Entrez Gene

Basic Information
Gene ID	2099
Name	ESR1
Synonymous	ER\|ESR\|ESRA\|ESTRR\|Era\|NR3A1;estrogen receptor 1;ESR1;estrogen receptor 1
Definition	ER-alpha\|estradiol receptor\|estrogen nuclear receptor alpha\|estrogen receptor\|estrogen receptor alpha E1-E2-1-2\|estrogen receptor alpha E1-N2-E2-1-2\|nuclear receptor subfamily 3 group A member 1
Position	6q25.1
Gene Type	protein-coding
Gene Regulation:	Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase [Top]

Experimentally validated miRNA-TS gene regulation information.

Regulation From TransFac database
Transcription Factors [Top]
progesterone:PR B(h) + ER-alpha(h) <==> progesterone:PR B(h):ER-alpha(h) (binding)
ER-alpha(h) --> CGA(h) (DNA binding).
ER-alpha(h) + ATP --cyclinA(h):Cdk2(h)--> ER-alpha(h){p} + ADP (phosphorylation)
ER-alpha(h) + NF-kappaB1-p50(h) <==> ER-alpha(h):NF-kappaB1-p50(h) (binding).
ER-alpha(h) + RelA-p65(h) <==> ER-alpha(h):RelA-p65(h) (binding).
Hsp90(h) + ER-alpha(h) <==> Hsp90(h):ER-alpha(h) (binding)
ER-beta-isoform1(h) + ER-alpha(h) <==> ER-beta-isoform1(h):ER-alpha(h) (binding).
ER-alpha(h) + TAFII30(h) <==> ER-alpha(h):TAFII30(h) (binding)
ER-alpha(h) + TIF1(m) <==> ER-alpha(h):TIF1(m) (binding)
SKIP(h) + ER-alpha(h) <==> SKIP(h):ER-alpha(h) (binding).
ZER6 p52(h) + ER-alpha(h) <==> ZER6 p52(h):ER-alpha(h) (binding).
ZAC-1b(m) + ER-alpha(h) <==> ZAC-1b(m):ER-alpha(h) (binding)
AhR(h) + ER-alpha(h) <==> AhR(h):ER-alpha(h) (binding)
ER-alpha(h) + ER-alpha(h) <==> ER-alpha(h):ER-alpha(h) (binding)
ER-alpha(h) + GATA-1(m) <==> ER-alpha(h):GATA-1(m) (binding).
ER-alpha(h) --> EBAG9(h) (DNA binding).
ER-alpha(h) --> BCK(r) (DNA binding; transactivation).
ER-alpha(h) --> HSP27(h) (DNA binding; transactivation).
ER-alpha(h) --> TFF1(h) (DNA binding; transactivation).
ER-alpha(h) --> BRCA1(h) (DNA binding).
ER-alpha(h) --> COX7A2L(h) (DNA binding).
RIP140(h) + ER-alpha(h) <==> RIP140(h):ER-alpha(h) (binding)
SRC-1(h) + ER-alpha(h) <==> SRC-1(h):ER-alpha(h) (binding)
TIF2(h) + ER-alpha(h) <==> TIF2(h):ER-alpha(h) (binding)
SRC3(h) + ER-alpha(h) <==> SRC3(h):ER-alpha(h) (binding)
ER-alpha(h) --> TP53(h) (DNA binding).
ER-alpha(h) --> HOXA10(h) (DNA binding; transactivation).
GADD45-alpha(h) + ER-alpha(h) <==> GADD45-alpha(h):ER-alpha(h) (binding)
GADD45-beta(m) + ER-alpha(h) <==> GADD45-beta(m):ER-alpha(h) (binding)
GADD45-gamma(h) + ER-alpha(h) <==> GADD45-gamma(h):ER-alpha(h) (binding)
TR2(h) + ER-alpha(h) <==> TR2(h):ER-alpha(h) (binding)
ER-alpha(h) + ATP --p65PAK(m.s.)--> ER-alpha(h){pS305} + ADP (phosphorylation)
ER-alpha(h) + NAG-7(h) <==> ER-alpha(h):NAG-7(h) (binding)
ER-alpha(h) + ER-alpha(m.s.) <==> ER-alpha(h):ER-alpha(m.s.) (binding)
ER-alpha(h) + PP32(h) <==> ER-alpha(h):PP32(h) (binding)
TIF2(m) + ER-alpha(h) <==> TIF2(m):ER-alpha(h) (binding)
MTA-1(m.s.) + MAT1(h) + ER-alpha(h) + cyclinH(h) <==> ER-alpha(h):cyclinH(h):MAT1(h):MTA-1(m.s.) (binding)
MAT1(h) + ER-alpha(h) + cyclinH(h) <==> MAT1(h):ER-alpha(h):cyclinH(h) (binding)
MAT1(h) + ER-alpha(h) <==> MAT1(h):ER-alpha(h) (binding)
ER-alpha(h) --> ER-alpha(h) (translocation)
MAT1(h) + ER-alpha(h) + MTA-1(m.s.) <==> MAT1(h):ER-alpha(h):MTA-1(m.s.) (binding)
ER-alpha(h) + ATP --> ER-alpha(h){p} + ADP (phosphorylation)
ER-alpha(h) + MPG(m.s.) <==> ER-alpha(h):MPG(m.s.) (binding)
MPG(h) + ER-alpha(h) <==> MPG(h):ER-alpha(h) (binding)
SET-isoform2(h) + ER-alpha(h) <==> SET-isoform2(h):ER-alpha(h) (binding)
ER-alpha(h) + acetyl-CoA --> ER-alpha(h){aceK} + CoA (acetylation)
ER-alpha(h) + MVP(h) <==> ER-alpha(h):MVP(h) (binding)
ER-alpha(h) + NSD1(m) <==> ER-alpha(h):NSD1(m) (binding)
ER-alpha(h) + ER(r) <==> ER-alpha(h):ER(r) (binding)
ER-alpha(h) + islet1(z) <==> ER-alpha(h):islet1(z) (binding)
ER-alpha(h) + pRb(h) + MTB-Zf(h) <==> ER-alpha(h):pRb(h):MTB-Zf(h) (binding)
ER-alpha(h) + MTB-Zf(m.s.) <==> ER-alpha(h):MTB-Zf(m.s.) (binding)
ER-alpha(h) + MRF1(h) <==> ER-alpha(h):MRF1(h) (binding)
ER-alpha(h) + RTA-isoform1(h) <==> ER-alpha(h):RTA-isoform1(h) (binding)
SRC-1(m.s.) + ER-alpha(h) <==> SRC-1(m.s.):ER-alpha(h) (binding)
ER-alpha(h) + prohibitin-2(h) <==> ER-alpha(h):prohibitin-2(h) (binding)
ER-alpha(h) + ING1b(h) <==> ER-alpha(h):ING1b(h) (binding)
ER-alpha(h) + TDG(h) <==> ER-alpha(h):TDG(h) (binding)
ER-alpha(h) + TDG(m) <==> ER-alpha(h):TDG(m) (binding)
ER-alpha(h) + ATP --> ER-alpha(h){pS118} + ADP (phosphorylation)
Hsp70(h) + Hsp90(h) + ER-alpha(h) + gamma-synuclein(m.s.) <==> Hsp70(h):Hsp90(h):ER-alpha(h):gamma-synuclein(m.s.) (binding)
Hsp90(h) + Hsp70(h) + ER-alpha(h) + gamma-synuclein(h) <==> Hsp90(h):Hsp70(h):ER-alpha(h):gamma-synuclein(h) (binding)
ER-alpha(h) + Hsp90(h) + Hsp70(h) <==> ER-alpha(h):Hsp90(h):Hsp70(h) (binding)
ER-alpha(h) + ATP --> ER-alpha(h){pS117} + ADP (phosphorylation)
ER-alpha(h) + SF3a60(h) + SF3a66(h) + SF3a120(h) <==> ER-alpha(h):SF3a60(h):SF3a66(h):SF3a120(h) (binding)
ER-alpha(h) + p300(m.s.) + p68(m.s.) + p72(m.s.) + SF3a120(m.s.) <==> ER-alpha(h):p300(m.s.):p68(m.s.):p72(m.s.):SF3a120(m.s.) (binding)
ER-alpha(h) + MICoA(h) <==> ER-alpha(h):MICoA(h) (binding)
ER-alpha(h) + BAF57(h) <==> ER-alpha(h):BAF57(h) (binding)
BAF57(m) + ER-alpha(h) <==> BAF57(m):ER-alpha(h) (binding)
BRG1(h) + ER-alpha(h) <==> BRG1(h):ER-alpha(h) (binding)
Brm(h) + ER-alpha(h) <==> Brm(h):ER-alpha(h) (binding)
PNRC2(h) + ER-alpha(h) <==> PNRC2(h):ER-alpha(h) (binding)
p68(m.s.) + ER-alpha(h) <==> p68(m.s.):ER-alpha(h) (binding)
p72(m.s.) + ER-alpha(h) <==> p72(m.s.):ER-alpha(h) (binding)
p300(m.s.) + ER-alpha(h) <==> p300(m.s.):ER-alpha(h) (binding)
DRIP205(m.s.) + ER-alpha(h) <==> DRIP205(m.s.):ER-alpha(h) (binding)
ER-alpha(h) + estradiol <==> ER-alpha(h):estradiol (binding)
trrap(m.s.) + ER-alpha(h) <==> trrap(m.s.):ER-alpha(h) (binding)
ER-alpha(h) + NCOR(h) <==> ER-alpha(h):NCOR(h) (binding)
SMRT(m.s.) + ER-alpha(h) <==> SMRT(m.s.):ER-alpha(h) (binding)
DP97-xbb2(h) + ER-alpha(h) <==> DP97-xbb2(h):ER-alpha(h) (binding)
ER-alpha(h) + JAB1(h) <==> ER-alpha(h):JAB1(h) (binding)
ER-alpha(h) --> MTA3(h) (transactivation; DNA binding)
ER-alpha(h) --> AR(h) (binding)
ER-alpha(h) --> AR(h) (activation)
DNTTIP2(h) + ER-alpha(h) <==> DNTTIP2(h):ER-alpha(h) (binding)
CHIP(h) + ER-alpha(h) <==> CHIP(h):ER-alpha(h) (binding)
ER-alpha(h) + Hsc70(h) <==> ER-alpha(h):Hsc70(h) (binding)
ER-alpha(h) + ubiquitin(h) --> ER-alpha(h){ub} (ubiquitination)
Hsp70(h) + ER-alpha(h) <==> Hsp70(h):ER-alpha(h) (binding)
ER-alpha(h) + Hsp40(h) <==> ER-alpha(h):Hsp40(h) (binding)
ER-alpha(h) + bag1(h) <==> ER-alpha(h):bag1(h) (binding)
JunB(m.s.) + ER-alpha(h) <==> JunB(m.s.):ER-alpha(h) (binding)
JunD(m.s.) + ER-alpha(h) <==> JunD(m.s.):ER-alpha(h) (binding)
ER-alpha(h) + XBP-1S(h) <==> ER-alpha(h):XBP-1S(h) (binding)
ER-alpha(h) + XBP-1U(h) <==> ER-alpha(h):XBP-1U(h) (binding)
NF-YA(h) + ER-alpha(h) <==> NF-YA(h):ER-alpha(h) (binding)
ER-alpha(h) + NF-YB(h) <==> ER-alpha(h):NF-YB(h) (binding)
ER-alpha(h) + NF-YC(h) <==> ER-alpha(h):NF-YC(h) (binding)
ADA3-xbb1(m) + ER-alpha(h) <==> ADA3-xbb1(m):ER-alpha(h) (binding)
ER-alpha(h) + ADA3(h) <==> ER-alpha(h):ADA3(h) (binding)
TAFII30(h) + ADA2(h) + ER-alpha(h) <==> TAFII30(h):ADA2(h):ER-alpha(h) (binding)
ER-alpha(h) + TFTC(h) <==> ER-alpha(h):TFTC(h) (binding)
ER-alpha(h) --> F12(h) (transactivation)
Striatin(h) + ER-alpha(h) <==> Striatin(h):ER-alpha(h) (binding)
G-alpha-i2(h) + Striatin(h) + ER-alpha(h) <==> G-alpha-i2(h):Striatin(h):ER-alpha(h) (binding)
Strn(m.s.) + ER-alpha(h) <==> Strn(m.s.):ER-alpha(h) (binding)
G-alpha-i2(m.s.) + striatin(r) + ER-alpha(h) <==> G-alpha-i2(m.s.):striatin(r):ER-alpha(h) (binding)
ER-alpha(h) --> Mapk(mo){p} (increase of phosphorylation)
ER-alpha(h) --> AKT(h){p} (increase of phosphorylation)
ER-alpha(h) --> eNOS(h){p} (increase of phosphorylation)
Shc-1-p52(h) + ER-alpha(h) <==> Shc-1-p52(h):ER-alpha(h) (binding)
ER-alpha(h) + Shc-1-p46(h) <==> ER-alpha(h):Shc-1-p46(h) (binding)
ER-alpha(h) + ASC-2(r) <==> ER-alpha(h):ASC-2(r) (binding)
ASC-2(h) + ER-alpha(h) <==> ASC-2(h):ER-alpha(h) (binding)
ER-alpha(h) + Shc-1(v.s.) <==> ER-alpha(h):Shc-1(v.s.) (binding)
MTA-1(h) + ER-alpha(h) <==> MTA-1(h):ER-alpha(h) (binding)
p55gamma(h) + ER-alpha(h) <==> p55gamma(h):ER-alpha(h) (binding)
ER-alpha(h) + ATP --ERK2(h)--> ER-alpha(h){p} + ADP (phosphorylation)
PPARgamma(h) + p85(h) + ER-alpha(h) <==> PPARgamma(h):p85(h):ER-alpha(h) (binding)
ER-alpha(h) + MNAR(h) <==> ER-alpha(h):MNAR(h) (binding)
ER-alpha(h) + MSH2(h) <==> ER-alpha(h):MSH2(h) (binding)
p85alpha(h) + ER-alpha(h) <==> p85alpha(h):ER-alpha(h) (binding)
p110alpha(h) + ER-alpha(h) <==> p110alpha(h):ER-alpha(h) (binding)
ER-alpha(h) + MNAR-isoform2(h) <==> ER-alpha(h):MNAR-isoform2(h) (binding)
ER-alpha(h) + FOXO1A(h) <==> ER-alpha(h):FOXO1A(h) (binding)
ER-alpha(h) + SRC3(m.s.) <==> ER-alpha(h):SRC3(m.s.) (binding)
ER-alpha(h) --> CYP1B1(h) (DNA binding; transactivation).
ER-alpha(h) + Ebi(h) <==> ER-alpha(h):Ebi(h) (binding)
ER-alpha(h) + sumo1(m.s.) --PIAS3(m.s.)--> ER-alpha(h){sumo} (sumoylation)
ER-alpha(h) + sumo1(m.s.) --PIAS1(m.s.)--> ER-alpha(h){sumo} (sumoylation)
ER-alpha(h) + sumo1(h) --> ER-alpha(h){sumo} (sumoylation)
ER-alpha(h) + sumo1(m.s.) --> ER-alpha(h){sumo} (sumoylation)
ER-alpha(h) --> CRHBP(h) (DNA binding; transactivation).
p65PAK(h) + ER-alpha(h) <==> p65PAK(h):ER-alpha(h) (binding)
ER-alpha(h) + brca1(h) <==> ER-alpha(h):brca1(h) (binding)
ER-alpha(h) + brca1(h) <==> ER-alpha(h):brca1(h) (binding)
brca1(m.s.) + ER-alpha(h) <==> brca1(m.s.):ER-alpha(h) (binding)
ER-alpha(h) + CBP(h) <==> ER-alpha(h):CBP(h) (binding)
ER-alpha(h) + cyclinD1(h) <==> ER-alpha(h):cyclinD1(h) (binding)
ER-alpha(h) + Tip60(h) <==> ER-alpha(h):Tip60(h) (binding)
ER-alpha(h) --> Avp(r) (DNA binding)
ER-alpha(h) --> BCAS3(h) (DNA binding).
COUP-TF1(h) + ER-alpha(h) <==> COUP-TF1(h):ER-alpha(h) (binding)
ER-alpha(h) --> STAT5A(r){pY} (decrease of phosphorylation)
ER-alpha(h) --> prl(h) (DNA binding).
Smad3(m.s.) + ER-alpha(h) <==> Smad3(m.s.):ER-alpha(h) (binding)
ER-alpha(h) + Smad2(m.s.) <==> ER-alpha(h):Smad2(m.s.) (binding)
ER-alpha(h) + Smad4(m.s.) <==> ER-alpha(h):Smad4(m.s.) (binding)
ER-alpha(h) + Smad3(h) <==> ER-alpha(h):Smad3(h) (binding)
STAT3(m) + ER-alpha(h) <==> STAT3(m):ER-alpha(h) (binding)
ER-alpha(h) + MNAR-isoform1(h) <==> ER-alpha(h):MNAR-isoform1(h) (binding)
ER-alpha(h) + p72(h) <==> ER-alpha(h):p72(h) (binding)
ER-alpha(h) + ATP --> ER-alpha(h){pT311} + ADP (phosphorylation)
ER-alpha(h) + TIF2(m.s.) <==> ER-alpha(h):TIF2(m.s.) (binding)
ER-alpha(h) + 8 ATP --> ER-alpha(h){pS104}{pS106}{pS118}{pS167}{pS236}{pS305}{pT311}{pY537} + 8 ADP (phosphorylation)
ER-alpha(h) + 2 ATP --> ER-alpha(h){pS118}{pS167} + 2 ADP (phosphorylation)
ER-alpha(h) --> MACROD1(h) (transactivation)
ER-alpha(h) + Sp1(m.s.) <==> ER-alpha(h):Sp1(m.s.) (binding)
ER-alpha(h) + ATP --p38alpha(m.s.)--> ER-alpha(h){p} + ADP (phosphorylation)
ER-alpha(h) --> VEGFA(h) (transactivation)
ER-alpha(h) + ATP --> ER-alpha(h){pS167} + ADP (phosphorylation)
ER-alpha(h) + palmityl-CoA --> ER-alpha(h){palC447} + CoA (palmitoylation)
c-Jun(h) + ER-alpha(h) <==> c-Jun(h):ER-alpha(h) (binding)
HSF2(h) + ER-alpha(h) <==> HSF2(h):ER-alpha(h) (binding)
C/EBPbeta(h) + ER-alpha(h) <==> C/EBPbeta(h):ER-alpha(h) (binding)
ER-alpha(h) --> LFER(m) (transactivation)
ER-alpha(h) --> LTF(h) (transactivation)
ER-alpha(h) --> PGR(h) (transactivation)
ER-alpha(h) --> CCND1(h) (DNA binding).
ER-alpha(h) --> MUC1(h) (DNA binding).
ER-alpha(h) --> BCL2L1(h) (DNA binding; transactivation).
ER-alpha(h) --> DSIPI(h) (DNA binding).
ER-alpha(h) --> CCNG2(h) (DNA binding).
CHIP(m.s.) + ER-alpha(h) <==> CHIP(m.s.):ER-alpha(h) (binding)
CHIP(m.s.) + ER-alpha(h) + Hsc70(h) + Hsp90(h) <==> CHIP(m.s.):ER-alpha(h):Hsc70(h):Hsp90(h) (binding)
ER-alpha(h) + n ubiquitin(h) --> ER-alpha(h){ub}n (ubiquitination)
ER-alpha(h) --> MMP2(h) (transactivation)
ER-alpha(h) --> BMP2(m) (transactivation)
ER-alpha(h) --/ TNF(h) (transrepression)
ER-alpha(h) --> TFAP2C(h) (DNA binding).
ER-alpha(h) + BAF155(h) <==> ER-alpha(h):BAF155(h) (binding)
ER-alpha(h) + PNRC2(h) <==> ER-alpha(h):PNRC2(h) (binding)
ER-alpha(h) + arhgef15(h) <==> ER-alpha(h):arhgef15(h) (binding)
ER-alpha(h) + Mtch2(h) <==> ER-alpha(h):Mtch2(h) (binding)
ER-alpha(h) + ICEN22(h) <==> ER-alpha(h):ICEN22(h) (binding)
ER-alpha(h) + ATSV(h) <==> ER-alpha(h):ATSV(h) (binding)
ER-alpha(h) + deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(h) <==> ER-alpha(h):deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial(h) (binding)
ErbB1(h) + ER-alpha(h) <==> ErbB1(h):ER-alpha(h) (binding)
ER-alpha(h) + GSK3beta(h) <==> ER-alpha(h):GSK3beta(h) (binding)
ER-alpha(h) --> ER-alpha(h) (translocation)
ER-alpha(h) + 4 ATP --GSK3beta(rb)--> ER-alpha(h){pS102}{pS104}{pS106}{pS118} + 4 ADP (phosphorylation)
ER-alpha(h) + ATP --GSK3beta(h)--> ER-alpha(h){pS118} + ADP (phosphorylation)
ER-alpha(h) + 3 ATP --> ER-alpha(h){pS104}{pS106}{pS118} + 3 ADP (phosphorylation)
GSK3beta(m.s.) + ER-alpha(h) <==> GSK3beta(m.s.):ER-alpha(h) (binding)
ER-alpha(h) --/ BTG2(h) (transrepression)
ER-alpha(h) + atad2(h) <==> ER-alpha(h):atad2(h) (binding)
ER-alpha(h) + HDAC1(h) <==> ER-alpha(h):HDAC1(h) (binding)
ER-alpha(h) --> GAS6(h) (DNA binding).
ER-alpha(h) --> UGT2B15(h) (DNA binding).
ER-alpha(h) --> vtga2(x) (DNA binding).
ER-alpha(h) --/ Slc10a1(r) (transrepression)
ER-alpha(h) --> NR5A2(h) (DNA binding; transactivation).
Beclin-1(h) + ER-alpha(h) <==> Beclin-1(h):ER-alpha(h) (binding)
ER-alpha(h) --> IGFBP6(h) (transactivation)
ER-alpha(h) --> SERPINE1(h) (transactivation)
ER-alpha(h) --> IRS1(m) (DNA binding).
ER-alpha(h) --> HMGCR(r) (transactivation)
ER-alpha(h) --> c-myc(h) (transactivation)
ER-alpha(h) --> VIT-A2(x) (DNA binding).
ER-alpha(h) --> PTMA(h) (DNA binding; transactivation).
ER-alpha(h) --> PROS1(h) (DNA binding).
ESR1(h) --> ER-alpha(h) (expression).
ER-alpha(h) --> ER-alpha(h) (translocation)
JAB1(m.s.) --/ ER-alpha(h) (decrease of abundance)
Cdc42(h) --> ER-alpha(h) (regulation of protein activity)
TIF2(m.s.) --> ER-alpha(h) (activation)
Src(h) --> ER-alpha(h) (binding)
AR(h) --> ER-alpha(h) (activation)
CHIP(h) --> ER-alpha(h) (degradation)
CHIP(m.s.) --> ER-alpha(h) (degradation)
ER-alpha(h) --> ER-alpha(h) (translocation)
ER-alpha-L(h) --> PGR(h) (DNA binding; transactivation).
ER-alpha-L(h) --> apoE(h) (DNA binding; transregulation).
ER-alpha-L(h) --> Fos(m) (DNA binding; transactivation).
ER-alpha-L(h) --> Ov(c) (DNA binding; transregulation).
ER-alpha-L(h) --> VIT-II(c) (DNA binding).
ER-alpha-L(h) --> C3(h) (DNA binding; transactivation).
ER-alpha-L(h) --> Lhb(r) (DNA binding; transregulation).
ER-alpha-L(h) --> CTSD(h) (DNA binding; transactivation).
ER-alpha-L(h) --> Vegfa(r) (DNA binding; transregulation).
ER-alpha-L(h) --> NQO1(h) (DNA binding; transactivation).
ER-alpha-L(h) --> Jun(r) (DNA binding).
ER-alpha-L(h) --> Chat(m) (DNA binding).
ER-alpha-L(h) --> FOS(h) (DNA binding; transactivation).
ER-alpha-L(h) --> TF(h) (DNA binding; transactivation).
ER-alpha-L(h) --> Ug(rb) (DNA binding; transactivation).
ER-alpha-L(h) --> VIT-A2(x) (DNA binding; transregulation).
ER-alpha-L(h) --> VIT-B1(x) (DNA binding).
ER-alpha-L(h) --> TGFA(h) (DNA binding; transactivation).
ER-alpha-L(h) --> SLC9A3R1(h) (DNA binding; transactivation).
ER-alpha-L(h) --> PTMA(h) (DNA binding; transactivation).
ER-alpha-L(h) --> Oxt(r) (DNA binding; transactivation).
ER-alpha-L(h) + MVP(h) <==> ER-alpha-L(h):MVP(h) (binding)
ER-alpha-L(h) --> TERT(h) (DNA binding; transactivation).
ER-alpha-L(h) + c-Jun(m.s.) <==> c-Jun(m.s.):ER-alpha-L(h) (binding)
c-Jun(m) + ER-alpha-L(h) <==> c-Jun(m):ER-alpha-L(h) (binding)
ER-alpha-L(h) + Slim-3(h) <==> ER-alpha-L(h):Slim-3(h) (binding)
ER-alpha-L(h) + Ubc9(h) <==> ER-alpha-L(h):Ubc9(h) (binding)
ER-alpha-L(h) + PIAS1(h) <==> ER-alpha-L(h):PIAS1(h) (binding)
ER-alpha-L(h) + SRC-1(m.s.) <==> ER-alpha-L(h):SRC-1(m.s.) (binding)
ER-alpha-L(h) --/ IL6(h) (transrepression)
RelA-p65(m.s.) + ER-alpha-L(h) <==> RelA-p65(m.s.):ER-alpha-L(h) (binding)
NF-kappaB1-p50(m.s.) + ER-alpha-L(h) <==> NF-kappaB1-p50(m.s.):ER-alpha-L(h) (binding)
C/EBPbeta(m.s.) + ER-alpha-L(h) <==> C/EBPbeta(m.s.):ER-alpha-L(h) (binding)
calmodulin(h) + ER-alpha-L(h) <==> calmodulin(h):ER-alpha-L(h) (binding)
ER-alpha-L(h) + C/EBPalpha(m.s.) <==> ER-alpha-L(h):C/EBPalpha(m.s.) (binding)
ER-alpha-L(h) + C/EBPbeta(m.s.) <==> ER-alpha-L(h):C/EBPbeta(m.s.) (binding)
NR1B1(h) + ER-alpha-L(h) <==> NR1B1(h):ER-alpha-L(h) (binding)
T3R-alpha(h) + ER-alpha-L(h) <==> T3R-alpha(h):ER-alpha-L(h) (binding)
HNF-4(r) + ER-alpha-L(h) <==> HNF-4(r):ER-alpha-L(h) (binding)
ER-beta(m) + ER-alpha-L(h) <==> ER-beta(m):ER-alpha-L(h) (binding)
RXR-alpha(h) + ER-alpha-L(h) <==> RXR-alpha(h):ER-alpha-L(h) (binding)
T3R-beta1(r) + ER-alpha-L(h) <==> T3R-beta1(r):ER-alpha-L(h) (binding)
HDAC4(h) + ER-alpha-L(h) <==> HDAC4(h):ER-alpha-L(h) (binding)
HDAC4(m.s.) + ER-alpha-L(h) <==> HDAC4(m.s.):ER-alpha-L(h) (binding)
HDAC4(mo) + ER-alpha-L(h) <==> HDAC4(mo):ER-alpha-L(h) (binding)
ER-alpha-L(h) + ADA3A(h) <==> ER-alpha-L(h):ADA3A(h) (binding)
ER-alpha-L(h) + ADA3(m) <==> ER-alpha-L(h):ADA3(m) (binding)
ER-alpha-L(h) + NR1B1(m.s.) <==> ER-alpha-L(h):NR1B1(m.s.) (binding)
ER-alpha-L(h) + DRIP205-isoform1(h) <==> ER-alpha-L(h):DRIP205-isoform1(h) (binding)
ER-alpha-L(h) + DRIP100(h) <==> ER-alpha-L(h):DRIP100(h) (binding)
ER-alpha-L(h) + MSH-2(h) <==> ER-alpha-L(h):MSH-2(h) (binding)
ER-alpha-L(h) + DRIP205(m.s.) <==> ER-alpha-L(h):DRIP205(m.s.) (binding)
TLS(r) + ER-alpha-L(h) <==> TLS(r):ER-alpha-L(h) (binding)
TLS(h) + ER-alpha-L(h) <==> TLS(h):ER-alpha-L(h) (binding)
14-3-3eta(h) + ER-alpha-L(h) <==> 14-3-3eta(h):ER-alpha-L(h) (binding)
CBP(m) + ER-alpha-L(h) <==> CBP(m):ER-alpha-L(h) (binding)
ER-alpha-L(h) + Rbp2(h) <==> ER-alpha-L(h):Rbp2(h) (binding)
ER-alpha-L(h) + Rbp2(h) <==> ER-alpha-L(h):Rbp2(h) (binding)
ER-alpha-L(h) + DAP3(h) <==> ER-alpha-L(h):DAP3(h) (binding)
ER-alpha-L(h) + GAC63(m) <==> ER-alpha-L(h):GAC63(m) (binding)
SRC-1 (-Q)(h) + ER-alpha-L(h) <==> SRC-1 (-Q)(h):ER-alpha-L(h) (binding)
ER-alpha-L(h) --> ER-alpha-L(h) (translocation)
p300(m.s.) + ER-alpha-L(h) <==> p300(m.s.):ER-alpha-L(h) (binding)
SRC-1(h) + ER-alpha-L(h) <==> SRC-1(h):ER-alpha-L(h) (binding)
ER-alpha-L(h) + TIF2(h) <==> ER-alpha-L(h):TIF2(h) (binding)
ER-alpha-L(h) + SRC3(h) <==> ER-alpha-L(h):SRC3(h) (binding)
ER-alpha-L(h) + 3 acetyl-CoA --p300(m.s.)--> ER-alpha-L(h){aceK299}{aceK302}{aceK303} + 3 CoA (acetylation)
ER-alpha-L(h) + p/CAF(h) <==> ER-alpha-L(h):p/CAF(h) (binding)
ER-alpha-L(h) + TIF2(m.s.) <==> ER-alpha-L(h):TIF2(m.s.) (binding)
NCOR1(m) + ER-alpha-L(h) <==> NCOR1(m):ER-alpha-L(h) (binding)
ER-alpha-L(h) + sumo1(m.s.) --> ER-alpha-L(h){sumo} (sumoylation)
ER-alpha-L(h) + sumo1(m.s.) --Ubc9(m.s.)--> ER-alpha-L(h){sumo} (sumoylation)
ER-alpha-L(h) + sumo1(m.s.) --PIAS1(m.s.)--> ER-alpha-L(h){sumo} (sumoylation)
ER-alpha-L(h) + sumo1(m.s.) --PIAS3(m.s.)--> ER-alpha-L(h){sumo} (sumoylation)
ER-alpha-L(h) + 2 acetyl-CoA --p300(h)--> ER-alpha-L(h){aceK266}{aceK268} + 2 CoA (acetylation)
ER-alpha-L(h) + 2 acetyl-CoA --> ER-alpha-L(h){aceK266}{aceK268} + 2 CoA (acetylation)
ER-alpha-L(h) + acetyl-CoA --p300(h)--> ER-alpha-L(h){aceK} + CoA (acetylation)
ER-alpha-L(h) --> TTF1(h) (transactivation)
estradiol + ER-alpha-L(h) <==> estradiol:ER-alpha-L(h) (binding)
prmt2(h) + ER-alpha-L(h) <==> prmt2(h):ER-alpha-L(h) (binding)
ER-alpha-L(h) + PAK6(h) <==> ER-alpha-L(h):PAK6(h) (binding)
ER-alpha-L(h) + Fe65(m.s.) <==> ER-alpha-L(h):Fe65(m.s.) (binding)
ER-alpha-L(h) + AICD59(m.s.) <==> ER-alpha-L(h):AICD59(m.s.) (binding)
ER-alpha-L(h) + Fe65(m.s.) + AICD59(m.s.) <==> ER-alpha-L(h):Fe65(m.s.):AICD59(m.s.) (binding)
ER-alpha-L(h) + APP(m.s.) <==> ER-alpha-L(h):APP(m.s.) (binding)
ASC-2(m) + ER-alpha-L(h) <==> ASC-2(m):ER-alpha-L(h) (binding)
ASC-2(h) + ER-alpha-L(h) <==> ASC-2(h):ER-alpha-L(h) (binding)
COUP-TF1(h) + ER-alpha-L(h) <==> COUP-TF1(h):ER-alpha-L(h) (binding)
ER-alpha-L(h) + 1 ATP --> ER-alpha-L(h){pS118} + 1 ADP (phosphorylation)
ER-alpha-L(h) + ERK2(m.s.){p} <==> ER-alpha-L(h):ERK2(m.s.){p} (binding)
ER-alpha-L(h) + palmityl-CoA --> ER-alpha-L(h){pal} + CoA (palmitoylation)
ER-alpha-L(h) --> C3(h) (transactivation)
ER-alpha-L(h) --> CCND1(h) (transactivation)
ER-alpha-L(h) + palmityl-CoA --> ER-alpha-L(h){palC447} + CoA (palmitoylation)
ER-alpha-L(h) --> RP11-49G10.8(h) (DNA binding).
ER-alpha-L(h) --26S proteasome(h)--> protein remnants (degradation)
ER-alpha-L(h) + CHIP(m.s.) <==> ER-alpha-L(h):CHIP(m.s.) (binding)
ER-alpha-L(h) + acetyl-CoA --p300(m.s.)--> ER-alpha-L(h){aceK303} + CoA (acetylation)
ER-alpha-L(h) + ATP --PKAc(m.s.)--> ER-alpha-L(h){pS305} + ADP (phosphorylation)
ER-alpha-L(h) + n ubiquitin(h) --> ER-alpha-L(h){ub(n)} (ubiquitination)
ER-alpha-L(h) + TEBP(h) <==> ER-alpha-L(h):TEBP(h) (binding)
ER-alpha-L(h) + bag1(h) <==> ER-alpha-L(h):bag1(h) (binding)
ER-alpha-L(h) + CHIP(h) <==> ER-alpha-L(h):CHIP(h) (binding)
ER-alpha-L(h) + Hsp90(h) <==> ER-alpha-L(h):Hsp90(h) (binding)
ER-alpha-L(h) + ATP --GSK3beta(rb)--> ER-alpha-L(h){pS118} + ADP (phosphorylation)
ESR1(h) --> ER-alpha-L(h) (expression).
ER-alpha-L(h) --> ER-alpha-L(h) (translocation)
ER-alpha-L(h){ace} --> ER-alpha-L(h) + acetyl (deacetylation)
ER-alpha-L(h){ace} --SIRT1(m)--> ER-alpha-L(h) + acetyl (deacetylation)
ESR1(h) --> ER-alpha-S(h) (expression).
ESR1(h) --> ER-alpha(h) (expression).
hsa-miR-206 --/ ER-alpha(h) (increase of mRNA decay).
hsa-miR-18a --/ ER-alpha(h)
hsa-miR-19b --/ ER-alpha(h) (translational repression).
hsa-miR-22 --/ ER-alpha(h) (increase of mRNA decay).
hsa-miR-20b --/ ER-alpha(h) (translational repression).

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
104	Phosphoserine (by CDK2).		Swiss-Prot 53.0
106	Phosphoserine (by CDK2).		Swiss-Prot 53.0
118	Phosphoserine.		Swiss-Prot 53.0
167	Phosphoserine (by CK2).		Swiss-Prot 53.0
537	Phosphotyrosine (by Tyr-kinases).		Swiss-Prot 53.0
537	Phosphotyrosine (Lck;Src)	7539106	Phospho.ELM 6.0
118	Phosphoserine (MAPKAPK2;GSK)	7838153;12093745;9528769;10949034;16076840;1552827	Phospho.ELM 6.0
104	Phosphoserine (GSK-3beta;CD)	8308015;10949034;16076840;10428798	Phospho.ELM 6.0
106	Phosphoserine (GSK-3beta;CD)	8308015;10949034;16076840;10428798	Phospho.ELM 6.0
102	Phosphoserine (GSK-3beta)	16076840	Phospho.ELM 6.0
305	Phosphoserine (PAK1)	12374744;15193262	Phospho.ELM 6.0

Chromosome	Location	Source
Methylation Profile [Top]
chr6	Promoter: 152168879 - 152170879	GoldenGate_Methylation_Cancer_Panel_I
chr6	Promoter: 152168879 - 152170879	GSE27584
chr6	Promoter: 152168879 - 152170879	PMID:15254780
chr6	Promoter: 152168879 - 152170879	PMID:16181550
chr6	Promoter: 152168879 - 152170879	PMID:15536519
chr6	Promoter: 152168879 - 152170879	PMID:15328171
chr6	Promoter: 152168879 - 152170879	PMID:15172987
chr6	Promoter: 152168879 - 152170879	PMID:12114423
chr6	Promoter: 152168879 - 152170879	PMID:12548613
chr6	Promoter: 152168879 - 152170879	PMID:11313277
chr6	Promoter: 152168879 - 152170879	PMID:12899712
chr6	Promoter: 152168879 - 152170879	PMID:16343268
chr6	Promoter: 152168879 - 152170879	PMID:15026333
chr6	Promoter: 152168879 - 152170879	PMID:11880477
chr6	Promoter: 152168879 - 152170879	PMID:15358197
chr6	Promoter: 152168879 - 152170879	PMID:12899921
chr6	Promoter: 152168879 - 152170879	PMID:16483154
chr6	Promoter: 152168879 - 152170879	PMID:15986439
chr6	Promoter: 152168879 - 152170879	PMID:11895880
chr6	Promoter: 152168879 - 152170879	PMID:15639718
chr6	Promoter: 152168879 - 152170879	PMID:16889486
chr6	Promoter: 152168879 - 152170879	PMID:16983315
chr6	Promoter: 152168879 - 152170879	PMID:15365725
chr6	Promoter: 152168879 - 152170879	PMID:9671399
chr6	Promoter: 152168879 - 152170879	PMID:11487055
chr6	Promoter: 152168879 - 152170879	PMID:16303245
chr6	Promoter: 152168879 - 152170879	PMID:16773633
chr6	Promoter: 152168879 - 152170879	PMID:15328194
chr6	Promoter: 152168879 - 152170879	PMID:14767512
chr6	Promoter: 152168879 - 152170879	PMID:12730870
chr6	Promoter: 152168879 - 152170879	PMID:17289889
chr6	Promoter: 152168879 - 152170879	PMID:12011226
chr6	Promoter: 152168879 - 152170879	PMID:12017277
chr6	Promoter: 152168879 - 152170879	PMID:11309276
chr6	Promoter: 152168879 - 152170879	PMID:16818643
chr6	Promoter: 152168879 - 152170879	PMID:15109538
chr6	Promoter: 152168879 - 152170879	PMID:11309301
chr6	Promoter: 152168879 - 152170879	PMID:15551306

Experimentally verified miRNA from miRTarBase [Top]

Transcription Factors [Top]

Post Transcriptional Modification [Top]

Methylation Profile [Top]