Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

27122

Name

DKK3

Synonymous

dickkopf WNT signaling pathway inhibitor 3;DKK3;dickkopf WNT signaling pathway inhibitor 3

Definition

RIG-like 5-6|RIG-like 7-1|dickkopf 3 homolog|dickkopf homolog 3|dickkopf-3|dickkopf-related protein 3|dkk-3|hDkk-3|regulated in glioma

Position

11p15.2

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.23.

The copy number variations for various cancers

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The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.202G>A; p.A68T; 11:12008381-12008381

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.113T>A; p.L38H; 11:12008470-12008470

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.340G>A; p.E114K; 11:12002311-12002311

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.196C>T; p.R66C; 11:12008387-12008387

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.630C>A; p.N210K; 11:11966997-11966997

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.630C>A; p.N210K; 11:11966997-11966997

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Missense

c.195G>A; p.L65L; 11:12008388-12008388

 pancreascarcinomaSubstitution - coding silent

c.698_699CC>TT; p.P233L; 11:11965940-11965941

 skinmalignant_melanomaSubstitution - Missense

c.943G>A; p.E315K; 11:11964574-11964574

 skinmalignant_melanomaSubstitution - Missense

c.278G>A; p.S93N; 11:12002373-12002373

 breastcarcinomaSubstitution - Missense

c.514C>T; p.R172W; 11:11968409-11968409

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.875G>A; p.R292H; 11:11964642-11964642

 skinmalignant_melanomaSubstitution - Missense

c.380T>A; p.V127D; 11:11998751-11998751

 prostateadenomaSubstitution - Missense

c.636G>A; p.R212R; 11:11966991-11966991

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.636G>A; p.R212R; 11:11966991-11966991

 upper_aerodigestive_tract; mouthcarcinomaSubstitution - coding silent

c.739C>T; p.R247W; 11:11965900-11965900

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.375A>G; p.Q125Q; 11:11998756-11998756

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.434A>T; p.H145L; 11:11998697-11998697

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.999G>A; p.A333A; 11:11964518-11964518

 upper_aerodigestive_tract; mouthcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.725A>C; p.H242P; 11:11965914-11965914

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; plasma_cell_myelomaSubstitution - Missense

c.566T>A; p.L189Q; 11:11967061-11967061

 breastcarcinomaSubstitution - Missense

c.839_840insT; p.V281fs*13; 11:11964677-11964678

 breastcarcinomaInsertion - Frameshift

c.183G>A; p.T61T; 11:12008400-12008400

 oesophaguscarcinoma; adenocarcinomaSubstitution - coding silent

c.439T>C; p.C147R; 11:11968484-11968484

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.386C>A; p.S129*; 11:11998745-11998745

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.795C>A; p.C265*; 11:11965844-11965844

 urinary_tract; bladdercarcinomaSubstitution - Nonsense

c.258C>G; p.N86K; 11:12002393-12002393

 lungcarcinoma; non_small_cell_carcinomaSubstitution - Missense

c.258C>G; p.N86K; 11:12002393-12002393

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.1003A>G; p.R335G; 11:11964514-11964514

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - Missense

c.1003A>G; p.R335G; 11:11964514-11964514

 thyroidother; neoplasmSubstitution - Missense

c.958G>C; p.E320Q; 11:11964559-11964559

 livercarcinoma; hepatocellular_carcinomaSubstitution - Missense

c.732C>T; p.P244P; 11:11965907-11965907

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.268T>C; p.L90L; 11:12002383-12002383

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.848T>A; p.V283E; 11:11964669-11964669

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.484G>T; p.A162S; 11:11968439-11968439

 oesophaguscarcinoma; adenocarcinomaSubstitution - Missense

c.910G>C; p.V304L; 11:11964607-11964607

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

c.500C>T; p.T167I; 11:11968423-11968423

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.357C>G; p.T119T; 11:11998774-11998774

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - coding silent

c.314G>C; p.G105A; 11:12002337-12002337

 pancreascarcinomaSubstitution - Missense

c.314G>C; p.G105A; 11:12002337-12002337

 pancreascarcinomaSubstitution - Missense

c.385T>C; p.S129P; 11:11998746-11998746

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - Missense

c.1021G>T; p.A341S; 11:11964496-11964496

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.69C>A; p.P23P; 11:12008514-12008514

 thyroidother; neoplasmSubstitution - coding silent

c.936C>T; p.S312S; 11:11964581-11964581

 livercarcinomaSubstitution - coding silent

c.314G>A; p.G105E; 11:12002337-12002337

 skinmalignant_melanomaSubstitution - Missense

c.543C>A; p.D181E; 11:11967084-11967084

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.543C>A; p.D181E; 11:11967084-11967084

 lungcarcinoma; bronchioloalveolar_adenocarcinomaSubstitution - Missense

c.314G>A; p.G105E; 11:12002337-12002337

 skinmalignant_melanomaSubstitution - Missense

c.894C>T; p.I298I; 11:11964623-11964623

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.667C>T; p.Q223*; 11:11966960-11966960

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Nonsense

c.922T>C; p.Y308H; 11:11964595-11964595

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.953G>A; p.R318H; 11:11964564-11964564

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.953G>A; p.R318H; 11:11964564-11964564

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.515G>A; p.R172Q; 11:11968408-11968408

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.386C>G; p.S129*; 11:11998745-11998745

 breastcarcinoma; ductal_carcinomaSubstitution - Nonsense

c.990A>G; p.E330E; 11:11964527-11964527

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - coding silent

c.685C>T; p.P229S; 11:11965954-11965954

 skinmalignant_melanomaSubstitution - Missense

c.1017_1018delTG; p.A340fs*>11; 11:11964499-11964500

 central_nervous_system; brainglioma; astrocytoma_Grade_IVDeletion - Frameshift

c.1017_1018delTG; p.A340fs*>11; 11:11964499-11964500

 central_nervous_system; brainglioma; astrocytoma_Grade_IVDeletion - Frameshift

c.171G>A; p.L57L; 11:12008412-12008412

 skinmalignant_melanomaSubstitution - coding silent

c.158A>G; p.E53G; 11:12008425-12008425

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.1009C>T; p.P337S; 11:11964508-11964508

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.711G>A; p.E237E; 11:11965928-11965928

 skinmalignant_melanomaSubstitution - coding silent

c.704C>T; p.P235L; 11:11965935-11965935

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.182C>T; p.T61M; 11:12008401-12008401

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.1034T>C; p.L345P; 11:11964483-11964483

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.340G>T; p.E114*; 11:12002311-12002311

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.835A>G; p.S279G; 11:11964682-11964682

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.381C>G; p.V127V; 11:11998750-11998750

 breastcarcinomaSubstitution - coding silent

c.673+2T>C; p.?; 11:11966952-11966952

 stomachcarcinoma; intestinal_adenocarcinomaUnknown

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