Entrez Gene

Basic Information
Gene ID	150094
Name	SIK1
Synonymous	salt-inducible kinase 1;SIK1;salt-inducible kinase 1
Definition	SIK-1\|SNF1-like kinase\|myocardial SNF1-like kinase\|salt-inducible protein kinase 1\|serine/threonine protein kinase\|serine/threonine-protein kinase SIK1\|serine/threonine-protein kinase SNF1-like kinase 1\|serine/threonine-protein kinase SNF1LK
Position	21q22.3
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Loss of Function mutations compare to missense mutations

Top

The ratio of the loss-of-function mutations over missense mutations is 0.13.

The copy number variations for various cancers

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1620G>A; p.S540S; 21:43418384-43418384	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.204G>A; p.L68L; 21:43425476-43425476	testis	germ_cell_tumour; non_seminoma	Substitution - coding silent
c.204G>A; p.L68L; 21:43425476-43425476	testis	germ_cell_tumour; non_seminoma	Substitution - coding silent
c.204G>A; p.L68L; 21:43425476-43425476	testis	germ_cell_tumour; non_seminoma	Substitution - coding silent
c.1368G>T; p.E456D; 21:43419115-43419115	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1538C>T; p.A513V; 21:43418466-43418466	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.723C>T; p.F241F; 21:43421035-43421035	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.723C>T; p.F241F; 21:43421035-43421035	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.563delC; p.P188fs*45; 21:43421304-43421304	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.909C>T; p.D303D; 21:43420297-43420297	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.563delC; p.P188fs*45; 21:43421304-43421304	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.419G>C; p.C140S; 21:43421718-43421718	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.879C>T; p.S293S; 21:43420327-43420327	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1844C>T; p.A615V; 21:43417675-43417675	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.234G>A; p.M78I; 21:43425446-43425446	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1530C>T; p.T510T; 21:43418474-43418474	breast	carcinoma	Substitution - coding silent
c.1572G>T; p.P524P; 21:43418432-43418432	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.689C>T; p.P230L; 21:43421069-43421069	ovary	other; neoplasm	Substitution - Missense
c.1196C>T; p.S399F; 21:43419402-43419402	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1196C>T; p.S399F; 21:43419402-43419402	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1550C>T; p.P517L; 21:43418454-43418454	skin	malignant_melanoma	Substitution - Missense
c.2341C>G; p.L781V; 21:43416753-43416753	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2087C>T; p.P696L; 21:43417007-43417007	thyroid	other; neoplasm	Substitution - Missense
c.1642G>A; p.A548T; 21:43418362-43418362	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.500-7C>T; p.?; 21:43421374-43421374	oesophagus	carcinoma; adenocarcinoma	Unknown
c.202T>C; p.L68L; 21:43425478-43425478	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1003G>A; p.A335T; 21:43419975-43419975	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.1743A>G; p.Q581Q; 21:43418261-43418261	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.400C>T; p.L134L; 21:43421737-43421737	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.203T>C; p.L68S; 21:43425477-43425477	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1934G>A; p.R645Q; 21:43417585-43417585	skin	malignant_melanoma	Substitution - Missense
c.270C>T; p.Y90Y; 21:43425410-43425410	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.203T>C; p.L68S; 21:43425477-43425477	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.400C>T; p.L134L; 21:43421737-43421737	skin	malignant_melanoma	Substitution - coding silent
c.2311C>T; p.L771L; 21:43416783-43416783	thyroid	carcinoma	Substitution - coding silent
c.1328C>T; p.A443V; 21:43419155-43419155	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1328C>T; p.A443V; 21:43419155-43419155	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1409G>A; p.R470Q; 21:43419074-43419074	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1405G>T; p.G469C; 21:43419078-43419078	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.788C>T; p.P263L; 21:43420418-43420418	skin	malignant_melanoma	Substitution - Missense
c.1733C>T; p.S578L; 21:43418271-43418271	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1733C>T; p.S578L; 21:43418271-43418271	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1884C>T; p.F628F; 21:43417635-43417635	skin	malignant_melanoma	Substitution - coding silent
c.43G>A; p.G15S; 21:43426136-43426136	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.226C>G; p.Q76E; 21:43425454-43425454	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2192A>T; p.H731L; 21:43416902-43416902	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.633C>A; p.G211G; 21:43421125-43421125	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.1646C>T; p.T549I; 21:43418358-43418358	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1529C>T; p.T510I; 21:43418475-43418475	central_nervous_system; brain	glioma; astrocytoma_Grade_II	Substitution - Missense
c.1257C>T; p.F419F; 21:43419226-43419226	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1024C>T; p.L342F; 21:43419954-43419954	skin	malignant_melanoma	Substitution - Missense
c.1731C>G; p.T577T; 21:43418273-43418273	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1088G>A; p.R363Q; 21:43419890-43419890	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.702G>T; p.Q234H; 21:43421056-43421056	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.524A>G; p.K175R; 21:43421343-43421343	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.2224C>T; p.P742S; 21:43416870-43416870	skin	malignant_melanoma	Substitution - Missense
c.2029C>T; p.P677S; 21:43417065-43417065	skin	malignant_melanoma	Substitution - Missense
c.1860C>T; p.A620A; 21:43417659-43417659	skin	malignant_melanoma	Substitution - coding silent
c.796C>T; p.R266C; 21:43420410-43420410	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2118C>A; p.L706L; 21:43416976-43416976	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1127A>G; p.Q376R; 21:43419471-43419471	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.372C>T; p.N124N; 21:43421765-43421765	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.595G>C; p.E199Q; 21:43421272-43421272	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.530G>A; p.G177E; 21:43421337-43421337	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.744_748+7delTCAAGGTGAGTC; p.?; 21:43421003-43421014	stomach	carcinoma; intestinal_adenocarcinoma	Unknown
c.1935G>A; p.R645R; 21:43417584-43417584	skin	malignant_melanoma	Substitution - coding silent
c.1539G>A; p.A513A; 21:43418465-43418465	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.563C>T; p.P188L; 21:43421304-43421304	skin	malignant_melanoma	Substitution - Missense
c.1908C>T; p.G636G; 21:43417611-43417611	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.947G>A; p.G316D; 21:43420259-43420259	ovary	other; neoplasm	Substitution - Missense
c.947G>A; p.G316D; 21:43420259-43420259	ovary	other; neoplasm	Substitution - Missense
c.355G>T; p.G119W; 21:43421782-43421782	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1126C>T; p.Q376*; 21:43419472-43419472	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.462C>A; p.N154K; 21:43421675-43421675	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.462C>A; p.N154K; 21:43421675-43421675	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.197G>T; p.S66I; 21:43425483-43425483	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.811C>A; p.Q271K; 21:43420395-43420395	urinary_tract; bladder	carcinoma	Substitution - Missense
c.811C>A; p.Q271K; 21:43420395-43420395	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.536C>T; p.P179L; 21:43421331-43421331	skin; mucosal	malignant_melanoma	Substitution - Missense
c.1138delT; p.S380fs*75; 21:43419460-43419460	breast	carcinoma	Deletion - Frameshift
c.876C>G; p.F292L; 21:43420330-43420330	ovary	other; neoplasm	Substitution - Missense
c.685C>A; p.L229M; 21:43421073-43421073	skin	malignant_melanoma	Substitution - Missense
c.1595C>T; p.A532V; 21:43418409-43418409	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1295G>A; p.R432Q; 21:43419188-43419188	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1304C>T; p.S435F; 21:43419179-43419179	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.769C>T; p.R257C; 21:43420437-43420437	oesophagus	carcinoma	Substitution - Missense
c.32C>T; p.P11L; 21:43426147-43426147	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1236G>A; p.S412S; 21:43419362-43419362	breast	carcinoma	Substitution - coding silent
c.1815C>T; p.I605I; 21:43417704-43417704	skin	malignant_melanoma	Substitution - coding silent
c.1817A>G; p.K606R; 21:43417702-43417702	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.609C>T; p.P203P; 21:43421258-43421258	skin	malignant_melanoma	Substitution - coding silent
c.1817A>G; p.K606R; 21:43417702-43417702	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1817A>G; p.K606R; 21:43417702-43417702	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.607C>A; p.P203T; 21:43421260-43421260	skin	malignant_melanoma	Substitution - Missense
c.1227C>T; p.L409L; 21:43419371-43419371	skin	malignant_melanoma	Substitution - coding silent
c.1417A>C; p.T473P; 21:43419066-43419066	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1417A>C; p.T473P; 21:43419066-43419066	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1417A>C; p.T473P; 21:43419066-43419066	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1417A>C; p.T473P; 21:43419066-43419066	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1417A>C; p.T473P; 21:43419066-43419066	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1417A>C; p.T473P; 21:43419066-43419066	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1417A>C; p.T473P; 21:43419066-43419066	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1417A>C; p.T473P; 21:43419066-43419066	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1417A>C; p.T473P; 21:43419066-43419066	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1417A>C; p.T473P; 21:43419066-43419066	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1417A>C; p.T473P; 21:43419066-43419066	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1417A>C; p.T473P; 21:43419066-43419066	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2175G>A; p.A725A; 21:43416919-43416919	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1745G>A; p.G582E; 21:43417774-43417774	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.631G>A; p.G211S; 21:43421127-43421127	central_nervous_system; brain	glioma	Substitution - Missense
c.631G>A; p.G211S; 21:43421127-43421127	central_nervous_system; brain	glioma	Substitution - Missense
c.717C>T; p.G239G; 21:43421041-43421041	prostate	carcinoma	Substitution - coding silent
c.1870G>T; p.G624C; 21:43417649-43417649	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1496C>T; p.P499L; 21:43418508-43418508	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1178C>T; p.P393L; 21:43419420-43419420	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1572G>A; p.P524P; 21:43418432-43418432	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.563C>G; p.P188R; 21:43421304-43421304	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; chronic_myeloid_leukaemia	Substitution - Missense
c.948C>T; p.G316G; 21:43420258-43420258	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - coding silent
c.948C>T; p.G316G; 21:43420258-43420258	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.948C>T; p.G316G; 21:43420258-43420258	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.367G>A; p.E123K; 21:43421770-43421770	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.862G>A; p.A288T; 21:43420344-43420344	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.202T>G; p.L68V; 21:43425478-43425478	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1406G>A; p.G469D; 21:43419077-43419077	skin	malignant_melanoma	Substitution - Missense
c.1406G>A; p.G469D; 21:43419077-43419077	skin	malignant_melanoma	Substitution - Missense
c.1172C>T; p.P391L; 21:43419426-43419426	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.570C>T; p.A190A; 21:43421297-43421297	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.64delC; p.L22fs*20; 21:43426115-43426115	lung	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1086G>A; p.P362P; 21:43419892-43419892	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.455C>T; p.T152I; 21:43421682-43421682	skin	malignant_melanoma	Substitution - Missense
c.353A>G; p.N118S; 21:43421784-43421784	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1019T>C; p.L340P; 21:43419959-43419959	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1553C>T; p.A518V; 21:43418451-43418451	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.28G>T; p.D10Y; 21:43426151-43426151	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2053G>T; p.V685L; 21:43417041-43417041	thyroid	other; neoplasm	Substitution - Missense
c.287A>G; p.K96R; 21:43422024-43422024	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.238C>A; p.L80I; 21:43425442-43425442	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1570C>T; p.P524S; 21:43418434-43418434	skin	malignant_melanoma	Substitution - Missense
c.645delC; p.Y215fs*1; 21:43421113-43421113	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Deletion - Frameshift
c.1072C>G; p.P358A; 21:43419906-43419906	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1901G>A; p.S634N; 21:43417618-43417618	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.469C>T; p.L157L; 21:43421668-43421668	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1477C>T; p.P493S; 21:43418527-43418527	skin	malignant_melanoma	Substitution - Missense
c.2305G>A; p.E769K; 21:43416789-43416789	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.378G>A; p.A126A; 21:43421759-43421759	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.789C>T; p.P263P; 21:43420417-43420417	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2154_2176del23; p.S719fs*31; 21:43416918-43416940	lung	carcinoma; non_small_cell_carcinoma	Deletion - Frameshift
c.2154_2176del23; p.S719fs*31; 21:43416918-43416940	lung	carcinoma; non_small_cell_carcinoma	Deletion - Frameshift
c.2154_2176del23; p.S719fs*31; 21:43416918-43416940	lung	carcinoma; non_small_cell_carcinoma	Deletion - Frameshift
c.2154_2176del23; p.S719fs*31; 21:43416918-43416940	lung	carcinoma; non_small_cell_carcinoma	Deletion - Frameshift
c.729C>T; p.I243I; 21:43421029-43421029	skin	malignant_melanoma	Substitution - coding silent
c.633C>T; p.G211G; 21:43421125-43421125	stomach	adenocarcinoma	Substitution - coding silent
c.1471G>A; p.V491I; 21:43418533-43418533	pancreas	carcinoma	Substitution - Missense
c.1848C>T; p.P616P; 21:43417671-43417671	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1848C>T; p.P616P; 21:43417671-43417671	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2295C>T; p.D765D; 21:43416799-43416799	skin	malignant_melanoma	Substitution - coding silent
c.1848C>T; p.P616P; 21:43417671-43417671	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.1432T>C; p.S478P; 21:43419051-43419051	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1432T>C; p.S478P; 21:43419051-43419051	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1432T>C; p.S478P; 21:43419051-43419051	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1432T>C; p.S478P; 21:43419051-43419051	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1432T>C; p.S478P; 21:43419051-43419051	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1185C>T; p.T395T; 21:43419413-43419413	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1432T>C; p.S478P; 21:43419051-43419051	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1432T>C; p.S478P; 21:43419051-43419051	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1432T>C; p.S478P; 21:43419051-43419051	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1432T>C; p.S478P; 21:43419051-43419051	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1432T>C; p.S478P; 21:43419051-43419051	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1435A>C; p.T479P; 21:43419048-43419048	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1435A>C; p.T479P; 21:43419048-43419048	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1435A>C; p.T479P; 21:43419048-43419048	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1435A>C; p.T479P; 21:43419048-43419048	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1435A>C; p.T479P; 21:43419048-43419048	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1435A>C; p.T479P; 21:43419048-43419048	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1435A>C; p.T479P; 21:43419048-43419048	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1435A>C; p.T479P; 21:43419048-43419048	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.96C>A; p.T32T; 21:43426083-43426083	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1435A>C; p.T479P; 21:43419048-43419048	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1070G>T; p.G357V; 21:43419908-43419908	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1435A>C; p.T479P; 21:43419048-43419048	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1435A>C; p.T479P; 21:43419048-43419048	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1435A>C; p.T479P; 21:43419048-43419048	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1435A>C; p.T479P; 21:43419048-43419048	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1435A>C; p.T479P; 21:43419048-43419048	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1828C>T; p.R610C; 21:43417691-43417691	NS	malignant_melanoma	Substitution - Missense
c.312A>G; p.E104E; 21:43421999-43421999	liver	carcinoma	Substitution - coding silent
c.672C>T; p.F224F; 21:43421086-43421086	skin	malignant_melanoma	Substitution - coding silent
c.672C>T; p.F224F; 21:43421086-43421086	breast	carcinoma	Substitution - coding silent
c.457G>A; p.E153K; 21:43421680-43421680	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense

Mutation summary in protein domains

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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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Loss of Function mutations compare to missense mutations

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The copy number variations for various cancers

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COSMIC somatic mutation [Top]