Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

1843

Name

DUSP1

Synonymous

CL100|HVH1|MKP-1|MKP1|PTPN10;dual specificity phosphatase 1;DUSP1;dual specificity phosphatase 1

Definition

MAP kinase phosphatase 1|dual specificity protein phosphatase 1|dual specificity protein phosphatase hVH1|mitogen-activated protein kinase phosphatase 1|protein-tyrosine phosphatase CL100|serine/threonine specific protein phosphatase

Position

5q34

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

ERK1(ha) + MKP-1(h) <==> ERK1(ha):MKP-1(h) (binding)
ERK2(m) + MKP-1(h) <==> ERK2(m):MKP-1(h) (binding)
JNK1(h) + MKP-1(h) <==> JNK1(h):MKP-1(h) (binding)
p38alpha(m) + MKP-1(h) <==> p38alpha(m):MKP-1(h) (binding)
MKP-1(h) + SPI1(m.s.) <==> MKP-1(h):SPI1(m.s.) (binding)
MKP-1(h) + p38alpha(m.s.) <==> MKP-1(h):p38alpha(m.s.) (binding)
ERK2(h) + MKP-1(h) <==> ERK2(h):MKP-1(h) (binding)
MKP-1(h) --> ERK(h){p} (decrease of phosphorylation)
MKP-1(h) + 2 ATP --> MKP-1(h){pS359}{pS364} + 2 ADP (phosphorylation)
DUSP1(h) --> MKP-1(h) (expression).
angiotensin II(m.s.) --> MKP-1(h) (increase of abundance)
Jak2(m) --> MKP-1(h) (increase of abundance)
BTEB2(h) --> MKP-1(h) (increase of abundance)
FGF-BP(h) --> MKP-1(h) (increase of abundance)
ERK2(v.s.){p} --MKP-1(h)--> ERK2(v.s.) + p (dephosphorylation)
ERK1(h){p} --MKP-1(h)--> ERK1(h) + p (dephosphorylation)
p38alpha(m) + ATP --MKK4(m){p}--> p38alpha(m){p} + ADP (phosphorylation)
p38alpha(m) + ATP --MKK3(h){p}--> p38alpha(m){p} + ADP (phosphorylation)
p38alpha(m) + ATP --MKK6(h){p}--> p38alpha(m){p} + ADP (phosphorylation)
p53(m) + ATP --JNK1(h){p}--> p53(m){pS34} + ADP (phosphorylation)
MBP(v.s.) + ATP --ERK2(m){p}--> MBP(v.s.){p} + ADP (phosphorylation)
ATF-2(v.s.) + ATP --JNK1(h){p}--> ATF-2(v.s.){p} + ADP (phosphorylation)
DUSP1(h) --> MKP-1(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

359Phosphoserine (MAP2K2)10617468Phospho.ELM 6.0
364Phosphoserine (MAP2K1)10617468Phospho.ELM 6.0
296Phosphoserine (MAPK1)16286470Phospho.ELM 6.0
323Phosphoserine (MAPK1)16286470Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr5

Promoter: 172130309 - 172132309Agilent_014791

chr5

Promoter: 172130309 - 172132309GSE27584

chr5

Promoter: 172130309 - 172132309Agilent_014791


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