| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 2114 |
Name | ETS2 |
Synonymous | v-ets avian erythroblastosis virus E26 oncogene homolog 2;ETS2;v-ets avian erythroblastosis virus E26 oncogene homolog 2 |
Definition | oncogene ETS-2|protein C-ets-2|v-ets avian erythroblastosis virus E2 oncogene homolog 2|v-ets erythroblastosis virus E26 oncogene homolog 2 |
Position | 21q22.2 |
Gene Type | protein-coding |
Mutation summary: | Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72 |
Mutation summary in protein domains | Top |
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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers | Top |
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Loss of Function mutations compare to missense mutations | Top |
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| The ratio of the loss-of-function mutations over missense mutations is 0.10. |
The copy number variations for various cancers | Top |
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The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract |
COSMIC somatic mutation [Top] | |||
|
Mutation (CDS; AA; Chr) |
Site |
Histology |
Mutation Type |
|---|---|---|---|
c.643G>A; p.G215S; 21:38818478-38818478 |
skin | malignant_melanoma | Substitution - Missense |
c.1374C>T; p.H458H; 21:38822853-38822853 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1356C>T; p.F452F; 21:38822835-38822835 |
lung | carcinoma; adenocarcinoma | Substitution - coding silent |
c.670G>T; p.A224S; 21:38818505-38818505 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.816T>G; p.T272T; 21:38819507-38819507 |
liver | carcinoma; hepatocellular_carcinoma | Substitution - coding silent |
c.431A>C; p.K144T; 21:38814907-38814907 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.816T>G; p.T272T; 21:38819507-38819507 |
thyroid | other; neoplasm | Substitution - coding silent |
c.816T>G; p.T272T; 21:38819507-38819507 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Substitution - coding silent |
c.816T>G; p.T272T; 21:38819507-38819507 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Substitution - coding silent |
c.816T>G; p.T272T; 21:38819507-38819507 |
breast | carcinoma | Substitution - coding silent |
c.409C>G; p.Q137E; 21:38814885-38814885 |
liver | carcinoma | Substitution - Missense |
c.1298C>G; p.T433R; 21:38822777-38822777 |
ovary | other; neoplasm | Substitution - Missense |
c.1298C>G; p.T433R; 21:38822777-38822777 |
ovary | other; neoplasm | Substitution - Missense |
c.563C>A; p.P188H; 21:38817065-38817065 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.933C>T; p.F311F; 21:38819624-38819624 |
skin | malignant_melanoma | Substitution - coding silent |
c.1326C>T; p.F442F; 21:38822805-38822805 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.1326C>T; p.F442F; 21:38822805-38822805 |
breast | carcinoma | Substitution - coding silent |
c.962C>T; p.S321F; 21:38819653-38819653 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.1130C>T; p.S377F; 21:38821640-38821640 |
skin | malignant_melanoma | Substitution - Missense |
c.1259G>A; p.G420D; 21:38822738-38822738 |
skin | malignant_melanoma | Substitution - Missense |
c.455C>A; p.P152H; 21:38814931-38814931 |
adrenal_gland; adrenal_gland | adrenal_cortical_carcinoma; functioning | Substitution - Missense |
c.936G>A; p.E312E; 21:38819627-38819627 |
urinary_tract; bladder | carcinoma | Substitution - coding silent |
c.498G>A; p.M166I; 21:38814974-38814974 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.1202G>A; p.R401H; 21:38822681-38822681 |
oesophagus; lower_third | carcinoma; adenocarcinoma | Substitution - Missense |
c.1066G>T; p.G356C; 21:38819757-38819757 |
ovary | carcinoma; serous_carcinoma | Substitution - Missense |
c.1236G>C; p.M412I; 21:38822715-38822715 |
breast | carcinoma | Substitution - Missense |
c.447G>C; p.E149D; 21:38814923-38814923 |
pancreas | carcinoma | Substitution - Missense |
c.447G>C; p.E149D; 21:38814923-38814923 |
pancreas | carcinoma | Substitution - Missense |
c.885C>T; p.S295S; 21:38819576-38819576 |
skin | malignant_melanoma | Substitution - coding silent |
c.1179C>T; p.L393L; 21:38821689-38821689 |
pancreas | carcinoma | Substitution - coding silent |
c.748A>C; p.T250P; 21:38818583-38818583 |
breast | carcinoma | Substitution - Missense |
c.888G>A; p.W296*; 21:38819579-38819579 |
skin | malignant_melanoma | Substitution - Nonsense |
c.803A>G; p.N268S; 21:38818638-38818638 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.520A>T; p.T174S; 21:38817022-38817022 |
oesophagus | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.981A>G; p.P327P; 21:38819672-38819672 |
skin | malignant_melanoma | Substitution - coding silent |
c.610C>G; p.P204A; 21:38818445-38818445 |
skin | malignant_melanoma | Substitution - Missense |
c.1152_1158delGACTGGA; p.G386fs*25; 21:38821662-38821668 |
endometrium | carcinoma; endometrioid_carcinoma | Deletion - Frameshift |
c.961_962delTC; p.C323fs*3; 21:38819652-38819653 |
stomach | carcinoma; intestinal_adenocarcinoma | Deletion - Frameshift |
c.646G>A; p.G216S; 21:38818481-38818481 |
breast | carcinoma; HER-positive_carcinoma | Substitution - Missense |
c.1301C>T; p.S434L; 21:38822780-38822780 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.653T>G; p.L218R; 21:38818488-38818488 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.718C>A; p.P240T; 21:38818553-38818553 |
kidney | other; neoplasm | Substitution - Missense |
c.852C>G; p.D284E; 21:38819543-38819543 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.817C>T; p.P273S; 21:38819508-38819508 |
skin | malignant_melanoma | Substitution - Missense |
c.1336C>A; p.L446I; 21:38822815-38822815 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.725C>T; p.S242F; 21:38818560-38818560 |
skin | malignant_melanoma | Substitution - Missense |
c.1232A>C; p.K411T; 21:38822711-38822711 |
lung; right_upper_lobe | carcinoma; adenocarcinoma | Substitution - Missense |
c.436C>T; p.R146C; 21:38814912-38814912 |
upper_aerodigestive_tract; mouth | carcinoma | Substitution - Missense |
c.436C>T; p.R146C; 21:38814912-38814912 |
upper_aerodigestive_tract; mouth | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.575A>G; p.N192S; 21:38817077-38817077 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.843C>T; p.N281N; 21:38819534-38819534 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.385C>T; p.L129L; 21:38814861-38814861 |
pancreas | NS | Substitution - coding silent |
c.1201C>T; p.R401C; 21:38822680-38822680 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.125C>T; p.S42F; 21:38813055-38813055 |
skin | malignant_melanoma | Substitution - Missense |
c.859G>A; p.E287K; 21:38819550-38819550 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.2T>C; p.M1T; 21:38810036-38810036 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.684C>T; p.S228S; 21:38818519-38818519 |
pancreas | carcinoma; adenocarcinoma | Substitution - coding silent |
c.905T>A; p.L302*; 21:38819596-38819596 |
breast | carcinoma | Substitution - Nonsense |
c.443T>C; p.L148P; 21:38814919-38814919 |
breast | carcinoma | Substitution - Missense |
c.343C>T; p.L115F; 21:38814819-38814819 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.963T>C; p.S321S; 21:38819654-38819654 |
large_intestine | carcinoma; adenocarcinoma | Substitution - coding silent |
c.825C>A; p.D275E; 21:38819516-38819516 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1189G>A; p.D397N; 21:38821699-38821699 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.348C>T; p.L116L; 21:38814824-38814824 |
oesophagus | carcinoma; adenocarcinoma | Substitution - coding silent |
c.51C>T; p.N17N; 21:38810085-38810085 |
cervix | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.554C>T; p.T185I; 21:38817056-38817056 |
breast | carcinoma | Substitution - Missense |
c.189C>T; p.S63S; 21:38814277-38814277 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1254C>A; p.S418R; 21:38822733-38822733 |
liver | carcinoma | Substitution - Missense |
c.1254C>A; p.S418R; 21:38822733-38822733 |
liver | carcinoma | Substitution - Missense |
c.829G>A; p.D277N; 21:38819520-38819520 |
breast | carcinoma | Substitution - Missense |
c.1084C>T; p.P362S; 21:38821594-38821594 |
skin; face | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.151G>T; p.E51*; 21:38813081-38813081 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Nonsense |
c.350G>T; p.W117L; 21:38814826-38814826 |
upper_aerodigestive_tract; mouth | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.709C>A; p.Q237K; 21:38818544-38818544 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.993C>T; p.F331F; 21:38819684-38819684 |
skin | malignant_melanoma | Substitution - coding silent |
c.562C>T; p.P188S; 21:38817064-38817064 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.148C>T; p.Q50*; 21:38813078-38813078 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Nonsense |
c.157C>T; p.P53S; 21:38813087-38813087 |
NS | malignant_melanoma | Substitution - Missense |
c.837T>C; p.P279P; 21:38819528-38819528 |
thyroid | carcinoma; anaplastic_carcinoma | Substitution - coding silent |
c.1359G>A; p.T453T; 21:38822838-38822838 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1359G>A; p.T453T; 21:38822838-38822838 |
urinary_tract; bladder | carcinoma | Substitution - coding silent |
c.121C>T; p.P41S; 21:38813051-38813051 |
skin | malignant_melanoma | Substitution - Missense |
c.214A>G; p.T72A; 21:38814302-38814302 |
lung | carcinoma; small_cell_carcinoma | Substitution - Missense |
c.1234_1248del15; p.M412_K416delMNYEK; 21:38822713-38822727 |
soft_tissue; striated_muscle | rhabdomyosarcoma | Deletion - In frame |
c.907C>T; p.L303L; 21:38819598-38819598 |
lung; right_upper_lobe | carcinoma; adenocarcinoma | Substitution - coding silent |
c.747C>T; p.V249V; 21:38818582-38818582 |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm | Substitution - coding silent |
c.1310G>A; p.R437H; 21:38822789-38822789 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.122C>T; p.P41L; 21:38813052-38813052 |
NS | malignant_melanoma | Substitution - Missense |
c.1253G>A; p.S418N; 21:38822732-38822732 |
liver | carcinoma | Substitution - Missense |
c.1253G>A; p.S418N; 21:38822732-38822732 |
liver | carcinoma | Substitution - Missense |
c.1040C>T; p.P347L; 21:38819731-38819731 |
skin | malignant_melanoma | Substitution - Missense |
c.942C>T; p.F314F; 21:38819633-38819633 |
skin | malignant_melanoma | Substitution - coding silent |
c.930C>T; p.S310S; 21:38819621-38819621 |
skin | malignant_melanoma | Substitution - coding silent |
c.1309C>T; p.R437C; 21:38822788-38822788 |
prostate | carcinoma | Substitution - Missense |
c.499A>T; p.I167F; 21:38814975-38814975 |
breast | carcinoma | Substitution - Missense |
c.1314C>T; p.Y438Y; 21:38822793-38822793 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.1386C>T; p.G462G; 21:38822865-38822865 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.441T>A; p.F147L; 21:38814917-38814917 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.1296G>T; p.K432N; 21:38822775-38822775 |
lung; right_upper_lobe | carcinoma; adenocarcinoma | Substitution - Missense |
c.608C>G; p.A203G; 21:38818443-38818443 |
skin | malignant_melanoma | Substitution - Missense |