Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

1843

Name

DUSP1

Synonymous

dual specificity phosphatase 1;DUSP1;dual specificity phosphatase 1

Definition

MAP kinase phosphatase 1|dual specificity protein phosphatase 1|dual specificity protein phosphatase hVH1|mitogen-activated protein kinase phosphatase 1|protein-tyrosine phosphatase CL100|serine/threonine specific protein phosphatase

Position

5q34

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

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We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.08.

The copy number variations for various cancers

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The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.471G>A; p.A157A; 5:172770203-172770203

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.617T>C; p.V206A; 5:172769691-172769691

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.617T>C; p.V206A; 5:172769691-172769691

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.617T>C; p.V206A; 5:172769691-172769691

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.617T>C; p.V206A; 5:172769691-172769691

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.617T>C; p.V206A; 5:172769691-172769691

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.977T>C; p.M326T; 5:172768889-172768889

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - Missense

c.584T>C; p.L195P; 5:172769724-172769724

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.497C>A; p.T166N; 5:172770177-172770177

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.55delG; p.E19fs*131; 5:172770898-172770898

 oesophaguscarcinoma; adenocarcinomaDeletion - Frameshift

c.1036C>T; p.P346S; 5:172768830-172768830

 skin; facecarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.971C>T; p.P324L; 5:172768895-172768895

 skinmalignant_melanomaSubstitution - Missense

c.973G>A; p.A325T; 5:172768893-172768893

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1059G>A; p.A353A; 5:172768807-172768807

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.856G>C; p.E286Q; 5:172769010-172769010

 breastcarcinoma; ER-PR-positive_carcinomaSubstitution - Missense

c.595G>A; p.G199S; 5:172769713-172769713

 breastcarcinomaSubstitution - Missense

c.1052A>G; p.N351S; 5:172768814-172768814

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - Missense

c.945G>A; p.P315P; 5:172768921-172768921

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.941C>G; p.A314G; 5:172768925-172768925

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.488C>T; p.S163F; 5:172770186-172770186

 breastcarcinoma; basal_(triple-negative)_carcinomaSubstitution - Missense

c.488C>T; p.S163F; 5:172770186-172770186

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Missense

c.157C>G; p.R53G; 5:172770796-172770796

 pancreascarcinomaSubstitution - Missense

c.513+2T>C; p.?; 5:172770159-172770159

 endometriumcarcinoma; endometrioid_carcinomaUnknown

c.1074G>A; p.Q358Q; 5:172768792-172768792

 skinmalignant_melanomaSubstitution - coding silent

c.616G>A; p.V206I; 5:172769692-172769692

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.1011C>T; p.T337T; 5:172768855-172768855

 breastcarcinomaSubstitution - coding silent

c.1023C>A; p.F341L; 5:172768843-172768843

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.547C>T; p.L183L; 5:172769761-172769761

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.1065C>A; p.S355R; 5:172768801-172768801

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; follicular_lymphomaSubstitution - Missense

c.419C>T; p.S140L; 5:172770255-172770255

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.1056T>A; p.S352R; 5:172768810-172768810

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.904A>G; p.M302V; 5:172768962-172768962

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.166G>A; p.A56T; 5:172770787-172770787

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.116A>T; p.H39L; 5:172770837-172770837

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1027G>A; p.V343I; 5:172768839-172768839

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.984G>T; p.V328V; 5:172768882-172768882

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.494G>T; p.S165I; 5:172770180-172770180

 pancreascarcinomaSubstitution - Missense

c.854T>A; p.F285Y; 5:172769012-172769012

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.426C>T; p.P142P; 5:172770248-172770248

 skinmalignant_melanomaSubstitution - coding silent

c.991C>T; p.R331*; 5:172768875-172768875

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Nonsense

c.1061T>C; p.L354P; 5:172768805-172768805

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1050G>A; p.T350T; 5:172768816-172768816

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.979G>A; p.A327T; 5:172768887-172768887

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

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