| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 400410 |
Name | ST20 |
Synonymous | suppressor of tumorigenicity 20;ST20;suppressor of tumorigenicity 20 |
Definition | cervical cancer suppressor-1|human cervical cancer suppressor gene 1 protein|suppressor of tumorigenicity 20 protein |
Position | 15q25.1 |
Gene Type | protein-coding |
Mutation summary: | Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72 |
Mutation summary in protein domains | Top |
 |
The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers | Top |
 |
 |
Loss of Function mutations compare to missense mutations | Top |
 |
| The ratio of the loss-of-function mutations over missense mutations is 0.11. |
The copy number variations for various cancers | Top |
 |
The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract |
COSMIC somatic mutation [Top] | |||
|
Mutation (CDS; AA; Chr) |
Site |
Histology |
Mutation Type |
|---|---|---|---|
c.207G>C; p.T69T; 15:79898964-79898964 |
liver | carcinoma | Substitution - coding silent |
c.206C>G; p.T69R; 15:79898965-79898965 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.130T>C; p.F44L; 15:79899041-79899041 |
kidney | carcinoma; clear_cell_renal_cell_carcinoma | Substitution - Missense |
c.170C>T; p.P57L; 15:79899001-79899001 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Substitution - Missense |
c.170C>T; p.P57L; 15:79899001-79899001 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Substitution - Missense |
c.58G>A; p.V20I; 15:79899113-79899113 |
urinary_tract; bladder | carcinoma | Substitution - Missense |
c.190A>T; p.I64F; 15:79898981-79898981 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.202C>G; p.L68V; 15:79898969-79898969 |
lung; right_upper_lobe | carcinoma; adenocarcinoma | Substitution - Missense |
c.202C>G; p.L68V; 15:79898969-79898969 |
oesophagus | carcinoma; adenocarcinoma | Substitution - Missense |
c.207G>T; p.T69T; 15:79898964-79898964 |
breast | carcinoma | Substitution - coding silent |
c.185G>A; p.G62D; 15:79898986-79898986 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.184G>A; p.G62S; 15:79898987-79898987 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.234C>G; p.Y78*; 15:79898937-79898937 |
lung | carcinoma; squamous_cell_carcinoma | Substitution - Nonsense |
c.202C>T; p.L68F; 15:79898969-79898969 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |