| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 1796 |
Name | DOK1 |
Synonymous | docking protein 1, 62kDa (downstream of tyrosine kinase 1);DOK1;docking protein 1, 62kDa (downstream of tyrosine kinase 1) |
Definition | Downstream of tyrosine kinase 1|docking protein 1|docking protein 1 (downstream of tyrosine kinase 1)|p62(dok)|pp62 |
Position | 2p13 |
Gene Type | protein-coding |
Mutation summary: | Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72 |
Mutation summary in protein domains | Top |
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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers | Top |
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Loss of Function mutations compare to missense mutations | Top |
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| The ratio of the loss-of-function mutations over missense mutations is 0.11. |
The copy number variations for various cancers | Top |
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The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract |
COSMIC somatic mutation [Top] | |||
|
Mutation (CDS; AA; Chr) |
Site |
Histology |
Mutation Type |
|---|---|---|---|
c.1400G>A; p.R467K; 2:74557068-74557068 |
skin | malignant_melanoma | Substitution - Missense |
c.949G>A; p.D317N; 2:74556617-74556617 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.929C>T; p.S310F; 2:74556597-74556597 |
breast | carcinoma | Substitution - Missense |
c.894G>A; p.E298E; 2:74556562-74556562 |
liver | carcinoma | Substitution - coding silent |
c.597G>A; p.L199L; 2:74556036-74556036 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.43C>A; p.Q15K; 2:74554797-74554797 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.1244G>A; p.R415Q; 2:74556912-74556912 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.1412A>G; p.D471G; 2:74557080-74557080 |
lung | carcinoma; small_cell_carcinoma | Substitution - Missense |
c.622C>T; p.R208C; 2:74556061-74556061 |
oesophagus | carcinoma; adenocarcinoma | Substitution - Missense |
c.651T>A; p.S217S; 2:74556319-74556319 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.94G>A; p.A32T; 2:74555187-74555187 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.376C>T; p.L126L; 2:74555590-74555590 |
oesophagus | carcinoma | Substitution - coding silent |
c.797G>C; p.R266T; 2:74556465-74556465 |
breast | carcinoma | Substitution - Missense |
c.1419_1420delTG; p.V475fs*>7; 2:74557087-74557088 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.1176G>T; p.R392R; 2:74556844-74556844 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.29delT; p.L12fs*26; 2:74554783-74554783 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.29delT; p.L12fs*26; 2:74554783-74554783 |
large_intestine | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.138G>T; p.K46N; 2:74555231-74555231 |
lung; right_lower_lobe | carcinoma; adenocarcinoma | Substitution - Missense |
c.43C>T; p.Q15*; 2:74554797-74554797 |
breast | carcinoma | Substitution - Nonsense |
c.570C>T; p.A190A; 2:74556009-74556009 |
lung | carcinoma; adenocarcinoma | Substitution - coding silent |
c.562G>T; p.V188L; 2:74556001-74556001 |
liver | carcinoma | Substitution - Missense |
c.562G>T; p.V188L; 2:74556001-74556001 |
liver | carcinoma | Substitution - Missense |
c.851G>A; p.G284D; 2:74556519-74556519 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.239delC; p.P82fs*76; 2:74555332-74555332 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.256G>T; p.A86S; 2:74555349-74555349 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.786C>T; p.H262H; 2:74556454-74556454 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.1031C>T; p.A344V; 2:74556699-74556699 |
oesophagus | carcinoma; adenocarcinoma | Substitution - Missense |
c.1412A>C; p.D471A; 2:74557080-74557080 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.632G>A; p.R211Q; 2:74556071-74556071 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1125C>T; p.G375G; 2:74556793-74556793 |
breast | carcinoma | Substitution - coding silent |
c.172C>T; p.R58C; 2:74555265-74555265 |
upper_aerodigestive_tract; larynx | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.380C>T; p.A127V; 2:74555594-74555594 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.1384G>A; p.D462N; 2:74557052-74557052 |
thyroid | carcinoma | Substitution - Missense |
c.1229C>A; p.A410D; 2:74556897-74556897 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.325G>T; p.A109S; 2:74555418-74555418 |
soft_tissue; striated_muscle | rhabdomyosarcoma; alveolar | Substitution - Missense |
c.78G>T; p.W26C; 2:74555171-74555171 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.526C>G; p.L176V; 2:74555965-74555965 |
oesophagus | carcinoma; adenocarcinoma | Substitution - Missense |
c.1094C>A; p.P365H; 2:74556762-74556762 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.1390G>A; p.G464R; 2:74557058-74557058 |
liver | carcinoma; hepatocellular_carcinoma | Substitution - Missense |
c.1390G>A; p.G464R; 2:74557058-74557058 |
liver | carcinoma; hepatocellular_carcinoma | Substitution - Missense |
c.36G>A; p.L12L; 2:74554790-74554790 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1330C>G; p.H444D; 2:74556998-74556998 |
oesophagus | carcinoma; adenocarcinoma | Substitution - Missense |
c.1118C>T; p.P373L; 2:74556786-74556786 |
skin | malignant_melanoma | Substitution - Missense |
c.896_897CC>TT; p.P299L; 2:74556564-74556565 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.905C>T; p.S302F; 2:74556573-74556573 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.1243C>T; p.R415W; 2:74556911-74556911 |
ovary | other; neoplasm | Substitution - Missense |
c.426G>T; p.E142D; 2:74555640-74555640 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.1177G>T; p.V393L; 2:74556845-74556845 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.620G>A; p.R207H; 2:74556059-74556059 |
prostate | carcinoma | Substitution - Missense |
c.238_239insC; p.E83fs*1; 2:74555331-74555332 |
large_intestine; colon | carcinoma; adenocarcinoma | Insertion - Frameshift |
c.643A>G; p.M215V; 2:74556311-74556311 |
biliary_tract; bile_duct | carcinoma; adenocarcinoma | Substitution - Missense |
c.354C>T; p.A118A; 2:74555447-74555447 |
skin | malignant_melanoma | Substitution - coding silent |
c.678A>G; p.S226S; 2:74556346-74556346 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.1255C>T; p.P419S; 2:74556923-74556923 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.1379G>T; p.S460I; 2:74557047-74557047 |
lung; right_upper_lobe | carcinoma; adenocarcinoma | Substitution - Missense |
c.555C>G; p.L185L; 2:74555994-74555994 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.493G>A; p.A165T; 2:74555932-74555932 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.971C>G; p.A324G; 2:74556639-74556639 |
prostate | carcinoma; adenocarcinoma | Substitution - Missense |
c.906C>T; p.S302S; 2:74556574-74556574 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.1200C>T; p.L400L; 2:74556868-74556868 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.1240C>T; p.P414S; 2:74556908-74556908 |
skin; face | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.776G>A; p.G259E; 2:74556444-74556444 |
skin; neck | malignant_melanoma | Substitution - Missense |
c.1065C>T; p.D355D; 2:74556733-74556733 |
skin | malignant_melanoma | Substitution - coding silent |
c.1000A>C; p.K334Q; 2:74556668-74556668 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1124G>T; p.G375V; 2:74556792-74556792 |
liver | carcinoma | Substitution - Missense |
c.845C>T; p.P282L; 2:74556513-74556513 |
liver | carcinoma; hepatocellular_carcinoma | Substitution - Missense |
c.1104G>T; p.L368L; 2:74556772-74556772 |
lung | carcinoma; adenocarcinoma | Substitution - coding silent |
c.28_29insT; p.L12fs*33; 2:74554782-74554783 |
large_intestine | carcinoma; adenocarcinoma | Insertion - Frameshift |
c.1445G>A; p.*482*; 2:74557113-74557113 |
lung | carcinoma; adenocarcinoma | Substitution - coding silent |
c.947C>G; p.S316*; 2:74556615-74556615 |
oesophagus | carcinoma; adenocarcinoma | Substitution - Nonsense |