Entrez Gene

Basic Information
Gene ID	4486
Name	MST1R
Synonymous	macrophage stimulating 1 receptor;MST1R;macrophage stimulating 1 receptor
Definition	MSP receptor\|MST1R variant RON30\|MST1R variant RON62\|PTK8 protein tyrosine kinase 8\|RON variant 21\|RON variant E2E3\|c-met-related tyrosine kinase\|macrophage stimulating 1 receptor (c-met-related tyrosine kinase)\|macrophage-stimulating protein receptor\|p18
Position	3p21.3
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Loss of Function mutations compare to missense mutations

Top

The ratio of the loss-of-function mutations over missense mutations is 0.10.

The copy number variations for various cancers

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.1548G>T; p.Q516H; 3:49898867-49898867	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3696C>T; p.D1232D; 3:49890599-49890599	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1980_1981delTA; p.N661fs*44; 3:49897585-49897586	ovary	carcinoma; serous_carcinoma	Deletion - Frameshift
c.3691C>T; p.R1231C; 3:49890604-49890604	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1182C>T; p.L394L; 3:49902428-49902428	skin	malignant_melanoma	Substitution - coding silent
c.199G>A; p.E67K; 3:49903411-49903411	breast	carcinoma	Substitution - Missense
c.1259C>T; p.T420I; 3:49899235-49899235	skin	malignant_melanoma	Substitution - Missense
c.3499G>A; p.G1167S; 3:49891434-49891434	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.2929G>T; p.V977F; 3:49895748-49895748	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1488G>A; p.Q496Q; 3:49898927-49898927	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1419+10C>T; p.?; 3:49899065-49899065	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Unknown
c.3610T>G; p.F1204V; 3:49891231-49891231	peritoneum; appendix	other; pseudomyxoma_peritonei	Substitution - Missense
c.4172G>A; p.R1391Q; 3:49887338-49887338	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1492G>A; p.V498M; 3:49898923-49898923	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2697C>T; p.T899T; 3:49896060-49896060	skin	malignant_melanoma	Substitution - coding silent
c.923G>A; p.R308H; 3:49902687-49902687	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1735G>T; p.G579*; 3:49898196-49898196	thyroid	other; neoplasm	Substitution - Nonsense
c.115G>T; p.D39Y; 3:49903495-49903495	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1163C>T; p.S388F; 3:49902447-49902447	skin	malignant_melanoma	Substitution - Missense
c.2918C>T; p.A973V; 3:49895759-49895759	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.560C>A; p.T187N; 3:49903050-49903050	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.418C>T; p.Q140*; 3:49903192-49903192	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.418C>T; p.Q140*; 3:49903192-49903192	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.619G>A; p.V207M; 3:49902991-49902991	breast	carcinoma	Substitution - Missense
c.4166G>A; p.R1389Q; 3:49887344-49887344	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3782C>T; p.T1261I; 3:49890513-49890513	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1964T>A; p.V655D; 3:49897602-49897602	ovary	other; neoplasm	Substitution - Missense
c.2650-1G>A; p.?; 3:49896108-49896108	thyroid	carcinoma	Unknown
c.1091C>A; p.S364Y; 3:49902519-49902519	urinary_tract; bladder	carcinoma	Substitution - Missense
c.3651C>T; p.D1217D; 3:49890644-49890644	liver	carcinoma	Substitution - coding silent
c.3651C>T; p.D1217D; 3:49890644-49890644	liver	carcinoma	Substitution - coding silent
c.1091C>A; p.S364Y; 3:49902519-49902519	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.3699C>T; p.I1233I; 3:49890596-49890596	skin	malignant_melanoma	Substitution - coding silent
c.2427A>T; p.A809A; 3:49896552-49896552	large_intestine; rectum	NS	Substitution - coding silent
c.206C>A; p.A69D; 3:49903404-49903404	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.4104G>C; p.S1368S; 3:49887406-49887406	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.4198A>T; p.T1400S; 3:49887312-49887312	skin; face	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.4094C>A; p.P1365H; 3:49887416-49887416	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.741T>C; p.I247I; 3:49902869-49902869	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.3500G>A; p.G1167D; 3:49891433-49891433	skin	malignant_melanoma	Substitution - Missense
c.3992G>A; p.R1331Q; 3:49887518-49887518	skin	malignant_melanoma	Substitution - Missense
c.1880+2T>C; p.?; 3:49898049-49898049	large_intestine; colon	carcinoma; adenocarcinoma	Unknown
c.1818C>T; p.T606T; 3:49898113-49898113	pancreas	carcinoma; ductal_carcinoma	Substitution - coding silent
c.4004G>T; p.R1335I; 3:49887506-49887506	liver	carcinoma	Substitution - Missense
c.2431G>A; p.E811K; 3:49896548-49896548	cervix	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2182C>T; p.R728W; 3:49897281-49897281	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3901G>A; p.A1301T; 3:49889970-49889970	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3901G>A; p.A1301T; 3:49889970-49889970	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.3898C>T; p.L1300L; 3:49889973-49889973	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2859C>T; p.V953V; 3:49895818-49895818	skin	malignant_melanoma	Substitution - coding silent
c.3883G>C; p.D1295H; 3:49889988-49889988	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2595A>C; p.P865P; 3:49896249-49896249	breast	carcinoma	Substitution - coding silent
c.101A>C; p.Y34S; 3:49903509-49903509	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2014G>A; p.G672S; 3:49897552-49897552	breast	carcinoma	Substitution - Missense
c.3321T>G; p.N1107K; 3:49891789-49891789	skin	malignant_melanoma	Substitution - Missense
c.1279C>T; p.L427L; 3:49899215-49899215	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2015G>A; p.G672D; 3:49897551-49897551	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.346G>T; p.G116C; 3:49903264-49903264	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1632C>A; p.G544G; 3:49898605-49898605	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2604C>A; p.A868A; 3:49896240-49896240	skin	malignant_melanoma	Substitution - coding silent
c.1632C>A; p.G544G; 3:49898605-49898605	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.3996C>T; p.P1332P; 3:49887514-49887514	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1892G>A; p.R631Q; 3:49897674-49897674	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.3528T>A; p.P1176P; 3:49891405-49891405	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2520G>A; p.G840G; 3:49896324-49896324	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.303C>T; p.C101C; 3:49903307-49903307	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.3187G>A; p.D1063N; 3:49895251-49895251	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.3187G>A; p.D1063N; 3:49895251-49895251	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.3897C>T; p.F1299F; 3:49889974-49889974	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.3705C>G; p.D1235E; 3:49890590-49890590	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3288C>T; p.V1096V; 3:49891822-49891822	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1499G>A; p.R500Q; 3:49898916-49898916	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2445G>C; p.E815D; 3:49896399-49896399	breast	carcinoma	Substitution - Missense
c.1540G>C; p.G514R; 3:49898875-49898875	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2057T>C; p.L686P; 3:49897406-49897406	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2620A>G; p.K874E; 3:49896224-49896224	oesophagus	carcinoma	Substitution - Missense
c.3603G>A; p.E1201E; 3:49891238-49891238	skin	malignant_melanoma	Substitution - coding silent
c.2797G>A; p.V933I; 3:49895880-49895880	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.3743G>A; p.R1248H; 3:49890552-49890552	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1098C>T; p.V366V; 3:49902512-49902512	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.479C>T; p.P160L; 3:49903131-49903131	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.4134G>C; p.P1378P; 3:49887376-49887376	bone; extraskeletal	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1390A>G; p.M464V; 3:49899104-49899104	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.3644+7G>A; p.?; 3:49891190-49891190	ovary	other; neoplasm	Unknown
c.3948-8C>T; p.?; 3:49887570-49887570	liver	carcinoma	Unknown
c.1390A>G; p.M464V; 3:49899104-49899104	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.3644+7G>A; p.?; 3:49891190-49891190	ovary	other; neoplasm	Unknown
c.3948-8C>T; p.?; 3:49887570-49887570	liver	carcinoma	Unknown
c.3561_3562insT; p.G1189fs*38; 3:49891279-49891280	endometrium	carcinoma; endometrioid_carcinoma	Insertion - Frameshift
c.594C>T; p.Y198Y; 3:49903016-49903016	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.2727C>T; p.F909F; 3:49896030-49896030	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.4103C>T; p.S1368L; 3:49887407-49887407	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.167A>G; p.Q56R; 3:49903443-49903443	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.189C>T; p.G63G; 3:49903421-49903421	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2665G>A; p.A889T; 3:49896092-49896092	urinary_tract; bladder	carcinoma	Substitution - Missense
c.189C>T; p.G63G; 3:49903421-49903421	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2557A>G; p.T853A; 3:49896287-49896287	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.3339C>G; p.I1113M; 3:49891771-49891771	urinary_tract; bladder	carcinoma	Substitution - Missense
c.849T>C; p.L283L; 3:49902761-49902761	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1771G>T; p.G591C; 3:49898160-49898160	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3742C>T; p.R1248C; 3:49890553-49890553	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.849T>C; p.L283L; 3:49902761-49902761	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.2495G>A; p.R832Q; 3:49896349-49896349	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3621G>C; p.R1207S; 3:49891220-49891220	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.3884A>G; p.D1295G; 3:49889987-49889987	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1078G>A; p.V360M; 3:49902532-49902532	liver	carcinoma	Substitution - Missense
c.3793A>G; p.T1265A; 3:49890502-49890502	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1078G>A; p.V360M; 3:49902532-49902532	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.474delA; p.A159fs*28; 3:49903136-49903136	stomach	carcinoma; diffuse_adenocarcinoma	Deletion - Frameshift
c.1135G>A; p.D379N; 3:49902475-49902475	breast	carcinoma	Substitution - Missense
c.562G>A; p.V188M; 3:49903048-49903048	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1719+1G>A; p.?; 3:49898517-49898517	lung	carcinoma; squamous_cell_carcinoma	Unknown
c.163G>C; p.V55L; 3:49903447-49903447	breast	carcinoma	Substitution - Missense
c.1408C>T; p.R470C; 3:49899086-49899086	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1408C>T; p.R470C; 3:49899086-49899086	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3866G>A; p.R1289H; 3:49890005-49890005	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.695T>A; p.F232Y; 3:49902915-49902915	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.3361G>T; p.E1121*; 3:49891572-49891572	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.2484A>C; p.E828D; 3:49896360-49896360	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.433C>T; p.L145L; 3:49903177-49903177	upper_aerodigestive_tract; mouth	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.433C>T; p.L145L; 3:49903177-49903177	upper_aerodigestive_tract; mouth	carcinoma	Substitution - coding silent
c.3260T>G; p.V1087G; 3:49895178-49895178	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1275C>T; p.F425F; 3:49899219-49899219	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.500A>C; p.H167P; 3:49903110-49903110	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.3212A>G; p.K1071R; 3:49895226-49895226	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.3192T>C; p.S1064S; 3:49895246-49895246	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2847G>T; p.G949G; 3:49895830-49895830	skin	malignant_melanoma	Substitution - coding silent
c.3140C>T; p.S1047F; 3:49895298-49895298	skin	malignant_melanoma	Substitution - Missense
c.3122C>T; p.S1041F; 3:49895316-49895316	skin	malignant_melanoma	Substitution - Missense
c.1722C>T; p.F574F; 3:49898209-49898209	skin	malignant_melanoma	Substitution - coding silent
c.1658G>A; p.G553D; 3:49898579-49898579	ovary	other; neoplasm	Substitution - Missense
c.2563C>T; p.P855S; 3:49896281-49896281	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1915G>C; p.E639Q; 3:49897651-49897651	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.392C>T; p.A131V; 3:49903218-49903218	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2534G>A; p.R845Q; 3:49896310-49896310	breast	carcinoma	Substitution - Missense
c.2668G>A; p.V890M; 3:49896089-49896089	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.206C>T; p.A69V; 3:49903404-49903404	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1603C>T; p.R535C; 3:49898634-49898634	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3556A>T; p.I1186F; 3:49891285-49891285	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1568A>G; p.Q523R; 3:49898669-49898669	skin	malignant_melanoma	Substitution - Missense
c.1844C>T; p.P615L; 3:49898087-49898087	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.3708G>A; p.R1236R; 3:49890587-49890587	skin	malignant_melanoma	Substitution - coding silent
c.1549G>A; p.V517I; 3:49898688-49898688	pancreas	carcinoma	Substitution - Missense
c.2841G>A; p.R947R; 3:49895836-49895836	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.958G>T; p.V320L; 3:49902652-49902652	prostate	carcinoma	Substitution - Missense
c.2841G>A; p.R947R; 3:49895836-49895836	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.4108G>C; p.E1370Q; 3:49887402-49887402	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2007G>T; p.R669R; 3:49897559-49897559	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.3195G>A; p.A1065A; 3:49895243-49895243	prostate	adenoma	Substitution - coding silent
c.142A>G; p.S48G; 3:49903468-49903468	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.4003A>G; p.R1335G; 3:49887507-49887507	skin	malignant_melanoma	Substitution - Missense
c.3900G>A; p.L1300L; 3:49889971-49889971	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.1991C>T; p.P664L; 3:49897575-49897575	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3460G>A; p.E1154K; 3:49891473-49891473	pancreas	carcinoma	Substitution - Missense
c.3235C>T; p.R1079W; 3:49895203-49895203	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3460G>A; p.E1154K; 3:49891473-49891473	pancreas	carcinoma; ductal_carcinoma	Substitution - Missense
c.1104C>T; p.A368A; 3:49902506-49902506	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1694A>T; p.D565V; 3:49898543-49898543	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2264delG; p.G755fs*19; 3:49896810-49896810	ovary	carcinoma; mucinous_carcinoma	Deletion - Frameshift
c.2264delG; p.G755fs*19; 3:49896810-49896810	ovary	carcinoma; mucinous_carcinoma	Deletion - Frameshift
c.2264delG; p.G755fs*19; 3:49896810-49896810	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.1209G>A; p.S403S; 3:49902401-49902401	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2264delG; p.G755fs*19; 3:49896810-49896810	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.3205G>T; p.E1069*; 3:49895233-49895233	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.3464G>A; p.G1155D; 3:49891469-49891469	skin	malignant_melanoma	Substitution - Missense
c.2871G>A; p.T957T; 3:49895806-49895806	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2995C>A; p.L999M; 3:49895516-49895516	urinary_tract; bladder	carcinoma	Substitution - Missense
c.148_150delTCC; p.S50delS; 3:49903460-49903462	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - In frame
c.3555C>T; p.L1185L; 3:49891286-49891286	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.3190T>C; p.S1064P; 3:49895248-49895248	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3190T>C; p.S1064P; 3:49895248-49895248	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1184G>A; p.R395Q; 3:49902426-49902426	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - Missense
c.1184G>A; p.R395Q; 3:49902426-49902426	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1543G>C; p.D515H; 3:49898872-49898872	liver	carcinoma	Substitution - Missense
c.3353-2A>G; p.?; 3:49891582-49891582	stomach	carcinoma; adenocarcinoma	Unknown
c.1543G>C; p.D515H; 3:49898872-49898872	liver	carcinoma	Substitution - Missense
c.3911G>A; p.R1304Q; 3:49889960-49889960	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.2865G>T; p.Q955H; 3:49895812-49895812	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1950G>T; p.V650V; 3:49897616-49897616	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.599C>G; p.A200G; 3:49903011-49903011	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.3581G>A; p.R1194H; 3:49891260-49891260	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.3190T>G; p.S1064A; 3:49895248-49895248	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3271+4T>G; p.?; 3:49895163-49895163	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Unknown
c.1729delC; p.H577fs*5; 3:49898202-49898202	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2840G>A; p.R947Q; 3:49895837-49895837	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1850G>A; p.R617Q; 3:49898081-49898081	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.184G>A; p.E62K; 3:49903426-49903426	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.3764C>T; p.A1255V; 3:49890531-49890531	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - Missense
c.240G>C; p.V80V; 3:49903370-49903370	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2649+1G>A; p.?; 3:49896194-49896194	large_intestine; caecum	carcinoma; adenocarcinoma	Unknown
c.155G>A; p.G52E; 3:49903455-49903455	breast	carcinoma	Substitution - Missense
c.2572C>T; p.R858C; 3:49896272-49896272	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.882G>A; p.R294R; 3:49902728-49902728	skin	malignant_melanoma	Substitution - coding silent
c.3191C>G; p.S1064C; 3:49895247-49895247	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.4120C>T; p.R1374C; 3:49887390-49887390	large_intestine; colon	NS	Substitution - Missense
c.1021G>A; p.E341K; 3:49902589-49902589	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.4202G>A; p.1401; 3:49887308-49887308	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.1843C>T; p.P615S; 3:49898088-49898088	skin	malignant_melanoma	Substitution - Missense
c.750G>A; p.V250V; 3:49902860-49902860	ovary	carcinoma; mucinous_carcinoma	Substitution - coding silent
c.750G>A; p.V250V; 3:49902860-49902860	ovary	carcinoma; mucinous_carcinoma	Substitution - coding silent
c.2017A>C; p.T673P; 3:49897549-49897549	thyroid	other; neoplasm	Substitution - Missense
c.1803G>T; p.L601L; 3:49898128-49898128	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.3999C>T; p.T1333T; 3:49887511-49887511	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.2588C>T; p.P863L; 3:49896256-49896256	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2588C>T; p.P863L; 3:49896256-49896256	skin	malignant_melanoma	Substitution - Missense
c.1282C>T; p.L428L; 3:49899212-49899212	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.3595C>T; p.L1199L; 3:49891246-49891246	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.3296G>C; p.G1099A; 3:49891814-49891814	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3353G>A; p.R1118H; 3:49891580-49891580	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.308C>T; p.T103M; 3:49903302-49903302	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1877T>C; p.L626P; 3:49898054-49898054	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1963G>A; p.V655I; 3:49897603-49897603	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.2274_2280delACCTGGT; p.S761fs*11; 3:49896794-49896800	large_intestine; caecum	carcinoma; adenocarcinoma	Deletion - Frameshift
c.296C>T; p.P99L; 3:49903314-49903314	skin	malignant_melanoma	Substitution - Missense
c.3423G>A; p.P1141P; 3:49891510-49891510	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.3578C>A; p.A1193D; 3:49891263-49891263	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.3735C>T; p.R1245R; 3:49890560-49890560	liver	carcinoma	Substitution - coding silent
c.425G>A; p.R142H; 3:49903185-49903185	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.3582C>T; p.R1194R; 3:49891259-49891259	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.3427G>A; p.V1143M; 3:49891506-49891506	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.3772A>G; p.S1258G; 3:49890523-49890523	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.1244C>A; p.A415D; 3:49899250-49899250	liver	carcinoma; hepatocellular_carcinoma	Substitution - Missense
c.3388C>T; p.R1130*; 3:49891545-49891545	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1836C>T; p.G612G; 3:49898095-49898095	pancreas	carcinoma; ductal_carcinoma	Substitution - coding silent

Mutation summary in protein domains

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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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Loss of Function mutations compare to missense mutations

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The copy number variations for various cancers

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COSMIC somatic mutation [Top]