General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information |
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---|---|
Gene ID | 25792 |
Name | CIZ1 |
Synonymous | CDKN1A interacting zinc finger protein 1;CIZ1;CDKN1A interacting zinc finger protein 1 |
Definition | cip1-interacting zinc finger protein|nuclear protein NP94|zinc finger protein 356 |
Position | 9q34.1 |
Gene Type | protein-coding |
Mutation summary: | Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72 |
Mutation summary in protein domains | Top |
The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers | Top |
Loss of Function mutations compare to missense mutations | Top |
The ratio of the loss-of-function mutations over missense mutations is 0.22. |
The copy number variations for various cancers | Top |
The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract |
COSMIC somatic mutation [Top] | |||
Mutation (CDS; AA; Chr) |
Site |
Histology |
Mutation Type |
---|---|---|---|
c.2268C>T; p.I756I; 9:128169079-128169079 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.565T>C; p.S189P; 9:128185570-128185570 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.2220C>A; p.F740L; 9:128169127-128169127 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - Missense |
c.2012G>A; p.R671H; 9:128170039-128170039 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.2012G>A; p.R671H; 9:128170039-128170039 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.216G>A; p.Q72Q; 9:128190399-128190399 |
large_intestine | carcinoma; adenocarcinoma | Substitution - coding silent |
c.695C>T; p.P232L; 9:128180511-128180511 |
pancreas | carcinoma | Substitution - Missense |
c.1961G>A; p.R654H; 9:128170090-128170090 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.2131G>A; p.D711N; 9:128169420-128169420 |
skin | malignant_melanoma | Substitution - Missense |
c.2074C>T; p.R692C; 9:128169477-128169477 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.2421C>A; p.F807L; 9:128166825-128166825 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.929G>A; p.R310Q; 9:128179278-128179278 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.2107C>T; p.H703Y; 9:128169444-128169444 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.1407G>T; p.P469P; 9:128178800-128178800 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.1512C>A; p.T504T; 9:128178477-128178477 |
liver | carcinoma | Substitution - coding silent |
c.664C>T; p.R222W; 9:128180739-128180739 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.664C>T; p.R222W; 9:128180739-128180739 |
stomach | carcinoma; intestinal_adenocarcinoma | Substitution - Missense |
c.1912G>A; p.V638M; 9:128176382-128176382 |
liver | carcinoma; hepatocellular_carcinoma | Substitution - Missense |
c.200C>T; p.P67L; 9:128190415-128190415 |
prostate | carcinoma | Substitution - Missense |
c.2218T>C; p.F740L; 9:128169129-128169129 |
upper_aerodigestive_tract; mouth | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.1411G>A; p.V471M; 9:128178796-128178796 |
ovary | carcinoma; serous_carcinoma | Substitution - Missense |
c.1497A>G; p.G499G; 9:128178710-128178710 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.832C>T; p.Q278*; 9:128179375-128179375 |
lung | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.1078C>T; p.Q360*; 9:128179129-128179129 |
stomach | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.1078C>T; p.Q360*; 9:128179129-128179129 |
lung | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.535C>T; p.R179W; 9:128185600-128185600 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.2337G>A; p.S779S; 9:128167123-128167123 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.1412T>C; p.V471A; 9:128178795-128178795 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.1412T>C; p.V471A; 9:128178795-128178795 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1412T>C; p.V471A; 9:128178795-128178795 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1906_1920del15; p.L636_R640delLPVPR; 9:128176374-128176388 |
breast | carcinoma | Deletion - In frame |
c.1910C>T; p.P637L; 9:128176384-128176384 |
stomach | carcinoma; intestinal_adenocarcinoma | Substitution - Missense |
c.1007A>T; p.Q336L; 9:128179200-128179200 |
liver | carcinoma; hepatocellular_carcinoma | Substitution - Missense |
c.2500G>T; p.A834S; 9:128166394-128166394 |
breast | carcinoma | Substitution - Missense |
c.1270C>T; p.Q424*; 9:128178937-128178937 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Nonsense |
c.1516C>T; p.P506S; 9:128178473-128178473 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1924G>A; p.V642I; 9:128176370-128176370 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.715G>A; p.A239T; 9:128180491-128180491 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.497G>T; p.G166V; 9:128185638-128185638 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.2617C>T; p.Q873*; 9:128166277-128166277 |
urinary_tract; bladder | carcinoma | Substitution - Nonsense |
c.1338G>T; p.Q446H; 9:128178869-128178869 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.2219T>G; p.F740C; 9:128169128-128169128 |
liver | carcinoma | Substitution - Missense |
c.1133A>G; p.Q378R; 9:128179074-128179074 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1911_1923del13; p.V638fs*26; 9:128176371-128176383 |
stomach | carcinoma; intestinal_adenocarcinoma | Deletion - Frameshift |
c.589G>A; p.D197N; 9:128180814-128180814 |
oesophagus | carcinoma; adenocarcinoma | Substitution - Missense |
c.557G>A; p.R186Q; 9:128185578-128185578 |
ovary | carcinoma; serous_carcinoma | Substitution - Missense |
c.1586G>C; p.G529A; 9:128178403-128178403 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.1498+3A>T; p.?; 9:128178706-128178706 |
pancreas | carcinoma | Unknown |
c.943G>A; p.V315I; 9:128179264-128179264 |
skin | malignant_melanoma | Substitution - Missense |
c.639G>T; p.E213D; 9:128180764-128180764 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.2275G>A; p.E759K; 9:128169072-128169072 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.2053C>T; p.P685S; 9:128169498-128169498 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - Missense |
c.685C>T; p.Q229*; 9:128180521-128180521 |
lung | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.277C>A; p.Q93K; 9:128190338-128190338 |
oesophagus | carcinoma | Substitution - Missense |
c.235C>T; p.L79F; 9:128190380-128190380 |
stomach | carcinoma; diffuse_adenocarcinoma | Substitution - Missense |
c.1918C>T; p.R640W; 9:128176376-128176376 |
oesophagus | carcinoma; adenocarcinoma | Substitution - Missense |
c.2220C>T; p.F740F; 9:128169127-128169127 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.2220C>T; p.F740F; 9:128169127-128169127 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.233C>T; p.S78F; 9:128190382-128190382 |
skin | malignant_melanoma | Substitution - Missense |
c.635C>T; p.P212L; 9:128180768-128180768 |
skin | malignant_melanoma | Substitution - Missense |
c.1818+2T>G; p.?; 9:128177564-128177564 |
large_intestine; colon | adenoma | Unknown |
c.1916C>T; p.P639L; 9:128176378-128176378 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.740C>G; p.P247R; 9:128180466-128180466 |
ovary | carcinoma; serous_carcinoma | Substitution - Missense |
c.1560T>G; p.N520K; 9:128178429-128178429 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.2513G>T; p.S838I; 9:128166381-128166381 |
thyroid | other; neoplasm | Substitution - Missense |
c.941G>C; p.R314P; 9:128179266-128179266 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.859A>T; p.M287L; 9:128179348-128179348 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.1594G>C; p.E532Q; 9:128178395-128178395 |
oesophagus | carcinoma; adenocarcinoma | Substitution - Missense |
c.455C>T; p.P152L; 9:128185680-128185680 |
skin | malignant_melanoma | Substitution - Missense |
c.455C>T; p.P152L; 9:128185680-128185680 |
skin | malignant_melanoma | Substitution - Missense |
c.985C>T; p.R329W; 9:128179222-128179222 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.2626delA; p.T876fs*5; 9:128166268-128166268 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.35_36insGTT; p.Q12_Q13insL; 9:128190822-128190823 |
breast | carcinoma | Insertion - In frame |
c.1223A>G; p.Q408R; 9:128178984-128178984 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.478C>T; p.L160L; 9:128185657-128185657 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.2544C>T; p.C848C; 9:128166350-128166350 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.733C>T; p.P245S; 9:128180473-128180473 |
skin | malignant_melanoma | Substitution - Missense |
c.1913T>C; p.V638A; 9:128176381-128176381 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1913T>C; p.V638A; 9:128176381-128176381 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.2642C>T; p.T881M; 9:128166252-128166252 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.1031A>G; p.Q344R; 9:128179176-128179176 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.1307A>T; p.H436L; 9:128178900-128178900 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.2476G>C; p.E826Q; 9:128166770-128166770 |
NS | NS | Substitution - Missense |
c.1028A>G; p.K343R; 9:128179179-128179179 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.1458C>T; p.C486C; 9:128178749-128178749 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1413G>A; p.V471V; 9:128178794-128178794 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1413G>A; p.V471V; 9:128178794-128178794 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1605G>A; p.A535A; 9:128178384-128178384 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.517C>T; p.Q173*; 9:128185618-128185618 |
liver | carcinoma | Substitution - Nonsense |
c.649G>A; p.E217K; 9:128180754-128180754 |
liver | carcinoma; hepatocellular_carcinoma | Substitution - Missense |
c.1330C>T; p.Q444*; 9:128178877-128178877 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; myelodysplastic_syndrome | Substitution - Nonsense |
c.517C>T; p.Q173*; 9:128185618-128185618 |
liver | carcinoma | Substitution - Nonsense |
c.2050C>T; p.R684*; 9:128169501-128169501 |
breast | carcinoma | Substitution - Nonsense |
c.1712G>A; p.R571H; 9:128177672-128177672 |
stomach | carcinoma; intestinal_adenocarcinoma | Substitution - Missense |
c.2050C>T; p.R684*; 9:128169501-128169501 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Nonsense |
c.2050C>T; p.R684*; 9:128169501-128169501 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.1712G>A; p.R571H; 9:128177672-128177672 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.2050C>T; p.R684*; 9:128169501-128169501 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.556C>T; p.R186W; 9:128185579-128185579 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.855C>T; p.A285A; 9:128179352-128179352 |
skin | malignant_melanoma | Substitution - coding silent |
c.567_569delCTC; p.S190delS; 9:128185566-128185568 |
endometrium | carcinoma; endometrioid_carcinoma | Deletion - In frame |
c.217G>A; p.G73S; 9:128190398-128190398 |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma | Substitution - Missense |
c.2404C>T; p.R802C; 9:128166842-128166842 |
central_nervous_system; brain | glioma; astrocytoma_Grade_III | Substitution - Missense |
c.2664A>C; p.P888P; 9:128166230-128166230 |
ovary | other; neoplasm | Substitution - coding silent |
c.401C>T; p.A134V; 9:128185734-128185734 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.176T>C; p.L59P; 9:128190439-128190439 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - Missense |
c.530C>T; p.S177L; 9:128185605-128185605 |
cervix | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.176T>C; p.L59P; 9:128190439-128190439 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - Missense |
c.765C>T; p.S255S; 9:128180441-128180441 |
prostate | carcinoma | Substitution - coding silent |
c.2653T>C; p.S885P; 9:128166241-128166241 |
breast | carcinoma | Substitution - Missense |
c.176T>C; p.L59P; 9:128190439-128190439 |
central_nervous_system; brain | glioma | Substitution - Missense |
c.1386T>C; p.H462H; 9:128178821-128178821 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.2510C>T; p.P837L; 9:128166384-128166384 |
thyroid | other; neoplasm | Substitution - Missense |
c.1292C>G; p.T431R; 9:128178915-128178915 |
ovary | other; neoplasm | Substitution - Missense |
c.2065G>A; p.V689I; 9:128169486-128169486 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1726G>A; p.V576I; 9:128177658-128177658 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.26_28delAGC; p.Q9delQ; 9:128190830-128190832 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - In frame |
c.26_28delAGC; p.Q9delQ; 9:128190830-128190832 |
liver | carcinoma | Deletion - In frame |
c.26_28delAGC; p.Q9delQ; 9:128190830-128190832 |
large_intestine; rectum | carcinoma; adenocarcinoma | Deletion - In frame |
c.26_28delAGC; p.Q9delQ; 9:128190830-128190832 |
skin; extremity | malignant_melanoma | Deletion - In frame |
c.26_28delAGC; p.Q9delQ; 9:128190830-128190832 |
skin; back | malignant_melanoma | Deletion - In frame |
c.2592C>T; p.G864G; 9:128166302-128166302 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.1361C>T; p.S454L; 9:128178846-128178846 |
breast | carcinoma; HER-positive_carcinoma | Substitution - Missense |
c.2253G>T; p.E751D; 9:128169094-128169094 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.1629C>T; p.G543G; 9:128177755-128177755 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.279G>C; p.Q93H; 9:128190336-128190336 |
skin | malignant_melanoma | Substitution - Missense |
c.955C>T; p.Q319*; 9:128179252-128179252 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Nonsense |
c.473C>T; p.S158F; 9:128185662-128185662 |
skin | malignant_melanoma | Substitution - Missense |