| General information | Literature | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 25792 |
Name | CIZ1 |
Synonymous | LSFR1|NP94|ZNF356;CDKN1A interacting zinc finger protein 1;CIZ1;CDKN1A interacting zinc finger protein 1 |
Definition | cip1-interacting zinc finger protein|nuclear protein NP94|zinc finger protein 356 |
Position | 9q34.1 |
Gene type | protein-coding |
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Title |
Abstract |
| CIZ1, a p21Cip1/Waf1-interacting protein, functions as a tumor suppressor in vivo. | CIZ1 is a nuclear protein involved in DNA replication and is also implicated in human diseases including cancers. To gain an insight into its function in vivo, we generated mice lacking Ciz1. Ciz1-deficient (Ciz1(-/-)) mice grew without any obvious abnormalities, and Ciz1(-/-) mouse embryonic fibroblasts (MEFs) did not show any defects in cell cycle status, cell growth, and DNA damage response. However, Ciz1(-/-) MEFs were sensitive to hydroxyurea-mediated replication stress and susceptible to oncogene-induced cellular transformation. In addition, Ciz1(-/-) mice developed various types of leukemias by retroviral insertional mutagenesis. These results indicate that CIZ1 functions as a tumor suppressor in vivo. |