Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

11009

Name

IL24

Synonymous

interleukin 24;IL24;interleukin 24

Definition

IL-4-induced secreted protein|interleukin-24|melanocyte-associated Mda-7|melanoma differentiation-associated gene 7 protein|suppression of tumorigenicity 16 (melanoma differentiation)

Position

1q32

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

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We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.05.

The copy number variations for various cancers

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The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.69G>A; p.A23A; 1:206899344-206899344

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.522G>A; p.R174R; 1:206902057-206902057

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.429C>G; p.N143K; 1:206901619-206901619

 soft_tissue; striated_musclerhabdomyosarcomaSubstitution - Missense

c.351G>A; p.L117L; 1:206901541-206901541

 skinmalignant_melanomaSubstitution - coding silent

c.125T>A; p.L42H; 1:206899400-206899400

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.147C>T; p.A49A; 1:206899422-206899422

 prostatecarcinomaSubstitution - coding silent

c.147C>T; p.A49A; 1:206899422-206899422

 livercarcinomaSubstitution - coding silent

c.147C>T; p.A49A; 1:206899422-206899422

 livercarcinomaSubstitution - coding silent

c.86A>G; p.Q29R; 1:206899361-206899361

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.597G>A; p.W199*; 1:206903035-206903035

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Nonsense

c.578T>C; p.V193A; 1:206903016-206903016

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.578T>C; p.V193A; 1:206903016-206903016

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.47C>T; p.P16L; 1:206899322-206899322

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.172C>T; p.P58S; 1:206899447-206899447

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.297C>T; p.N99N; 1:206900351-206900351

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.40G>T; p.A14S; 1:206897872-206897872

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.298G>A; p.V100I; 1:206900352-206900352

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.278A>T; p.Q93L; 1:206900332-206900332

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.565G>A; p.A189T; 1:206903003-206903003

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.146C>T; p.A49V; 1:206899421-206899421

 kidneyother; neoplasmSubstitution - Missense

c.87G>T; p.Q29H; 1:206899362-206899362

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.454C>A; p.Q152K; 1:206901644-206901644

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.397A>G; p.T133A; 1:206901587-206901587

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.397A>G; p.T133A; 1:206901587-206901587

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.428A>C; p.N143T; 1:206901618-206901618

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.439A>G; p.I147V; 1:206901629-206901629

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.460A>T; p.S154C; 1:206901650-206901650

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.163C>T; p.H55Y; 1:206899438-206899438

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.211G>A; p.E71K; 1:206899486-206899486

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.211G>A; p.E71K; 1:206899486-206899486

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.149A>G; p.Q50R; 1:206899424-206899424

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.568C>T; p.L190F; 1:206903006-206903006

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.27C>T; p.S9S; 1:206897859-206897859

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.345C>G; p.F115L; 1:206901535-206901535

 breastcarcinomaSubstitution - Missense

c.442G>A; p.V148M; 1:206901632-206901632

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.249G>A; p.Q83Q; 1:206900303-206900303

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.508T>A; p.F170I; 1:206902043-206902043

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.363C>G; p.F121L; 1:206901553-206901553

 breastcarcinomaSubstitution - Missense

c.564A>C; p.K188N; 1:206903002-206903002

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.388G>A; p.E130K; 1:206901578-206901578

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.416C>A; p.T139N; 1:206901606-206901606

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.334C>T; p.L112L; 1:206901524-206901524

 livercarcinomaSubstitution - coding silent

c.334C>T; p.L112L; 1:206901524-206901524

 livercarcinomaSubstitution - coding silent

c.133C>A; p.Q45K; 1:206899408-206899408

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

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