| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 3627 |
Name | CXCL10 |
Synonymous | chemokine (C-X-C motif) ligand 10;CXCL10;chemokine (C-X-C motif) ligand 10 |
Definition | 10 kDa interferon gamma-induced protein|C-X-C motif chemokine 10|gamma IP10|gamma-IP10|interferon-inducible cytokine IP-10|protein 10 from interferon (gamma)-induced cell line|small inducible cytokine subfamily B (Cys-X-Cys), member 10|small-inducible cyt |
Position | 4q21 |
Gene Type | protein-coding |
Mutation summary: | Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72 |
Mutation summary in protein domains | Top |
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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers | Top |
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Loss of Function mutations compare to missense mutations | Top |
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| The ratio of the loss-of-function mutations over missense mutations is 0.00. |
The copy number variations for various cancers | Top |
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The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract |
COSMIC somatic mutation [Top] | |||
|
Mutation (CDS; AA; Chr) |
Site |
Histology |
Mutation Type |
|---|---|---|---|
c.249G>T; p.K83N; 4:76022395-76022395 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.249G>T; p.K83N; 4:76022395-76022395 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.138A>G; p.E46E; 4:76022741-76022741 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Substitution - coding silent |
c.223C>T; p.L75L; 4:76022421-76022421 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.100A>G; p.S34G; 4:76022779-76022779 |
skin | malignant_melanoma | Substitution - Missense |
c.114A>G; p.Q38Q; 4:76022765-76022765 |
skin | malignant_melanoma | Substitution - coding silent |
c.108T>C; p.S36S; 4:76022771-76022771 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - coding silent |
c.82G>A; p.V28I; 4:76022797-76022797 |
breast | carcinoma | Substitution - Missense |
c.279G>A; p.R93R; 4:76021948-76021948 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Substitution - coding silent |
c.279G>A; p.R93R; 4:76021948-76021948 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Substitution - coding silent |
c.279G>A; p.R93R; 4:76021948-76021948 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Substitution - coding silent |
c.279G>A; p.R93R; 4:76021948-76021948 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Substitution - coding silent |
c.279G>A; p.R93R; 4:76021948-76021948 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Substitution - coding silent |
c.237G>A; p.S79S; 4:76022407-76022407 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.273G>A; p.K91K; 4:76022371-76022371 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - coding silent |
c.22A>G; p.I8V; 4:76023410-76023410 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.23T>C; p.I8T; 4:76023409-76023409 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.178G>A; p.V60I; 4:76022701-76022701 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.236C>T; p.S79L; 4:76022408-76022408 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.42G>A; p.L14L; 4:76023390-76023390 |
stomach | carcinoma; adenocarcinoma | Substitution - coding silent |
c.236C>T; p.S79L; 4:76022408-76022408 |
skin | malignant_melanoma | Substitution - Missense |
c.279G>T; p.R93S; 4:76021948-76021948 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Substitution - Missense |
c.279G>T; p.R93S; 4:76021948-76021948 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Substitution - Missense |
c.279G>T; p.R93S; 4:76021948-76021948 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Substitution - Missense |
c.279G>T; p.R93S; 4:76021948-76021948 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Substitution - Missense |
c.279G>T; p.R93S; 4:76021948-76021948 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Substitution - Missense |
c.279G>T; p.R93S; 4:76021948-76021948 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Substitution - Missense |
c.279G>T; p.R93S; 4:76021948-76021948 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Substitution - Missense |
c.279G>T; p.R93S; 4:76021948-76021948 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Substitution - Missense |
c.292C>T; p.P98S; 4:76021935-76021935 |
skin | malignant_melanoma | Substitution - Missense |
c.275A>T; p.E92V; 4:76022369-76022369 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.69T>A; p.P23P; 4:76022810-76022810 |
pancreas | carcinoma | Substitution - coding silent |
c.61G>A; p.G21R; 4:76023371-76023371 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.279G>C; p.R93S; 4:76021948-76021948 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Substitution - Missense |