Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

50486

Name

G0S2

Synonymous

G0/G1 switch 2;G0S2;G0/G1 switch 2

Definition

G0/G1 switch protein 2|G0/G1 switch regulatory protein 2|G0/G1switch 2

Position

1q32.2

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

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We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.00.

The copy number variations for various cancers

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The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.28C>A; p.L10M; 1:209675712-209675712

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.108C>T; p.F36F; 1:209675792-209675792

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.192G>A; p.A64A; 1:209675876-209675876

 large_intestine; caecumcarcinoma; adenocarcinomaSubstitution - coding silent

c.241C>A; p.Q81K; 1:209675925-209675925

 stomachcarcinoma; adenocarcinomaSubstitution - Missense

c.276C>T; p.G92G; 1:209675960-209675960

 central_nervous_system; braingliomaSubstitution - coding silent

c.126G>A; p.L42L; 1:209675810-209675810

 breastcarcinomaSubstitution - coding silent

c.243G>C; p.Q81H; 1:209675927-209675927

 livercarcinomaSubstitution - Missense

c.295C>A; p.R99R; 1:209675979-209675979

 prostatecarcinoma; adenocarcinomaSubstitution - coding silent

c.26C>T; p.P9L; 1:209675710-209675710

 skinmalignant_melanomaSubstitution - Missense

c.266C>A; p.T89K; 1:209675950-209675950

 breastcarcinomaSubstitution - Missense

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