX2BIOGRID;

interacts with

 RBFOX2HPRD;

interacts with

 RBM23HPRD;

interacts with

 RBM39BIOGRID;

interacts with

 RBM39HPRD;

interacts with

 RELABIOGRID;

interacts with

 RELAHPRD;

interacts with

 REXO4BIOGRID;

interacts with

 REXO4HPRD;

interacts with

 RFX4HPRD;

interacts with

 RGS3HPRD;

interacts with

 RLIMBIOGRID;

interacts with

 RLIMHPRD;

interacts with

 RNF14HPRD;

interacts with

 RNF4BIOGRID;

interacts with

 RNF4HPRD;

interacts with

 RPL18BIOGRID;

interacts with

 RPL7BIOGRID;

interacts with

 RPLP0BIOGRID;

interacts with

 RPS6KA1BIOGRID;

interacts with

 RPS6KA1HPRD;

interacts with

 RPS6KA3HPRD;

interacts with

 RPS9BIOGRID;

interacts with

 SAFB2BIOGRID;

interacts with

 SAFB2HPRD;

interacts with

 SAFBBIOGRID;

interacts with

 SAFBHPRD;

interacts with

 SENP5INTACT;

interacts with

 SETD7BIOGRID;

interacts with

 SHC1BIOGRID;

interacts with

 SHC1HPRD;

interacts with

 SIN3ABIOGRID;

interacts with

 SLC30A9HPRD;

interacts with

 SMAD2BIOGRID;

interacts with

 SMAD2CELL_MAP;

interacts with

 SMAD2HPRD;

interacts with

 SMAD4CELL_MAP;

interacts with

 SMAD4HPRD;

interacts with

 SMARCA2BIOGRID;

interacts with

 SMARCA4BIOGRID;

interacts with

 SMARCA4MINT;

interacts with

 SMARCB1MINT;

interacts with

 SMARCC2MINT;

interacts with

 SMARCD1BIOGRID;

interacts with

 SMARCD3HPRD;

interacts with

 SMARCE1BIOGRID;

interacts with

 SMARCE1HPRD;

interacts with

 SMURF1BIOGRID;

interacts with

 SMYD3BIOGRID;

interacts with

 SOS1HPRD;

interacts with

 SP1BIOGRID;

interacts with

 SP1HPRD;

interacts with

 SP2BIOGRID;

interacts with

 SP3BIOGRID;

interacts with

 SP3HPRD;

interacts with

 SRA1BIOGRID;

interacts with

 SRCBIOGRID;

interacts with

 SRCHPRD;

interacts with

 SRCMINT;

interacts with

 SREBF1HPRD;

interacts with

 STAT3BIOGRID;

interacts with

 STAT5ABIOGRID;

interacts with

 STAT5AHPRD;

interacts with

 STAT5AMINT;

interacts with

 STRNHPRD;

interacts with

 STUB1BIOGRID;

interacts with

 STUB1HPRD;

interacts with

 SVILBIOGRID;

interacts with

 Tada3BIOGRID;

interacts with

 TADA3BIOGRID;

interacts with

 TAF10HPRD;

interacts with

 TAF1ABIOGRID;

interacts with

 TAF1BBIOGRID;

interacts with

 TAP1HPRD;

interacts with

 TBPBIOGRID;

interacts with

 TBPHPRD;

interacts with

 TCF20HPRD;

interacts with

 TDGBIOGRID;

interacts with

 TDGHPRD;

interacts with

 THRAHPRD;

interacts with

 THRBHPRD;

interacts with

 TNFRSF14HPRD;

interacts with

 TOP2BBIOGRID;

interacts with

 TP53BIOGRID;

interacts with

 TRAM1BIOGRID;

interacts with

 TRIM24BIOGRID;

interacts with

 TRIM24HPRD;

interacts with

 TRIM25BIOGRID;

interacts with

 TRIM28HPRD;

interacts with

 TRIM59HPRD;

interacts with

 TRIP4BIOGRID;

interacts with

 TRIP4HPRD;

interacts with

 TRRAPBIOGRID;

interacts with

 TRRAPHPRD;

interacts with

 TSC2HPRD;

interacts with

 TUBBHPRD;

interacts with

 UBE2IHPRD;

interacts with

 UBE3ABIOGRID;

interacts with

 WDR5HPRD;

interacts with

 WIPI1HPRD;

interacts with

 XBP1BIOGRID;

interacts with

 XBP1HPRD;

interacts with

 XRCC5BIOGRID;

interacts with

 XRCC6BIOGRID;

interacts with

 YWHAHHPRD;

interacts with

 YWHAQBIOGRID;

interacts with

 ZBTB16BIOGRID;

interacts with

 ZBTB16HPRD;

interacts with

 ZBTB17HPRD;

interacts with

 ZNF398BIOGRID;

interacts with

 ZNF398HPRD;

Metabolic Interaction   [Top]

Interaction Type

Interactor

Data Source

metabolic catalysis

 ATF2NCI_NATURE;

metabolic catalysis

 ESR1NCI_NATURE;

metabolic catalysis

 FOSNCI_NATURE;

metabolic catalysis

 JUNNCI_NATURE;

Signaling Interaction   [Top]

Interaction Type

Interactor

Data Source

reacts with

 ANP32ANCI_NATURE;

reacts with

 APBB1NCI_NATURE;

reacts with

 ATF2NCI_NATURE;

reacts with

 BCAR1NCI_NATURE;

reacts with

 BRCA1NCI_NATURE;

reacts with

 CALCOCO1NCI_NATURE;

reacts with

 CEBPBNCI_NATURE;

reacts with

 DDX17NCI_NATURE;

reacts with

 DDX54NCI_NATURE;

reacts with

 EP300NCI_NATURE;

reacts with

 ESR1NCI_NATURE;

reacts with

 ESR2NCI_NATURE;

reacts with

 FOSNCI_NATURE;

reacts with

 GNG2NCI_NATURE;

reacts with

 HDAC1NCI_NATURE;

reacts with

 HDAC4NCI_NATURE;

reacts with

 HSF2NCI_NATURE;

reacts with

 JUNNCI_NATURE;

reacts with

 LCORNCI_NATURE;

reacts with

 MED1NCI_NATURE;

reacts with

 MPGNCI_NATURE;

reacts with

 MTA1NCI_NATURE;

reacts with

 NCOA1NCI_NATURE;

reacts with

 NCOA2NCI_NATURE;

reacts with

 NCOA3NCI_NATURE;

reacts with

 NCOA7NCI_NATURE;

reacts with

 NCOR1NCI_NATURE;

reacts with

 NCOR2NCI_NATURE;

reacts with

 NEDD8NCI_NATURE;

reacts with

 NR0B1NCI_NATURE;

reacts with

 NR0B2NCI_NATURE;

reacts with

 PCNANCI_NATURE;

reacts with

 PDIA2NCI_NATURE;

reacts with

 PELP1NCI_NATURE;

reacts with

 PHB2NCI_NATURE;

reacts with

 PIK3CANCI_NATURE;

reacts with

 PIK3R1NCI_NATURE;

reacts with

 POU4F1NCI_NATURE;

reacts with

 POU4F2NCI_NATURE;

reacts with

 SAFBNCI_NATURE;

reacts with

 SMAD4NCI_NATURE;

reacts with

 SOS1NCI_NATURE;

reacts with

 SRA1NCI_NATURE;

reacts with

 SRCNCI_NATURE;

reacts with

 STAT5ANCI_NATURE;

reacts with

 STK11NCI_NATURE;

reacts with

 STRNNCI_NATURE;

reacts with

 TRIM59NCI_NATURE;

reacts with

 UBA3NCI_NATURE;

reacts with

 UBE2MNCI_NATURE;

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