| General information | Literature | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 51247 |
Name | PAIP2 |
Synonymous | PAIP-2|PAIP2A;poly(A) binding protein interacting protein 2;PAIP2;poly(A) binding protein interacting protein 2 |
Definition | PABC1-interacting protein 2|PABP-interacting protein 2|polyA-binding protein-interacting protein 2|polyadenylate-binding protein-interacting protein 2 |
Position | 5q31.2 |
Gene type | protein-coding |
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Title |
Abstract |
| Suppression of cellular transformation by poly (A) binding protein interacting protein 2 (Paip2). | Controlling translation is crucial for the homeostasis of a cell. Its deregulation can facilitate the development and progression of many diseases including cancer. Poly (A) binding protein interacting protein 2 (Paip2) inhibits efficient initiation of translation by impairing formation of the necessary closed loop of mRNA. The over production of Paip2 in the presence of a constitutively active form of hRas(V12) can reduce colony formation in a semi-solid matrix and focus formation on a cell monolayer. The ability of Paip2 to bind to Pabp is required to suppress the transformed phenotype mediated by hRas(V12). These observations indicate that Paip2 is able to function as a tumor suppressor. |