| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 2114 |
Name | ETS2 |
Synonymous | ETS2IT1;v-ets avian erythroblastosis virus E26 oncogene homolog 2;ETS2;v-ets avian erythroblastosis virus E26 oncogene homolog 2 |
Definition | oncogene ETS-2|protein C-ets-2|v-ets avian erythroblastosis virus E2 oncogene homolog 2|v-ets erythroblastosis virus E26 oncogene homolog 2 |
Position | 21q22.2 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
c-Ets-2(h) --> Py(PA) (DNA binding). | c-Ets-2(h) --> mim-1(c) (DNA binding; transregulation). | c-Ets-2(h) --> CDC2(h) (DNA binding). | c-Ets-2(h) --> CCND1(h) (DNA binding). | c-Ets-2(h) --> SURF-1/SURF-2(h) (DNA binding). | c-Ets-2(h) --> uPA(h) (DNA binding). | c-Ets-2(h) + ATP --ERK1(m)--> c-Ets-2(h){pT72} + ADP (phosphorylation) | c-Ets-2(h) + ATP --ERK2(m)--> c-Ets-2(h){pT72} + ADP (phosphorylation) | c-Ets-2(h) + GR(r) <==> GR(r):c-Ets-2(h) (binding; assembly) | c-Ets-2(h) --> IL12B(h) (DNA binding; transactivation). | c-Ets-2(h) --> FOSL1(h) (DNA binding; transactivation). | c-Ets-2(h) --> Cyp27a1(r) (DNA binding; transactivation). | c-Ets-2(h) --> PSEN1(h) (DNA binding; transactivation). | c-Ets-2(h) --> MGAT2(h) (DNA binding; transactivation). | c-Ets-2(h) --> KIT(h) (DNA binding; transactivation). | c-Ets-2(h) + CBP(h) <==> c-Ets-2(h):CBP(h) (binding) | c-Ets-2(h) + CBP(m.s.) <==> c-Ets-2(h):CBP(m.s.) (binding) | c-Ets-2(h) + p300(m.s.) <==> c-Ets-2(h):p300(m.s.) (binding) | c-Ets-2(h) --> TCR-beta(h) (DNA binding). | c-Ets-2(h) --> SPP1(r) (DNA binding; transactivation). | c-Ets-2(h) + ATP --JNK(m):AKT(m)--> c-Ets-2(h){pT72} + ADP (phosphorylation) | c-Ets-2(h) --> CGA(h) (transactivation) | BS69(m) + c-Ets-2(h) <==> BS69(m):c-Ets-2(h) (binding) | c-Ets-2(h) --> uPA(m) (transactivation) | c-Ets-2(h) --> BRCA1(h) (transactivation) | BS69(m) + c-Ets-2(h) <==> BS69(m):c-Ets-2(h) (binding) | c-Ets-2(h) + ATP --> c-Ets-2(h){p} + ADP (phosphorylation) | c-Ets-2(h) + CREB1(m.s.) <==> c-Ets-2(h):CREB1(m.s.) (binding) | c-Ets-2(h) --> Mmp14(m) (transactivation) | c-Ets-2(h) --/ BRCA1(h) (transrepression) | c-Ets-2(h) + ATP --> c-Ets-2(h){pT72} + ADP (phosphorylation) | c-Ets-2(h) --> MMP3(h) (transactivation) | c-Ets-2(h) + BRG1(m) <==> c-Ets-2(h):BRG1(m) (binding) | BRG1(h) + c-Ets-2(h) <==> BRG1(h):c-Ets-2(h) (binding) | BAF47(h) + c-Ets-2(h) <==> BAF47(h):c-Ets-2(h) (binding) | BAF57(m) + c-Ets-2(h) <==> BAF57(m):c-Ets-2(h) (binding) | BAF47(m) + c-Ets-2(h) <==> BAF47(m):c-Ets-2(h) (binding) | BRG1(m.s.) + c-Ets-2(h) <==> BRG1(m.s.):c-Ets-2(h) (binding) | c-Ets-2(h) + ATP --ERK2(m.s.)--> c-Ets-2(h){p} + ADP (phosphorylation) | c-Ets-2(h) --> uPA(h) (transactivation) | c-Ets-2(h) --> Csh2(r) (transactivation) | ETS2(h) --> c-Ets-2(h) (expression). | c-Fos(r) + c-Ets-2(h) <==> c-Fos(r):c-Ets-2(h) (binding) [re. | c-Jun(r) + c-Ets-2(h) <==> c-Jun(r):c-Ets-2(h) (binding) [re. | c-Jun(r):c-Fos(r) + c-Ets-2(h) <==> c-Jun(r):c-Fos(r):c-Ets-2(h) (binding) [re. | c-Jun(m.s.) + c-Ets-2(h) <==> c-Jun(m.s.):c-Ets-2(h) (binding) [re. | Erg(h) + c-Ets-2(h) <==> Erg(h):c-Ets-2(h) (binding) [re. | c-Ets-1(h) + c-Ets-2(h) <==> c-Ets-1(h):c-Ets-2(h) (binding) [re. | c-Ets-2(h) --> TERT(h) (transregulation; DNA binding) | c-Ets-2(h) + SRC-1(h) <==> c-Ets-2(h):SRC-1(h) (binding) | SRC3(h) + c-Ets-2(h) <==> SRC3(h):c-Ets-2(h) (binding) | NCOR(h) + c-Ets-2(h) <==> NCOR(h):c-Ets-2(h) (binding) | EAPII(h) + c-Ets-2(h) <==> EAPII(h):c-Ets-2(h) (binding) | c-Ets-2(h) --> CG-alpha(h) (increase of abundance) | c-Ets-2(h) --> CG-beta3(h) (increase of abundance) | c-Ets-2(h) + CREB1(h) <==> c-Ets-2(h):CREB1(h) (binding) | c-Ets-2(h) + ATP --> c-Ets-2(h){pT72} + ADP (phosphorylation) | c-Ets-2(h) --> TGM3(h) (DNA binding). | c-Ets-2(h) --> PSEN1(h) (DNA binding; transactivation). | c-Ets-2(h) --> ERBB2(h) (DNA binding). | c-Ets-2(h) --> TLR9(h) (DNA binding). | c-Ets-2(h) --> AIRE(h) (DNA binding). | c-Ets-2(h) --> CGA(h) (DNA binding). | c-Ets-2(h) --> prl(h) (DNA binding). | c-Ets-2(h) --> SOCS1(h) (DNA binding). | c-Ets-2(h) --> NOS2A(c) (DNA binding). | c-Ets-2(h) --> SERPINE1(h) (DNA binding). | c-Ets-2(h) --> MMP2(h) (DNA binding). | c-Ets-2(h) --> TNFSF14(h) (DNA binding). | ETS2(h) --> c-Ets-2(h) (expression). | EGF(m.s.) --> c-Ets-2(h) (increase of abundance) |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
72 | Phosphothreonine (MAP3K1) | 12511603;12095911;11027273 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr21 |
Promoter: 39098219 - 39100219 | Agilent_014791 |
chr21 |
Promoter: 39098219 - 39100219 | GoldenGate_Methylation_Cancer_Panel_I |
chr21 |
Promoter: 39098219 - 39100219 | GSE27584 |
chr21 |
Promoter: 39098219 - 39100219 | Agilent_014791_44K |