Entrez Gene

Basic Information
Gene ID
Name
Synonymous	;;
Definition
Position
Gene Type
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

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There is no record for

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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There is no record for

Loss of Function mutations compare to missense mutations

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There is no record for

The ratio of the loss-of-function mutations over missense mutations is .

The copy number variations for various cancers

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There is no record for

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.826G>A; p.G276S; 18:79411140-79411140	thyroid	carcinoma	Substitution - Missense
c.1310C>G; p.A437G; 18:79433701-79433701	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1820A>T; p.N607I; 18:79451772-79451772	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2609G>A; p.R870H; 18:79486803-79486803	oesophagus; lower_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.616G>A; p.E206K; 18:79410930-79410930	skin	malignant_melanoma	Substitution - Missense
c.697G>A; p.V233I; 18:79411011-79411011	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1920+1G>T; p.?; 18:79461367-79461367	lung	carcinoma; adenocarcinoma	Unknown
c.1333C>A; p.H445N; 18:79433724-79433724	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2754A>G; p.I918M; 18:79527538-79527538	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.229G>A; p.G77R; 18:79410543-79410543	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.397C>T; p.P133S; 18:79410711-79410711	skin	malignant_melanoma	Substitution - Missense
c.1002G>A; p.A334A; 18:79411316-79411316	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.684G>T; p.S228S; 18:79410998-79410998	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1702G>T; p.A568S; 18:79451105-79451105	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.136C>T; p.P46S; 18:79410450-79410450	NS	malignant_melanoma	Substitution - Missense
c.1587C>T; p.S529S; 18:79450990-79450990	breast	carcinoma	Substitution - coding silent
c.554C>T; p.A185V; 18:79410868-79410868	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.981G>C; p.L327L; 18:79411295-79411295	pancreas	carcinoma	Substitution - coding silent
c.422C>T; p.T141M; 18:79410736-79410736	breast	carcinoma	Substitution - Missense
c.981G>C; p.L327L; 18:79411295-79411295	pancreas	carcinoma; ductal_carcinoma	Substitution - coding silent
c.981G>C; p.L327L; 18:79411295-79411295	pancreas	carcinoma	Substitution - coding silent
c.422C>T; p.T141M; 18:79410736-79410736	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1764G>A; p.Q588Q; 18:79451716-79451716	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.830C>T; p.S277F; 18:79411144-79411144	skin	malignant_melanoma	Substitution - Missense
c.774C>T; p.N258N; 18:79411088-79411088	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2743G>A; p.V915I; 18:79486937-79486937	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1430C>G; p.A477G; 18:79448864-79448864	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.1887G>A; p.M629I; 18:79461333-79461333	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1368T>A; p.N456K; 18:79448802-79448802	liver	carcinoma	Substitution - Missense
c.1292C>T; p.T431M; 18:79433683-79433683	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1292C>T; p.T431M; 18:79433683-79433683	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.660C>T; p.S220S; 18:79410974-79410974	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.201C>T; p.I67I; 18:79410515-79410515	skin	malignant_melanoma	Substitution - coding silent
c.1052C>G; p.A351G; 18:79411366-79411366	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1302C>T; p.S434S; 18:79433693-79433693	stomach	adenocarcinoma	Substitution - coding silent
c.1662C>T; p.H554H; 18:79451065-79451065	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.2009G>T; p.R670I; 18:79467538-79467538	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.206C>T; p.P69L; 18:79410520-79410520	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.904G>A; p.A302T; 18:79411218-79411218	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.779G>T; p.R260L; 18:79411093-79411093	urinary_tract; bladder	carcinoma	Substitution - Missense
c.243C>T; p.D81D; 18:79410557-79410557	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2241G>A; p.A747A; 18:79486435-79486435	thyroid	other; neoplasm	Substitution - coding silent
c.2630C>A; p.A877D; 18:79486824-79486824	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.224G>T; p.G75V; 18:79410538-79410538	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.821C>T; p.P274L; 18:79411135-79411135	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1848C>T; p.F616F; 18:79451800-79451800	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1717G>T; p.E573*; 18:79451120-79451120	lung	carcinoma; small_cell_carcinoma	Substitution - Nonsense
c.2052C>T; p.N684N; 18:79467581-79467581	lung; right_lower_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.1983C>T; p.V661V; 18:79467512-79467512	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.332C>T; p.S111L; 18:79410646-79410646	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1613C>T; p.T538M; 18:79451016-79451016	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1549G>A; p.V517I; 18:79448983-79448983	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.433A>C; p.S145R; 18:79410747-79410747	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.812C>T; p.T271M; 18:79411126-79411126	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1905G>T; p.R635R; 18:79461351-79461351	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.836G>A; p.R279Q; 18:79411150-79411150	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1656C>T; p.R552R; 18:79451059-79451059	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1216_1217delCT; p.L406fs*8; 18:79433607-79433608	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Deletion - Frameshift
c.738C>T; p.P246P; 18:79411052-79411052	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2212T>G; p.C738G; 18:79486406-79486406	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Substitution - Missense
c.1904G>A; p.R635Q; 18:79461350-79461350	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1800G>A; p.K600K; 18:79451752-79451752	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - coding silent
c.2212T>G; p.C738G; 18:79486406-79486406	breast	carcinoma	Substitution - Missense
c.2212T>G; p.C738G; 18:79486406-79486406	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1136A>C; p.H379P; 18:79411450-79411450	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1279G>A; p.A427T; 18:79433670-79433670	haematopoietic_and_lymphoid_tissue; central_nervous_system	lymphoid_neoplasm; primary_central_nervous_system_lymphoma	Substitution - Missense
c.1136A>C; p.H379P; 18:79411450-79411450	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1136A>C; p.H379P; 18:79411450-79411450	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1136A>C; p.H379P; 18:79411450-79411450	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1136A>C; p.H379P; 18:79411450-79411450	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2336A>G; p.Q779R; 18:79486530-79486530	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1136A>C; p.H379P; 18:79411450-79411450	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1136A>C; p.H379P; 18:79411450-79411450	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1136A>C; p.H379P; 18:79411450-79411450	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1136A>C; p.H379P; 18:79411450-79411450	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1136A>C; p.H379P; 18:79411450-79411450	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1136A>C; p.H379P; 18:79411450-79411450	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1136A>C; p.H379P; 18:79411450-79411450	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1136A>C; p.H379P; 18:79411450-79411450	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1136A>C; p.H379P; 18:79411450-79411450	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1136A>C; p.H379P; 18:79411450-79411450	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1136A>C; p.H379P; 18:79411450-79411450	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.747T>G; p.P249P; 18:79411061-79411061	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.776G>T; p.G259V; 18:79411090-79411090	liver	carcinoma	Substitution - Missense
c.1947A>G; p.P649P; 18:79467476-79467476	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.747T>G; p.P249P; 18:79411061-79411061	thyroid	other; neoplasm	Substitution - coding silent
c.1992C>T; p.Y664Y; 18:79467521-79467521	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.747T>G; p.P249P; 18:79411061-79411061	thyroid	other; neoplasm	Substitution - coding silent
c.776G>T; p.G259V; 18:79411090-79411090	liver	carcinoma	Substitution - Missense
c.481G>A; p.A161T; 18:79410795-79410795	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.602C>T; p.T201I; 18:79410916-79410916	skin; hand	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1920G>A; p.P640P; 18:79461366-79461366	autonomic_ganglia	neuroblastoma	Substitution - coding silent
c.807G>A; p.S269S; 18:79411121-79411121	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1543C>T; p.R515*; 18:79448977-79448977	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2208G>A; p.P736P; 18:79486402-79486402	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1483G>A; p.E495K; 18:79448917-79448917	skin	malignant_melanoma	Substitution - Missense
c.2346A>G; p.G782G; 18:79486540-79486540	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.2738A>G; p.D913G; 18:79486932-79486932	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2783C>T; p.T928I; 18:79527567-79527567	skin	malignant_melanoma	Substitution - Missense
c.161delC; p.P55fs*55; 18:79410475-79410475	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.2564G>T; p.C855F; 18:79486758-79486758	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.1328G>A; p.G443E; 18:79433719-79433719	skin	malignant_melanoma	Substitution - Missense
c.284G>A; p.R95K; 18:79410598-79410598	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2164G>A; p.A722T; 18:79486358-79486358	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1221G>A; p.P407P; 18:79433612-79433612	pancreas	carcinoma	Substitution - coding silent
c.295G>A; p.A99T; 18:79410609-79410609	large_intestine; caecum	adenoma	Substitution - Missense
c.1247G>A; p.R416Q; 18:79433638-79433638	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.2014C>T; p.R672*; 18:79467543-79467543	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Nonsense
c.383T>A; p.V128E; 18:79410697-79410697	central_nervous_system; brain	glioma	Substitution - Missense
c.631G>A; p.G211R; 18:79410945-79410945	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2101A>C; p.T701P; 18:79486295-79486295	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - Missense
c.1828C>T; p.Q610*; 18:79451780-79451780	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Nonsense
c.685C>T; p.P229S; 18:79410999-79410999	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.154C>T; p.L52L; 18:79410468-79410468	skin	malignant_melanoma	Substitution - coding silent
c.203C>T; p.P68L; 18:79410517-79410517	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2193C>T; p.L731L; 18:79486387-79486387	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1190C>T; p.P397L; 18:79433581-79433581	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1053C>T; p.A351A; 18:79411367-79411367	prostate	carcinoma	Substitution - coding silent
c.1691C>T; p.S564F; 18:79451094-79451094	skin	malignant_melanoma	Substitution - Missense
c.1786G>A; p.V596M; 18:79451738-79451738	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1310C>T; p.A437V; 18:79433701-79433701	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.131C>T; p.P44L; 18:79410445-79410445	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.787C>G; p.P263A; 18:79411101-79411101	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1147T>G; p.W383G; 18:79411461-79411461	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.322G>A; p.E108K; 18:79410636-79410636	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1147T>G; p.W383G; 18:79411461-79411461	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1147T>G; p.W383G; 18:79411461-79411461	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1147T>G; p.W383G; 18:79411461-79411461	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1147T>G; p.W383G; 18:79411461-79411461	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1147T>G; p.W383G; 18:79411461-79411461	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1147T>G; p.W383G; 18:79411461-79411461	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1147T>G; p.W383G; 18:79411461-79411461	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.825C>T; p.H275H; 18:79411139-79411139	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2030G>A; p.R677H; 18:79467559-79467559	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1147T>G; p.W383G; 18:79411461-79411461	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1147T>G; p.W383G; 18:79411461-79411461	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1147T>G; p.W383G; 18:79411461-79411461	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1147T>G; p.W383G; 18:79411461-79411461	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.209C>T; p.A70V; 18:79410523-79410523	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.2762A>G; p.N921S; 18:79527546-79527546	liver	carcinoma	Substitution - Missense
c.890C>T; p.S297L; 18:79411204-79411204	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.666G>T; p.R222R; 18:79410980-79410980	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1907A>T; p.D636V; 18:79461353-79461353	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2001C>T; p.N667N; 18:79467530-79467530	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.852C>T; p.D284D; 18:79411166-79411166	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2568G>A; p.P856P; 18:79486762-79486762	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2568G>A; p.P856P; 18:79486762-79486762	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1634C>T; p.T545I; 18:79451037-79451037	pancreas	carcinoma	Substitution - Missense
c.520T>G; p.S174A; 18:79410834-79410834	skin	malignant_melanoma	Substitution - Missense
c.219C>T; p.P73P; 18:79410533-79410533	skin	malignant_melanoma	Substitution - coding silent
c.1425G>A; p.P475P; 18:79448859-79448859	bone	Ewings_sarcoma-peripheral_primitive_neuroectodermal_tumour	Substitution - coding silent
c.2041C>T; p.L681F; 18:79467570-79467570	skin	malignant_melanoma	Substitution - Missense
c.1323G>A; p.S441S; 18:79433714-79433714	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2239G>A; p.A747T; 18:79486433-79486433	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.169C>T; p.H57Y; 18:79410483-79410483	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.124delG; p.A42fs*68; 18:79410438-79410438	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Deletion - Frameshift
c.1620C>T; p.I540I; 18:79451023-79451023	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1620C>T; p.I540I; 18:79451023-79451023	skin	malignant_melanoma	Substitution - coding silent
c.298C>T; p.P100S; 18:79410612-79410612	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.132G>T; p.P44P; 18:79410446-79410446	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - coding silent
c.2125delT; p.L709fs*1; 18:79486319-79486319	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.2690C>T; p.P897L; 18:79486884-79486884	skin	malignant_melanoma	Substitution - Missense
c.1818C>A; p.H606Q; 18:79451770-79451770	breast	carcinoma	Substitution - Missense
c.664C>T; p.R222W; 18:79410978-79410978	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1158_1159insA; p.P388fs*27; 18:79411472-79411473	urinary_tract; bladder	carcinoma; transitional_cell_carcinoma	Insertion - Frameshift
c.460G>C; p.D154H; 18:79410774-79410774	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.870C>A; p.N290K; 18:79411184-79411184	endometrium	carcinoma; serous_carcinoma	Substitution - Missense
c.1476C>T; p.T492T; 18:79448910-79448910	prostate	carcinoma	Substitution - coding silent
c.2755A>T; p.I919L; 18:79527539-79527539	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.391G>A; p.V131I; 18:79410705-79410705	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2776A>G; p.T926A; 18:79527560-79527560	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.552C>T; p.Y184Y; 18:79410866-79410866	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1686G>A; p.T562T; 18:79451089-79451089	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1812T>C; p.S604S; 18:79451764-79451764	liver	carcinoma; hepatocellular_carcinoma	Substitution - coding silent
c.1808T>C; p.L603P; 18:79451760-79451760	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.115G>A; p.V39I; 18:79410429-79410429	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2269G>T; p.D757Y; 18:79486463-79486463	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1111G>A; p.D371N; 18:79411425-79411425	liver	carcinoma	Substitution - Missense
c.1111G>A; p.D371N; 18:79411425-79411425	liver	carcinoma	Substitution - Missense
c.1111G>A; p.D371N; 18:79411425-79411425	liver	carcinoma	Substitution - Missense
c.1716C>T; p.I572I; 18:79451119-79451119	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1474A>C; p.T492P; 18:79448908-79448908	breast	carcinoma	Substitution - Missense
c.2759G>A; p.R920Q; 18:79527543-79527543	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.746C>T; p.P249L; 18:79411060-79411060	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.529G>A; p.E177K; 18:79410843-79410843	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2510C>G; p.P837R; 18:79486704-79486704	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.557delC; p.Q188fs*95; 18:79410871-79410871	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2759G>A; p.R920Q; 18:79527543-79527543	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.625C>T; p.P209S; 18:79410939-79410939	skin	malignant_melanoma	Substitution - Missense
c.149C>G; p.S50C; 18:79410463-79410463	parathyroid	carcinoma	Substitution - Missense
c.423G>A; p.T141T; 18:79410737-79410737	oesophagus; lower_third	carcinoma; adenocarcinoma	Substitution - coding silent
c.706G>T; p.E236*; 18:79411020-79411020	lung	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1657G>A; p.V553I; 18:79451060-79451060	breast	carcinoma	Substitution - Missense
c.1093A>T; p.R365W; 18:79411407-79411407	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1614G>A; p.T538T; 18:79451017-79451017	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1112A>G; p.D371G; 18:79411426-79411426	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.2165C>T; p.A722V; 18:79486359-79486359	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.628C>A; p.R210S; 18:79410942-79410942	prostate	carcinoma; adenocarcinoma	Substitution - Missense
c.686C>T; p.P229L; 18:79411000-79411000	skin	malignant_melanoma	Substitution - Missense
c.1813G>T; p.G605C; 18:79451765-79451765	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1164C>T; p.P388P; 18:79411478-79411478	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.951C>T; p.G317G; 18:79411265-79411265	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.537C>A; p.N179K; 18:79410851-79410851	liver	carcinoma	Substitution - Missense
c.537C>A; p.N179K; 18:79410851-79410851	liver	carcinoma	Substitution - Missense
c.1536C>G; p.N512K; 18:79448970-79448970	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1189C>T; p.P397S; 18:79433580-79433580	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.258C>A; p.G86G; 18:79410572-79410572	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.553G>A; p.A185T; 18:79410867-79410867	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.952G>A; p.V318I; 18:79411266-79411266	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.952G>A; p.V318I; 18:79411266-79411266	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1400C>T; p.T467M; 18:79448834-79448834	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1400C>T; p.T467M; 18:79448834-79448834	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.2199C>T; p.A733A; 18:79486393-79486393	prostate	carcinoma	Substitution - coding silent
c.2085T>G; p.D695E; 18:79486279-79486279	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.706G>A; p.E236K; 18:79411020-79411020	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.107C>T; p.S36F; 18:79410421-79410421	skin	malignant_melanoma	Substitution - Missense
c.1392C>A; p.F464L; 18:79448826-79448826	pancreas	carcinoid-endocrine_tumour	Substitution - Missense
c.1298G>A; p.G433D; 18:79433689-79433689	breast	carcinoma	Substitution - Missense
c.1730G>A; p.R577H; 18:79451682-79451682	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1893G>A; p.A631A; 18:79461339-79461339	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1420C>T; p.R474C; 18:79448854-79448854	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1246C>T; p.R416W; 18:79433637-79433637	liver	carcinoma	Substitution - Missense
c.1925C>A; p.S642Y; 18:79467454-79467454	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1925C>A; p.S642Y; 18:79467454-79467454	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1925C>A; p.S642Y; 18:79467454-79467454	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1681C>T; p.R561C; 18:79451084-79451084	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.1191G>A; p.P397P; 18:79433582-79433582	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1817A>G; p.H606R; 18:79451769-79451769	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1054G>A; p.D352N; 18:79411368-79411368	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.987G>A; p.Q329Q; 18:79411301-79411301	pancreas	carcinoma	Substitution - coding silent
c.684G>A; p.S228S; 18:79410998-79410998	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.684G>A; p.S228S; 18:79410998-79410998	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.136_137CC>TT; p.P46F; 18:79410450-79410451	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2029C>T; p.R677C; 18:79467558-79467558	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.549G>A; p.P183P; 18:79410863-79410863	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.549G>A; p.P183P; 18:79410863-79410863	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1470C>T; p.S490S; 18:79448904-79448904	skin	malignant_melanoma	Substitution - coding silent
c.1342G>A; p.V448M; 18:79433733-79433733	large_intestine; colon	adenoma	Substitution - Missense
c.2493C>T; p.P831P; 18:79486687-79486687	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.1629G>T; p.K543N; 18:79451032-79451032	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.163C>T; p.P55S; 18:79410477-79410477	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1740G>T; p.Q580H; 18:79451692-79451692	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2036C>T; p.T679I; 18:79467565-79467565	pancreas	carcinoma	Substitution - Missense
c.1649T>G; p.V550G; 18:79451052-79451052	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2036C>T; p.T679I; 18:79467565-79467565	pancreas	carcinoma	Substitution - Missense
c.2036C>T; p.T679I; 18:79467565-79467565	pancreas	carcinoma	Substitution - Missense
c.1649T>G; p.V550G; 18:79451052-79451052	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1649T>G; p.V550G; 18:79451052-79451052	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2036C>T; p.T679I; 18:79467565-79467565	pancreas	carcinoma	Substitution - Missense
c.2036C>T; p.T679I; 18:79467565-79467565	pancreas	carcinoma	Substitution - Missense
c.2577G>A; p.T859T; 18:79486771-79486771	pancreas	carcinoma	Substitution - coding silent
c.2177A>G; p.D726G; 18:79486371-79486371	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm	Substitution - Missense
c.1304delG; p.A437fs*2; 18:79433695-79433695	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2058A>G; p.P686P; 18:79486252-79486252	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1825C>T; p.L609L; 18:79451777-79451777	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.2186C>G; p.S729C; 18:79486380-79486380	urinary_tract; bladder	carcinoma	Substitution - Missense
c.2134C>T; p.L712F; 18:79486328-79486328	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1171C>T; p.P391S; 18:79411485-79411485	skin	malignant_melanoma	Substitution - Missense
c.1066G>A; p.E356K; 18:79411380-79411380	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.990G>A; p.P330P; 18:79411304-79411304	soft_tissue; striated_muscle	rhabdoid_tumour	Substitution - coding silent
c.2175C>T; p.P725P; 18:79486369-79486369	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - coding silent
c.2175C>T; p.P725P; 18:79486369-79486369	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.214C>T; p.H72Y; 18:79410528-79410528	skin	malignant_melanoma	Substitution - Missense
c.2250C>T; p.G750G; 18:79486444-79486444	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1301G>T; p.S434I; 18:79433692-79433692	liver	carcinoma	Substitution - Missense
c.1301G>T; p.S434I; 18:79433692-79433692	liver	carcinoma	Substitution - Missense
c.1320G>A; p.A440A; 18:79433711-79433711	breast	carcinoma	Substitution - coding silent
c.1744C>T; p.L582L; 18:79451696-79451696	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1212G>A; p.W404*; 18:79433603-79433603	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.2598G>A; p.P866P; 18:79486792-79486792	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2359G>A; p.V787I; 18:79486553-79486553	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1212G>A; p.W404*; 18:79433603-79433603	large_intestine	carcinoma; adenocarcinoma	Substitution - Nonsense
c.1565G>C; p.G522A; 18:79450968-79450968	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1428C>T; p.H476H; 18:79448862-79448862	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.2046C>T; p.P682P; 18:79467575-79467575	central_nervous_system; brain	glioma	Substitution - coding silent
c.1269C>G; p.S423S; 18:79433660-79433660	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1993G>A; p.V665I; 18:79467522-79467522	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1993G>A; p.V665I; 18:79467522-79467522	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.2213G>A; p.C738Y; 18:79486407-79486407	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.2053+8C>A; p.?; 18:79467590-79467590	liver	carcinoma	Unknown
c.2053+8C>A; p.?; 18:79467590-79467590	liver	carcinoma; hepatocellular_carcinoma	Unknown
c.1921-1G>C; p.?; 18:79467449-79467449	lung; right_lower_lobe	carcinoma; adenocarcinoma	Unknown
c.353A>G; p.N118S; 18:79410667-79410667	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.566C>T; p.T189M; 18:79410880-79410880	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1920+1G>A; p.?; 18:79461367-79461367	skin	malignant_melanoma	Unknown
c.1061C>T; p.A354V; 18:79411375-79411375	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense

Mutation summary in protein domains

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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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Loss of Function mutations compare to missense mutations

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The copy number variations for various cancers

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COSMIC somatic mutation [Top]