Entrez Gene

Basic Information
Gene ID	4773
Name	NFATC2
Synonymous	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2;NFATC2;nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
Definition	NF-ATc2\|NFAT pre-existing subunit\|NFAT transcription complex, preexisting component\|T cell transcription factor NFAT1\|T-cell transcription factor NFAT1\|nuclear factor of activated T-cells, cytoplasmic 2\|nuclear factor of activated T-cells, preexisting com
Position	20q13.2
Gene Type	protein-coding
Mutation summary:	Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72

Mutation summary in protein domains

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

Loss of Function mutations compare to missense mutations

Top

The ratio of the loss-of-function mutations over missense mutations is 0.06.

The copy number variations for various cancers

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

Mutation (CDS; AA; Chr)	Site	Histology	Mutation Type
COSMIC somatic mutation [Top]
c.249_250insC; p.G84fs*8; 20:51523991-51523992	large_intestine	carcinoma; adenocarcinoma	Insertion - Frameshift
c.1199C>T; p.P400L; 20:51516917-51516917	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1115C>T; p.P372L; 20:51523126-51523126	oesophagus; middle_third	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1028G>A; p.R343H; 20:51523213-51523213	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1028G>A; p.R343H; 20:51523213-51523213	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1516A>C; p.K506Q; 20:51475477-51475477	prostate	carcinoma	Substitution - Missense
c.1516A>C; p.K506Q; 20:51475477-51475477	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.887delC; p.P296fs*7; 20:51523354-51523354	stomach	carcinoma; intestinal_adenocarcinoma	Deletion - Frameshift
c.1516A>C; p.K506Q; 20:51475477-51475477	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1494C>T; p.V498V; 20:51475499-51475499	skin	malignant_melanoma	Substitution - coding silent
c.2675T>G; p.V892G; 20:51432114-51432114	breast	carcinoma	Substitution - Missense
c.1880C>T; p.T627M; 20:51435731-51435731	pancreas	carcinoma	Substitution - Missense
c.1905C>T; p.P635P; 20:51435706-51435706	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1880C>T; p.T627M; 20:51435731-51435731	pancreas	carcinoma	Substitution - Missense
c.1905C>T; p.P635P; 20:51435706-51435706	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1905C>T; p.P635P; 20:51435706-51435706	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2466C>T; p.C822C; 20:51432323-51432323	breast	carcinoma	Substitution - coding silent
c.1000G>A; p.A334T; 20:51523241-51523241	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.346A>T; p.T116S; 20:51523895-51523895	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; hairy_cell_leukaemia	Substitution - Missense
c.1075G>A; p.E359K; 20:51523166-51523166	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1075G>A; p.E359K; 20:51523166-51523166	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1994G>A; p.R665K; 20:51435226-51435226	skin; trunk	malignant_melanoma	Substitution - Missense
c.2348C>T; p.S783F; 20:51432441-51432441	pancreas	carcinoma	Substitution - Missense
c.2304G>A; p.P768P; 20:51432485-51432485	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.154G>A; p.A52T; 20:51524087-51524087	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.154G>A; p.A52T; 20:51524087-51524087	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.154G>A; p.A52T; 20:51524087-51524087	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1337A>G; p.H446R; 20:51475656-51475656	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2623G>A; p.A875T; 20:51432166-51432166	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.1672G>A; p.V558I; 20:51474016-51474016	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.977G>A; p.S326N; 20:51523264-51523264	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1944G>T; p.K648N; 20:51435276-51435276	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1288C>T; p.R430*; 20:51516828-51516828	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Nonsense
c.2750C>T; p.S917L; 20:51391424-51391424	skin	malignant_melanoma	Substitution - Missense
c.1288C>T; p.R430*; 20:51516828-51516828	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Nonsense
c.950G>A; p.G317E; 20:51523291-51523291	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.175G>A; p.A59T; 20:51524066-51524066	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2772G>T; p.Q924H; 20:51391402-51391402	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.99C>A; p.L33L; 20:51542401-51542401	lung	carcinoma; small_cell_carcinoma	Substitution - coding silent
c.175G>A; p.A59T; 20:51524066-51524066	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.950G>A; p.G317E; 20:51523291-51523291	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.366C>G; p.I122M; 20:51523875-51523875	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.711C>A; p.P237P; 20:51523530-51523530	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2391G>T; p.L797L; 20:51432398-51432398	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.182C>T; p.P61L; 20:51524059-51524059	skin	malignant_melanoma	Substitution - Missense
c.1923G>A; p.E641E; 20:51435297-51435297	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - coding silent
c.718C>G; p.R240G; 20:51523523-51523523	urinary_tract; bladder	carcinoma	Substitution - Missense
c.701_702insC; p.H235fs*94; 20:51523539-51523540	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Insertion - Frameshift
c.1433G>A; p.R478Q; 20:51475560-51475560	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1433G>A; p.R478Q; 20:51475560-51475560	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.590G>A; p.G197E; 20:51523651-51523651	skin; scalp	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2199G>A; p.T733T; 20:51432590-51432590	skin	malignant_melanoma	Substitution - coding silent
c.1535C>T; p.T512I; 20:51475458-51475458	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.2660T>C; p.V887A; 20:51432129-51432129	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.2034C>T; p.V678V; 20:51432755-51432755	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1498G>A; p.E500K; 20:51475495-51475495	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.469G>A; p.G157S; 20:51523772-51523772	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.571G>A; p.V191I; 20:51523670-51523670	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.831G>T; p.P277P; 20:51523410-51523410	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.698G>A; p.G233D; 20:51523543-51523543	liver	carcinoma	Substitution - Missense
c.963G>T; p.K321N; 20:51523278-51523278	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1505C>A; p.P502H; 20:51475488-51475488	breast	carcinoma	Substitution - Missense
c.2674delG; p.V892fs*1; 20:51432115-51432115	large_intestine; colon	carcinoma; adenocarcinoma	Deletion - Frameshift
c.2070C>G; p.D690E; 20:51432719-51432719	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.21G>A; p.Q7Q; 20:51542479-51542479	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.842C>T; p.S281F; 20:51523399-51523399	skin	malignant_melanoma	Substitution - Missense
c.960_961insC; p.K321fs*8; 20:51523280-51523281	large_intestine; colon	carcinoma; adenocarcinoma	Insertion - Frameshift
c.366C>T; p.I122I; 20:51523875-51523875	skin	malignant_melanoma	Substitution - coding silent
c.2082C>T; p.I694I; 20:51432707-51432707	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2571G>A; p.P857P; 20:51432218-51432218	lung	carcinoma; adenocarcinoma	Substitution - coding silent
c.2776T>C; p.*926Q; 20:51391398-51391398	endometrium	carcinoma; endometrioid_carcinoma	Nonstop extension
c.1065C>T; p.C355C; 20:51523176-51523176	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2450A>G; p.N817S; 20:51432339-51432339	skin	malignant_melanoma	Substitution - Missense
c.2344C>T; p.R782C; 20:51432445-51432445	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1921G>A; p.E641K; 20:51435299-51435299	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.2511C>T; p.F837F; 20:51432278-51432278	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2511C>T; p.F837F; 20:51432278-51432278	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.989C>T; p.S330L; 20:51523252-51523252	skin; mucosal	malignant_melanoma	Substitution - Missense
c.491C>T; p.P164L; 20:51523750-51523750	kidney	carcinoma; clear_cell_renal_cell_carcinoma	Substitution - Missense
c.534C>A; p.F178L; 20:51523707-51523707	urinary_tract; bladder	carcinoma	Substitution - Missense
c.712G>C; p.V238L; 20:51523529-51523529	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.462C>G; p.P154P; 20:51523779-51523779	skin	malignant_melanoma	Substitution - coding silent
c.2672G>T; p.G891V; 20:51432117-51432117	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.941C>T; p.S314L; 20:51523300-51523300	central_nervous_system; brain	glioma	Substitution - Missense
c.2334G>A; p.A778A; 20:51432455-51432455	breast	carcinoma	Substitution - coding silent
c.1782G>A; p.Q594Q; 20:51454615-51454615	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - coding silent
c.2099G>T; p.G700V; 20:51432690-51432690	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1460_1462delCCA; p.T487delT; 20:51475531-51475533	thyroid	carcinoma; anaplastic_carcinoma	Deletion - In frame
c.668G>A; p.R223Q; 20:51523573-51523573	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1546G>T; p.A516S; 20:51474142-51474142	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1044C>T; p.A348A; 20:51523197-51523197	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1382G>A; p.G461E; 20:51475611-51475611	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.280C>T; p.P94S; 20:51523961-51523961	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2048C>T; p.T683M; 20:51432741-51432741	pancreas	carcinoma	Substitution - Missense
c.2248G>A; p.V750I; 20:51432541-51432541	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1261C>T; p.R421W; 20:51516855-51516855	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1377C>T; p.F459F; 20:51475616-51475616	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.648C>T; p.T216T; 20:51523593-51523593	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.1233G>A; p.R411R; 20:51516883-51516883	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.223C>T; p.L75F; 20:51524018-51524018	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1869G>A; p.E623E; 20:51435742-51435742	liver	carcinoma	Substitution - coding silent
c.1869G>A; p.E623E; 20:51435742-51435742	liver	carcinoma	Substitution - coding silent
c.836C>A; p.P279H; 20:51523405-51523405	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.667C>T; p.R223*; 20:51523574-51523574	skin	malignant_melanoma	Substitution - Nonsense
c.878G>C; p.G293A; 20:51523363-51523363	kidney	carcinoma; papillary_renal_cell_carcinoma	Substitution - Missense
c.1887T>C; p.D629D; 20:51435724-51435724	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1887T>C; p.D629D; 20:51435724-51435724	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1887T>C; p.D629D; 20:51435724-51435724	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.2715G>A; p.L905L; 20:51432074-51432074	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.754C>T; p.R252W; 20:51523487-51523487	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.986C>T; p.P329L; 20:51523255-51523255	skin	malignant_melanoma	Substitution - Missense
c.430G>A; p.G144R; 20:51523811-51523811	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2146G>A; p.E716K; 20:51432643-51432643	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2146G>A; p.E716K; 20:51432643-51432643	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1626G>C; p.V542V; 20:51474062-51474062	breast	carcinoma	Substitution - coding silent
c.1287C>T; p.S429S; 20:51516829-51516829	skin	malignant_melanoma	Substitution - coding silent
c.105C>T; p.D35D; 20:51542395-51542395	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.2209T>C; p.S737P; 20:51432580-51432580	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1079G>T; p.R360M; 20:51523162-51523162	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1115C>A; p.P372Q; 20:51523126-51523126	skin; trunk	malignant_melanoma	Substitution - Missense
c.978C>T; p.S326S; 20:51523263-51523263	oesophagus	carcinoma; adenocarcinoma	Substitution - coding silent
c.2221C>T; p.R741C; 20:51432568-51432568	upper_aerodigestive_tract; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2758C>T; p.P920S; 20:51391416-51391416	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2536_2537CC>TT; p.P846L; 20:51432252-51432253	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.736T>G; p.S246A; 20:51523505-51523505	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.592_594delCCC; p.P198delP; 20:51523647-51523649	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Deletion - In frame
c.299C>T; p.A100V; 20:51523942-51523942	ovary	other; neoplasm	Substitution - Missense
c.299C>T; p.A100V; 20:51523942-51523942	pancreas	carcinoma	Substitution - Missense
c.299C>T; p.A100V; 20:51523942-51523942	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1117C>A; p.P373T; 20:51523124-51523124	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1547C>T; p.A516V; 20:51474141-51474141	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.792G>A; p.P264P; 20:51523449-51523449	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.394G>A; p.D132N; 20:51523847-51523847	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2194C>T; p.R732C; 20:51432595-51432595	skin	malignant_melanoma	Substitution - Missense
c.111G>C; p.E37D; 20:51542389-51542389	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.1777G>A; p.G593S; 20:51454620-51454620	stomach	carcinoma; diffuse_adenocarcinoma	Substitution - Missense
c.1685C>A; p.T562N; 20:51474003-51474003	breast	carcinoma; basal_(triple-negative)_carcinoma	Substitution - Missense
c.810G>T; p.Q270H; 20:51523431-51523431	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.131-1G>A; p.?; 20:51524111-51524111	urinary_tract; bladder	carcinoma	Unknown
c.2260C>T; p.R754W; 20:51432529-51432529	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_leukaemia	Substitution - Missense
c.1987G>T; p.G663W; 20:51435233-51435233	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2260C>T; p.R754W; 20:51432529-51432529	haematopoietic_and_lymphoid_tissue	lymphoid_neoplasm; acute_lymphoblastic_T_cell_leukaemia	Substitution - Missense
c.2260C>T; p.R754W; 20:51432529-51432529	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.893C>G; p.A298G; 20:51523348-51523348	urinary_tract; bladder	carcinoma	Substitution - Missense
c.1992G>C; p.K664N; 20:51435228-51435228	breast	carcinoma	Substitution - Missense
c.2613C>T; p.S871S; 20:51432176-51432176	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.2630A>G; p.N877S; 20:51432159-51432159	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.266C>T; p.P89L; 20:51523975-51523975	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.266C>T; p.P89L; 20:51523975-51523975	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.321G>A; p.S107S; 20:51523920-51523920	ovary	carcinoma; serous_carcinoma	Substitution - coding silent
c.2596C>T; p.Q866*; 20:51432193-51432193	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Nonsense
c.429C>T; p.A143A; 20:51523812-51523812	breast	carcinoma	Substitution - coding silent
c.1621C>A; p.R541R; 20:51474067-51474067	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1489A>G; p.K497E; 20:51475504-51475504	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.320C>T; p.S107L; 20:51523921-51523921	ovary	other; neoplasm	Substitution - Missense
c.1011C>T; p.S337S; 20:51523230-51523230	skin	malignant_melanoma	Substitution - coding silent
c.2261G>A; p.R754Q; 20:51432528-51432528	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.884C>T; p.P295L; 20:51523357-51523357	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.2723-4G>T; p.?; 20:51391455-51391455	liver	carcinoma; hepatocellular_carcinoma	Unknown
c.222C>T; p.P74P; 20:51524019-51524019	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.865G>A; p.G289S; 20:51523376-51523376	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1509G>T; p.L503F; 20:51475484-51475484	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.865G>A; p.G289S; 20:51523376-51523376	urinary_tract; bladder	carcinoma	Substitution - Missense
c.731G>A; p.R244H; 20:51523510-51523510	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1598C>T; p.T533M; 20:51474090-51474090	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1937G>C; p.R646P; 20:51435283-51435283	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.796G>A; p.G266R; 20:51523445-51523445	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.1396C>T; p.R466W; 20:51475597-51475597	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.741G>A; p.S247S; 20:51523500-51523500	thyroid	other; neoplasm	Substitution - coding silent
c.741G>A; p.S247S; 20:51523500-51523500	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.893C>T; p.A298V; 20:51523348-51523348	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - Missense
c.1715G>A; p.R572Q; 20:51454682-51454682	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.777C>T; p.A259A; 20:51523464-51523464	skin	malignant_melanoma	Substitution - coding silent
c.1503A>C; p.I501I; 20:51475490-51475490	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm; acute_myeloid_leukaemia	Substitution - coding silent
c.2046G>A; p.K682K; 20:51432743-51432743	urinary_tract; bladder	carcinoma	Substitution - coding silent
c.1118C>A; p.P373H; 20:51523123-51523123	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.349C>G; p.P117A; 20:51523892-51523892	breast	carcinoma	Substitution - Missense
c.1776C>T; p.G592G; 20:51454621-51454621	thyroid	carcinoma	Substitution - coding silent
c.1776C>T; p.G592G; 20:51454621-51454621	prostate	carcinoma; adenocarcinoma	Substitution - coding silent
c.224T>C; p.L75P; 20:51524017-51524017	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.818G>T; p.R273L; 20:51523423-51523423	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.854C>A; p.P285H; 20:51523387-51523387	autonomic_ganglia	neuroblastoma	Substitution - Missense
c.2528G>A; p.R843K; 20:51432261-51432261	liver	carcinoma	Substitution - Missense
c.221C>T; p.P74L; 20:51524020-51524020	skin; trunk	malignant_melanoma; nodular	Substitution - Missense
c.666T>C; p.P222P; 20:51523575-51523575	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.666T>C; p.P222P; 20:51523575-51523575	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.1321C>T; p.P441S; 20:51516795-51516795	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1553T>C; p.I518T; 20:51474135-51474135	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.269A>G; p.D90G; 20:51523972-51523972	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1553T>C; p.I518T; 20:51474135-51474135	ovary	carcinoma; serous_carcinoma	Substitution - Missense
c.801C>T; p.A267A; 20:51523440-51523440	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.1734C>T; p.P578P; 20:51454663-51454663	lung	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.438C>T; p.A146A; 20:51523803-51523803	pancreas	carcinoma	Substitution - coding silent
c.1909A>G; p.M637V; 20:51435311-51435311	urinary_tract; bladder	carcinoma	Substitution - Missense
c.701G>A; p.R234H; 20:51523540-51523540	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.268G>A; p.D90N; 20:51523973-51523973	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.268G>T; p.D90Y; 20:51523973-51523973	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.977G>T; p.S326I; 20:51523264-51523264	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Missense
c.1175C>T; p.A392V; 20:51516941-51516941	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1602C>T; p.D534D; 20:51474086-51474086	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.2000G>A; p.R667Q; 20:51435220-51435220	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.811C>A; p.R271S; 20:51523430-51523430	stomach	carcinoma; intestinal_adenocarcinoma	Substitution - Missense
c.1573G>A; p.D525N; 20:51474115-51474115	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2079G>T; p.L693L; 20:51432710-51432710	breast	carcinoma	Substitution - coding silent
c.2011C>T; p.Q671*; 20:51435209-51435209	urinary_tract; bladder	carcinoma	Substitution - Nonsense
c.421C>T; p.P141S; 20:51523820-51523820	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.282G>A; p.P94P; 20:51523959-51523959	large_intestine	carcinoma; adenocarcinoma	Substitution - coding silent
c.791C>T; p.P264L; 20:51523450-51523450	oesophagus	carcinoma; adenocarcinoma	Substitution - Missense
c.791C>T; p.P264L; 20:51523450-51523450	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - Missense
c.647C>G; p.T216S; 20:51523594-51523594	skin; leg	malignant_melanoma	Substitution - Missense
c.1936C>T; p.R646W; 20:51435284-51435284	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.474C>T; p.F158F; 20:51523767-51523767	skin	malignant_melanoma	Substitution - coding silent
c.474C>T; p.F158F; 20:51523767-51523767	pancreas	carcinoma	Substitution - coding silent
c.1977C>T; p.Y659Y; 20:51435243-51435243	stomach	carcinoma; adenocarcinoma	Substitution - coding silent
c.1977C>T; p.Y659Y; 20:51435243-51435243	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - coding silent
c.610C>T; p.Q204*; 20:51523631-51523631	skin	malignant_melanoma	Substitution - Nonsense
c.1725C>A; p.H575Q; 20:51454672-51454672	soft_tissue; striated_muscle	rhabdomyosarcoma; embryonal	Substitution - Missense
c.12C>T; p.P4P; 20:51542488-51542488	skin	malignant_melanoma	Substitution - coding silent
c.877G>T; p.G293W; 20:51523364-51523364	liver	carcinoma	Substitution - Missense
c.1413C>T; p.H471H; 20:51475580-51475580	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1460C>G; p.T487S; 20:51475533-51475533	large_intestine; colon	carcinoma; adenocarcinoma	Substitution - Missense
c.2423C>T; p.S808L; 20:51432366-51432366	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1441G>A; p.G481R; 20:51475552-51475552	skin	malignant_melanoma	Substitution - Missense
c.2775G>A; p.T925T; 20:51391399-51391399	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.952A>T; p.I318F; 20:51523289-51523289	liver	carcinoma	Substitution - Missense
c.1441G>A; p.G481R; 20:51475552-51475552	skin	malignant_melanoma	Substitution - Missense
c.2423C>T; p.S808L; 20:51432366-51432366	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.2775G>A; p.T925T; 20:51391399-51391399	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.952A>T; p.I318F; 20:51523289-51523289	liver	carcinoma	Substitution - Missense
c.340G>T; p.E114*; 20:51523901-51523901	lung; right_upper_lobe	carcinoma; adenocarcinoma	Substitution - Nonsense
c.935C>T; p.T312M; 20:51523306-51523306	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.935C>T; p.T312M; 20:51523306-51523306	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.904G>T; p.V302L; 20:51523337-51523337	lung	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.1535+1G>A; p.?; 20:51475457-51475457	central_nervous_system; brain	glioma	Unknown
c.1527G>T; p.M509I; 20:51475466-51475466	lung	carcinoma; adenocarcinoma	Substitution - Missense
c.1134G>A; p.P378P; 20:51523107-51523107	large_intestine; caecum	carcinoma; adenocarcinoma	Substitution - coding silent
c.1677T>C; p.S559S; 20:51474011-51474011	endometrium	carcinoma; endometrioid_carcinoma	Substitution - coding silent
c.955C>T; p.P319S; 20:51523286-51523286	skin	malignant_melanoma	Substitution - Missense
c.2525C>T; p.T842I; 20:51432264-51432264	skin	malignant_melanoma	Substitution - Missense
c.2696A>G; p.N899S; 20:51432093-51432093	endometrium	carcinoma; endometrioid_carcinoma	Substitution - Missense
c.1585C>T; p.R529W; 20:51474103-51474103	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.729C>T; p.S243S; 20:51523512-51523512	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.1232G>A; p.R411Q; 20:51516884-51516884	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.1014G>A; p.K338K; 20:51523227-51523227	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - coding silent
c.420G>A; p.P140P; 20:51523821-51523821	central_nervous_system; brain	glioma; astrocytoma_Grade_IV	Substitution - coding silent
c.2563C>T; p.L855L; 20:51432226-51432226	skin	malignant_melanoma	Substitution - coding silent
c.2328_2329CC>TT; p.L777F; 20:51432460-51432461	skin; head_neck	carcinoma; squamous_cell_carcinoma	Substitution - Missense
c.2719G>T; p.D907Y; 20:51432070-51432070	large_intestine; rectum	carcinoma; adenocarcinoma	Substitution - Missense
c.811C>T; p.R271C; 20:51523430-51523430	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.811C>T; p.R271C; 20:51523430-51523430	stomach	carcinoma; adenocarcinoma	Substitution - Missense
c.2719G>T; p.D907Y; 20:51432070-51432070	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1073G>A; p.G358D; 20:51523168-51523168	large_intestine	carcinoma; adenocarcinoma	Substitution - Missense
c.1053C>T; p.F351F; 20:51523188-51523188	skin	malignant_melanoma	Substitution - coding silent
c.2638C>T; p.P880S; 20:51432151-51432151	lung	carcinoma; small_cell_carcinoma	Substitution - Missense
c.2293T>C; p.Y765H; 20:51432496-51432496	skin	malignant_melanoma	Substitution - Missense

Mutation summary in protein domains

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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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Loss of Function mutations compare to missense mutations

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The copy number variations for various cancers

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COSMIC somatic mutation [Top]