Entrez Gene

Basic Information
Gene ID	23035
Name	PHLPP2
Synonymous	PH domain and leucine rich repeat protein phosphatase 2;PHLPP2;PH domain and leucine rich repeat protein phosphatase 2
Definition	PH domain leucine-rich repeat-containing protein phosphatase 2
Position	16q22.2
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Loss of Function mutations compare to missense mutations

Top

The ratio of the loss-of-function mutations over missense mutations is 0.13.

The copy number variations for various cancers

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1112C>T; p.S371F; 16:71678911-71678911	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1028A>C; p.N343T; 16:71679398-71679398	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1180G>A; p.D394N; 16:71678843-71678843	skin	malignant_melanoma	Substitution - Missense
c.2744C>T; p.S915F; 16:71652863-71652863	skin; scalp	malignant_melanoma	Substitution - Missense
c.1833C>T; p.S611S; 16:71664051-71664051	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.736-1G>A; p.?; 16:71681906-71681906	skin	malignant_melanoma	Unknown
c.280G>C; p.V94L; 16:71714516-71714516	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.305G>A; p.R102Q; 16:71702711-71702711	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1200A>G; p.G400G; 16:71678823-71678823	breast	carcinoma	Substitution - coding silent
c.3051G>A; p.A1017A; 16:71649811-71649811	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.3540G>A; p.E1180E; 16:71649322-71649322	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2384G>T; p.R795I; 16:71656577-71656577	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.3056G>A; p.S1019N; 16:71649806-71649806	breast	carcinoma	Substitution - Missense
c.192C>T; p.L64L; 16:71714604-71714604	skin	malignant_melanoma	Substitution - coding silent
c.3143C>T; p.T1048I; 16:71649719-71649719	skin	malignant_melanoma	Substitution - Missense
c.192C>T; p.L64L; 16:71714604-71714604	skin	malignant_melanoma	Substitution - coding silent
c.833A>G; p.N278S; 16:71681808-71681808	breast	carcinoma	Substitution - Missense
c.1925_1926delGG; p.G642fs*24; 16:71663958-71663959	breast	carcinoma	Deletion - Frameshift
c.3047T>C; p.L1016S; 16:71649815-71649815	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3047T>C; p.L1016S; 16:71649815-71649815	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.145A>G; p.T49A; 16:71714651-71714651	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.876C>T; p.L292L; 16:71681765-71681765	skin	malignant_melanoma	Substitution - coding silent
c.2532G>A; p.Q844Q; 16:71655293-71655293	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1225G>A; p.G409R; 16:71678798-71678798	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2844C>T; p.C948C; 16:71650018-71650018	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1014A>C; p.P338P; 16:71679412-71679412	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.3777A>C; p.T1259T; 16:71649085-71649085	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.318C>T; p.I106I; 16:71702698-71702698	skin	malignant_melanoma	Substitution - coding silent
c.96T>G; p.C32W; 16:71714700-71714700	breast	carcinoma	Substitution - Missense
c.3002G>A; p.R1001H; 16:71649860-71649860	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3778G>T; p.E1260*; 16:71649084-71649084	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.3535C>T; p.L1179L; 16:71649327-71649327	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.3778G>T; p.E1260*; 16:71649084-71649084	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.3616C>T; p.R1206*; 16:71649246-71649246	pancreas	carcinoma	Substitution - Nonsense
c.3727G>A; p.G1243S; 16:71649135-71649135	skin	malignant_melanoma	Substitution - Missense
c.2697C>T; p.G899G; 16:71652910-71652910	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 16:71678907-71678907	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.3006C>T; p.H1002H; 16:71649856-71649856	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1116C>T; p.S372S; 16:71678907-71678907	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1442C>T; p.S481F; 16:71676476-71676476	skin	malignant_melanoma	Substitution - Missense
c.1442C>T; p.S481F; 16:71676476-71676476	skin	malignant_melanoma	Substitution - Missense
c.2852G>A; p.R951Q; 16:71650010-71650010	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.31A>C; p.N11H; 16:71714765-71714765	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.624G>C; p.K208N; 16:71684587-71684587	urinary_tract; bladder	carcinoma	Substitution - Missense
c.793C>T; p.P265S; 16:71681848-71681848	skin	malignant_melanoma	Substitution - Missense
c.838C>T; p.R280*; 16:71681803-71681803	skin; trunk	malignant_melanoma	Substitution - Nonsense
c.564T>C; p.D188D; 16:71690564-71690564	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1242G>A; p.M414I; 16:71678781-71678781	ovary	carcinoma; clear_cell_carcinoma	Substitution - Missense
c.2468G>A; p.R823Q; 16:71655357-71655357	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2576T>C; p.V859A; 16:71655249-71655249	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2576T>C; p.V859A; 16:71655249-71655249	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2486G>A; p.R829H; 16:71655339-71655339	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2858T>G; p.L953R; 16:71650004-71650004	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.439C>T; p.R147C; 16:71690689-71690689	skin	malignant_melanoma	Substitution - Missense
c.976G>A; p.E326K; 16:71679450-71679450	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.439C>T; p.R147C; 16:71690689-71690689	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.2964G>T; p.W988C; 16:71649898-71649898	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.3198_3199insC; p.A1068fs*6; 16:71649663-71649664	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Insertion - Frameshift
c.3260C>T; p.S1087L; 16:71649602-71649602	skin	malignant_melanoma	Substitution - Missense
c.1918C>T; p.L640L; 16:71663966-71663966	skin	malignant_melanoma	Substitution - coding silent
c.2881T>G; p.W961G; 16:71649981-71649981	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.3966A>T; p.A1322A; 16:71648896-71648896	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.2555T>G; p.F852C; 16:71655270-71655270	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.315_316GA>TT; p.Q105_I106>HF; 16:71702700-71702701	ovary	carcinoma; serous_carcinoma	Complex - compound substitution
c.1448_1449GG>AA; p.R483Q; 16:71676469-71676470	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3230C>A; p.A1077D; 16:71649632-71649632	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3318G>A; p.L1106L; 16:71649544-71649544	skin	malignant_melanoma	Substitution - coding silent
c.757A>T; p.T253S; 16:71681884-71681884	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1000T>C; p.F334L; 16:71679426-71679426	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2092G>A; p.A698T; 16:71658709-71658709	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1393C>T; p.L465L; 16:71676525-71676525	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1374C>T; p.S458S; 16:71676544-71676544	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1598G>A; p.S533N; 16:71669305-71669305	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3904C>T; p.R1302W; 16:71648958-71648958	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3196A>G; p.K1066E; 16:71649666-71649666	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.958G>A; p.E320K; 16:71679468-71679468	skin	malignant_melanoma	Substitution - Missense
c.919T>A; p.S307T; 16:71679507-71679507	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1330G>A; p.V444M; 16:71676588-71676588	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.648C>T; p.F216F; 16:71684563-71684563	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1392G>T; p.Q464H; 16:71676526-71676526	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1505G>T; p.S502I; 16:71672289-71672289	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1666G>T; p.G556*; 16:71667296-71667296	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2585G>T; p.R862M; 16:71655240-71655240	breast	carcinoma	Substitution - Missense
c.3485G>A; p.G1162D; 16:71649377-71649377	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2170G>T; p.D724Y; 16:71658342-71658342	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.20G>T; p.R7I; 16:71714776-71714776	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1531C>A; p.R511R; 16:71672263-71672263	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - coding silent
c.1260G>T; p.V420V; 16:71678763-71678763	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.798G>A; p.E266E; 16:71681843-71681843	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1471A>T; p.R491W; 16:71676447-71676447	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1770C>G; p.F590L; 16:71667192-71667192	pancreas	carcinoma	Substitution - Missense
c.960G>T; p.E320D; 16:71679466-71679466	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1532G>C; p.R511P; 16:71672262-71672262	skin	malignant_melanoma	Substitution - Missense
c.1433G>T; p.S478I; 16:71676485-71676485	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.479G>A; p.R160H; 16:71690649-71690649	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3447T>C; p.S1149S; 16:71649415-71649415	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1712C>T; p.P571L; 16:71667250-71667250	skin	malignant_melanoma	Substitution - Missense
c.3063C>A; p.G1021G; 16:71649799-71649799	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1509G>T; p.L503L; 16:71672285-71672285	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.3063C>A; p.G1021G; 16:71649799-71649799	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2479C>T; p.L827F; 16:71655346-71655346	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1127C>T; p.S376F; 16:71678896-71678896	breast	carcinoma	Substitution - Missense
c.2928A>C; p.Q976H; 16:71649934-71649934	liver	carcinoma	Substitution - Missense
c.2079G>A; p.L693L; 16:71658722-71658722	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2928A>C; p.Q976H; 16:71649934-71649934	liver	carcinoma	Substitution - Missense
c.3946_3947CC>GT; p.P1316V; 16:71648915-71648916	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2815G>T; p.E939*; 16:71652792-71652792	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.2117T>C; p.F706S; 16:71658684-71658684	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3915T>C; p.P1305P; 16:71648947-71648947	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.2426C>T; p.A809V; 16:71655399-71655399	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2467C>T; p.R823*; 16:71655358-71655358	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.3198G>C; p.K1066N; 16:71649664-71649664	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.2585+1G>T; p.?; 16:71655239-71655239	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.1224A>C; p.L408F; 16:71678799-71678799	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1174A>G; p.M392V; 16:71678849-71678849	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1623C>T; p.P541P; 16:71669280-71669280	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1623C>T; p.P541P; 16:71669280-71669280	pancreas	carcinoma	Substitution - coding silent
c.1648C>T; p.L550F; 16:71667314-71667314	breast	carcinoma	Substitution - Missense
c.2942T>A; p.I981N; 16:71649920-71649920	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.3462C>T; p.P1154P; 16:71649400-71649400	skin	malignant_melanoma	Substitution - coding silent
c.1265T>G; p.L422*; 16:71678758-71678758	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.3964G>T; p.A1322S; 16:71648898-71648898	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3692C>T; p.S1231F; 16:71649170-71649170	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1772C>T; p.S591F; 16:71667190-71667190	skin	malignant_melanoma	Substitution - Missense
c.639C>T; p.S213S; 16:71684572-71684572	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1261G>A; p.D421N; 16:71678762-71678762	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.3156T>C; p.P1052P; 16:71649706-71649706	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1140T>C; p.F380F; 16:71678883-71678883	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.3762C>T; p.L1254L; 16:71649100-71649100	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1140T>C; p.F380F; 16:71678883-71678883	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.2752T>G; p.F918V; 16:71652855-71652855	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2912C>G; p.T971S; 16:71649950-71649950	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2443G>T; p.V815L; 16:71655382-71655382	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.2493G>A; p.L831L; 16:71655332-71655332	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.2751C>A; p.V917V; 16:71652856-71652856	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.64G>A; p.D22N; 16:71714732-71714732	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3378_3399del22; p.G1127fs*26; 16:71649463-71649484	skin; head_neck	carcinoma; squamous_cell_carcinoma	Deletion - Frameshift
c.679C>T; p.H227Y; 16:71684532-71684532	NS	malignant_melanoma	Substitution - Missense
c.679C>T; p.H227Y; 16:71684532-71684532	NS	malignant_melanoma	Substitution - Missense
c.1115C>A; p.S372Y; 16:71678908-71678908	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.547G>A; p.V183I; 16:71690581-71690581	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.514C>T; p.R172C; 16:71690614-71690614	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2914C>T; p.P972S; 16:71649948-71649948	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.629G>T; p.R210L; 16:71684582-71684582	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.3199_3200delCC; p.P1067fs*6; 16:71649662-71649663	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Deletion - Frameshift
c.2501C>T; p.T834M; 16:71655324-71655324	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3868G>C; p.E1290Q; 16:71648994-71648994	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2284A>G; p.I762V; 16:71656677-71656677	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.478C>T; p.R160C; 16:71690650-71690650	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2836G>T; p.V946L; 16:71650026-71650026	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2343A>G; p.S781S; 16:71656618-71656618	skin	malignant_melanoma	Substitution - coding silent
c.3200_3201insC; p.A1068fs*6; 16:71649661-71649662	breast	carcinoma	Insertion - Frameshift
c.223G>T; p.E75*; 16:71714573-71714573	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1448G>A; p.R483Q; 16:71676470-71676470	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3197A>T; p.K1066M; 16:71649665-71649665	oesophagus	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2618C>T; p.S873F; 16:71652989-71652989	skin	malignant_melanoma	Substitution - Missense
c.1010T>C; p.L337P; 16:71679416-71679416	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.158C>T; p.S53F; 16:71714638-71714638	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3339G>A; p.R1113R; 16:71649523-71649523	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.690C>T; p.F230F; 16:71684521-71684521	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2485C>T; p.R829C; 16:71655340-71655340	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.3108T>C; p.G1036G; 16:71649754-71649754	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.3561G>A; p.E1187E; 16:71649301-71649301	skin	malignant_melanoma	Substitution - coding silent
c.3460C>A; p.P1154T; 16:71649402-71649402	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2053A>G; p.T685A; 16:71658748-71658748	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3529A>G; p.R1177G; 16:71649333-71649333	thyroid	carcinoma	Substitution - Missense
c.572C>G; p.T191S; 16:71690556-71690556	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2119C>A; p.P707T; 16:71658682-71658682	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; follicular_lymphoma	Substitution - Missense
c.274G>C; p.D92H; 16:71714522-71714522	breast	carcinoma	Substitution - Missense
c.3335C>T; p.P1112L; 16:71649527-71649527	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.38G>A; p.R13K; 16:71714758-71714758	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3940G>A; p.E1314K; 16:71648922-71648922	breast	carcinoma	Substitution - Missense
c.1532G>T; p.R511L; 16:71672262-71672262	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.3969A>G; p.L1323L; 16:71648893-71648893	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.3969A>G; p.L1323L; 16:71648893-71648893	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.2377G>T; p.G793W; 16:71656584-71656584	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3505G>A; p.V1169I; 16:71649357-71649357	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2660C>A; p.P887Q; 16:71652947-71652947	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.2024T>C; p.L675P; 16:71658777-71658777	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3566C>A; p.S1189Y; 16:71649296-71649296	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3566C>A; p.S1189Y; 16:71649296-71649296	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.193G>A; p.V65I; 16:71714603-71714603	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3217A>G; p.S1073G; 16:71649645-71649645	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2677T>C; p.L893L; 16:71652930-71652930	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.3617G>A; p.R1206Q; 16:71649245-71649245	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2155G>A; p.D719N; 16:71658357-71658357	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1527C>G; p.L509L; 16:71672267-71672267	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.3083C>T; p.A1028V; 16:71649779-71649779	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3083C>T; p.A1028V; 16:71649779-71649779	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1527C>G; p.L509L; 16:71672267-71672267	upper_aerodigestive_tract; mouth	carcinoma	Substitution - coding silent
c.1577A>C; p.K526T; 16:71669326-71669326	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1577A>C; p.K526T; 16:71669326-71669326	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.609G>T; p.K203N; 16:71690519-71690519	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.666_667insA; p.A223fs*44; 16:71684544-71684545	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.3957C>T; p.F1319F; 16:71648905-71648905	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.3223G>A; p.G1075R; 16:71649639-71649639	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1991T>C; p.L664P; 16:71658810-71658810	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1087G>T; p.E363*; 16:71678936-71678936	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.1184G>A; p.R395K; 16:71678839-71678839	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3160G>T; p.G1054*; 16:71649702-71649702	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.304C>T; p.R102*; 16:71702712-71702712	stomach	carcinoma; adenocarcinoma	Substitution - Nonsense
c.3683A>G; p.K1228R; 16:71649179-71649179	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1271T>C; p.M424T; 16:71676647-71676647	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.2434G>A; p.V812M; 16:71655391-71655391	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1028A>G; p.N343S; 16:71679398-71679398	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.558G>T; p.V186V; 16:71690570-71690570	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1461C>T; p.A487A; 16:71676457-71676457	skin	malignant_melanoma	Substitution - coding silent
c.2454G>T; p.M818I; 16:71655371-71655371	liver	carcinoma	Substitution - Missense
c.2606A>G; p.Q869R; 16:71653001-71653001	pancreas	carcinoid-endocrine_tumour	Substitution - Missense
c.789G>C; p.E263D; 16:71681852-71681852	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1734G>T; p.Q578H; 16:71667228-71667228	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1359C>T; p.D453D; 16:71676559-71676559	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1359C>T; p.D453D; 16:71676559-71676559	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1359C>T; p.D453D; 16:71676559-71676559	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.3282_3283insG; p.S1095fs*5; 16:71649579-71649580	large_intestine; caecum	carcinoma; adenocarcinoma	Insertion - Frameshift
c.754A>C; p.S252R; 16:71681887-71681887	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.783C>T; p.L261L; 16:71681858-71681858	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.754A>C; p.S252R; 16:71681887-71681887	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3055A>G; p.S1019G; 16:71649807-71649807	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.3055A>G; p.S1019G; 16:71649807-71649807	pancreas	carcinoma	Substitution - Missense
c.1716C>G; p.L572L; 16:71667246-71667246	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.534T>C; p.G178G; 16:71690594-71690594	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent

Mutation summary in protein domains

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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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Loss of Function mutations compare to missense mutations

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The copy number variations for various cancers

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COSMIC somatic mutation [Top]