Entrez Gene

Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)

General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information
Gene ID	11334
Name	TUSC2
Synonymous	tumor suppressor candidate 2;TUSC2;tumor suppressor candidate 2
Definition	PDGFA associated protein 2\|PDGFA-associated protein 2\|fus-1 protein\|fusion 1 protein
Position	3p21.3
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

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We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.

The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.

The ratio of the loss-of-function mutations over missense mutations is 0.67.

The copy number variations for various cancers

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There is no record for TUSC2

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.160G>T; p.D54Y; 3:50326464-50326464	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.160G>T; p.D54Y; 3:50326464-50326464	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.193G>T; p.E65*; 3:50326431-50326431	breast	carcinoma	Substitution - Nonsense
c.311C>T; p.P104L; 3:50326143-50326143	skin	malignant_melanoma	Substitution - Missense
c.310C>T; p.P104S; 3:50326144-50326144	NS	malignant_melanoma	Substitution - Missense
c.310C>T; p.P104S; 3:50326144-50326144	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Missense
c.216C>T; p.N72N; 3:50326408-50326408	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.289C>T; p.P97S; 3:50326165-50326165	skin	malignant_melanoma	Substitution - Missense
c.184G>A; p.E62K; 3:50326440-50326440	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.241C>T; p.R81*; 3:50326383-50326383	lung	carcinoma; bronchioloalveolar_adenocarcinoma	Substitution - Nonsense
c.204C>T; p.I68I; 3:50326420-50326420	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.141C>A; p.R47R; 3:50327959-50327959	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent

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