Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

51247

Name

PAIP2

Synonymous

poly(A) binding protein interacting protein 2;PAIP2;poly(A) binding protein interacting protein 2

Definition

PABC1-interacting protein 2|PABP-interacting protein 2|polyA-binding protein-interacting protein 2|polyadenylate-binding protein-interacting protein 2

Position

5q31.2

Gene Type

protein-coding

Mutation summary:

Mutations in domains
Mutational pattern in 17 major cancer types
LoF vs missense mutations
All the copy number variations from COSMIC database V72
All the mutations from COSMIC database V72

Mutation summary in protein domains

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We used uniprot protein structure data from ensemble BioMart database. The size of circle shows the relative mutation number.

The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers

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The non-synonymous mutational pattern in 17 major cancer types.
The synonymous mutational pattern in 17 major cancer types.

Loss of Function mutations compare to missense mutations

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Loss of Function mutations compare to missense mutation.
The ratio of the loss-of-function mutations over missense mutations is 0.00.

The copy number variations for various cancers

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The copy number variations in 17 major cancer groups: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; NS, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract

COSMIC somatic mutation [Top]

Mutation (CDS; AA; Chr)

Site

Histology

Mutation Type

c.64G>A; p.G22S; 5:139363848-139363848

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.110T>A; p.M37K; 5:139363894-139363894

 kidneyother; neoplasmSubstitution - Missense

c.262C>T; p.Q88*; 5:139364687-139364687

 skinmalignant_melanomaSubstitution - Nonsense

c.262C>T; p.Q88*; 5:139364687-139364687

 skinmalignant_melanomaSubstitution - Nonsense

c.218G>T; p.W73L; 5:139364643-139364643

 prostatecarcinoma; adenocarcinomaSubstitution - Missense

c.233G>A; p.R78Q; 5:139364658-139364658

 large_intestine; coloncarcinoma; adenocarcinomaSubstitution - Missense

c.2T>C; p.M1T; 5:139363786-139363786

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

c.195G>A; p.L65L; 5:139364620-139364620

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - coding silent

c.153A>T; p.L51F; 5:139364578-139364578

 urinary_tract; bladdercarcinomaSubstitution - Missense

c.84C>G; p.D28E; 5:139363868-139363868

 large_intestine; rectumcarcinoma; adenocarcinomaSubstitution - Missense

c.362G>T; p.G121V; 5:139368776-139368776

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.362G>T; p.G121V; 5:139368776-139368776

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.362G>T; p.G121V; 5:139368776-139368776

 large_intestine; coloncarcinomaSubstitution - Missense

c.362G>T; p.G121V; 5:139368776-139368776

 large_intestinecarcinoma; adenocarcinomaSubstitution - Missense

c.329A>T; p.N110I; 5:139368743-139368743

 lung; right_upper_lobecarcinoma; adenocarcinomaSubstitution - Missense

c.374G>A; p.G125E; 5:139368788-139368788

 skin; head_neckcarcinoma; squamous_cell_carcinomaSubstitution - Missense

c.61A>G; p.N21D; 5:139363845-139363845

 skinmalignant_melanomaSubstitution - Missense

c.366G>T; p.V122V; 5:139368780-139368780

 lungcarcinoma; squamous_cell_carcinomaSubstitution - coding silent

c.66T>C; p.G22G; 5:139363850-139363850

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - coding silent

c.250A>G; p.M84V; 5:139364675-139364675

 livercarcinomaSubstitution - Missense

c.250A>G; p.M84V; 5:139364675-139364675

 livercarcinomaSubstitution - Missense

c.63C>T; p.N21N; 5:139363847-139363847

 breastcarcinomaSubstitution - coding silent

c.253G>T; p.D85Y; 5:139364678-139364678

 lungcarcinoma; adenocarcinomaSubstitution - Missense

c.341A>G; p.N114S; 5:139368755-139368755

 kidneycarcinoma; clear_cell_renal_cell_carcinomaSubstitution - Missense

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