Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

2950

Name

GSTP1

Synonymous

glutathione S-transferase pi 1;GSTP1;glutathione S-transferase pi 1

Definition

GST class-pi|GSTP1-1|deafness, X-linked 7|epididymis secretory protein Li 22|fatty acid ethyl ester synthase III|glutathione S-transferase P

Position

11q13

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

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We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.07.

The copy number variations for various cancers

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The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.127T>G; p.S43A; 11:67584553-67584553

 pancreascarcinomaSubstitution - Missense

c.570C>G; p.L190L; 11:67586514-67586514

 cervixcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.570C>G; p.L190L; 11:67586514-67586514

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.174C>T; p.D58D; 11:67584714-67584714

 central_nervous_system; brainprimitive_neuroectodermal_tumour-medulloblastomaSubstitution - coding silent

c.450C>T; p.S150S; 11:67586394-67586394

 skinmalignant_melanomaSubstitution - coding silent

c.437G>T; p.G146V; 11:67586204-67586204

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.604C>A; p.L202I; 11:67586548-67586548

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.187C>A; p.L63M; 11:67584727-67584727

 skinmalignant_melanomaSubstitution - Missense

c.623G>T; p.G208V; 11:67586567-67586567

 large_intestine; coloncarcinomaSubstitution - Missense

c.623G>T; p.G208V; 11:67586567-67586567

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.628C>T; p.Q210*; 11:67586572-67586572

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Nonsense

c.628C>T; p.Q210*; 11:67586572-67586572

 large_intestinecarcinoma; adenocarcinomaSubstitution - Nonsense

c.601A>G; p.N201D; 11:67586545-67586545

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.500C>A; p.A167D; 11:67586444-67586444

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.563_564CC>TT; p.P188L; 11:67586507-67586508

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.487C>T; p.H163Y; 11:67586431-67586431

 lungcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.597C>T; p.Y199Y; 11:67586541-67586541

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.200A>C; p.N67T; 11:67584740-67584740

 skinmalignant_melanomaSubstitution - Missense

c.180C>A; p.D60E; 11:67584720-67584720

 livercarcinomaSubstitution - Missense

c.180C>A; p.D60E; 11:67584720-67584720

 livercarcinomaSubstitution - Missense

c.578T>C; p.F193S; 11:67586522-67586522

 skinmalignant_melanomaSubstitution - Missense

c.188T>C; p.L63P; 11:67584728-67584728

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.163A>G; p.K55E; 11:67584703-67584703

 oesophaguscarcinomaSubstitution - Missense

c.420C>G; p.G140G; 11:67586187-67586187

 breastcarcinomaSubstitution - coding silent

c.533C>T; p.S178L; 11:67586477-67586477

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.483G>T; p.L161L; 11:67586427-67586427

 ovarycarcinoma; serous_carcinomaSubstitution - coding silent

c.264C>T; p.A88A; 11:67585169-67585169

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.507C>T; p.G169G; 11:67586451-67586451

 skinmalignant_melanomaSubstitution - coding silent

c.548G>C; p.R183P; 11:67586492-67586492

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.237C>A; p.L79L; 11:67585142-67585142

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.555T>G; p.S185R; 11:67586499-67586499

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - Missense

c.156G>A; p.Q52Q; 11:67584696-67584696

 stomachcarcinoma; adenocarcinomaSubstitution - coding silent

c.408G>A; p.Q136Q; 11:67586175-67586175

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.519G>A; p.A173A; 11:67586463-67586463

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.330C>A; p.T110T; 11:67585235-67585235

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.203C>G; p.T68S; 11:67584743-67584743

 breastcarcinomaSubstitution - Missense

c.224G>A; p.R75H; 11:67584764-67584764

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.352G>T; p.D118Y; 11:67586119-67586119

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.561G>C; p.R187R; 11:67586505-67586505

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.400C>T; p.L134L; 11:67586167-67586167

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - coding silent

c.313A>G; p.I105V; 11:67585218-67585218

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.580C>T; p.L194L; 11:67586524-67586524

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.555T>C; p.S185S; 11:67586499-67586499

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.555T>C; p.S185S; 11:67586499-67586499

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - coding silent

c.555T>C; p.S185S; 11:67586499-67586499

 haematopoietic_and_lymphoid_tissuehaematopoietic_neoplasm; acute_myeloid_leukaemiaSubstitution - coding silent

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