| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 1028 |
Name | CDKN1C |
Synonymous | cyclin-dependent kinase inhibitor 1C (p57, Kip2);CDKN1C;cyclin-dependent kinase inhibitor 1C (p57, Kip2) |
Definition | cyclin-dependent kinase inhibitor 1C|cyclin-dependent kinase inhibitor p57 |
Position | 11p15.5 |
Gene Type | protein-coding |
Mutation summary: | Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72 |
Mutation summary in protein domains | Top |
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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers | Top |
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Loss of Function mutations compare to missense mutations | Top |
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| The ratio of the loss-of-function mutations over missense mutations is 0.25. |
The copy number variations for various cancers | Top |
There is no record for CDKN1C |
COSMIC somatic mutation [Top] | |||
|
Mutation (CDS; AA; Chr) |
Site |
Histology |
Mutation Type |
|---|---|---|---|
c.776C>A; p.A259D; 11:2884714-2884714 |
liver | carcinoma | Substitution - Missense |
c.135_136insT; p.L46fs*79; 11:2885354-2885355 |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; mantle_cell_lymphoma | Insertion - Frameshift |
c.768C>T; p.A256A; 11:2884722-2884722 |
lung | carcinoma; adenocarcinoma | Substitution - coding silent |
c.466C>A; p.P156T; 11:2885024-2885024 |
thyroid | other; neoplasm | Substitution - Missense |
c.147C>T; p.R49R; 11:2885343-2885343 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.496G>C; p.A166P; 11:2884994-2884994 |
haematopoietic_and_lymphoid_tissue; lymph_node | lymphoid_neoplasm; diffuse_large_B_cell_lymphoma | Substitution - Missense |
c.805G>A; p.G269R; 11:2884685-2884685 |
liver | carcinoma | Substitution - Missense |
c.303C>T; p.R101R; 11:2885187-2885187 |
ovary | other; neoplasm | Substitution - coding silent |
c.735G>A; p.G245G; 11:2884755-2884755 |
skin | malignant_melanoma | Substitution - coding silent |
c.262C>T; p.P88S; 11:2885228-2885228 |
stomach | carcinoma; intestinal_adenocarcinoma | Substitution - Missense |
c.205A>G; p.M69V; 11:2885285-2885285 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.48C>T; p.V16V; 11:2885442-2885442 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.196delC; p.Q66fs*206; 11:2885294-2885294 |
prostate | adenoma | Deletion - Frameshift |
c.182G>A; p.W61*; 11:2885308-2885308 |
upper_aerodigestive_tract; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Nonsense |
c.908G>T; p.G303V; 11:2884047-2884047 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.171C>A; p.D57E; 11:2885319-2885319 |
thyroid | other; neoplasm | Substitution - Missense |
c.102C>T; p.F34F; 11:2885388-2885388 |
skin | malignant_melanoma | Substitution - coding silent |