Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

1847

Name

DUSP5

Synonymous

dual specificity phosphatase 5;DUSP5;dual specificity phosphatase 5

Definition

VH1-like phosphatase 3|dual specificity protein phosphatase 5|dual specificity protein phosphatase hVH3|serine/threonine specific protein phosphatase

Position

10q25

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

Top

Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.00.

The copy number variations for various cancers

Top

The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.585C>G; p.S195S; 10:110506991-110506991

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.50A>G; p.K17R; 10:110498171-110498171

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1009T>G; p.S337A; 10:110510280-110510280

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.853C>T; p.R285C; 10:110510124-110510124

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.383G>A; p.G128E; 10:110502724-110502724

 central_nervous_system; braingliomaSubstitution - Missense

c.460G>A; p.E154K; 10:110502801-110502801

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.163G>T; p.A55S; 10:110498284-110498284

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.677A>C; p.K226T; 10:110507083-110507083

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.951C>A; p.I317I; 10:110510222-110510222

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.937T>C; p.Y313H; 10:110510208-110510208

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.705G>A; p.T235T; 10:110507111-110507111

 upper_aerodigestive_tract; pharynxcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.102C>A; p.F34L; 10:110498223-110498223

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.390G>T; p.E130D; 10:110502731-110502731

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.137A>T; p.N46I; 10:110498258-110498258

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.427G>T; p.V143L; 10:110502768-110502768

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.392C>T; p.T131I; 10:110502733-110502733

 pancreascarcinomaSubstitution - Missense

c.994G>A; p.E332K; 10:110510265-110510265

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1007C>G; p.S336C; 10:110510278-110510278

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.759G>C; p.R253S; 10:110510030-110510030

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.601G>A; p.A201T; 10:110507007-110507007

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.906C>A; p.P302P; 10:110510177-110510177

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.769G>A; p.G257S; 10:110510040-110510040

 central_nervous_system; brainglioma; astrocytoma_Grade_IVSubstitution - Missense

c.898G>C; p.V300L; 10:110510169-110510169

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.15G>A; p.S5S; 10:110498136-110498136

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.160C>A; p.R54R; 10:110498281-110498281

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.835A>G; p.M279V; 10:110510106-110510106

 central_nervous_system; braingliomaSubstitution - Missense

c.1039C>T; p.P347S; 10:110510310-110510310

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.38A>G; p.K13R; 10:110498159-110498159

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.185C>T; p.A62V; 10:110498306-110498306

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.871G>A; p.D291N; 10:110510142-110510142

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.850T>G; p.F284V; 10:110510121-110510121

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.56C>A; p.A19E; 10:110498177-110498177

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.775G>A; p.V259I; 10:110510046-110510046

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.607C>T; p.L203L; 10:110507013-110507013

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.607C>T; p.L203L; 10:110507013-110507013

 thyroidother; neoplasmSubstitution - coding silent

c.607C>T; p.L203L; 10:110507013-110507013

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - coding silent

c.902C>T; p.S301L; 10:110510173-110510173

 stomachcarcinoma; diffuse_adenocarcinomaSubstitution - Missense

c.468C>T; p.A156A; 10:110502809-110502809

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.172G>A; p.G58S; 10:110498293-110498293

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.706G>A; p.A236T; 10:110507112-110507112

 upper_aerodigestive_tract; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.805C>T; p.R269C; 10:110510076-110510076

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.880A>C; p.K294Q; 10:110510151-110510151

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.936G>T; p.Q312H; 10:110510207-110510207

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.356G>T; p.G119V; 10:110498477-110498477

 livercarcinomaSubstitution - Missense

c.356G>T; p.G119V; 10:110498477-110498477

 livercarcinomaSubstitution - Missense

c.744C>T; p.F248F; 10:110507150-110507150

 skinmalignant_melanomaSubstitution - coding silent

c.59C>T; p.A20V; 10:110498180-110498180

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1018G>T; p.G340C; 10:110510289-110510289

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.589T>G; p.C197G; 10:110506995-110506995

 skinmalignant_melanomaSubstitution - Missense

c.830A>G; p.Y277C; 10:110510101-110510101

 livercarcinomaSubstitution - Missense

c.801C>A; p.I267I; 10:110510072-110510072

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.209C>T; p.A70V; 10:110498330-110498330

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.373C>A; p.L125I; 10:110498494-110498494

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.288G>A; p.W96*; 10:110498409-110498409

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.183G>T; p.S61S; 10:110498304-110498304

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - coding silent

c.597C>T; p.F199F; 10:110507003-110507003

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.378A>T; p.K126N; 10:110498499-110498499

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.948G>T; p.E316D; 10:110510219-110510219

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.673T>C; p.Y225H; 10:110507079-110507079

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.673T>C; p.Y225H; 10:110507079-110507079

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.132C>G; p.N44K; 10:110498253-110498253

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.226C>A; p.L76M; 10:110498347-110498347

 upper_aerodigestive_tract; pharynxcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.30G>A; p.Q10Q; 10:110498151-110498151

 stomachadenocarcinomaSubstitution - coding silent

c.641G>A; p.R214Q; 10:110507047-110507047

 skinmalignant_melanomaSubstitution - Missense

c.581C>T; p.A194V; 10:110506987-110506987

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.963G>C; p.T321T; 10:110510234-110510234

 breastcarcinomaSubstitution - coding silent

c.780G>C; p.L260L; 10:110510051-110510051

 ovaryother; neoplasmSubstitution - coding silent

c.780G>C; p.L260L; 10:110510051-110510051

 ovaryother; neoplasmSubstitution - coding silent

')