| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 3621 |
Name | ING1 |
Synonymous | inhibitor of growth family, member 1;ING1;inhibitor of growth family, member 1 |
Definition | growth inhibitor ING1|growth inhibitory protein ING1|inhibitor of growth protein 1|tumor suppressor ING1 |
Position | 13q34 |
Gene Type | protein-coding |
Mutation summary: | Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72 |
Mutation summary in protein domains | Top |
 |
The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers | Top |
 |
 |
Loss of Function mutations compare to missense mutations | Top |
 |
| The ratio of the loss-of-function mutations over missense mutations is 0.34. |
The copy number variations for various cancers | Top |
 |
The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract |
COSMIC somatic mutation [Top] | |||
|
Mutation (CDS; AA; Chr) |
Site |
Histology |
Mutation Type |
|---|---|---|---|
c.576C>T; p.A192A; 13:110719668-110719668 |
lung; middle_lobe | carcinoma; adenocarcinoma | Substitution - coding silent |
c.625G>T; p.E209*; 13:110719717-110719717 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Nonsense |
c.494A>C; p.N165T; 13:110719586-110719586 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.603C>T; p.A201A; 13:110719695-110719695 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.767G>A; p.C256Y; 13:110719859-110719859 |
oesophagus | carcinoma; adenocarcinoma | Substitution - Missense |
c.253G>A; p.G85S; 13:110719345-110719345 |
lung; right_upper_lobe | carcinoma; adenocarcinoma | Substitution - Missense |
c.700G>A; p.E234K; 13:110719792-110719792 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.763A>T; p.K255*; 13:110719855-110719855 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.585G>C; p.E195D; 13:110719677-110719677 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.679G>T; p.D227Y; 13:110719771-110719771 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.679G>T; p.D227Y; 13:110719771-110719771 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.703T>C; p.W235R; 13:110719795-110719795 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.703T>C; p.W235R; 13:110719795-110719795 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.674G>A; p.G225D; 13:110719766-110719766 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.705G>A; p.W235*; 13:110719797-110719797 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Nonsense |
c.391G>A; p.A131T; 13:110719483-110719483 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.178C>T; p.R60C; 13:110719270-110719270 |
oesophagus | carcinoma | Substitution - Missense |
c.445C>T; p.R149C; 13:110719537-110719537 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.705G>T; p.W235C; 13:110719797-110719797 |
ovary | carcinoma; serous_carcinoma | Substitution - Missense |
c.740C>A; p.P247H; 13:110719832-110719832 |
ovary | carcinoma; adenocarcinoma | Substitution - Missense |
c.154G>T; p.D52Y; 13:110719246-110719246 |
autonomic_ganglia | neuroblastoma | Substitution - Missense |
c.505G>A; p.D169N; 13:110719597-110719597 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.485C>T; p.A162V; 13:110719577-110719577 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.514G>T; p.A172S; 13:110719606-110719606 |
breast | carcinoma | Substitution - Missense |
c.657C>A; p.S219S; 13:110719749-110719749 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.414G>A; p.A138A; 13:110719506-110719506 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.33C>T; p.H11H; 13:110714182-110714182 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.469G>A; p.E157K; 13:110719561-110719561 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.727C>T; p.L243F; 13:110719819-110719819 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.487T>C; p.S163P; 13:110719579-110719579 |
thyroid | other; neoplasm | Substitution - Missense |
c.514G>A; p.A172T; 13:110719606-110719606 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.586C>T; p.R196*; 13:110719678-110719678 |
central_nervous_system; brain | glioma | Substitution - Nonsense |
c.586C>T; p.R196*; 13:110719678-110719678 |
stomach | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.586C>T; p.R196*; 13:110719678-110719678 |
stomach | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.586C>T; p.R196*; 13:110719678-110719678 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.586C>T; p.R196*; 13:110719678-110719678 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Nonsense |
c.586C>T; p.R196*; 13:110719678-110719678 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Nonsense |
c.586C>T; p.R196*; 13:110719678-110719678 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.586C>T; p.R196*; 13:110719678-110719678 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.586C>T; p.R196*; 13:110719678-110719678 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Nonsense |
c.586C>T; p.R196*; 13:110719678-110719678 |
urinary_tract; bladder | carcinoma; transitional_cell_carcinoma | Substitution - Nonsense |
c.586C>T; p.R196*; 13:110719678-110719678 |
urinary_tract; bladder | carcinoma | Substitution - Nonsense |
c.586C>T; p.R196*; 13:110719678-110719678 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.586C>T; p.R196*; 13:110719678-110719678 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Nonsense |
c.507C>T; p.D169D; 13:110719599-110719599 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.513C>T; p.G171G; 13:110719605-110719605 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.513C>T; p.G171G; 13:110719605-110719605 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.230C>T; p.A77V; 13:110719322-110719322 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - Missense |
c.512G>A; p.G171D; 13:110719604-110719604 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.345G>A; p.A115A; 13:110719437-110719437 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.305G>A; p.R102H; 13:110719397-110719397 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.274G>A; p.V92M; 13:110719366-110719366 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.305G>A; p.R102H; 13:110719397-110719397 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.202C>T; p.R68W; 13:110719294-110719294 |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; acute_lymphoblastic_leukaemia | Substitution - Missense |
c.273C>T; p.I91I; 13:110719365-110719365 |
skin | malignant_melanoma | Substitution - coding silent |
c.484G>A; p.A162T; 13:110719576-110719576 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.435C>T; p.P145P; 13:110719527-110719527 |
breast | carcinoma | Substitution - coding silent |
c.575C>T; p.A192V; 13:110719667-110719667 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.688G>T; p.E230*; 13:110719780-110719780 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Nonsense |
c.259G>A; p.E87K; 13:110719351-110719351 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.630C>G; p.P210P; 13:110719722-110719722 |
lung; right_upper_lobe | carcinoma; adenocarcinoma | Substitution - coding silent |
c.259G>A; p.E87K; 13:110719351-110719351 |
breast | carcinoma | Substitution - Missense |
c.58C>G; p.L20V; 13:110714207-110714207 |
breast | carcinoma | Substitution - Missense |
c.492C>A; p.S164R; 13:110719584-110719584 |
central_nervous_system; brain | glioma; astrocytoma_Grade_IV | Substitution - Missense |
c.777G>A; p.E259E; 13:110719869-110719869 |
breast | carcinoma | Substitution - coding silent |
c.644G>A; p.C215Y; 13:110719736-110719736 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.475C>A; p.R159S; 13:110719567-110719567 |
skin | malignant_melanoma | Substitution - Missense |
c.678C>T; p.C226C; 13:110719770-110719770 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.770G>A; p.R257Q; 13:110719862-110719862 |
oesophagus | carcinoma; adenocarcinoma | Substitution - Missense |
c.770delG; p.E259fs*>21; 13:110719862-110719862 |
large_intestine; colon | carcinoma; adenocarcinoma | Deletion - Frameshift |
c.625G>A; p.E209K; 13:110719717-110719717 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.247G>C; p.E83Q; 13:110719339-110719339 |
breast | carcinoma | Substitution - Missense |
c.69C>T; p.I23I; 13:110714218-110714218 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.483C>T; p.N161N; 13:110719575-110719575 |
large_intestine | carcinoma; adenocarcinoma | Substitution - coding silent |