| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 51330 |
Name | TNFRSF12A |
Synonymous | tumor necrosis factor receptor superfamily, member 12A;TNFRSF12A;tumor necrosis factor receptor superfamily, member 12A |
Definition | FGF-inducible 14|fibroblast growth factor-inducible immediate-early response protein 14|tumor necrosis factor receptor superfamily member 12A|tweak-receptor|type I transmembrane protein Fn14 |
Position | 16p13.3 |
Gene Type | protein-coding |
Mutation summary: | Mutations in domains Mutational pattern in 17 major cancer types LoF vs missense mutations All the copy number variations from COSMIC database V72 All the mutations from COSMIC database V72 |
Mutation summary in protein domains | Top |
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The non-synonymous (top) and synonymous (bottom) mutational percentage for various cancers | Top |
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Loss of Function mutations compare to missense mutations | Top |
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| The ratio of the loss-of-function mutations over missense mutations is 0.00. |
The copy number variations for various cancers | Top |
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The copy number variations in 17 major cancer types: 1; Breast, 2; Central nervous system, 3; Cervix, 4; Endometrium, 5; Haematopoietic and lymphoid_tissue, 6; Kidney, 7; Large intestine, 8; Liver, 9; Lung, 10; Not specific, 11; Ovary, 12; Pancreas, 13; Prostate, 14; Skin, 15; Stomach, 16; Thyroid, 17; Urinary tract |
COSMIC somatic mutation [Top] | |||
|
Mutation (CDS; AA; Chr) |
Site |
Histology |
Mutation Type |
|---|---|---|---|
c.48G>A; p.G16G; 16:3020445-3020445 |
large_intestine | carcinoma; adenocarcinoma | Substitution - coding silent |
c.301T>A; p.W101R; 16:3021656-3021656 |
pancreas | carcinoma | Substitution - Missense |
c.244C>T; p.L82F; 16:3021599-3021599 |
lung | carcinoma; adenocarcinoma | Substitution - Missense |
c.320G>A; p.R107K; 16:3021675-3021675 |
skin; face | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.221_222CC>TT; p.P74L; 16:3021576-3021577 |
skin; head_neck | carcinoma; squamous_cell_carcinoma | Substitution - Missense |
c.215C>A; p.P72H; 16:3021570-3021570 |
large_intestine | carcinoma; adenocarcinoma | Substitution - Missense |
c.72C>A; p.S24S; 16:3020469-3020469 |
thyroid | other; neoplasm | Substitution - coding silent |
c.274C>T; p.L92L; 16:3021629-3021629 |
large_intestine; caecum | carcinoma; adenocarcinoma | Substitution - coding silent |
c.71C>T; p.S24F; 16:3020468-3020468 |
skin | malignant_melanoma | Substitution - Missense |