Entrez Gene

Basic Information
Gene ID	22806
Name	IKZF3
Synonymous	IKAROS family zinc finger 3 (Aiolos);IKZF3;IKAROS family zinc finger 3 (Aiolos)
Definition	zinc finger DNA binding protein Aiolos\|zinc finger protein Aiolos\|zinc finger protein, subfamily 1A, 3 (Aiolos)
Position	17q21
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Loss of Function mutations compare to missense mutations

Top

The ratio of the loss-of-function mutations over missense mutations is 0.12.

The copy number variations for various cancers

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.406C>T; p.H136Y; 17:39792691-39792691	skin	malignant_melanoma	Substitution - Missense
c.82G>A; p.D28N; 17:39829468-39829468	skin	malignant_melanoma	Substitution - Missense
c.855C>A; p.N285K; 17:39766465-39766465	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1260G>T; p.E420D; 17:39766060-39766060	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1050G>C; p.E350D; 17:39766270-39766270	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.23C>T; p.A8V; 17:39832136-39832136	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1378C>T; p.L460F; 17:39765942-39765942	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.23C>T; p.A8V; 17:39832136-39832136	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1378C>T; p.L460F; 17:39765942-39765942	skin	malignant_melanoma	Substitution - Missense
c.483C>T; p.L161L; 17:39791525-39791525	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.512A>G; p.E171G; 17:39791496-39791496	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1330A>G; p.K444E; 17:39765990-39765990	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1010T>G; p.V337G; 17:39766310-39766310	biliary_tract; gallbladder	carcinoma; adenocarcinoma	Substitution - Missense
c.1010T>G; p.V337G; 17:39766310-39766310	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1153G>C; p.D385H; 17:39766167-39766167	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1440C>T; p.F480F; 17:39765880-39765880	skin	malignant_melanoma	Substitution - coding silent
c.1281C>T; p.L427L; 17:39766039-39766039	skin	malignant_melanoma	Substitution - coding silent
c.829G>C; p.E277Q; 17:39766491-39766491	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1357C>T; p.R453W; 17:39765963-39765963	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.468T>G; p.T156T; 17:39791540-39791540	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.269C>T; p.S90L; 17:39792828-39792828	skin	malignant_melanoma	Substitution - Missense
c.274G>T; p.E92*; 17:39792823-39792823	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.274G>T; p.E92*; 17:39792823-39792823	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1230G>C; p.R410R; 17:39766090-39766090	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.837C>A; p.R279R; 17:39766483-39766483	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.522delT; p.F174fs*86; 17:39791486-39791486	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.469C>T; p.Q157*; 17:39791539-39791539	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.965C>T; p.P322L; 17:39766355-39766355	skin	malignant_melanoma	Substitution - Missense
c.965C>T; p.P322L; 17:39766355-39766355	skin	malignant_melanoma	Substitution - Missense
c.1276G>A; p.E426K; 17:39766044-39766044	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.965C>T; p.P322L; 17:39766355-39766355	skin	malignant_melanoma	Substitution - Missense
c.1462C>T; p.R488*; 17:39765858-39765858	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Nonsense
c.1384C>T; p.L462L; 17:39765936-39765936	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.962G>A; p.R321H; 17:39766358-39766358	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.406C>A; p.H136N; 17:39792691-39792691	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - Missense
c.952G>A; p.E318K; 17:39766368-39766368	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; blast_phase_chronic_myeloid_leukaemia	Substitution - Missense
c.952G>A; p.E318K; 17:39766368-39766368	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; blastic_plasmacytoid_dendritic_cell_neoplasm	Substitution - Missense
c.952G>A; p.E318K; 17:39766368-39766368	skin	malignant_melanoma	Substitution - Missense
c.952G>A; p.E318K; 17:39766368-39766368	skin	malignant_melanoma	Substitution - Missense
c.952G>A; p.E318K; 17:39766368-39766368	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.952G>A; p.E318K; 17:39766368-39766368	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; chronic_myeloid_leukaemia	Substitution - Missense
c.293A>G; p.N98S; 17:39792804-39792804	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1124G>A; p.R375K; 17:39766196-39766196	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.234A>T; p.G78G; 17:39792863-39792863	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1039A>G; p.T347A; 17:39766281-39766281	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.314T>G; p.V105G; 17:39792783-39792783	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1463G>A; p.R488Q; 17:39765857-39765857	skin	malignant_melanoma	Substitution - Missense
c.509G>A; p.G170E; 17:39791499-39791499	skin	malignant_melanoma	Substitution - Missense
c.1187G>A; p.R396H; 17:39766133-39766133	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1046C>T; p.A349V; 17:39766274-39766274	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.818A>G; p.K273R; 17:39777659-39777659	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - Missense
c.1275C>T; p.Y425Y; 17:39766045-39766045	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1347G>A; p.M449I; 17:39765973-39765973	skin	malignant_melanoma	Substitution - Missense
c.1012A>G; p.I338V; 17:39766308-39766308	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.996G>A; p.S332S; 17:39766324-39766324	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.996G>A; p.S332S; 17:39766324-39766324	breast	carcinoma	Substitution - coding silent
c.557G>A; p.R186K; 17:39791451-39791451	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.135C>T; p.G45G; 17:39829415-39829415	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.664G>A; p.E222K; 17:39788303-39788303	skin	malignant_melanoma	Substitution - Missense
c.673C>T; p.R225C; 17:39788294-39788294	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1296C>G; p.P432P; 17:39766024-39766024	autonomic_ganglia	neuroblastoma	Substitution - coding silent
c.997G>A; p.E333K; 17:39766323-39766323	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.207G>A; p.E69E; 17:39792890-39792890	skin	malignant_melanoma	Substitution - coding silent
c.1487C>T; p.S496L; 17:39765833-39765833	skin	malignant_melanoma	Substitution - Missense
c.1380C>G; p.L460L; 17:39765940-39765940	breast	carcinoma	Substitution - coding silent
c.14A>G; p.Q5R; 17:39832145-39832145	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.689G>T; p.S230I; 17:39788278-39788278	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.689G>T; p.S230I; 17:39788278-39788278	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1160C>A; p.T387K; 17:39766160-39766160	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - Missense
c.797G>A; p.R266Q; 17:39777680-39777680	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.82G>C; p.D28H; 17:39829468-39829468	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.82G>C; p.D28H; 17:39829468-39829468	upper_aerodigestive_tract; mouth	carcinoma	Substitution - Missense
c.797G>A; p.R266Q; 17:39777680-39777680	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.420T>A; p.H140Q; 17:39792677-39792677	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.444T>C; p.C148C; 17:39791564-39791564	central_nervous_system; brain	glioma	Substitution - coding silent
c.1373G>A; p.R458H; 17:39765947-39765947	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1373G>A; p.R458H; 17:39765947-39765947	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - Missense
c.77T>G; p.L26W; 17:39829473-39829473	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.324C>T; p.F108F; 17:39792773-39792773	skin	malignant_melanoma	Substitution - coding silent
c.1336G>A; p.G446R; 17:39765984-39765984	skin	malignant_melanoma	Substitution - Missense
c.1395G>A; p.V465V; 17:39765925-39765925	skin	malignant_melanoma	Substitution - coding silent
c.480C>T; p.N160N; 17:39791528-39791528	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.567C>T; p.L189L; 17:39791441-39791441	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1013T>C; p.I338T; 17:39766307-39766307	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1128C>T; p.G376G; 17:39766192-39766192	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.94delA; p.T32fs*22; 17:39829456-39829456	skin; lower_leg	malignant_melanoma	Deletion - Frameshift
c.438C>T; p.F146F; 17:39791570-39791570	skin; shoulder	malignant_melanoma	Substitution - coding silent
c.920C>T; p.A307V; 17:39766400-39766400	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.272_273insGGGGG; p.E92fs*29; 17:39792824-39792825	haematopoietic_and_lymphoid_tissue; lymph_node	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Insertion - Frameshift
c.516A>C; p.K172N; 17:39791492-39791492	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1314C>T; p.S438S; 17:39766006-39766006	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1505G>A; p.G502E; 17:39765815-39765815	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.233G>A; p.G78E; 17:39792864-39792864	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1314C>T; p.S438S; 17:39766006-39766006	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.663G>A; p.K221K; 17:39788304-39788304	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1160C>T; p.T387M; 17:39766160-39766160	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.43G>A; p.E15K; 17:39832116-39832116	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.412C>T; p.R138*; 17:39792685-39792685	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.836_837GC>CA; p.R279P; 17:39766483-39766484	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.38C>T; p.T13I; 17:39832121-39832121	breast	carcinoma	Substitution - Missense
c.1176C>T; p.N392N; 17:39766144-39766144	skin	malignant_melanoma	Substitution - coding silent
c.1488G>A; p.S496S; 17:39765832-39765832	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.837C>T; p.R279R; 17:39766483-39766483	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1372C>T; p.R458C; 17:39765948-39765948	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.571G>A; p.G191R; 17:39791437-39791437	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.227C>T; p.P76L; 17:39792870-39792870	urinary_tract; bladder	carcinoma	Substitution - Missense
c.701G>C; p.G234A; 17:39788266-39788266	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1374C>T; p.R458R; 17:39765946-39765946	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.569C>T; p.T190M; 17:39791439-39791439	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1114C>G; p.P372A; 17:39766206-39766206	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.256C>T; p.P86S; 17:39792841-39792841	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.563C>T; p.A188V; 17:39791445-39791445	breast	carcinoma	Substitution - Missense
c.1429C>T; p.R477C; 17:39765891-39765891	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1241G>T; p.G414V; 17:39766079-39766079	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.201A>C; p.R67S; 17:39792896-39792896	skin	malignant_melanoma	Substitution - Missense
c.582G>C; p.R194S; 17:39791426-39791426	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.582G>C; p.R194S; 17:39791426-39791426	large_intestine; colon	carcinoma	Substitution - Missense
c.1169A>G; p.D390G; 17:39766151-39766151	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1014C>G; p.I338M; 17:39766306-39766306	lung	carcinoma; non_small_cell_carcinoma	Substitution - Missense
c.375A>G; p.L125L; 17:39792722-39792722	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.58G>T; p.A20S; 17:39832101-39832101	breast	carcinoma	Substitution - Missense
c.1419C>T; p.C473C; 17:39765901-39765901	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.815_816delAG; p.K273fs*4; 17:39777661-39777662	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Deletion - Frameshift
c.8-1G>A; p.?; 17:39832152-39832152	skin	malignant_melanoma	Unknown
c.485T>G; p.L162R; 17:39791523-39791523	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.485T>G; p.L162R; 17:39791523-39791523	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - Missense
c.485T>G; p.L162R; 17:39791523-39791523	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; mantle_cell_lymphoma	Substitution - Missense
c.485T>G; p.L162R; 17:39791523-39791523	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.485T>G; p.L162R; 17:39791523-39791523	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.485T>G; p.L162R; 17:39791523-39791523	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.485T>G; p.L162R; 17:39791523-39791523	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.485T>G; p.L162R; 17:39791523-39791523	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.517C>T; p.P173S; 17:39791491-39791491	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.974_975insC; p.Q325fs*26; 17:39766345-39766346	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; blastic_plasmacytoid_dendritic_cell_neoplasm	Insertion - Frameshift
c.974_975insC; p.Q325fs*26; 17:39766345-39766346	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; blastic_plasmacytoid_dendritic_cell_neoplasm	Insertion - Frameshift
c.140C>T; p.A47V; 17:39829410-39829410	central_nervous_system; brain	glioma	Substitution - Missense
c.257C>A; p.P86H; 17:39792840-39792840	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1491T>C; p.S497S; 17:39765829-39765829	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.479A>C; p.N160T; 17:39791529-39791529	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - Missense
c.639G>A; p.Q213Q; 17:39788328-39788328	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.272G>A; p.R91K; 17:39792825-39792825	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1202A>C; p.Y401S; 17:39766118-39766118	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.360C>T; p.C120C; 17:39792737-39792737	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1017C>A; p.S339R; 17:39766303-39766303	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.863C>G; p.S288*; 17:39766457-39766457	NS	NS	Substitution - Nonsense
c.904C>T; p.R302C; 17:39766416-39766416	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.530A>G; p.H177R; 17:39791478-39791478	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.479A>G; p.N160S; 17:39791529-39791529	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; diffuse_large_B_cell_lymphoma	Substitution - Missense
c.718G>A; p.E240K; 17:39777759-39777759	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.1333G>A; p.E445K; 17:39765987-39765987	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1333G>A; p.E445K; 17:39765987-39765987	skin	malignant_melanoma	Substitution - Missense
c.1430G>A; p.R477H; 17:39765890-39765890	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.71C>T; p.A24V; 17:39829479-39829479	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.161G>C; p.G54A; 17:39829389-39829389	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.161G>C; p.G54A; 17:39829389-39829389	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.334A>C; p.R112R; 17:39792763-39792763	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1186C>T; p.R396C; 17:39766134-39766134	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.82G>T; p.D28Y; 17:39829468-39829468	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.951C>T; p.A317A; 17:39766369-39766369	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1264C>T; p.P422S; 17:39766056-39766056	skin	malignant_melanoma	Substitution - Missense
c.836G>C; p.R279P; 17:39766484-39766484	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1485C>A; p.F495L; 17:39765835-39765835	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1485C>A; p.F495L; 17:39765835-39765835	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1275C>A; p.Y425*; 17:39766045-39766045	lung	carcinoma; adenocarcinoma	Substitution - Nonsense

Mutation summary in protein domains

Top

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Top

Loss of Function mutations compare to missense mutations

Top

The copy number variations for various cancers

Top

COSMIC somatic mutation [Top]