Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

10912

Name

GADD45G

Synonymous

growth arrest and DNA-damage-inducible, gamma;GADD45G;growth arrest and DNA-damage-inducible, gamma

Definition

DDIT-2|DNA damage-inducible transcript 2 protein|GADD45-gamma|cytokine-responsive protein CR6|gadd-related protein, 17 kD|growth arrest and DNA damage-inducible protein GADD45 gamma

Position

9q22.1-q22.2

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.00.

The copy number variations for various cancers

Top

There is no record for GADD45G

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.303G>T; p.L101L; 9:89605814-89605814

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.398C>A; p.P133H; 9:89605997-89605997

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.192G>A; p.A64A; 9:89605703-89605703

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.370-4G>A; p.?; 9:89605965-89605965

 pancreascarcinomaUnknown

c.423T>C; p.F141F; 9:89606022-89606022

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.212A>G; p.D71G; 9:89605723-89605723

 lung; middle_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.3G>A; p.M1I; 9:89605124-89605124

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.356G>A; p.C119Y; 9:89605867-89605867

 pancreascarcinoma; acinar_carcinomaSubstitution - Missense

c.457C>A; p.P153T; 9:89606056-89606056

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.324C>T; p.G108G; 9:89605835-89605835

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - coding silent

c.286G>A; p.G96S; 9:89605797-89605797

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.389G>C; p.W130S; 9:89605988-89605988

 skinmalignant_melanomaSubstitution - Missense

c.363C>T; p.L121L; 9:89605874-89605874

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.300G>A; p.R100R; 9:89605811-89605811

 breastcarcinomaSubstitution - coding silent

c.250T>G; p.F84V; 9:89605761-89605761

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.228C>T; p.I76I; 9:89605739-89605739

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.270C>T; p.I90I; 9:89605781-89605781

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.261G>T; p.E87D; 9:89605772-89605772

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

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