Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

28996

Name

HIPK2

Synonymous

PRO0593;homeodomain interacting protein kinase 2;HIPK2;homeodomain interacting protein kinase 2

Definition

hHIPk2|homeodomain-interacting protein kinase 2

Position

7q34

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

hipk2(h) + p53(h) <==> hipk2(h):p53(h) (binding)
hipk2(h) + PML-3(h) <==> hipk2(h):PML-3(h) (binding)
hipk2(h) + CBP(h) <==> hipk2(h):CBP(h) (binding)
p73alpha(h) + hipk2(h) <==> p73alpha(h):hipk2(h) (binding)
p73beta(h) + hipk2(h) <==> p73beta(h):hipk2(h) (binding)
p63alpha(h) + hipk2(h) <==> p63alpha(h):hipk2(h) (binding)
p63gamma(h) + hipk2(h) <==> p63gamma(h):hipk2(h) (binding)
AML1b(h) + hipk2(h) <==> AML1b(h):hipk2(h) (binding)
hipk2(h) + ATP --> hipk2(h){p} + ADP (phosphorylation; automodification)
hipk2(h) + p300(m.s.) <==> hipk2(h):p300(m.s.) (binding)
hipk2(h) --> hipk2(h) (expression).
AML1b(h) + 2 ATP --hipk2(h)--> AML1b(h){pS249}{pS276} + 2 ADP (phosphorylation)
p300(m.s.) + ATP --hipk2(h)--> p300(m.s.){p} + ADP (phosphorylation)
MOZ(h) + ATP --hipk2(h)--> MOZ(h){p} + ADP (phosphorylation)
HMGIY-isoform1(h) + 3 ATP --hipk2(h)--> HMGIY-isoform1(h){pS36}{pT53}{pT78} + 3 ADP (phosphorylation)
HMGIY-isoform2(h) + 2 ATP --hipk2(h)--> HMGIY-isoform2(h){pT42}{pT67} + 2 ADP (phosphorylation)
HIPK2(h) --> hipk2-isoform1(h) (expression).
HIPK2(h) --> hipk2-isoform2(h) (expression).
HIPK2(h) --> hipk2-isoform3(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

32Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in SUMO).Swiss-Prot 53.0
1191Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in SUMO) (Bysimilarity).Swiss-Prot 53.0

Methylation Profile   [Top]

There is no record for HIPK2



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