| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 4773 |
Name | NFATC2 |
Synonymous | NFAT1|NFATP;nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2;NFATC2;nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 |
Definition | NF-ATc2|NFAT pre-existing subunit|NFAT transcription complex, preexisting component|T cell transcription factor NFAT1|T-cell transcription factor NFAT1|nuclear factor of activated T-cells, cytoplasmic 2|nuclear factor of activated T-cells, preexisting com |
Position | 20q13.2 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
calcineurin(h) + NF-AT1(h) <==> calcineurin(h):NF-AT1(h) (binding) | PKCzeta(v.s.) + NF-AT1(h) <==> PKCzeta(v.s.):NF-AT1(h) (binding) | NF-AT1(h) + ATP --PKCzeta(v.s.)--> NF-AT1(h){p} + ADP (phosphorylation) | NF-AT1(h) + ATP --JNK1(h)--> NF-AT1(h){p} + ADP (phosphorylation) | NF-AT1(h) --> IL-4(h) (DNA binding; transactivation). | NF-AT1(h) --> EGR3(h) (DNA binding; transactivation). | NF-AT1(h) --> ICAM1(h) (DNA binding). | NF-AT1(h) + C/EBPalpha(h) <==> NF-AT1(h):C/EBPalpha(h) (binding; assembly; interaction) | NF-AT1(h) + C/EBPbeta(h) <==> NF-AT1(h):C/EBPbeta(h) (interaction; assembly; binding) | NF-AT1(h) + TAF(II)135(h) <==> NF-AT1(h):TAF(II)135(h) (assembly; binding; interaction) | NF-AT1(h) + CBP(h) <==> NF-AT1(h):CBP(h) (assembly; binding; interaction) | NF-AT1(h) --> CSF2(h) (DNA binding; transactivation). | NF-AT1(h) --> IL2(h) (DNA binding; transactivation). | NF-AT1(h) --> TNF(h) (DNA binding; transactivation). | NF-AT1(h) --> Il2(m) (DNA binding). | NF-AT1(h) --> IRF4(h) (DNA binding). | NF-AT1(h) --> ITGB3(h) (DNA binding). | NF-AT1(h) --> FCER2(h) (DNA binding). | NF-AT1(h) --> Il4(m) (DNA binding). | NF-AT1(h) --> Nfatc1(m) (transactivation) | NF-AT1(h) --> MMP1(h) (DNA binding). | NF-AT1(h) --> IL-5(h) (DNA binding). | NF-AT1(h) --> CD40LG(h) (DNA binding). | NF-AT1(h) --> FASLG(h) (DNA binding). | NF-AT1(h) --> SCYC1(h) (DNA binding). | NF-AT1(h) --> IL17A(h) (DNA binding). | NF-AT1(h) --> IL12RB2(h) (DNA binding). | NF-AT1(h) --> BACE1(h) (DNA binding). | NF-AT1(h) --> CTLA4(h) (DNA binding). | NF-AT1(h) --> F3(h) (DNA binding). | NF-AT1(h) --> TNFSF14(h) (DNA binding). | NF-AT1(h) --> CD3G(h) (DNA binding). | NFATC2(h) --> NF-AT1(h) (expression). | NF-AT1C(h) --> CSF2(h) (DNA binding; transactivation). | NF-AT1C(h) --> IL3(h) (DNA binding; transactivation). | NF-AT1C(h) --> Il2(m) (DNA binding; transactivation). | NF-AT1C(h) --> Ghrh(r) (DNA binding; transactivation). | NFATC2(h) --> NF-AT1C(h) (expression). | TAF(II)31(h) + NF-AT1B(h) <==> TAF(II)31(h):NF-AT1B(h) (binding) | NFATC2(h) --> NF-AT1B(h) (expression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
53 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 56 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 99 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 110 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 168 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 171 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 172 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 174 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 175 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 177 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 180 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 213 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 217 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 221 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 236 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 243 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 268 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 274 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 276 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 280 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 326 | Phosphoserine. | Swiss-Prot 53.0 | 330 | Phosphoserine. | Swiss-Prot 53.0 | 363 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 326 | Phosphoserine | 15144186 | Phospho.ELM 6.0 | 330 | Phosphoserine | 15144186 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr20 |
Promoter: 49592165 - 49594165 | Agilent_014791 |
chr20 |
Promoter: 49592165 - 49594165 | GSE27584 |
chr20 |
Promoter: 49592165 - 49594165 | GSE27584 |
chr20 |
Promoter: 49592165 - 49594165 | Agilent_014791_44K |
chr20 |
Promoter: 49592165 - 49594165 | Agilent_014791 |