Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

11178

Name

LZTS1

Synonymous

leucine zipper, putative tumor suppressor 1;LZTS1;leucine zipper, putative tumor suppressor 1

Definition

F37/Esophageal cancer-related gene-coding leucine-zipper motif|leucine zipper putative tumor suppressor 1

Position

8p22

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

Top

Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.05.

The copy number variations for various cancers

Top

The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.1249G>A; p.A417T; 8:20250264-20250264

 pancreascarcinomaSubstitution - Missense

c.1249G>A; p.A417T; 8:20250264-20250264

 pancreascarcinomaSubstitution - Missense

c.1249G>A; p.A417T; 8:20250264-20250264

 pancreascarcinomaSubstitution - Missense

c.1616T>G; p.V539G; 8:20249897-20249897

 thyroidother; neoplasmSubstitution - Missense

c.1743G>A; p.L581L; 8:20249770-20249770

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.885C>T; p.Y295Y; 8:20253046-20253046

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.885C>T; p.Y295Y; 8:20253046-20253046

 oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.801G>A; p.E267E; 8:20253130-20253130

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - coding silent

c.873C>T; p.S291S; 8:20253058-20253058

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.187G>A; p.E63K; 8:20254995-20254995

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.898C>T; p.R300W; 8:20253033-20253033

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.114C>T; p.S38S; 8:20255068-20255068

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.106C>T; p.R36W; 8:20255076-20255076

 pancreaspancreatic_intraepithelial_neoplasia_(PanIN)Substitution - Missense

c.106C>T; p.R36W; 8:20255076-20255076

 breastcarcinomaSubstitution - Missense

c.1702G>T; p.A568S; 8:20249811-20249811

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.411C>T; p.I137I; 8:20253520-20253520

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.409A>T; p.I137F; 8:20253522-20253522

 lungcarcinoma; small_cell_carcinomaSubstitution - Missense

c.116A>G; p.D39G; 8:20255066-20255066

 breastcarcinomaSubstitution - Missense

c.1607A>C; p.K536T; 8:20249906-20249906

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1366C>T; p.R456C; 8:20250147-20250147

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.702C>T; p.D234D; 8:20253229-20253229

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1053C>T; p.S351S; 8:20252878-20252878

 skinmalignant_melanomaSubstitution - coding silent

c.813G>T; p.L271F; 8:20253118-20253118

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1088T>A; p.L363H; 8:20252843-20252843

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.750G>A; p.S250S; 8:20253181-20253181

 breastcarcinomaSubstitution - coding silent

c.969G>C; p.K323N; 8:20252962-20252962

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.969G>C; p.K323N; 8:20252962-20252962

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.186C>T; p.S62S; 8:20254996-20254996

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.186C>T; p.S62S; 8:20254996-20254996

 pancreascarcinoma; ductal_carcinomaSubstitution - coding silent

c.253C>T; p.L85L; 8:20254929-20254929

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.253C>A; p.L85M; 8:20254929-20254929

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1555G>C; p.D519H; 8:20249958-20249958

 breastcarcinomaSubstitution - Missense

c.77G>A; p.R26H; 8:20255105-20255105

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1413_1414GG>TT; p.L471>?; 8:20250099-20250100

 lungcarcinoma; adenocarcinomaComplex

c.775G>T; p.D259Y; 8:20253156-20253156

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1169A>G; p.E390G; 8:20250344-20250344

 skinmalignant_melanomaSubstitution - Missense

c.415C>A; p.H139N; 8:20253516-20253516

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1000C>T; p.Q334*; 8:20252931-20252931

 large_intestinecarcinoma; adenocarcinomaSubstitution - Nonsense

c.1000C>T; p.Q334*; 8:20252931-20252931

 large_intestine; coloncarcinomaSubstitution - Nonsense

c.62C>T; p.S21L; 8:20255120-20255120

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1650C>T; p.Y550Y; 8:20249863-20249863

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.905_919del15; p.C302_E307>*; 8:20253012-20253026

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaComplex - deletion inframe

c.678C>T; p.S226S; 8:20253253-20253253

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1667G>A; p.R556Q; 8:20249846-20249846

 pancreascarcinomaSubstitution - Missense

c.756C>A; p.V252V; 8:20253175-20253175

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.292T>G; p.F98V; 8:20254890-20254890

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.565A>T; p.S189C; 8:20253366-20253366

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.334C>G; p.Q112E; 8:20254848-20254848

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1265C>T; p.T422M; 8:20250248-20250248

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1265C>T; p.T422M; 8:20250248-20250248

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1423C>G; p.L475V; 8:20250090-20250090

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1719C>T; p.A573A; 8:20249794-20249794

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - coding silent

c.1471C>T; p.P491S; 8:20250042-20250042

 livercarcinomaSubstitution - Missense

c.1471C>T; p.P491S; 8:20250042-20250042

 livercarcinomaSubstitution - Missense

c.963G>A; p.S321S; 8:20252968-20252968

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.939C>T; p.G313G; 8:20252992-20252992

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.1761C>T; p.P587P; 8:20249752-20249752

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1048G>T; p.E350*; 8:20252883-20252883

 urinary_tract; bladdercarcinomaSubstitution - Nonsense

c.1576C>A; p.Q526K; 8:20249937-20249937

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.880G>A; p.A294T; 8:20253051-20253051

 stomachadenocarcinomaSubstitution - Missense

c.1276C>T; p.L426L; 8:20250237-20250237

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.768C>A; p.I256I; 8:20253163-20253163

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1666C>T; p.R556W; 8:20249847-20249847

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1128G>A; p.A376A; 8:20252803-20252803

 livercarcinomaSubstitution - coding silent

c.263G>T; p.G88V; 8:20254919-20254919

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1056_1057CA>GT; p.M353L; 8:20252874-20252875

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.1569G>C; p.S523S; 8:20249944-20249944

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.118G>A; p.G40R; 8:20255064-20255064

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.299C>T; p.P100L; 8:20254883-20254883

 pancreascarcinomaSubstitution - Missense

c.438C>T; p.S146S; 8:20253493-20253493

 livercarcinoma; hepatocellular_carcinomaSubstitution - coding silent

c.981G>A; p.A327A; 8:20252950-20252950

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.981G>A; p.A327A; 8:20252950-20252950

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1047C>T; p.L349L; 8:20252884-20252884

 oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.114C>G; p.S38S; 8:20255068-20255068

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1119C>T; p.F373F; 8:20252812-20252812

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.574C>G; p.Q192E; 8:20253357-20253357

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - Missense

c.1597A>G; p.K533E; 8:20249916-20249916

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.509C>T; p.A170V; 8:20253422-20253422

 breastcarcinomaSubstitution - Missense

c.1790G>A; p.*597*; 8:20249723-20249723

 cervixcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.1135G>C; p.E379Q; 8:20252796-20252796

 breastcarcinomaSubstitution - Missense

c.311C>A; p.P104H; 8:20254871-20254871

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.1367G>A; p.R456H; 8:20250146-20250146

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1504C>T; p.R502W; 8:20250009-20250009

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.63G>A; p.S21S; 8:20255119-20255119

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.1543C>A; p.R515R; 8:20249970-20249970

 thyroidother; neoplasmSubstitution - coding silent

c.1331G>T; p.G444V; 8:20250182-20250182

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.977G>A; p.R326H; 8:20252954-20252954

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1106A>G; p.E369G; 8:20252825-20252825

 livercarcinomaSubstitution - Missense

c.1142A>G; p.Q381R; 8:20252789-20252789

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.1126G>C; p.A376P; 8:20252805-20252805

 livercarcinomaSubstitution - Missense

c.1126G>C; p.A376P; 8:20252805-20252805

 livercarcinomaSubstitution - Missense

c.1716C>T; p.S572S; 8:20249797-20249797

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.886G>A; p.E296K; 8:20253045-20253045

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.171C>G; p.S57S; 8:20255011-20255011

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.886G>A; p.E296K; 8:20253045-20253045

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.171C>G; p.S57S; 8:20255011-20255011

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - coding silent

c.30C>T; p.G10G; 8:20255152-20255152

 breastcarcinomaSubstitution - coding silent

c.1729T>C; p.L577L; 8:20249784-20249784

 skin; trunkmalignant_melanoma; nodularSubstitution - coding silent

c.1315G>A; p.A439T; 8:20250198-20250198

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.661G>T; p.D221Y; 8:20253270-20253270

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.597C>A; p.P199P; 8:20253334-20253334

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.845G>A; p.R282H; 8:20253086-20253086

 oesophagus; middle_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.448C>T; p.H150Y; 8:20253483-20253483

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.300G>A; p.P100P; 8:20254882-20254882

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.1568C>T; p.S523L; 8:20249945-20249945

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1127C>T; p.A376V; 8:20252804-20252804

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.758G>A; p.R253H; 8:20253173-20253173

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.265G>A; p.D89N; 8:20254917-20254917

 skinmalignant_melanomaSubstitution - Missense

c.980C>T; p.A327V; 8:20252951-20252951

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.926C>T; p.P309L; 8:20253005-20253005

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.926C>T; p.P309L; 8:20253005-20253005

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1013T>A; p.L338H; 8:20252918-20252918

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.540C>T; p.S180S; 8:20253391-20253391

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.899G>A; p.R300Q; 8:20253032-20253032

 stomachcarcinoma; intestinal_adenocarcinomaSubstitution - Missense

c.1084A>T; p.K362*; 8:20252847-20252847

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - Nonsense

c.1198delG; p.E400fs*6; 8:20250315-20250315

 lungcarcinoma; adenocarcinomaDeletion - Frameshift

c.196T>C; p.F66L; 8:20254986-20254986

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.196T>C; p.F66L; 8:20254986-20254986

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1314C>T; p.G438G; 8:20250199-20250199

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1314C>T; p.G438G; 8:20250199-20250199

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1209G>A; p.T403T; 8:20250304-20250304

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.628G>A; p.A210T; 8:20253303-20253303

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.1020_1021GG>TT; p.Q340_E341>H*; 8:20252910-20252911

 lung; right_upper_lobecarcinoma; adenocarcinomaComplex - compound substitution

c.1528G>A; p.E510K; 8:20249985-20249985

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.902G>A; p.R301H; 8:20253029-20253029

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.537G>C; p.M179I; 8:20253394-20253394

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.1777G>T; p.A593S; 8:20249736-20249736

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.338T>C; p.L113P; 8:20254844-20254844

 pancreascarcinoma; ductal_carcinomaSubstitution - Missense

c.338T>C; p.L113P; 8:20254844-20254844

 pancreaspancreatic_intraepithelial_neoplasia_(PanIN)Substitution - Missense

c.338T>C; p.L113P; 8:20254844-20254844

 pancreaspancreatic_intraepithelial_neoplasia_(PanIN)Substitution - Missense

c.338T>C; p.L113P; 8:20254844-20254844

 soft_tissue; fibrous_tissue_and_uncertain_ogastrointestinal_stromal_tumourSubstitution - Missense

c.231C>T; p.S77S; 8:20254951-20254951

 soft_tissue; striated_musclerhabdomyosarcomaSubstitution - coding silent

c.726G>A; p.S242S; 8:20253205-20253205

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.231C>T; p.S77S; 8:20254951-20254951

 soft_tissue; striated_musclerhabdomyosarcoma; embryonalSubstitution - coding silent

c.231C>T; p.S77S; 8:20254951-20254951

 soft_tissue; striated_musclerhabdomyosarcoma; embryonalSubstitution - coding silent

c.1174T>C; p.S392P; 8:20250339-20250339

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.292T>A; p.F98I; 8:20254890-20254890

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.261C>T; p.S87S; 8:20254921-20254921

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.261C>T; p.S87S; 8:20254921-20254921

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.261C>T; p.S87S; 8:20254921-20254921

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.261C>T; p.S87S; 8:20254921-20254921

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.261C>T; p.S87S; 8:20254921-20254921

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.298C>T; p.P100S; 8:20254884-20254884

 soft_tissue; striated_musclerhabdomyosarcomaSubstitution - Missense

c.298C>T; p.P100S; 8:20254884-20254884

 soft_tissue; striated_musclerhabdomyosarcoma; embryonalSubstitution - Missense

c.698C>T; p.S233F; 8:20253233-20253233

 skinmalignant_melanomaSubstitution - Missense

c.156C>T; p.H52H; 8:20255026-20255026

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.778G>A; p.E260K; 8:20253153-20253153

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.598G>A; p.V200M; 8:20253333-20253333

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1295G>T; p.R432M; 8:20250218-20250218

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1252C>A; p.Q418K; 8:20250261-20250261

 oesophagus; lower_thirdcarcinoma; adenocarcinomaSubstitution - Missense

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