Entrez Gene

Basic Information
Gene ID	1843
Name	DUSP1
Synonymous	CL100\|HVH1\|MKP-1\|MKP1\|PTPN10;dual specificity phosphatase 1;DUSP1;dual specificity phosphatase 1
Definition	MAP kinase phosphatase 1\|dual specificity protein phosphatase 1\|dual specificity protein phosphatase hVH1\|mitogen-activated protein kinase phosphatase 1\|protein-tyrosine phosphatase CL100\|serine/threonine specific protein phosphatase
Position	5q34
Gene Type	protein-coding
Gene Regulation:	Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase [Top]

Regulation From TransFac database
Transcription Factors [Top]
ERK1(ha) + MKP-1(h) <==> ERK1(ha):MKP-1(h) (binding)
ERK2(m) + MKP-1(h) <==> ERK2(m):MKP-1(h) (binding)
JNK1(h) + MKP-1(h) <==> JNK1(h):MKP-1(h) (binding)
p38alpha(m) + MKP-1(h) <==> p38alpha(m):MKP-1(h) (binding)
MKP-1(h) + SPI1(m.s.) <==> MKP-1(h):SPI1(m.s.) (binding)
MKP-1(h) + p38alpha(m.s.) <==> MKP-1(h):p38alpha(m.s.) (binding)
ERK2(h) + MKP-1(h) <==> ERK2(h):MKP-1(h) (binding)
MKP-1(h) --> ERK(h){p} (decrease of phosphorylation)
MKP-1(h) + 2 ATP --> MKP-1(h){pS359}{pS364} + 2 ADP (phosphorylation)
DUSP1(h) --> MKP-1(h) (expression).
angiotensin II(m.s.) --> MKP-1(h) (increase of abundance)
Jak2(m) --> MKP-1(h) (increase of abundance)
BTEB2(h) --> MKP-1(h) (increase of abundance)
FGF-BP(h) --> MKP-1(h) (increase of abundance)
ERK2(v.s.){p} --MKP-1(h)--> ERK2(v.s.) + p (dephosphorylation)
ERK1(h){p} --MKP-1(h)--> ERK1(h) + p (dephosphorylation)
p38alpha(m) + ATP --MKK4(m){p}--> p38alpha(m){p} + ADP (phosphorylation)
p38alpha(m) + ATP --MKK3(h){p}--> p38alpha(m){p} + ADP (phosphorylation)
p38alpha(m) + ATP --MKK6(h){p}--> p38alpha(m){p} + ADP (phosphorylation)
p53(m) + ATP --JNK1(h){p}--> p53(m){pS34} + ADP (phosphorylation)
MBP(v.s.) + ATP --ERK2(m){p}--> MBP(v.s.){p} + ADP (phosphorylation)
ATF-2(v.s.) + ATP --JNK1(h){p}--> ATF-2(v.s.){p} + ADP (phosphorylation)
DUSP1(h) --> MKP-1(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
359	Phosphoserine (MAP2K2)	10617468	Phospho.ELM 6.0
364	Phosphoserine (MAP2K1)	10617468	Phospho.ELM 6.0
296	Phosphoserine (MAPK1)	16286470	Phospho.ELM 6.0
323	Phosphoserine (MAPK1)	16286470	Phospho.ELM 6.0