Entrez Gene

Basic Information
Gene ID	28996
Name	HIPK2
Synonymous	homeodomain interacting protein kinase 2;HIPK2;homeodomain interacting protein kinase 2
Definition	hHIPk2\|homeodomain-interacting protein kinase 2
Position	7q34
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Loss of Function mutations compare to missense mutations

Top

The ratio of the loss-of-function mutations over missense mutations is 0.07.

The copy number variations for various cancers

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.2781C>T; p.S927S; 7:139584001-139584001	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.1945G>C; p.D649H; 7:139614331-139614331	breast	carcinoma	Substitution - Missense
c.2633C>T; p.P878L; 7:139596801-139596801	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3540C>G; p.T1180T; 7:139572984-139572984	breast	carcinoma	Substitution - coding silent
c.3464C>T; p.S1155L; 7:139573060-139573060	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2581G>C; p.D861H; 7:139596853-139596853	liver	carcinoma	Substitution - Missense
c.3584A>G; p.Y1195C; 7:139572940-139572940	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3216C>T; p.S1072S; 7:139573308-139573308	skin	malignant_melanoma	Substitution - coding silent
c.925G>T; p.A309S; 7:139716110-139716110	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.481G>T; p.A161S; 7:139716554-139716554	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1597C>T; p.L533F; 7:139626623-139626623	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3210G>T; p.P1070P; 7:139573314-139573314	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - coding silent
c.2220G>C; p.E740D; 7:139604116-139604116	breast	carcinoma	Substitution - Missense
c.1309C>T; p.R437C; 7:139631203-139631203	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3123C>G; p.S1041R; 7:139575131-139575131	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.1867T>G; p.S623A; 7:139614409-139614409	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.324delC; p.G109fs*6; 7:139716711-139716711	skin; head_neck	carcinoma; squamous_cell_carcinoma	Deletion - Frameshift
c.3198G>A; p.M1066I; 7:139573326-139573326	skin	malignant_melanoma	Substitution - Missense
c.1807A>G; p.I603V; 7:139614469-139614469	liver	carcinoma	Substitution - Missense
c.1807A>G; p.I603V; 7:139614469-139614469	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.1496A>G; p.E499G; 7:139626724-139626724	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1500C>T; p.F500F; 7:139626720-139626720	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1103+8C>T; p.?; 7:139715924-139715924	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.1103+8C>T; p.?; 7:139715924-139715924	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.2912C>T; p.P971L; 7:139583870-139583870	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3031G>T; p.G1011C; 7:139575223-139575223	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.538A>T; p.S180C; 7:139716497-139716497	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1064A>C; p.K355T; 7:139715971-139715971	liver	carcinoma	Substitution - Missense
c.1064A>C; p.K355T; 7:139715971-139715971	liver	carcinoma	Substitution - Missense
c.1782G>A; p.Q594Q; 7:139620401-139620401	breast	carcinoma	Substitution - coding silent
c.3405C>A; p.A1135A; 7:139573119-139573119	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1657C>T; p.R553C; 7:139620526-139620526	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.518C>T; p.S173F; 7:139716517-139716517	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.890C>T; p.P297L; 7:139716145-139716145	skin	malignant_melanoma	Substitution - Missense
c.2523C>T; p.R841R; 7:139596911-139596911	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1490G>A; p.R497Q; 7:139626730-139626730	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelodysplastic_syndrome	Substitution - Missense
c.1493G>A; p.R498Q; 7:139626727-139626727	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.437T>C; p.I146T; 7:139716598-139716598	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2364C>T; p.A788A; 7:139600488-139600488	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.2810C>T; p.S937F; 7:139583972-139583972	skin	malignant_melanoma	Substitution - Missense
c.2776T>C; p.Y926H; 7:139584006-139584006	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1871C>T; p.A624V; 7:139614405-139614405	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2661C>T; p.V887V; 7:139596773-139596773	skin	malignant_melanoma	Substitution - coding silent
c.1811C>T; p.S604F; 7:139614465-139614465	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1811C>T; p.S604F; 7:139614465-139614465	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.504G>A; p.T168T; 7:139716531-139716531	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2112+3A>G; p.?; 7:139613199-139613199	liver	carcinoma	Unknown
c.620G>A; p.R207Q; 7:139716415-139716415	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.2112+3A>G; p.?; 7:139613199-139613199	liver	carcinoma	Unknown
c.3411A>G; p.P1137P; 7:139573113-139573113	breast	carcinoma	Substitution - coding silent
c.2267C>T; p.A756V; 7:139600585-139600585	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2823T>C; p.R941R; 7:139583959-139583959	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2912C>A; p.P971H; 7:139583870-139583870	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1046C>T; p.S349L; 7:139715989-139715989	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2823T>C; p.R941R; 7:139583959-139583959	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2921C>T; p.T974I; 7:139583861-139583861	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3331C>T; p.L1111L; 7:139573193-139573193	skin	malignant_melanoma	Substitution - coding silent
c.1158C>T; p.S386S; 7:139631671-139631671	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1477G>A; p.E493K; 7:139626743-139626743	breast	carcinoma	Substitution - Missense
c.455C>T; p.P152L; 7:139716580-139716580	skin	malignant_melanoma	Substitution - Missense
c.2108C>G; p.A703G; 7:139613206-139613206	breast	carcinoma	Substitution - Missense
c.22_23insA; p.M8fs*20; 7:139717012-139717013	endometrium	carcinoma; endometrioid_carcinoma	Insertion - Frameshift
c.154A>G; p.S52G; 7:139716881-139716881	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3448C>T; p.P1150S; 7:139573076-139573076	skin	malignant_melanoma	Substitution - Missense
c.253G>A; p.V85I; 7:139716782-139716782	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.253G>A; p.V85I; 7:139716782-139716782	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.3030C>T; p.S1010S; 7:139575224-139575224	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.253G>A; p.V85I; 7:139716782-139716782	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2467C>T; p.Q823*; 7:139596967-139596967	upper_aerodigestive_tract; pharynx	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.2208C>T; p.T736T; 7:139604128-139604128	biliary_tract; bile_duct	carcinoma; adenocarcinoma	Substitution - coding silent
c.2742C>T; p.N914N; 7:139584040-139584040	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.344T>G; p.M115R; 7:139716691-139716691	thyroid	other; neoplasm	Substitution - Missense
c.1907C>T; p.P636L; 7:139614369-139614369	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2522G>A; p.R841H; 7:139596912-139596912	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2316C>T; p.T772T; 7:139600536-139600536	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1976C>T; p.P659L; 7:139614300-139614300	skin	malignant_melanoma	Substitution - Missense
c.1901G>A; p.S634N; 7:139614375-139614375	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1661G>A; p.R554Q; 7:139620522-139620522	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2688G>C; p.E896D; 7:139596746-139596746	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2688G>C; p.E896D; 7:139596746-139596746	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2315C>T; p.T772I; 7:139600537-139600537	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1980delC; p.G661fs*63; 7:139614296-139614296	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1980delC; p.G661fs*63; 7:139614296-139614296	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1980delC; p.G661fs*63; 7:139614296-139614296	large_intestine	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1661G>A; p.R554Q; 7:139620522-139620522	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2688G>C; p.E896D; 7:139596746-139596746	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.2688G>C; p.E896D; 7:139596746-139596746	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2905G>A; p.V969M; 7:139583877-139583877	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2905G>A; p.V969M; 7:139583877-139583877	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3461C>T; p.P1154L; 7:139573063-139573063	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.511G>A; p.A171T; 7:139716524-139716524	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3391G>A; p.V1131M; 7:139573133-139573133	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2097A>T; p.P699P; 7:139613217-139613217	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.2690A>G; p.E897G; 7:139596744-139596744	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.3190C>A; p.P1064T; 7:139573334-139573334	breast	carcinoma	Substitution - Missense
c.1599C>T; p.L533L; 7:139626621-139626621	oesophagus	carcinoma	Substitution - coding silent
c.2056G>A; p.V686I; 7:139613258-139613258	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2123C>T; p.P708L; 7:139604213-139604213	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelodysplastic_syndrome	Substitution - Missense
c.2074G>A; p.A692T; 7:139613240-139613240	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2271C>T; p.H757H; 7:139600581-139600581	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.745C>T; p.R249W; 7:139716290-139716290	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelodysplastic_syndrome	Substitution - Missense
c.3524C>T; p.A1175V; 7:139573000-139573000	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1432C>T; p.Q478*; 7:139628955-139628955	skin	malignant_melanoma	Substitution - Nonsense
c.2663T>A; p.I888N; 7:139596771-139596771	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2664C>T; p.I888I; 7:139596770-139596770	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.49C>T; p.P17S; 7:139716986-139716986	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2552G>A; p.C851Y; 7:139596882-139596882	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelodysplastic_syndrome	Substitution - Missense
c.2580C>T; p.G860G; 7:139596854-139596854	breast	carcinoma	Substitution - coding silent
c.1812C>A; p.S604S; 7:139614464-139614464	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2580C>T; p.G860G; 7:139596854-139596854	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.143G>A; p.S48N; 7:139716892-139716892	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelodysplastic_syndrome	Substitution - Missense
c.478G>A; p.G160R; 7:139716557-139716557	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelodysplastic_syndrome	Substitution - Missense
c.124_125insCTG; p.T42_G43insA; 7:139716910-139716911	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelodysplastic_syndrome	Insertion - In frame
c.891C>T; p.P297P; 7:139716144-139716144	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.891C>T; p.P297P; 7:139716144-139716144	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1940G>A; p.R647Q; 7:139614336-139614336	prostate	carcinoma	Substitution - Missense
c.3486G>T; p.Q1162H; 7:139573038-139573038	central_nervous_system; brain	primitive_neuroectodermal_tumour-medulloblastoma	Substitution - Missense
c.3120C>T; p.L1040L; 7:139575134-139575134	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2301G>A; p.Q767Q; 7:139600551-139600551	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2314A>G; p.T772A; 7:139600538-139600538	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2314A>G; p.T772A; 7:139600538-139600538	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2314A>G; p.T772A; 7:139600538-139600538	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1921A>G; p.T641A; 7:139614355-139614355	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.2404C>A; p.R802R; 7:139600448-139600448	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.398G>A; p.R133H; 7:139716637-139716637	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3096C>T; p.F1032F; 7:139575158-139575158	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.3549T>G; p.T1183T; 7:139572975-139572975	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2405G>A; p.R802Q; 7:139600447-139600447	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2405G>A; p.R802Q; 7:139600447-139600447	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2405G>A; p.R802Q; 7:139600447-139600447	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2405G>A; p.R802Q; 7:139600447-139600447	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.696C>A; p.N232K; 7:139716339-139716339	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2822G>T; p.R941L; 7:139583960-139583960	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.2616G>A; p.R872R; 7:139596818-139596818	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.875A>G; p.K292R; 7:139716160-139716160	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1231C>T; p.R411W; 7:139631281-139631281	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.429C>T; p.S143S; 7:139716606-139716606	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.711C>T; p.A237A; 7:139716324-139716324	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.347G>A; p.R116H; 7:139716688-139716688	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1812C>G; p.S604S; 7:139614464-139614464	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.2007C>T; p.P669P; 7:139613307-139613307	breast	carcinoma	Substitution - coding silent
c.2316C>A; p.T772T; 7:139600536-139600536	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1949delC; p.P650fs*74; 7:139614327-139614327	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Deletion - Frameshift
c.1119C>T; p.I373I; 7:139631710-139631710	skin	malignant_melanoma	Substitution - coding silent
c.292G>A; p.A98T; 7:139716743-139716743	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1119C>T; p.I373I; 7:139631710-139631710	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.780C>T; p.F260F; 7:139716255-139716255	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.780C>T; p.F260F; 7:139716255-139716255	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.3464C>A; p.S1155*; 7:139573060-139573060	lung	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1231C>A; p.R411R; 7:139631281-139631281	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2628C>T; p.V876V; 7:139596806-139596806	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.209C>T; p.S70F; 7:139716826-139716826	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelodysplastic_syndrome	Substitution - Missense
c.350G>A; p.R117Q; 7:139716685-139716685	breast	carcinoma	Substitution - Missense
c.47C>T; p.S16F; 7:139716988-139716988	skin	malignant_melanoma	Substitution - Missense
c.2375G>T; p.R792L; 7:139600477-139600477	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.366C>T; p.L122L; 7:139716669-139716669	skin	malignant_melanoma	Substitution - coding silent
c.1705A>G; p.I569V; 7:139620478-139620478	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma	Substitution - Missense
c.414C>T; p.I138I; 7:139716621-139716621	skin	malignant_melanoma	Substitution - coding silent
c.955G>T; p.G319C; 7:139716080-139716080	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2546C>T; p.P849L; 7:139596888-139596888	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1059C>G; p.V353V; 7:139715976-139715976	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1059C>G; p.V353V; 7:139715976-139715976	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.210C>A; p.S70S; 7:139716825-139716825	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1059C>G; p.V353V; 7:139715976-139715976	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.1051A>G; p.S351G; 7:139715984-139715984	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia_associated_with_MDS	Substitution - Missense
c.963C>G; p.I321M; 7:139716072-139716072	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1232G>A; p.R411Q; 7:139631280-139631280	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.514A>C; p.T172P; 7:139716521-139716521	breast	carcinoma	Substitution - Missense
c.2767G>A; p.D923N; 7:139584015-139584015	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2332C>T; p.P778S; 7:139600520-139600520	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1338G>A; p.W446*; 7:139631174-139631174	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Nonsense
c.3396G>A; p.Q1132Q; 7:139573128-139573128	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1977C>T; p.P659P; 7:139614299-139614299	skin	malignant_melanoma	Substitution - coding silent
c.1619+5G>T; p.?; 7:139626596-139626596	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.3087C>T; p.G1029G; 7:139575167-139575167	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.932C>T; p.A311V; 7:139716103-139716103	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelodysplastic_syndrome	Substitution - Missense
c.254T>C; p.V85A; 7:139716781-139716781	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.254T>C; p.V85A; 7:139716781-139716781	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.254T>C; p.V85A; 7:139716781-139716781	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.349C>T; p.R117*; 7:139716686-139716686	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.254T>C; p.V85A; 7:139716781-139716781	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.254T>C; p.V85A; 7:139716781-139716781	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2913C>T; p.P971P; 7:139583869-139583869	skin	malignant_melanoma	Substitution - coding silent
c.2913C>T; p.P971P; 7:139583869-139583869	skin	malignant_melanoma	Substitution - coding silent
c.3413C>T; p.A1138V; 7:139573111-139573111	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.713G>A; p.R238Q; 7:139716322-139716322	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1149C>A; p.D383E; 7:139631680-139631680	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.104C>T; p.P35L; 7:139716931-139716931	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2220G>A; p.E740E; 7:139604116-139604116	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.326G>A; p.G109D; 7:139716709-139716709	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2665A>G; p.T889A; 7:139596769-139596769	breast	carcinoma	Substitution - Missense
c.1771G>A; p.V591I; 7:139620412-139620412	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3523G>A; p.A1175T; 7:139573001-139573001	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2508G>A; p.E836E; 7:139596926-139596926	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.831C>T; p.F277F; 7:139716204-139716204	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1627T>G; p.S543A; 7:139620556-139620556	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1087C>T; p.Q363*; 7:139715948-139715948	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1699_1700CC>TT; p.P567F; 7:139620483-139620484	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2374C>T; p.R792W; 7:139600478-139600478	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2726C>T; p.S909F; 7:139584056-139584056	skin; trunk	malignant_melanoma	Substitution - Missense
c.2647C>T; p.P883S; 7:139596787-139596787	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelodysplastic_syndrome	Substitution - Missense
c.1574C>T; p.P525L; 7:139626646-139626646	skin	malignant_melanoma	Substitution - Missense
c.199G>A; p.V67I; 7:139716836-139716836	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.199G>A; p.V67I; 7:139716836-139716836	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.199G>A; p.V67I; 7:139716836-139716836	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.199G>A; p.V67I; 7:139716836-139716836	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1975C>T; p.P659S; 7:139614301-139614301	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1313A>G; p.D438G; 7:139631199-139631199	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2865C>T; p.S955S; 7:139583917-139583917	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1325C>T; p.P442L; 7:139631187-139631187	oesophagus	carcinoma	Substitution - Missense
c.818C>T; p.T273M; 7:139716217-139716217	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2651C>A; p.T884K; 7:139596783-139596783	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2245G>A; p.A749T; 7:139604091-139604091	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.96A>C; p.K32N; 7:139716939-139716939	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2148T>C; p.L716L; 7:139604188-139604188	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.280G>A; p.V94M; 7:139716755-139716755	breast	carcinoma	Substitution - Missense
c.1710G>A; p.T570T; 7:139620473-139620473	prostate	carcinoma	Substitution - coding silent
c.6C>T; p.A2A; 7:139777618-139777618	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.6C>T; p.A2A; 7:139777618-139777618	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.284T>C; p.V95A; 7:139716751-139716751	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.727G>T; p.E243*; 7:139716308-139716308	breast	carcinoma	Substitution - Nonsense
c.1330C>T; p.P444S; 7:139631182-139631182	skin	malignant_melanoma	Substitution - Missense
c.1734C>T; p.T578T; 7:139620449-139620449	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2602C>T; p.R868W; 7:139596832-139596832	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.763G>T; p.A255S; 7:139716272-139716272	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.320delT; p.V107fs*8; 7:139716715-139716715	skin; head_neck	carcinoma; squamous_cell_carcinoma	Deletion - Frameshift
c.3395A>G; p.Q1132R; 7:139573129-139573129	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3362T>C; p.V1121A; 7:139573162-139573162	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.361A>G; p.S121G; 7:139716674-139716674	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3560T>G; p.L1187R; 7:139572964-139572964	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2265T>C; p.H755H; 7:139600587-139600587	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.612C>A; p.F204L; 7:139716423-139716423	liver	carcinoma	Substitution - Missense
c.1883C>T; p.A628V; 7:139614393-139614393	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1898G>A; p.R633Q; 7:139614378-139614378	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; myelodysplastic_syndrome	Substitution - Missense
c.29C>G; p.S10*; 7:139717006-139717006	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Nonsense
c.1010G>T; p.R337I; 7:139716025-139716025	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2694G>A; p.E898E; 7:139596740-139596740	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.3586C>T; p.P1196S; 7:139572938-139572938	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3150C>T; p.D1050D; 7:139573374-139573374	breast	carcinoma	Substitution - coding silent
c.2822G>A; p.R941H; 7:139583960-139583960	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2581G>A; p.D861N; 7:139596853-139596853	ovary	other; neoplasm	Substitution - Missense
c.405C>T; p.S135S; 7:139716630-139716630	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2684A>G; p.D895G; 7:139596750-139596750	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2878T>G; p.C960G; 7:139583904-139583904	lung	carcinoma; adenocarcinoma	Substitution - Missense

Mutation summary in protein domains

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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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Loss of Function mutations compare to missense mutations

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The copy number variations for various cancers

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COSMIC somatic mutation [Top]