Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

388

Name

RHOB

Synonymous

ras homolog family member B;RHOB;ras homolog family member B

Definition

Aplysia RAS-related homolog 6|h6|oncogene RHO H6|ras homolog gene family, member B|rho cDNA clone 6|rho-related GTP-binding protein RhoB

Position

2p24

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

Top

We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.00.

The copy number variations for various cancers

Top

There is no record for RHOB

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.263G>A; p.S88N; 2:20447728-20447728

 endometriumcarcinoma; endometrioid_carcinomaSubstitution - Missense

c.436G>T; p.A146S; 2:20447901-20447901

 lung; right_lower_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.195C>T; p.D65D; 2:20447660-20447660

 lungcarcinoma; adenocarcinomaSubstitution - coding silent

c.223C>T; p.P75S; 2:20447688-20447688

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.223C>T; p.P75S; 2:20447688-20447688

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.223C>T; p.P75S; 2:20447688-20447688

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Missense

c.223C>A; p.P75T; 2:20447688-20447688

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.381C>A; p.V127V; 2:20447846-20447846

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.37G>T; p.D13Y; 2:20447502-20447502

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.37G>T; p.D13Y; 2:20447502-20447502

 breastcarcinomaSubstitution - Missense

c.287C>T; p.P96L; 2:20447752-20447752

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.397C>A; p.R133S; 2:20447862-20447862

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.285C>T; p.I95I; 2:20447750-20447750

 urinary_tract; bladdercarcinomaSubstitution - coding silent

c.403A>C; p.K135Q; 2:20447868-20447868

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Missense

c.403A>C; p.K135Q; 2:20447868-20447868

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.25G>C; p.V9L; 2:20447490-20447490

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.39C>T; p.D13D; 2:20447504-20447504

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - coding silent

c.18G>A; p.K6K; 2:20447483-20447483

 skinmalignant_melanomaSubstitution - coding silent

c.318C>T; p.F106F; 2:20447783-20447783

 breastcarcinomaSubstitution - coding silent

c.111C>T; p.T37T; 2:20447576-20447576

 skinmalignant_melanomaSubstitution - coding silent

c.224C>T; p.P75L; 2:20447689-20447689

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.514G>A; p.E172K; 2:20447979-20447979

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.514G>A; p.E172K; 2:20447979-20447979

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.514G>A; p.E172K; 2:20447979-20447979

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaSubstitution - Missense

c.188A>C; p.Q63P; 2:20447653-20447653

 skinmalignant_melanomaSubstitution - Missense

c.373G>A; p.E125K; 2:20447838-20447838

 breastcarcinomaSubstitution - Missense

c.77G>C; p.S26T; 2:20447542-20447542

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.339C>A; p.I113I; 2:20447804-20447804

 breastcarcinomaSubstitution - coding silent

c.77G>C; p.S26T; 2:20447542-20447542

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.318C>G; p.F106L; 2:20447783-20447783

 oesophagus; lower_thirdcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.171G>A; p.L57L; 2:20447636-20447636

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.171G>A; p.L57L; 2:20447636-20447636

 large_intestinecarcinoma; adenocarcinomaSubstitution - coding silent

c.353A>T; p.K118I; 2:20447818-20447818

 skinmalignant_melanomaSubstitution - Missense

c.101A>G; p.Y34C; 2:20447566-20447566

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.510C>G; p.V170V; 2:20447975-20447975

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.88T>C; p.F30L; 2:20447553-20447553

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.197_205delACGACCGCC; p.Y66_R68delYDR; 2:20447662-20447670

 urinary_tract; bladdercarcinoma; transitional_cell_carcinomaDeletion - In frame

c.415G>A; p.V139M; 2:20447880-20447880

 haematopoietic_and_lymphoid_tissuelymphoid_neoplasm; acute_lymphoblastic_leukaemiaSubstitution - Missense

c.86A>G; p.E29G; 2:20447551-20447551

 kidneycarcinoma; papillary_renal_cell_carcinomaSubstitution - Missense

c.323C>G; p.P108R; 2:20447788-20447788

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.380T>G; p.V127G; 2:20447845-20447845

 ovarycarcinoma; serous_carcinomaSubstitution - Missense

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