| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 3662 |
Name | IRF4 |
Synonymous | interferon regulatory factor 4;IRF4;interferon regulatory factor 4 |
Definition | lymphocyte-specific interferon regulatory factor|multiple myeloma oncogene 1 |
Position | 6p25-p23 |
Gene Type | protein-coding |
Mutation summary: | Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72 |
Mutation summary in protein domains | Top |
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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers | Top |
 |
 |
Loss of Function mutations compare to missense mutations | Top |
 |
| The ratio of the loss-of-function mutations over missense mutations is 0.33. |
The copy number variations for various cancers | Top |
 |
The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract |
COSMIC somatic mutation [Top] | |||
|
Mutation (CDS; AA; Chr) |
Site |
Histology |
Mutation Type |
|---|---|---|---|
c.823C>T; p.R275W; 6:401501-401501 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.342C>A; p.S114R; 6:394946-394946 |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; chronic_lymphocytic_leukaemia-small_lymphocytic_lymphoma | Substitution - Missense |
c.1149G>A; p.V383V; 6:405067-405067 |
ovary | carcinoma; serous_carcinoma | Substitution - coding silent |
c.1351G>T; p.E451*; 6:407593-407593 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.282_283GA>TC; p.K94_T95>NP; 6:394886-394887 |
ovary | carcinoma; serous_carcinoma | Complex - compound substitution |