| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 4499 |
Name | MT1M |
Synonymous | metallothionein 1M;MT1M;metallothionein 1M |
Definition | metallothionein 1K|metallothionein 1Y|metallothionein-1M |
Position | 16q13 |
Gene Type | protein-coding |
Mutation summary: | Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72 |
Mutation summary in protein domains | Top |
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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers | Top |
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Loss of Function mutations compare to missense mutations | Top |
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| The ratio of the loss-of-function mutations over missense mutations is 0.13. |
The copy number variations for various cancers | Top |
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The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract |
COSMIC somatic mutation [Top] | |||
|
Mutation (CDS; AA; Chr) |
Site |
Histology |
Mutation Type |
|---|---|---|---|
c.24C>A; p.T8T; 16:56632755-56632755 |
lung | carcinoma; adenocarcinoma | Substitution - coding silent |
c.177C>G; p.C59W; 16:56633833-56633833 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - Missense |
c.88A>G; p.K30E; 16:56633399-56633399 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.123T>A; p.C41*; 16:56633779-56633779 |
lung; right_upper_lobe | carcinoma; adenocarcinoma | Substitution - Nonsense |
c.59C>G; p.T20R; 16:56633370-56633370 |
haematopoietic_and_lymphoid_tissue | haematopoietic_neoplasm; acute_myeloid_leukaemia | Substitution - Missense |
c.108C>T; p.C36C; 16:56633764-56633764 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - coding silent |
c.11A>C; p.N4T; 16:56632742-56632742 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - Missense |
c.37T>C; p.C13R; 16:56633348-56633348 |
ovary | carcinoma; serous_carcinoma | Substitution - Missense |
c.4G>A; p.D2N; 16:56632735-56632735 |
breast | carcinoma | Substitution - Missense |
c.39C>T; p.C13C; 16:56633350-56633350 |
breast | carcinoma | Substitution - coding silent |
c.8C>G; p.P3R; 16:56632739-56632739 |
haematopoietic_and_lymphoid_tissue | lymphoid_neoplasm; plasma_cell_myeloma | Substitution - Missense |
c.47C>G; p.T16S; 16:56633358-56633358 |
bone | Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour | Substitution - Missense |
c.83C>A; p.S28Y; 16:56633394-56633394 |
biliary_tract; gallbladder | carcinoma; adenocarcinoma | Substitution - Missense |
c.102C>T; p.C34C; 16:56633758-56633758 |
endometrium | carcinoma; endometrioid_carcinoma | Substitution - coding silent |
c.102C>T; p.C34C; 16:56633758-56633758 |
lung | carcinoma; adenocarcinoma | Substitution - coding silent |
c.80C>A; p.T27N; 16:56633391-56633391 |
large_intestine; rectum | carcinoma; adenocarcinoma | Substitution - Missense |
c.143G>A; p.C48Y; 16:56633799-56633799 |
large_intestine; colon | carcinoma; adenocarcinoma | Substitution - Missense |
c.85T>A; p.C29S; 16:56633396-56633396 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |
c.71G>A; p.C24Y; 16:56633382-56633382 |
salivary_gland | carcinoma; adenoid_cystic_carcinoma | Substitution - Missense |
c.71G>A; p.C24Y; 16:56633382-56633382 |
stomach | carcinoma; adenocarcinoma | Substitution - Missense |